Despite major achievements in the treatment ofchronic hepatitis C with the combination ofinterferons and the nucleoside analog ribavirin themajority of patients with chronic hepatitis C virus(HCV) infection cannot be ...Despite major achievements in the treatment ofchronic hepatitis C with the combination ofinterferons and the nucleoside analog ribavirin themajority of patients with chronic hepatitis C virus(HCV) infection cannot be treated effectively.Toimprove this response rate we used antisensetechnologies to inhibit HCV translation as possibleadditional option for experimental treatment.Antisense oligodeoxynucleotides(ODN) are展开更多
The plant Aloe vera is used in Ayurvedic, Homoeopathic and Allopathic streams of medicine, and not only tribal community but also most of the people for food and medicine. The plant leaves contains numerous vitamins, ...The plant Aloe vera is used in Ayurvedic, Homoeopathic and Allopathic streams of medicine, and not only tribal community but also most of the people for food and medicine. The plant leaves contains numerous vitamins, minerals, enzymes, amino acids, natural sugars and other bioactive compounds with emollient, purgative, anti-microbial, anti inflammatory, antioxidant, aphrodisiac, anti-helmenthic, antifungal, antiseptic and cosmetic values for health care. This plant has potential to cure sunburns, burns and minor cuts, and even skin cancer. The external use in cosmetic primarily acts as skin healer and prevents injury of epithelial tissues, cures acne and gives a youthful glow to skin, also acts as extremely powerful laxative.展开更多
Choroidal neovascularization characterizes wet age-related macular degeneration.Choroidal neovascularization formation involves a primarily angiogenic process that is combined with both inflammation and proteolysis.A ...Choroidal neovascularization characterizes wet age-related macular degeneration.Choroidal neovascularization formation involves a primarily angiogenic process that is combined with both inflammation and proteolysis.A primary cause of choroidal neovascularization pathogenesis is alterations in pro-and anti-angiogenic factors derived from the retinal pigment epithelium,with vascular endothelium growth factor being mainly responsible for both clinical and experimental choroidal neovascularization.MicroRNAs(miRNAs)which are short,non-coding,endogenous RNA molecules have a major role in regulating various pathological processes,including inflammation and angiogenesis.A review of recent studies with the mouse laser-induced choroidal neovascularization model has shown alterations in miRNA expression in choroidal neovascularization tissues and could be potential therapeutic targets for wet age-related macular degeneration.Upregulation of miR-505(days 1 and 3 post-laser),miR-155(day 14)occurred in retina;miR-342-5p(days 3 and 7),miR-126-3p(day 14)in choroid;miR-23a,miR-24,miR-27a(day 7)in retina/choroid;miR-505(days 1 and 3)in retinal pigment epithelium/choroid;downregulation of miR-155(days 1 and 3),miR-29a,miR-29b,miR-29c(day 5),miR-93(day 14),miR-126(day 14)occurred in retinal pigment epithelium/choroid.Therapies using miRNA mimics or inhibitors were found to decrease choroidal neovascularization lesions.Choroidal neovascularization development was reduced by overexpression of miR-155,miR-188-5p,miR-(5,B,7),miR-126-3p,miR-342-5p,miR-93,miR-126,miR-195a-3p,miR-24,miR-21,miR-31,miR-150,and miR-184,or suppression of miR-505,miR-126-3p,miR-155,and miR-23/27.Further studies are warranted to determine miRNA expression in mouse laser-induced choroidal neovascularization models in order to validate and extend the reported findings.Important experimental variables need to be standardized;these include the strain and age of animals,gender,number and position of laser burns to the eye,laser parameters to induce choroidal neovascularization lesions including wavelength,power,spot size,and duration.展开更多
Purpose: To investigate the efficacy and complications of continuous wear of etafilcon A for therapeutic use. Materials and Methods: The subjects were 228 eyes of 219 outpatients prescribed contact lens (CL) for one w...Purpose: To investigate the efficacy and complications of continuous wear of etafilcon A for therapeutic use. Materials and Methods: The subjects were 228 eyes of 219 outpatients prescribed contact lens (CL) for one week of continuous therapeutic wear during 10 years. The reason for prescription of CLs, the primary disease, the duration of CL wear and the complications were assessed retrospectively. Results: The predominant reason for prescription of CLs was relief of pain or a foreign-body sensation (62.3%) and protection of the corneal epithelium (20.6%). The primary disease was post-penetrating keratoplasty (36.8%), followed by corneal epithelial erosion (14.5%), post-lamellar keratoplasty (14.0%) and bullous keratopathy (12.2%). The average duration of wearing single lens was 6.5 ± 3.2 days. The average duration of wearing CLs in total was 9.2 ± 10.7 months. The most frequent problem associated with continuous wear of CLs was their dropping out of CLs (12.3%). The complications associated with CLs included conjunctivitis with papillary hyperplasia, corneal erosion and superficial punctate keratitis, but corneal ulcer and corneal infiltrates were not found. Conclusion: Serious complications were not shown changing the lenses every week to keep to the prescribed time limit for continuous therapeutic wear, even if corneal epithelial barrier function is impaired.展开更多
Lymphadenectomy for urothelial carcinoma of the upper urinary tract has attracted the attention of physicians. The mapping study of lymphatic spread has shown that a relatively wide area should comprise the regional n...Lymphadenectomy for urothelial carcinoma of the upper urinary tract has attracted the attention of physicians. The mapping study of lymphatic spread has shown that a relatively wide area should comprise the regional nodes for tumors of the right renal pelvis or the right upper two-thirds of the ureter. A prospective study showed that an anatomical templatebased lymphadenectomy significantly improved patient survival in tumors of the renal pelvis. This benefit was more evident for patients with p T2 stage tumors or higher. The risk of regional node recurrence is significant reduced by template-based lymphadenectomy,which is likely to be associated with improved patient survival. The removal of lymph node micrometastases is assumed to be the reason for therapeutic benefit following lymphadenectomy. The number of resected lymph nodes can be used to assess the quality of lymphadenectomy,but not to determine the extent of lymphadenectomy. The guidelines currently recommend lymphadenectomy for patients with muscle-invasive disease,even though the current recommendation grades are still low. The present limitation of lymphadenectomy is the lack of standardization of the extent of lymphadenectomy and the randomized trials. Further studies are warranted to collect the evidence to support lymphadenectomy.展开更多
The surface modification of materials such as Ti-6Al-4V is necessary to improve their wear resistant properties for use in tribological applications. In this paper it is shown that a laser with low power and tungsten ...The surface modification of materials such as Ti-6Al-4V is necessary to improve their wear resistant properties for use in tribological applications. In this paper it is shown that a laser with low power and tungsten inert gas (TIG) can be combined together for surface modification of Ti-6Al-4V alloy, and when performed in a controlled atmosphere of pure nitrogen or a mixture of nitrogen and argon, can produce a wear-resistant surface alloy. Compared with laser processing, a cheaper surface modification process has been developed involving a shorter processing time, which is free of stringent requirements such as a vacuum system.展开更多
A cw operation and a passively Q-switched （PQS） Ho：SSO laser （Cr2＋ ：ZnSe as a saturable absorber） end-pumped by a TIn：YAP laser operating at near room temperature are reported. It is the first time to report a...A cw operation and a passively Q-switched （PQS） Ho：SSO laser （Cr2＋ ：ZnSe as a saturable absorber） end-pumped by a TIn：YAP laser operating at near room temperature are reported. It is the first time to report a PQS Ho：SSO laser. For the ew mode, a maximum cw output power of 3.0 W is obtMned, corresponding to a slope efficiency of 31.4%. For the PQS mode, a Cr2＋ ：ZnSe is used as the saturable absorber, with transmission of 88.4% at 2112nm. A maximum pulse energy of 1.29mJ is obtained, corresponding to the pulse repetition frequency of 2.42kHz. In this study, we change the distance between Cr2＋ ：ZnSe and the output mirror to research the pulse characteristic of the PQ, S Ho：SSO laser. The minimum pulse width of 73.5ns is obtained, corresponding to the pulse energy of O. 9 mJ and the pulse repetition frequency of 2.65 kHz.展开更多
Mesenchymal stem cells(MSCs)have tantalized regenerative medicine with their therapeutic potential,yet a cloud of controversies looms over their clinical tran-splantation.This comprehensive review navigates the intric...Mesenchymal stem cells(MSCs)have tantalized regenerative medicine with their therapeutic potential,yet a cloud of controversies looms over their clinical tran-splantation.This comprehensive review navigates the intricate landscape of MSC controversies,drawing upon 15 years of clinical experience and research.We delve into the fundamental properties of MSCs,exploring their unique immuno-modulatory capabilities and surface markers.The heart of our inquiry lies in the controversial applications of MSC transplantation,including the perennial debate between autologous and allogeneic sources,concerns about efficacy,and lingering safety apprehensions.Moreover,we unravel the enigmatic mechanisms surro-unding MSC transplantation,such as homing,integration,and the delicate balance between differentiation and paracrine effects.We also assess the current status of clinical trials and the ever-evolving regulatory landscape.As we peer into the future,we examine emerging trends,envisioning personalized medicine and innovative delivery methods.Our review provides a balanced and informed perspective on the controversies,offering readers a clear understanding of the complexities,challenges,and potential solutions in MSC transplantation.展开更多
目的比较等离子射频消融术与CO_(2)激光治疗早期声门型喉癌(EGC)的效果。方法根据治疗方法的不同将80例EGC患者分为对照组(n=40,CO_(2)激光)与研究组(n=40,等离子射频消融术),比较两组患者的围手术期指标[手术时间、术中出血量、术后住...目的比较等离子射频消融术与CO_(2)激光治疗早期声门型喉癌(EGC)的效果。方法根据治疗方法的不同将80例EGC患者分为对照组(n=40,CO_(2)激光)与研究组(n=40,等离子射频消融术),比较两组患者的围手术期指标[手术时间、术中出血量、术后住院时间、术后24 h视觉模拟评分法(VAS)评分]、嗓音功能[振幅微扰、谐噪比(HNR)、基频微扰]、生活质量[嗓音障碍指数(VHI)]、吞咽功能[电视透视吞咽功能检查(VFSS)]、局部复发情况及并发症发生情况。结果研究组患者手术时间、术后住院时间均明显短于对照组,术中出血量明显少于对照组,术后24 h VAS评分明显低于照组,差异均有统计学意义(P﹤0.01)。术后4周,两组患者HNR均高于本组术前,基频微扰、振幅微扰均低于本组术前,研究组患者HNR高于对照组,基频微扰、振幅微扰均低于对照组,差异均有统计学意义(P﹤0.05)。术后6个月,两组患者VHI评分均低于本组术前,VFSS评分均高于本组术前,研究组患者VHI评分低于对照组,VFSS评分高于对照组,差异均有统计学意义(P﹤0.05)。研究患者的局部复发率和并发症总发生率均低于对照组,但差异均无统计学意义(P﹥0.05)。结论与CO_(2)激光相比,等离子射频消融术治疗EGC的效果更好,可以缩短手术时间,减少术中出血量,减轻术后疼痛感,同时对患者嗓音、吞咽功能的影响较小,可以促进患者术后快速康复,并且提高生活质量。展开更多
Clinacanthus nutans Lindau is known as snake grass belonging to the Acanlhaceae family.This plant has diverse and potential medicinal uses in traditional herbal medicine for treating skin rashes,insects and snake bite...Clinacanthus nutans Lindau is known as snake grass belonging to the Acanlhaceae family.This plant has diverse and potential medicinal uses in traditional herbal medicine for treating skin rashes,insects and snake bites,lesions caused by herpes simplex virus,diabetes,and gout in Malaysia.Indonesia.Thailand and China.Phylochemieal investigations documented the varied contents of bioaclive compounds from litis plant namely flavonoids,glycosides,glycoglyeerolipids.cerebrosides and monoacylmonogalatosylglycerol.The pharmacological experiment proved that various types of extracts and pure compounds from this species exhibited a broad range of biological properties such as anti-inflammatory,antiviral,antioxidant,and anti-diabetic activities.The lindings of toxicity study showed that extracts from this plant did not show any toxicity thus it can be used as strong therapeutic agents for specific diseased conditions.However,further experiments on chemical components and their mode of action showing biological activities are required to elucidate the complete phytochemical profile and assess to confirm their suitability tor future drugs.This review summarizes the medicinal uses,phytochemistry and pharmacology of this plant in order to explore its therapeutic potential and gaps necessitating for prospected research work.展开更多
INTRODUCTIONEndoscopy has revolutionised our management of many gastrointestinal disorders over the past 30 years .We are increasingly able to diagnose gastrointestinal (GI) tumors at an early stage,and endoscopic the...INTRODUCTIONEndoscopy has revolutionised our management of many gastrointestinal disorders over the past 30 years .We are increasingly able to diagnose gastrointestinal (GI) tumors at an early stage,and endoscopic therapy has made a difference to the outcome of GI haemorrhage. We still rely on surgery for cure of cancer of cancer but as diagnostic techniques improve the goal of minimally invasive diagnosis and therapy appears ever more attainable diagnosis and therapy appears vevr more attainable . As populations get older ,it is also increasingly desirable .Laser light can be used for both diagnosis and therapy in the gut .This article reviews the value of lasers in these areas .展开更多
By employing three reflecting volume Bragg gratings, a near-infrared 4-channel spectral-beam-combining system is demonstrated to present 720 W combined power with a combining efficiency of 94.7%. The combined laser be...By employing three reflecting volume Bragg gratings, a near-infrared 4-channel spectral-beam-combining system is demonstrated to present 720 W combined power with a combining efficiency of 94.7%. The combined laser beam is near-diffraction-limited with a beam factor M^2-1.54. During this 4-channel beam-combining process, no special active cooling measures are used to evaluate the volume Bragg gratings as combining elements are under the higher power laser operation. Thermal expansion and period distortion are verified in a 2 k W 2-channel beam-combining process, and the heat issue in the transmission case is found to be more remarkable than that in the diffraction e-se. Transmitted and diffracted beams experience wave-front aberrations with different degrees, thus leading to distinct beam deterioration.展开更多
A compact linearly polarized, low-noise, narrow-linewidth, single-frequency fiber laser at 1950nm is demonstrated. This compact fiber laser is based on a 21-mm-long homemade Tm3＋-doped germanate glass fiber. Over 100...A compact linearly polarized, low-noise, narrow-linewidth, single-frequency fiber laser at 1950nm is demonstrated. This compact fiber laser is based on a 21-mm-long homemade Tm3＋-doped germanate glass fiber. Over 100-mW stable continuous-wave single transverse and longitudinal mode lasing at 195Ohm are achieved. The measured relative intensity noise is less than -135dB/Hz at frequencies over 5 MHz. The signal-to-noise ratio of the laser is larger than 72dB, and the laser linewidth is less than 6kHz, while the obtained linear polarization extinction ratio is higher than 22 dB.展开更多
文摘Despite major achievements in the treatment ofchronic hepatitis C with the combination ofinterferons and the nucleoside analog ribavirin themajority of patients with chronic hepatitis C virus(HCV) infection cannot be treated effectively.Toimprove this response rate we used antisensetechnologies to inhibit HCV translation as possibleadditional option for experimental treatment.Antisense oligodeoxynucleotides(ODN) are
文摘The plant Aloe vera is used in Ayurvedic, Homoeopathic and Allopathic streams of medicine, and not only tribal community but also most of the people for food and medicine. The plant leaves contains numerous vitamins, minerals, enzymes, amino acids, natural sugars and other bioactive compounds with emollient, purgative, anti-microbial, anti inflammatory, antioxidant, aphrodisiac, anti-helmenthic, antifungal, antiseptic and cosmetic values for health care. This plant has potential to cure sunburns, burns and minor cuts, and even skin cancer. The external use in cosmetic primarily acts as skin healer and prevents injury of epithelial tissues, cures acne and gives a youthful glow to skin, also acts as extremely powerful laxative.
文摘Choroidal neovascularization characterizes wet age-related macular degeneration.Choroidal neovascularization formation involves a primarily angiogenic process that is combined with both inflammation and proteolysis.A primary cause of choroidal neovascularization pathogenesis is alterations in pro-and anti-angiogenic factors derived from the retinal pigment epithelium,with vascular endothelium growth factor being mainly responsible for both clinical and experimental choroidal neovascularization.MicroRNAs(miRNAs)which are short,non-coding,endogenous RNA molecules have a major role in regulating various pathological processes,including inflammation and angiogenesis.A review of recent studies with the mouse laser-induced choroidal neovascularization model has shown alterations in miRNA expression in choroidal neovascularization tissues and could be potential therapeutic targets for wet age-related macular degeneration.Upregulation of miR-505(days 1 and 3 post-laser),miR-155(day 14)occurred in retina;miR-342-5p(days 3 and 7),miR-126-3p(day 14)in choroid;miR-23a,miR-24,miR-27a(day 7)in retina/choroid;miR-505(days 1 and 3)in retinal pigment epithelium/choroid;downregulation of miR-155(days 1 and 3),miR-29a,miR-29b,miR-29c(day 5),miR-93(day 14),miR-126(day 14)occurred in retinal pigment epithelium/choroid.Therapies using miRNA mimics or inhibitors were found to decrease choroidal neovascularization lesions.Choroidal neovascularization development was reduced by overexpression of miR-155,miR-188-5p,miR-(5,B,7),miR-126-3p,miR-342-5p,miR-93,miR-126,miR-195a-3p,miR-24,miR-21,miR-31,miR-150,and miR-184,or suppression of miR-505,miR-126-3p,miR-155,and miR-23/27.Further studies are warranted to determine miRNA expression in mouse laser-induced choroidal neovascularization models in order to validate and extend the reported findings.Important experimental variables need to be standardized;these include the strain and age of animals,gender,number and position of laser burns to the eye,laser parameters to induce choroidal neovascularization lesions including wavelength,power,spot size,and duration.
文摘Purpose: To investigate the efficacy and complications of continuous wear of etafilcon A for therapeutic use. Materials and Methods: The subjects were 228 eyes of 219 outpatients prescribed contact lens (CL) for one week of continuous therapeutic wear during 10 years. The reason for prescription of CLs, the primary disease, the duration of CL wear and the complications were assessed retrospectively. Results: The predominant reason for prescription of CLs was relief of pain or a foreign-body sensation (62.3%) and protection of the corneal epithelium (20.6%). The primary disease was post-penetrating keratoplasty (36.8%), followed by corneal epithelial erosion (14.5%), post-lamellar keratoplasty (14.0%) and bullous keratopathy (12.2%). The average duration of wearing single lens was 6.5 ± 3.2 days. The average duration of wearing CLs in total was 9.2 ± 10.7 months. The most frequent problem associated with continuous wear of CLs was their dropping out of CLs (12.3%). The complications associated with CLs included conjunctivitis with papillary hyperplasia, corneal erosion and superficial punctate keratitis, but corneal ulcer and corneal infiltrates were not found. Conclusion: Serious complications were not shown changing the lenses every week to keep to the prescribed time limit for continuous therapeutic wear, even if corneal epithelial barrier function is impaired.
文摘Lymphadenectomy for urothelial carcinoma of the upper urinary tract has attracted the attention of physicians. The mapping study of lymphatic spread has shown that a relatively wide area should comprise the regional nodes for tumors of the right renal pelvis or the right upper two-thirds of the ureter. A prospective study showed that an anatomical templatebased lymphadenectomy significantly improved patient survival in tumors of the renal pelvis. This benefit was more evident for patients with p T2 stage tumors or higher. The risk of regional node recurrence is significant reduced by template-based lymphadenectomy,which is likely to be associated with improved patient survival. The removal of lymph node micrometastases is assumed to be the reason for therapeutic benefit following lymphadenectomy. The number of resected lymph nodes can be used to assess the quality of lymphadenectomy,but not to determine the extent of lymphadenectomy. The guidelines currently recommend lymphadenectomy for patients with muscle-invasive disease,even though the current recommendation grades are still low. The present limitation of lymphadenectomy is the lack of standardization of the extent of lymphadenectomy and the randomized trials. Further studies are warranted to collect the evidence to support lymphadenectomy.
文摘The surface modification of materials such as Ti-6Al-4V is necessary to improve their wear resistant properties for use in tribological applications. In this paper it is shown that a laser with low power and tungsten inert gas (TIG) can be combined together for surface modification of Ti-6Al-4V alloy, and when performed in a controlled atmosphere of pure nitrogen or a mixture of nitrogen and argon, can produce a wear-resistant surface alloy. Compared with laser processing, a cheaper surface modification process has been developed involving a shorter processing time, which is free of stringent requirements such as a vacuum system.
基金Supported by the National Natural Science Foundation of China under Grant No 61405046the Natural Science Foundation of Heilongjiang Province under Grant No 51305089
文摘A cw operation and a passively Q-switched （PQS） Ho：SSO laser （Cr2＋ ：ZnSe as a saturable absorber） end-pumped by a TIn：YAP laser operating at near room temperature are reported. It is the first time to report a PQS Ho：SSO laser. For the ew mode, a maximum cw output power of 3.0 W is obtMned, corresponding to a slope efficiency of 31.4%. For the PQS mode, a Cr2＋ ：ZnSe is used as the saturable absorber, with transmission of 88.4% at 2112nm. A maximum pulse energy of 1.29mJ is obtained, corresponding to the pulse repetition frequency of 2.42kHz. In this study, we change the distance between Cr2＋ ：ZnSe and the output mirror to research the pulse characteristic of the PQ, S Ho：SSO laser. The minimum pulse width of 73.5ns is obtained, corresponding to the pulse energy of O. 9 mJ and the pulse repetition frequency of 2.65 kHz.
基金Supported by The National Recovery and Resilience Plan of the Republic of Bulgaria,No.BG-RRP-2.004-0008-C01.
文摘Mesenchymal stem cells(MSCs)have tantalized regenerative medicine with their therapeutic potential,yet a cloud of controversies looms over their clinical tran-splantation.This comprehensive review navigates the intricate landscape of MSC controversies,drawing upon 15 years of clinical experience and research.We delve into the fundamental properties of MSCs,exploring their unique immuno-modulatory capabilities and surface markers.The heart of our inquiry lies in the controversial applications of MSC transplantation,including the perennial debate between autologous and allogeneic sources,concerns about efficacy,and lingering safety apprehensions.Moreover,we unravel the enigmatic mechanisms surro-unding MSC transplantation,such as homing,integration,and the delicate balance between differentiation and paracrine effects.We also assess the current status of clinical trials and the ever-evolving regulatory landscape.As we peer into the future,we examine emerging trends,envisioning personalized medicine and innovative delivery methods.Our review provides a balanced and informed perspective on the controversies,offering readers a clear understanding of the complexities,challenges,and potential solutions in MSC transplantation.
文摘目的比较等离子射频消融术与CO_(2)激光治疗早期声门型喉癌(EGC)的效果。方法根据治疗方法的不同将80例EGC患者分为对照组(n=40,CO_(2)激光)与研究组(n=40,等离子射频消融术),比较两组患者的围手术期指标[手术时间、术中出血量、术后住院时间、术后24 h视觉模拟评分法(VAS)评分]、嗓音功能[振幅微扰、谐噪比(HNR)、基频微扰]、生活质量[嗓音障碍指数(VHI)]、吞咽功能[电视透视吞咽功能检查(VFSS)]、局部复发情况及并发症发生情况。结果研究组患者手术时间、术后住院时间均明显短于对照组,术中出血量明显少于对照组,术后24 h VAS评分明显低于照组,差异均有统计学意义(P﹤0.01)。术后4周,两组患者HNR均高于本组术前,基频微扰、振幅微扰均低于本组术前,研究组患者HNR高于对照组,基频微扰、振幅微扰均低于对照组,差异均有统计学意义(P﹤0.05)。术后6个月,两组患者VHI评分均低于本组术前,VFSS评分均高于本组术前,研究组患者VHI评分低于对照组,VFSS评分高于对照组,差异均有统计学意义(P﹤0.05)。研究患者的局部复发率和并发症总发生率均低于对照组,但差异均无统计学意义(P﹥0.05)。结论与CO_(2)激光相比,等离子射频消融术治疗EGC的效果更好,可以缩短手术时间,减少术中出血量,减轻术后疼痛感,同时对患者嗓音、吞咽功能的影响较小,可以促进患者术后快速康复,并且提高生活质量。
文摘Clinacanthus nutans Lindau is known as snake grass belonging to the Acanlhaceae family.This plant has diverse and potential medicinal uses in traditional herbal medicine for treating skin rashes,insects and snake bites,lesions caused by herpes simplex virus,diabetes,and gout in Malaysia.Indonesia.Thailand and China.Phylochemieal investigations documented the varied contents of bioaclive compounds from litis plant namely flavonoids,glycosides,glycoglyeerolipids.cerebrosides and monoacylmonogalatosylglycerol.The pharmacological experiment proved that various types of extracts and pure compounds from this species exhibited a broad range of biological properties such as anti-inflammatory,antiviral,antioxidant,and anti-diabetic activities.The lindings of toxicity study showed that extracts from this plant did not show any toxicity thus it can be used as strong therapeutic agents for specific diseased conditions.However,further experiments on chemical components and their mode of action showing biological activities are required to elucidate the complete phytochemical profile and assess to confirm their suitability tor future drugs.This review summarizes the medicinal uses,phytochemistry and pharmacology of this plant in order to explore its therapeutic potential and gaps necessitating for prospected research work.
文摘INTRODUCTIONEndoscopy has revolutionised our management of many gastrointestinal disorders over the past 30 years .We are increasingly able to diagnose gastrointestinal (GI) tumors at an early stage,and endoscopic therapy has made a difference to the outcome of GI haemorrhage. We still rely on surgery for cure of cancer of cancer but as diagnostic techniques improve the goal of minimally invasive diagnosis and therapy appears ever more attainable diagnosis and therapy appears vevr more attainable . As populations get older ,it is also increasingly desirable .Laser light can be used for both diagnosis and therapy in the gut .This article reviews the value of lasers in these areas .
基金Supported by the National Natural Science Foundation of China under Grant Nos 11474257 and 61605183
文摘By employing three reflecting volume Bragg gratings, a near-infrared 4-channel spectral-beam-combining system is demonstrated to present 720 W combined power with a combining efficiency of 94.7%. The combined laser beam is near-diffraction-limited with a beam factor M^2-1.54. During this 4-channel beam-combining process, no special active cooling measures are used to evaluate the volume Bragg gratings as combining elements are under the higher power laser operation. Thermal expansion and period distortion are verified in a 2 k W 2-channel beam-combining process, and the heat issue in the transmission case is found to be more remarkable than that in the diffraction e-se. Transmitted and diffracted beams experience wave-front aberrations with different degrees, thus leading to distinct beam deterioration.
基金Supported by the National High-Technology Research and Development Program of China under Grant Nos 2013AA031502 and 2014AA041902the National Natural Science Foundation of China under Grant Nos 11174085,51132004,and 51302086+3 种基金the Natural Science Foundation of Guangdong Province under Grant Nos S2011030001349 and S20120011380the China National Funds for Distinguished Young Scientists under Grant No 61325024the Science and Technology Project of Guangdong Province under Grant No 2013B090500028the ’Cross and Cooperative’ Science and Technology Innovation Team Project of Chinese Academy of Sciences under Grant No 2012-119
文摘A compact linearly polarized, low-noise, narrow-linewidth, single-frequency fiber laser at 1950nm is demonstrated. This compact fiber laser is based on a 21-mm-long homemade Tm3＋-doped germanate glass fiber. Over 100-mW stable continuous-wave single transverse and longitudinal mode lasing at 195Ohm are achieved. The measured relative intensity noise is less than -135dB/Hz at frequencies over 5 MHz. The signal-to-noise ratio of the laser is larger than 72dB, and the laser linewidth is less than 6kHz, while the obtained linear polarization extinction ratio is higher than 22 dB.
