Adaptive optics scanning laser ophthalmoscopy in fundus imaging, a review and update

Adaptive optics scanning laser ophthalmoscopy（AOSLO） has been a promising technique in funds imaging with growing popularity. This review firstly gives a brief history of adaptive optics（AO） and AO-SLO. Then it compares AO-SLO with conventional imaging methods（fundus fluorescein angiography, fundus autofluorescence, indocyanine green angiography and optical coherence tomography） and other AO techniques（adaptive optics flood-illumination ophthalmoscopy and adaptive optics optical coherence tomography）. Furthermore, an update of current research situation in AO-SLO is made based on different fundus structures as photoreceptors（cones and rods）, fundus vessels, retinal pigment epithelium layer, retinal nerve fiber layer, ganglion cell layer and lamina cribrosa. Finally, this review indicates possible research directions of AO-SLO in future.

Automated cone photoreceptor cell identication in confocal adaptive optics scanning laser ophthalmoscope images based on object detection

Cone photoreceptor cell identication is important for the early diagnosis of retinopathy.In this study,an object detection algorithm is used for cone cell identication in confocal adaptive optics scanning laser ophthalmoscope(AOSLO)images.An effectiveness evaluation of identication using the proposed method reveals precision,recall,and F_(1)-score of 95.8%,96.5%,and 96.1%,respectively,considering manual identication as the ground truth.Various object detection and identication results from images with different cone photoreceptor cell distributions further demonstrate the performance of the proposed method.Overall,the proposed method can accurately identify cone photoreceptor cells on confocal adaptive optics scanning laser ophthalmoscope images,being comparable to manual identication.

Configuration optimization of laser guide stars and wavefront correctors for multi-conjugation adaptive optics

Multi-conjugation adaptive optics（MCAOs） have been investigated and used in the large aperture optical telescopes for high-resolution imaging with large field of view（FOV）.The atmospheric tomographic phase reconstruction and projection of three-dimensional turbulence volume onto wavefront correctors,such as deformable mirrors（DMs） or liquid crystal wavefront correctors（LCWCs）,is a very important step in the data processing of an MCAO＇s controller.In this paper,a method according to the wavefront reconstruction performance of MCAO is presented to evaluate the optimized configuration of multi laser guide stars（LGSs） and the reasonable conjugation heights of LCWCs.Analytical formulations are derived for the different configurations and are used to generate optimized parameters for MCAO.Several examples are given to demonstrate our LGSs configuration optimization method.Compared with traditional methods,our method has minimum wavefront tomographic error,which will be helpful to get higher imaging resolution at large FOV in MCAO.

Joint Performance for Laser Cutting-welding of Zinc-coated Tailored Blanks

The process of laser bull welding of zinc-coated steel（SGCD3 and WLZn）blanks was presented.whose edges were prepared by laser cutting.The properties of the butt joints.such as tensile strength.bending,stamping.weld shape,and corrosion-resisant were tested.The experiments of laser cutting and welding were carried ont on a custom-made system designed.which is a set of equipment for wide sheet butt welding based on a laser cutting-welding combination process.The experiments proved the technological feasibility of laser butt welding for thin zinc coated steel sheets whose edges were prepared by laser cutting on the same equipment.

Laser vision based adaptive fill control system for TIG welding

The variation of joint groove size during tungsten inert gas （TIG） welding will result in the non-uniform fill of deposited metal. To solve this problem, an adaptive fill control system was developed based on laser vision sensing. The system hardware consists of a modular development kit （MDK） as the real-time image capturing system, a computer as the controller, a D/A conversion card as the interface of controlled variable output, and a DC TIG welding system as the controlled device. The system software is developed and the developed feature extraction algorithm and control strategy are of good accuracy and robustness. Experimental results show that the system can implement adaptive fill of melting metal with high stability, reliability and accuracy. The groove is filled well and the quality of the weld formation satisfies the relevant industry criteria.

A high precision phase reconstruction algorithm for multi-laser guide stars adaptive optics

Adaptive optics（AO） systems are widespread and considered as an essential part of any large aperture telescope for obtaining a high resolution imaging at present.To enlarge the imaging field of view（FOV）,multi-laser guide stars（LGSs） are currently being investigated and used for the large aperture optical telescopes.LGS measurement is necessary and pivotal to obtain the cumulative phase distortion along a target in the multi-LGSs AO system.We propose a high precision phase reconstruction algorithm to estimate the phase for a target with an uncertain turbulence profile based on the interpolation.By comparing with the conventional average method,the proposed method reduces the root mean square（RMS） error from 130 nm to 85 nm with a 30% reduction for narrow FOV.We confirm that such phase reconstruction algorithm is validated for both narrow field AO and wide field AO.

A novel absorptive thin film for laser welding in optoelectronic device capsulation

A kind of absorptive thin film was designed and used in laser welding of SiO2, Si and LiNbO3. This absorptive thin film of three-layer metal-dielectric-metal structure is designed for further reducing the high reflectance of the Nd:YAG laser beam on the surface of the tin layer that is utilized as solder between the transparent parent materials. The actual absorption of laser energy in experiment exceeds 99%. This combination of absorber and solder transformed the laser energy into heat efficiently and decreased the minimum necessary incident laser power transmitting through the transparent parent materials. As a result, the damage of the parent materials, which is suffered from laser transmission, was avoided; On the other hand, mechanical stability of the welded materials had been improved. Experiment had been made to show the difference between welding with and without the absorptive thin film.

激光系统组件化仿真软件EasyLaser

针对国内一直以来缺乏一套能够对复杂激光系统进行全面仿真模拟工具的问题,在成熟仿真模块的基础上,基于组件化建模仿真思想研发了通用易用的激光系统仿真软件EasyLaser。它由通用的组件化建模仿真支撑平台SciSimu和8个仿真组件库构成,具备对光束的光学元件间传输、大气传输、电视成像、自适应光学校正、识别提取跟踪等复杂过程的建模与仿真能力。详细介绍了EasyLaser的物理仿真能力和软件特色,并利用EasyLaser软件搭建仿真光路模型,进行自适应光学系统对大气湍流效应的校正效果的分析和研究。

Research on laser weld penetration monitoring with laser induced plasma signals

In this paper, laser induced plasma signals were analyzed during keyhole welding through three methods. According to the results, the relativity between optical and acoustic signals of plasma is shown when welds are in full-penetration, or partial-penetration and non-penetration.

Laser speckle contrast imaging for monitoring of acutepancreatitis at ischemia-reperfusion injury of thepancreas in rats

The influence of ischemia-reperfusion(I/R)action on pancreatic blood flow(PBF)and the development of acute pancreatitis(AP)in laboratory rats is evaluated in vivo by using the laser speckle contrast imaging(LSCI).Additionally,the optical properties in norm and under condition of AP in rats were assessed using a modied integrating sphere spectrometer and inverse Monte Carlo(IMC)software.The results of the experimental study of microcirculation of the pancreas in 82 rats in the ischemic model are presented.The data obtained conrm the fact that local ischemia and changes in the blood°ow velocity of the main vessels cause and provoke acute pancreatitis.

Development and Demonstration of Australian First Working Sodium Guide Star Laser

The Australian first working sodium guide star laser system has been designed and developed for various astronomical and space-related applications. A completely diode-pumped pulsed system was developed initially followed by a largely fiber-based continuous wave (CW) system operating at 589 nm achieved through a unique wavelength conversion scheme by combining 1342 and 1050 nm through a sum frequency generation process. For the CW system, single-mode laser beams at both 1342 and 1050 nm are achieved from fiber-based seed oscillators and fiber amplifiers. The output power of ~25 W at 1342 nm is achieved from a single frequency fiber Raman amplifier. Output power up to 70 W at 1050 nm is achieved from a Yb-doped fiber pre-amplifier followed by a Yb-doped fiber power amplifier. For the sum frequency generation process, optimum focusing parameters are evaluated and determined. The CW system has generated more than 20 W output power at 589 nm, a circularly polarised beam with a good beam quality, spectral linewidth ≤ 2 MHz, and the laser output locked on the sodium D2 line at 589.159 nm. The system has been successfully demonstrated at EOS Space Research Centre, Mt Stromlo, Canberra, and become the Australian first working sodium guide star laser system.

Welding depth measurement for different mode lasers using optical coherence tomography

Optical coherence tomography(OCT)allows a direct and precise measurement of laser welding depth by coaxially measuring the keyhole depth and can be used for process monitoring and control.When OCT measurement was taken during single-beam laser welding,the keyhole instability of aluminum welding resulted in highly scattered OCT data and complicated the welding depth extraction methods.As a combination of an inner core beam and an outer ring beam,a novel adjustable ring mode(ARM)laser for producing a stable keyhole was applied to the OCT measurement.Different ARM laser power arrangements were conducted on aluminum and copper.The results indicated that the ring beam greatly improved the stability of the core beam-induced keyhole,and smooth welding depth can be extracted from the concentrated OCT data.

Wave-front correction of high-intensity fs laser beams by using closed-loop adaptive optics system

We developed an adaptive optics system to correct the wave-front distortion of an intense fs laser beam from our multi-TW laser system, Jiguang II. In this paper, the instruments of the adaptive optical system are described and the experimental results of the closed-loop wave-front correction are presented. A distorted laser wave-front of 20 wavelengths of P-V values was corrected to 0.15 wavelength of P-V values. The beam quality of the laser system varies from 3.5 diffraction limit to 1.5 diffraction limit.

21.2 kW,1.94 times diffraction-limit quasi-continuouswave laser based on a multi-stage,power-scalable and adaptive optics controlled Yb:YAG masteroscillator-power-amplifier system

A 21.2 kW,1.94 times the diffraction-limit quasi-continuous-wave laser is presented in this Letter based on a multi-stage,power-scalable Yb:YAG master-oscillator-power-amplifier(MOPA)system under adaptive optics(AO)control.The output laser of the MOPA system is a rectangular beam with a length-width ratio of 2:1,a 200μs pulse duration,and a 1000 Hz repetition rate.With the AO control system,the beam quality of the laser is improved from 4.20 to 1.94 times the diffraction limit.To our knowledge,this is the best quality laser in the 20 kW class except for combined lasers.

Automated superpixels-based identification and mosaicking of cone photoreceptor cells for adaptive optics scanning laser ophthalmoscope

An automated superpixels identification/mosaicking method is presented for the analysis of cone photoreceptor cells with the use of adaptive optics scanning laser ophthalmoscope(AO-SLO) images. This is an image oversegmentation method used for the identification and mosaicking of cone photoreceptor cells in AO-SLO images.It includes image denoising, estimation of the cone photoreceptor cell number, superpixels segmentation, merging of superpixels, and final identification and mosaicking processing steps. The effectiveness of the presented method was confirmed based on its comparison with a manual method in terms of precision, recall, and F1-score of 77.3%, 95.2%, and 85.3%, respectively.

Bimorph deformable mirror based adaptive optics scanning laser ophthalmoscope for retina imaging in vivo

A bimorph deformable mirror （DM） with a large stroke of more than 30 μm using 35 actuators is presented and characterized for an adaptive optics （AO） confocal scanning laser ophthalmoscope application. Facilitated with a Shack-Hartmann wavefront sensor, the bimorph DM-based AO operates closed-loop AO corrections for hu- man eyes and reduces wavefront aberrations in most eyes to below 0.1 μm rms. Results from living eyes, including one exhibiting ~5D of myopia and ~2D of astigmatism along with notable high-order aberrations, reveal a prac- tical efficient aberration correction and demonstrate a great benefit for retina imaging, including improving resolution, increasing brightness, and enhancing the contrast of images.

激光技术在塑料加工中的应用与案例

激光技术在工业中应用得到了很大的发展,尤其在塑料加工中应用逐步取代传统的加工方式,这对塑料加工质量和加工效率等都有较好地成效。本文就激光原理、特点与类型作些介绍,围绕了激光技术在塑料加工中应用作了描述,结合对3D打印、切割(打孔)、焊接、表面打标、表面处理、表面清洗等原理和应用案例进行详细分享,并对激光在塑料加工中应用趋势作些预料。

基于BP神经网络薄板P-PAW搭接的间隙自适应工艺参数优化

对大型LNG燃料薄膜舱中1.2 mm厚SUS304L不锈钢板薄板的搭接焊,存在的搭接间隙会带来焊缝成形不良等严重影响船舱安全性的问题。本文通过激光传感器检测搭接间隙变化,设计了不同的峰值电流和焊接速度在不同间隙下的工艺实验,研究了间隙对焊缝成形质量的影响机制;基于BP神经网络建立不同间隙下的脉冲等离子弧焊(P-PAW)的工艺参数和间隙及焊缝成形尺寸之间的拓扑关系模型,通过工艺实验获取模型的训练样本,实现了基于BP神经网络的间隙自适应工艺参数优化系统。结果表明,该系统实现了不同搭接间隙下进行实时工艺参数优化的功能,并对搭接间隙在0~0.6 mm变化时所带来的空洞等缺陷起到了有效的抑制作用,实现了良好的焊接成形一致性控制,提高了在LNG薄膜舱中不锈钢板焊接的自适应能力。

基于投影光瞳分布的星地激光通信波前探测

为了解决星地自由空间光学通信系统中的提前角问题,采用了一种基于光强传输的新型波前探测技术——投影光瞳面分布(Projected Pupil Plane Pattern,PPPP),并通过实验室实验验证了该技术的可行性。PPPP基于TIE光强传输公式,根据不同传输距离下光强分布的变化反解出大气湍流引起的波前畸变。由于PPPP采用的是上行通信激光本身的后向瑞利散射,其测量的大气湍流方向与通信卫星方向一致,因此可以有效解决星地激光通信中的提前角问题。实验模拟了1 m口径的地基望远镜作为上行激光发射装置和后向散射光斑成像设备,通过等效高度分别为10 km和17 km的上行激光后向散射光斑图像来实现对10 km以下大气湍流的波前探测。实验采用的波前畸变模拟装置包括空间光调制器和透明塑料片,实验结果表明,对不同的波前畸变PPPP和通用的夏克-哈特曼波前探测器可以实现相似的波前重构,两者重构相位的残差约为初始相位的30%。

变厚截面材料激光穿透焊接自适应功率控制研究

激光焊接变厚截面板是实现汽车轻量化的有效举措,但在激光焊接过程中,因工艺不稳定易导致焊缝熔透状态不一致,工件焊接质量较差。由于激光功率易于控制且对熔深影响显著,因此从变厚截面板激光焊接过程中的功率控制需求入手,设计了功率控制软硬件系统,完成了功率控制平台的搭建;采用卷积神经网络对同轴图像采集系统获取的小孔穿透孔图像进行分类,依据穿透孔面积分为未熔透、适度熔透和过熔透,采用PID控制系统根据分类结果编码实时改变焊接功率以获得适度熔透状态;通过采用变截面板进行激光焊接功率自适应调控试验,获得了背部余高均匀的焊缝,验证了自适应功率监测和控制算法的有效性。