Transmissive multifocal laser speckle contrast imaging through thick tissue

Laser speckle contrast imaging(LSCI)is a powerful tool for monitoring blood flow changes in tissue or vessels in vivo,but its applications are limited by shallow penetration depth under reflective imaging configuration.The traditional LSCI setup has been used in transmissive imaging for depth extension up to 2l_(t)–3l_(t)(l_(t)is the transport mean free path),but the blood flow estimation is biased due to the depth uncertainty in large depth of field(DOF)images.In this study,we propose a transmissive multifocal LSCI for depth-resolved blood flow in thick tissue,further extending the transmissive LSCI for tissue thickness up to 12lt.The limited-DOF imaging system is applied to the multifocal acquisition,and the depth of the vessel is estimated using a robust visibility parameter V_(r)in the coherent domain.The accuracy and linearity of depth estimation are tested by Monte Carlo simulations.Based on the proposed method,the model of contrast analysis resolving the depth information is established and verified in a phantom experiment.We demonstrated its effectiveness in acquiring depth-resolved vessel structures and flow dynamics in in vivo imaging of chick embryos.

Statistical fluctuations in a saturation laser model with correlated noises

We study the effects of correlations between quantum and pump noises on fluctuations of the laser intensity in a saturation laser model. An approximative Fokker-Planck equation and analytic expressions of the steady-state probability distribution function （SPD） of the laser system are derived. Based on the SPD, the normalized mean, the normalized variance, and the normalized skewness of the steady-state laser intensity are calculated numerically. The results indicate that （i） the correlation strength A of correlated noises always enhances the fluctuation of laser intensity; （ii） the correlation time v of correlated noises strengthens the fluctuation of laser intensity for the below-threshold case but τ weakens it for the above-threshold case.

MODELING OF LASER MACHINING ON POLYMETHYL METHACRYLATE TO FABRICATE MICROFLUIDIC CHIP

The use of a CO2 laser system for fabrication of microfluidic chip on polymethyl methacrylate （PMMA） is presented to reduce fabrication cost and time of chip. The grooving process of the laser system and a model for the depth of microchannels are investigated. The relations between the depth of laser-cut channels and the laser beam power, velocity or the number of passes of the beam along the same channel are evaluated. In the experiments, the laser beam power varies from 0 to 50 W, the laser beam scanning velocity varies from 0 to 1 000 mm/s and the passes vary in the range of 1 to 10 times. Based on the principle of conservation of energy, the influence of the laser beam velocity, the laser power and the number of groove passes are examine. Considering the grooving interval energy loss, a modified mathematical model has been obtained and experimental data show good agreement with the theoretical model. This approach provides a simple way of predicting groove depths. The system provides a cost alternative of the other methods and it is especially useful on research work of rnicrofluidic prototyping due to the short cycle time of production.

Effects of correlations between the real and imaginary parts of quantum noise on intensity fluctuation for a saturation laser model

This paper studies the effects of cross-correlations between the real and imaginary parts of quantum noise on the laser intensity in a saturation laser model. It derives the analytic expressions of the intensity correlation function C（τ） and the associated relaxation time T（C） in the case of a stable locked phase resulting from the cross-correlation λq between the real and imaginary parts of quantum noise. Based on numerical computations it finds that the presence of cross correlations between the real and imaginary parts of quantum noise slow down the decay of intensity fluctuation, i.e., it causes the increase of intensity fluctuation.

Hydrodynamics of Exploding Foil X-Ray Lasers with Time-Dependent Ionization Effect

A simple modified model is presented based on R. A. London＇s self-similarity model on time-independent ionization hydrodynamics of exploding foil X-ray lasers. In our model, the time-dependent ionization effect is under consideration and the average ion charge depends on the temperature. Then we obtain the new scaling laws for temperature, scale length and electron density, which have better agreement with experimental results.

Modeling and analysis of actively Q-switched Fe:ZnSe laser pumped by a 2.8μm fiber laser

A theoretical model concerning active Q-switching of an Fe:ZnSe laser pumped by a continuous-wave(CW)2.8μm fiber laser is developed.Calculations are compared with the recently reported experiment results,and good agreement is achieved.Effects of principal parameters,including pump power,output reflectivity,ion concentration and temperature of crystal,on the laser output performance are investigated and analyzed.Numerical results demonstrate that similar to highly efficient CWFe:ZnSe laser,low temperature of the crystal is significant to obtain high peak power Q-switched pulses.The numerical simulation results are useful for optimizing the design of actively Q-switched Fe:ZnSe laser.

High-energy plain and composite pulses in a laser modeled by the complex Swift–Hohenberg equation

In this work, new plain and composite high-energy solitons of the cubic–quintic Swift–Hohenberg equation were numerically found. Starting from a composite pulse found by Soto-Crespo and Akhmediev and changing some parameter values allowed us to find these high energy pulses. We also found the region in the parameter space in which these solutions exist. Some pulse characteristics, namely, temporal and spectral profiles and chirp, are presented. The study of the pulse energy shows its independence of the dispersion parameter but its dependence on the nonlinear gain. An extreme amplitude pulse has also been found.

High-energy plain and composite pulses in a laser modeled by the complex Swift–Hohenberg equation:publisher's note

This publisher's note reports corrections to three of the figures in [Photon. Res. 4, 49(2016)].

Effects of Substrate Crystallographic Orientations on Microstructure in Laser Surface-Melted Single-Crystal Superalloy:Theoretical Analysis

A geometric analysis technique for crystal growth and microstructure development in single-crystal welds had been previously developed.And the effect of welding conditions on the tendency of stray grains formation during solidification was researched.In the present work,these analytical methods were further extended.Combined with an original vectorization method,a 3D Rosenthal solution was used to determine thermal conditions of the welds.Afterward,the dendrite growth orientation,the dendrite growth velocity and the thermal gradient along dendrite direction were calculated and lively plotted.Finally,the tendency of stray grains formation in the solidification front was forecasted and its distribution was presented with a 3D plot.The results indicate that substrate orientation has some impacts on the crystal growth pattern,dendrite growth velocity,distribution of thermal gradient and stray grain.Based on the research methods proposed in this work,any substrate crystallographic orientation can be studied,and predicted stray grains distribution can be visualized.

Steady-state property and dynamics in graphene-nanoribbon- array lasers

In this work, we present a schematic configuration and device model for a graphene-nanoribbon （GNR）-array-based nanolaser, which consists of a three-variable rate equations that takes into account carrier capture and Pauli blocking in semiconductor GNR-array lasers to analyze the steady- state properties and dynamics in terms of the role of the capture rate and the gain coefficient in GNR array nanolasers. Furthermore, our GNR-array nanolaser device model can be determined as two distinct two-variable reductions of the rate equations in the limit of large capture rates, depending on their relative values. The first case leads to the rate equations for quantum well lasers, exhibiting relaxation oscillations dynamics. The second case corresponds to GNRs nearly saturated by the carriers and is characterized by the absence of relaxation oscillations. Our results here demonstrated that GNR-array as gain material embedded into a high finesse microcavity can serve as an ultralow lasing threshold nanolaser with promising applications ranging widely from optical fiber communi- cation with increasing data processing speed to digital optical recording and biology spectroscopy.

Physics and applications with laser-induced relativistic shock waves

The laser-induced relativistic shock waves are described. The shock waves can be created directly by a high irradiance laser or indirectly by a laser acceleration of a foil that collides with a second static foil. A special case of interest is the creation of laser-induced fusion where the created alpha particles create a detonation wave. A novel application is suggested with the shock wave or the detonation wave to ignite a pre-compressed target. In particular, the deuterium–tritium fusion is considered. It is suggested that the collision of two laser accelerated foils might serve as a novel relativistic accelerator for bulk material collisions.

Influence of facet reflection of SOA on SOA-integrated SGDBR laser

A combined model of the transmission-line laser model （TLLM） and the digital filter approach is developed to simulate the shuttering characteristic of a semiconductor optical amplifier （SOA）, which is inte- grated with a sampled grating distributed Bragg reflector （SGDBR） laser, to create a so called SOA-SGDBR laser. The SOA section acts as a shutter to blank the laser output during wavelength switching events. Simulated results show that the turn-on edge of the SOA blanking process will oscillate when the facet reflection of SOA is relatively high. This phenomenon is also observed by experiments.

Serum peptidome profiling for identifying pathological patterns in patients with primary nephrotic syndrome

Background Renal biopsy is necessary for diagnosing the pathological changes of primary nephrotic syndrome （NS）. However, it is invasive, time-consuming and can not be performed frequent on the same patient. Thus, development of a non-invasive and rapid diagnostic method may improve clinical patient management. Methods Proteomic tool magnetic bead-based matrix-assisted laser desorption/ionization time-of-flight mass spectrometry （MB-based MALDI TOF MS） was applied to serum to determine peptidome patterns that are characteristic of different pathological changes. Results Serum specimen from 114 patients with NS （62 were minimal change disease （MCD）, 30 were membranous nephropathy （MN）, and 22 were focal segmental glomerulosclerosis （FSGS）） and 60 normal individuals were analyzed using MB-based MALDI TOF MS. The peptidome pattern was generated by genetic algorithms using a training set of 31 MCD, 15 MN, 11 FSGS and 30 normal individuals and was validated by an independent testing set of the remaining samples. The serum peptidome pattern, based on a panel of 14 peaks, accurately recognized samples from MCD, MN, FSGS and healthy control with sensitivities of 93.5%, 86.7%, 63.6% and 90.0%, and specificities of 98.2%, 94.4%, 100% and 89.5%, respectively. Moreover, one peptide from peptidome pattern was identified by liquid chromatography tandem mass spectrometry （LC MS/MS） as fibrinogen A. Conclusion Detection of the serum peptidome pattern is a rapid, non-invasive, high-throughout, and reproducible method for identifying the pathological patterns of patients with nephrotic syndrome.

EXPERIMENTAL AND THEORETICAL STUDY OF CAVITATION-INDUCED MECHANICAL EFFECT ON A SOLID BOUNDARY

The mechanical effect induced by the cavitati- on bubble collapse in the neighborhood of a solid boundary was investigated by focusing a Q-switched laser pulse on a metal target in water. By means of a fiber-coupling optical beam deflection technique, the displacement generated by liquid jet impact at the final stage of the bubble collapse was detected at the epicenter of the rear metal surface. Furthermore, by combining a widely used laser ablation model with the detection principles of this detector, the transient impact force exerting on the target material could be easily estimated. Besides, according to experimental results and the modified Ray leigh theory, the maximum bubble radius and the liquid-jet pressure were also obtained, which are in good agreement with previous results,