上颌Le Fort Ⅰ型截骨术是正颌外科中矫治上颌骨畸形最常采用术式之一。但是,上颌骨的移动、肌肉的剥离会影响周围软组织的形态,其中鼻形态的改变越来越受到重视。已有研究报道,正颌手术后鼻形态的不利改变是降低患者手术满意度的主要...上颌Le Fort Ⅰ型截骨术是正颌外科中矫治上颌骨畸形最常采用术式之一。但是,上颌骨的移动、肌肉的剥离会影响周围软组织的形态,其中鼻形态的改变越来越受到重视。已有研究报道,正颌手术后鼻形态的不利改变是降低患者手术满意度的主要原因之一。明确上颌Le Fort Ⅰ型截骨术对鼻形态的影响能够帮助医生更准确地预测术后鼻形态的变化,从而优化手术设计、提高医患沟通效率。本文将对上颌Le Fort Ⅰ型截骨术后鼻部形态变化的研究进展作一综述,旨在为临床实践提供相应的参考。展开更多
上颌窦炎是Le Fort Ⅰ型截骨术后常见的并发症,对正颌术后的骨质愈合等非常不利。明确Le Fort Ⅰ型截骨术后上颌窦炎发生的相关因素,针对性采取预防措施,早期发现与及时治疗,对于降低上颌窦炎的发生率,加快患者术后康复,以及提升患者术...上颌窦炎是Le Fort Ⅰ型截骨术后常见的并发症,对正颌术后的骨质愈合等非常不利。明确Le Fort Ⅰ型截骨术后上颌窦炎发生的相关因素,针对性采取预防措施,早期发现与及时治疗,对于降低上颌窦炎的发生率,加快患者术后康复,以及提升患者术后生活质量具有重要意义。本文就上颌骨Le Fort Ⅰ型截骨术后并发上颌窦炎的影响、病因、诊断、治疗和预防等进行总结,为正颌外科相关医护人员早期诊治上颌窦炎提供参考。展开更多
目的:探讨改良鼻旁植骨是否能减少Le Fort 1型截骨下降手术术后上颌骨垂直向的复发。方法:选择双颌手术中上颌骨下降幅度>3 mm的患者30例,分为改良鼻旁植骨组和非改良鼻旁植骨组。利用术前(T0)、术后3天(T1)和术后6个月(T2)的颌面CT...目的:探讨改良鼻旁植骨是否能减少Le Fort 1型截骨下降手术术后上颌骨垂直向的复发。方法:选择双颌手术中上颌骨下降幅度>3 mm的患者30例,分为改良鼻旁植骨组和非改良鼻旁植骨组。利用术前(T0)、术后3天(T1)和术后6个月(T2)的颌面CT数据对上颌骨位置进行三维测量;同时利用T1与T2的CT数据计算植骨块厚度的变化。采用SPSS 22.0软件包对数据进行统计学分析。结果:术后6个月,在垂直方向上,改良鼻旁植骨组上切牙点复发量为(0.54±0.35)mm,非改良鼻旁植骨组上切牙点复发量为(1.18±0.76)mm(P=0.3997)。2组在前后、水平方向的复发率无显著差异。改良鼻旁植骨组的植骨块厚度降低(11.75±6.25)%,非改良鼻旁植骨组的植骨块厚度降低(33.77±11.56)%(P<0.0001)。结果:改良鼻旁植骨可有效减少植骨块吸收,以及术后上颌骨垂直向复发。展开更多
Food safety is a major issue to public health and have attracted global attention.Fast,sensitive,and reliable detection methods for food hazardous substances is highly desirable.Aptamers which can bind to the target m...Food safety is a major issue to public health and have attracted global attention.Fast,sensitive,and reliable detection methods for food hazardous substances is highly desirable.Aptamers which can bind to the target molecules with high affinity and specificity represent an attractive tool for the recognition of food hazardous substances,which play an important role in the development and application of new food safety detection technology.But current assays for characterizing small molecule-aptamer binding are limited by either the mass sensitivity or the size differentiation ability.Herein,we proposed a comprehensive method for assessing the dissociation equilibria of small molecule-aptamer,which is immobilized-free under ambient conditions.The design employs the Le Chatelier’s principle and could be used to effectively measure small molecule-aptamer interactions.ATP binding aptamer and anti-aflatoxin B1 aptamer were used as the model system to determine their affinity,in which their dissociation equilibria measurements are in excellent close to their previous work.Due to the simplicity and sensitivity of this new method,we believe that it could be recommended as an effective tool for characterizing small molecule-aptamer interactions and promote the further application of small molecular aptamer in food safety.展开更多
Background: Ischaemic heart disease is the cause of 7.4 million deaths per year. Their prevention is based on the management of cardiovascular risk factors, but also on the early detection and management of chronic co...Background: Ischaemic heart disease is the cause of 7.4 million deaths per year. Their prevention is based on the management of cardiovascular risk factors, but also on the early detection and management of chronic coronary syndromes (CCS), for which few data are available in Africa. The main objective of our study was to determine the factors related to significative coronary artery disease in patients undergoing coronarography for suspected chronic coronary syndrome (CCS). Methodology: We conducted a retrospective descriptive and analytical study over 2 years (from January, 1<sup>st</sup>, 2018 to December 31<sup>st</sup>, 2019) in the Cardiology Department of the University Hospital Aristide Le DANTEC in Dakar. All patients admitted for coronary angiography for suspected chronic coronary syndrome were included. Results: One hundred and fifty-two patients were included with a mean age of 60.79 ± 9.73 years, the most represented age group was 60 - 69 years. Advanced age was the most frequent risk factor (77.63%) followed by sedentary lifestyle (56.58%) and hypertension (41.45%). Diabetes was present in 17.1% of cases. A history of angioplasty was found in 1.97% of patients. Typical pain was found in 71.05% of cases, atypical pain in 19.74% and exertional dyspnoea in 2.63%. The pre-test probability was intermediate in 67.1% of cases, low in 25% and high in 7.9%. Significative coronary lesion was found in 52.63% of the patients, while coronary angiography was normal in the remaining cases. Tritroncular status was observed in 37.50%, it was bitroncular in 26.25% and monotroncular in 36.25% of cases. Factors associated with significative coronary artery disease were age (p = 0.0001), diabetes (p = 0.006), previous angioplasty (p = 0.023), previous myocardial infarction (p = 0.018), typical angina (p = 0.001), intermediate pretest probability (p = 0.001). Low pretest probability was significantly correlated with the absence of a coronary lesion with a p = 0.001. Conclusion: Our study shows that screening for chronic coronary disease should be done especially in diabetics, elderly subjects and those with previous angioplasty taking into account symptoms and pretest probability to avoid unnecessary invasive procedures.展开更多
From 1924 to1926,with the CitéFrugès in Pessac,Le Corbusier and Pierre Jeanneret realized an urban area as a laboratory where research on architecture polychromy was achieved among others.Colored facade was ...From 1924 to1926,with the CitéFrugès in Pessac,Le Corbusier and Pierre Jeanneret realized an urban area as a laboratory where research on architecture polychromy was achieved among others.Colored facade was applied as a tool to modify urban space.This neighbourhood has always been inhabited and transformed by its inhabitants over time.In the 90’s,studies for the global image protection of the neighbourhood included polychromy research conducted to restore the shades of origin.However,the colors have often been interpreted in various ways.Nowadays,besides the shade problems,other challenges have arisen linked to the preservation of the facade materials.This paper presents the recent archive research done to clarify the shade references and lay the groundwork so as to choose the right material to use and further research in the future.展开更多
The theme of the restoration and conservation of polychrome surfaces will be addressed through several recent case studies of interventions on Le Corbusier’s work owned by the Fondation Le Corbusier:the Petite Villa ...The theme of the restoration and conservation of polychrome surfaces will be addressed through several recent case studies of interventions on Le Corbusier’s work owned by the Fondation Le Corbusier:the Petite Villa sur Le Lac Léman(1923-1924),the Maisons La Roche and Jeanneret(1923-1925),and his apartment-studio in the Immeuble Molitor(1931-1934).The recent interventions allowed for numerous preliminary studies(in situ,archival,and laboratory),and proved to be an opportunity for historical and material knowledge,paying close attention to discoveries and observations during the construction phase.An important aspect of these experiences was the in-depth study of polychromes,conducted on architectural surfaces but also on furniture and fixed furnishings made of concrete,metal and wood.This was an important moment in the knowledge of the work during the restoration phase because of the richness of the stratigraphic surveys related to the many modifications made over time sometimes by Le Corbusier himself.This text exposes technical,scientific,and operational aspects specific to the study of interior and exterior polychromes,and in parallel raises theoretical-methodological questions of restoration of the polychromies and the painting.展开更多
目的 探讨联合应用高位Le Fort Ⅰ型截骨同期牙槽嵴裂植骨矫治唇腭裂术后面中部畸形的可行性。方法2002年1月～2005年1月，共收治10例唇腭裂术后面中部畸形患者，男4例，女6例。年龄16～32岁。单侧唇腭裂8例，双侧2例。影像学检查均有...目的 探讨联合应用高位Le Fort Ⅰ型截骨同期牙槽嵴裂植骨矫治唇腭裂术后面中部畸形的可行性。方法2002年1月～2005年1月，共收治10例唇腭裂术后面中部畸形患者，男4例，女6例。年龄16～32岁。单侧唇腭裂8例，双侧2例。影像学检查均有继发面中部畸形的主要表现。均采用高位Le Fort Ⅰ型截骨和牙槽嵴裂自体髂骨游离移植一期手术矫正。高位Le Fort Ⅰ型截骨的截骨线在上颌骨前壁比常规Le Fort Ⅰ型截骨线高，最高可达眶下孔下5mm左右，水平截开至颧牙槽嵴处再弧形转向下后方。结果术后伤口均I期愈合。复查头部X线片，所有患者上颌骨位置均得到明显改善。随访6～24个月，牙弓外形良好，X线片示无明显骨质吸收，植骨区密度与周围接近。10例均获得满意面容，其中9例获得良好的牙骀关系。结论高位Le Fort Ⅰ型截骨术不仅可前移上颌骨，还可前移部分眶下区及整个鼻旁区和鼻底，更明显地改善畸形。同期行牙槽嵴裂自体髂骨游离移植，可减少手术次数、降低费用、获得理想效果，是矫治唇腭裂术后面中部继发畸形的一种有效方法。展开更多
目的:采用多片段Le Fort I型截骨术矫治严重牙颌面畸形,并为克服术后骨段固位不良之缺点自制一种腭侧固定夹板。方法:以该手术方法联合双侧下颌升支矢状劈开术（BSSRO）矫治上颌宽度不足伴上下颌其它严重畸形的患者19例。采用单纯多片...目的:采用多片段Le Fort I型截骨术矫治严重牙颌面畸形,并为克服术后骨段固位不良之缺点自制一种腭侧固定夹板。方法:以该手术方法联合双侧下颌升支矢状劈开术（BSSRO）矫治上颌宽度不足伴上下颌其它严重畸形的患者19例。采用单纯多片段Le FortI型截骨6例,联合BSSRO13例。19例中上颌两片段Le FortI型截骨12例,3片段7例。结果:术后随访16例,平均22.6m,66间距离平均扩宽7.3mm,33间平均扩宽3.9mm。无严重并发症及明显复发,咬合关系满意。结论:应用良好的腭侧固定夹板,采用多片段 Le FortI截骨联合BSSRO可一次满意矫治严重双颌畸形。展开更多
文摘上颌Le Fort Ⅰ型截骨术是正颌外科中矫治上颌骨畸形最常采用术式之一。但是,上颌骨的移动、肌肉的剥离会影响周围软组织的形态,其中鼻形态的改变越来越受到重视。已有研究报道,正颌手术后鼻形态的不利改变是降低患者手术满意度的主要原因之一。明确上颌Le Fort Ⅰ型截骨术对鼻形态的影响能够帮助医生更准确地预测术后鼻形态的变化,从而优化手术设计、提高医患沟通效率。本文将对上颌Le Fort Ⅰ型截骨术后鼻部形态变化的研究进展作一综述,旨在为临床实践提供相应的参考。
文摘上颌窦炎是Le Fort Ⅰ型截骨术后常见的并发症,对正颌术后的骨质愈合等非常不利。明确Le Fort Ⅰ型截骨术后上颌窦炎发生的相关因素,针对性采取预防措施,早期发现与及时治疗,对于降低上颌窦炎的发生率,加快患者术后康复,以及提升患者术后生活质量具有重要意义。本文就上颌骨Le Fort Ⅰ型截骨术后并发上颌窦炎的影响、病因、诊断、治疗和预防等进行总结,为正颌外科相关医护人员早期诊治上颌窦炎提供参考。
文摘目的:探讨改良鼻旁植骨是否能减少Le Fort 1型截骨下降手术术后上颌骨垂直向的复发。方法:选择双颌手术中上颌骨下降幅度>3 mm的患者30例,分为改良鼻旁植骨组和非改良鼻旁植骨组。利用术前(T0)、术后3天(T1)和术后6个月(T2)的颌面CT数据对上颌骨位置进行三维测量;同时利用T1与T2的CT数据计算植骨块厚度的变化。采用SPSS 22.0软件包对数据进行统计学分析。结果:术后6个月,在垂直方向上,改良鼻旁植骨组上切牙点复发量为(0.54±0.35)mm,非改良鼻旁植骨组上切牙点复发量为(1.18±0.76)mm(P=0.3997)。2组在前后、水平方向的复发率无显著差异。改良鼻旁植骨组的植骨块厚度降低(11.75±6.25)%,非改良鼻旁植骨组的植骨块厚度降低(33.77±11.56)%(P<0.0001)。结果:改良鼻旁植骨可有效减少植骨块吸收,以及术后上颌骨垂直向复发。
基金supported by the National Key R&D Program of China(2017YFC1600603)the Funds for Huangshan Professorship of Hefei University of Technology(407-037019).
文摘Food safety is a major issue to public health and have attracted global attention.Fast,sensitive,and reliable detection methods for food hazardous substances is highly desirable.Aptamers which can bind to the target molecules with high affinity and specificity represent an attractive tool for the recognition of food hazardous substances,which play an important role in the development and application of new food safety detection technology.But current assays for characterizing small molecule-aptamer binding are limited by either the mass sensitivity or the size differentiation ability.Herein,we proposed a comprehensive method for assessing the dissociation equilibria of small molecule-aptamer,which is immobilized-free under ambient conditions.The design employs the Le Chatelier’s principle and could be used to effectively measure small molecule-aptamer interactions.ATP binding aptamer and anti-aflatoxin B1 aptamer were used as the model system to determine their affinity,in which their dissociation equilibria measurements are in excellent close to their previous work.Due to the simplicity and sensitivity of this new method,we believe that it could be recommended as an effective tool for characterizing small molecule-aptamer interactions and promote the further application of small molecular aptamer in food safety.
文摘Background: Ischaemic heart disease is the cause of 7.4 million deaths per year. Their prevention is based on the management of cardiovascular risk factors, but also on the early detection and management of chronic coronary syndromes (CCS), for which few data are available in Africa. The main objective of our study was to determine the factors related to significative coronary artery disease in patients undergoing coronarography for suspected chronic coronary syndrome (CCS). Methodology: We conducted a retrospective descriptive and analytical study over 2 years (from January, 1<sup>st</sup>, 2018 to December 31<sup>st</sup>, 2019) in the Cardiology Department of the University Hospital Aristide Le DANTEC in Dakar. All patients admitted for coronary angiography for suspected chronic coronary syndrome were included. Results: One hundred and fifty-two patients were included with a mean age of 60.79 ± 9.73 years, the most represented age group was 60 - 69 years. Advanced age was the most frequent risk factor (77.63%) followed by sedentary lifestyle (56.58%) and hypertension (41.45%). Diabetes was present in 17.1% of cases. A history of angioplasty was found in 1.97% of patients. Typical pain was found in 71.05% of cases, atypical pain in 19.74% and exertional dyspnoea in 2.63%. The pre-test probability was intermediate in 67.1% of cases, low in 25% and high in 7.9%. Significative coronary lesion was found in 52.63% of the patients, while coronary angiography was normal in the remaining cases. Tritroncular status was observed in 37.50%, it was bitroncular in 26.25% and monotroncular in 36.25% of cases. Factors associated with significative coronary artery disease were age (p = 0.0001), diabetes (p = 0.006), previous angioplasty (p = 0.023), previous myocardial infarction (p = 0.018), typical angina (p = 0.001), intermediate pretest probability (p = 0.001). Low pretest probability was significantly correlated with the absence of a coronary lesion with a p = 0.001. Conclusion: Our study shows that screening for chronic coronary disease should be done especially in diabetics, elderly subjects and those with previous angioplasty taking into account symptoms and pretest probability to avoid unnecessary invasive procedures.
文摘From 1924 to1926,with the CitéFrugès in Pessac,Le Corbusier and Pierre Jeanneret realized an urban area as a laboratory where research on architecture polychromy was achieved among others.Colored facade was applied as a tool to modify urban space.This neighbourhood has always been inhabited and transformed by its inhabitants over time.In the 90’s,studies for the global image protection of the neighbourhood included polychromy research conducted to restore the shades of origin.However,the colors have often been interpreted in various ways.Nowadays,besides the shade problems,other challenges have arisen linked to the preservation of the facade materials.This paper presents the recent archive research done to clarify the shade references and lay the groundwork so as to choose the right material to use and further research in the future.
文摘The theme of the restoration and conservation of polychrome surfaces will be addressed through several recent case studies of interventions on Le Corbusier’s work owned by the Fondation Le Corbusier:the Petite Villa sur Le Lac Léman(1923-1924),the Maisons La Roche and Jeanneret(1923-1925),and his apartment-studio in the Immeuble Molitor(1931-1934).The recent interventions allowed for numerous preliminary studies(in situ,archival,and laboratory),and proved to be an opportunity for historical and material knowledge,paying close attention to discoveries and observations during the construction phase.An important aspect of these experiences was the in-depth study of polychromes,conducted on architectural surfaces but also on furniture and fixed furnishings made of concrete,metal and wood.This was an important moment in the knowledge of the work during the restoration phase because of the richness of the stratigraphic surveys related to the many modifications made over time sometimes by Le Corbusier himself.This text exposes technical,scientific,and operational aspects specific to the study of interior and exterior polychromes,and in parallel raises theoretical-methodological questions of restoration of the polychromies and the painting.
文摘目的 探讨联合应用高位Le Fort Ⅰ型截骨同期牙槽嵴裂植骨矫治唇腭裂术后面中部畸形的可行性。方法2002年1月～2005年1月，共收治10例唇腭裂术后面中部畸形患者，男4例，女6例。年龄16～32岁。单侧唇腭裂8例，双侧2例。影像学检查均有继发面中部畸形的主要表现。均采用高位Le Fort Ⅰ型截骨和牙槽嵴裂自体髂骨游离移植一期手术矫正。高位Le Fort Ⅰ型截骨的截骨线在上颌骨前壁比常规Le Fort Ⅰ型截骨线高，最高可达眶下孔下5mm左右，水平截开至颧牙槽嵴处再弧形转向下后方。结果术后伤口均I期愈合。复查头部X线片，所有患者上颌骨位置均得到明显改善。随访6～24个月，牙弓外形良好，X线片示无明显骨质吸收，植骨区密度与周围接近。10例均获得满意面容，其中9例获得良好的牙骀关系。结论高位Le Fort Ⅰ型截骨术不仅可前移上颌骨，还可前移部分眶下区及整个鼻旁区和鼻底，更明显地改善畸形。同期行牙槽嵴裂自体髂骨游离移植，可减少手术次数、降低费用、获得理想效果，是矫治唇腭裂术后面中部继发畸形的一种有效方法。
文摘目的:采用多片段Le Fort I型截骨术矫治严重牙颌面畸形,并为克服术后骨段固位不良之缺点自制一种腭侧固定夹板。方法:以该手术方法联合双侧下颌升支矢状劈开术（BSSRO）矫治上颌宽度不足伴上下颌其它严重畸形的患者19例。采用单纯多片段Le FortI型截骨6例,联合BSSRO13例。19例中上颌两片段Le FortI型截骨12例,3片段7例。结果:术后随访16例,平均22.6m,66间距离平均扩宽7.3mm,33间平均扩宽3.9mm。无严重并发症及明显复发,咬合关系满意。结论:应用良好的腭侧固定夹板,采用多片段 Le FortI截骨联合BSSRO可一次满意矫治严重双颌畸形。
