Introduction: Prolonged air leak (PAL) is a common complication following pulmonary resection. It is associated with pneumonia, empyema, increased length of hospital stay and health-care costs. Intraoperative techniqu...Introduction: Prolonged air leak (PAL) is a common complication following pulmonary resection. It is associated with pneumonia, empyema, increased length of hospital stay and health-care costs. Intraoperative techniques have been developed to mitigate the risk of developing a PAL, but for their use to be efficient, identification of patients at risk for PAL is necessary. Aim: To determine the incidence of PAL following lobectomy and lesser pulmonary resections, risk factors for development of PALs, and the impact of PAL on hospital stay and readmission rates. Methods: The following variables were analyzed as PAL risk factors: patient characteristics of age, sex, body mass index (BMI), forced minute expiratory volume and capacity ratio (FEV1 and FEV1/FVC), diffusion capacity (DCLO), and transplant recipient status. Validated scoring systems included the Charlson Comorbidity Index (CCI), Medical Research Council (MRC) dyspnea score, and Eastern Cooperative Oncology Group (EGOC) score. Surgical factors included surgical technique, unplanned conversion from video-assisted thoracoscopic surgery (VATS) to thoracotomy, location and extent of resection, presence of adhesions, completeness of fissures, and method of fissure completion. Length of hospital stay and readmission rates were analyzed. Statistical tests performed on the data include univariate and multivariate logistic regression analyses. Results: Over the 9-month study duration there were 269 lung resections, of which 31 (11.52%) had an air leak lasting longer than 5 days. Mean length of stay in hospital was significantly longer in patients with PAL compared to the control group (13 vs 5 days, P P = 0.009), right upper lobectomy (P = 0.001), and unplanned conversion from video-assisted thoracoscopic surgery (VATS) to thoracotomy (P = 0.023). Conclusion: The incidence of PAL in our study population is similar to that found in previous studies. PAL prolongs hospital length of stay. Normal BMI, right upper lobectomy, and unplanned conversion from VATS to thoracotomy are risk factors for PAL.展开更多
目的:长时间漏气(prolonged air leak,PAL)是肺手术后最常见的术后并发症之一。这项研究旨在确定肺切除后PAL的风险因素,并构建一个术前预测模型,以估计其对单个患者的风险。方法:回顾性分析2017年01月至2021年06月期间接受解剖性肺切...目的:长时间漏气(prolonged air leak,PAL)是肺手术后最常见的术后并发症之一。这项研究旨在确定肺切除后PAL的风险因素,并构建一个术前预测模型,以估计其对单个患者的风险。方法:回顾性分析2017年01月至2021年06月期间接受解剖性肺切除的肺恶性肿瘤患者。PAL被定义为手术后7天以上的空气泄漏,并分析了风险因素。通过多因素Logistic回归模型,以识别独立的风险因素,并构建了列线图模型。采用重复抽样1000次的Bootstrap检验对列线图模型进行内部验证。采用一致性指数(concordance index,C-index)和校准曲线来表示模型的预测性能和预测准确度。决策曲线分析(decision curve analysis,DCA)评价该列线图模型的临床应用价值。结果:共有738名符合研究标准的患者纳入了这项研究。PAL的总体发病率为8.3%(61/738)。最终模型中包括身体质量指数(body mass index,BMI)、吸烟状况、手术时间、胸腔粘连和晚期肺癌炎症指数(advanced lung cancer inflammation index,ALI)。校准曲线表明该模型拟合较好;ROC曲线下面积(area under curve,AUC)为0.784(95%CI:0.720~0.848);DCA结果表明该模型具有较高的净获益水平。结论:本研究建立了列线图模型,对肺癌患者解剖性肺切除术后PAL的发生有较好的预测能力及良好的临床应用价值。展开更多
文摘Introduction: Prolonged air leak (PAL) is a common complication following pulmonary resection. It is associated with pneumonia, empyema, increased length of hospital stay and health-care costs. Intraoperative techniques have been developed to mitigate the risk of developing a PAL, but for their use to be efficient, identification of patients at risk for PAL is necessary. Aim: To determine the incidence of PAL following lobectomy and lesser pulmonary resections, risk factors for development of PALs, and the impact of PAL on hospital stay and readmission rates. Methods: The following variables were analyzed as PAL risk factors: patient characteristics of age, sex, body mass index (BMI), forced minute expiratory volume and capacity ratio (FEV1 and FEV1/FVC), diffusion capacity (DCLO), and transplant recipient status. Validated scoring systems included the Charlson Comorbidity Index (CCI), Medical Research Council (MRC) dyspnea score, and Eastern Cooperative Oncology Group (EGOC) score. Surgical factors included surgical technique, unplanned conversion from video-assisted thoracoscopic surgery (VATS) to thoracotomy, location and extent of resection, presence of adhesions, completeness of fissures, and method of fissure completion. Length of hospital stay and readmission rates were analyzed. Statistical tests performed on the data include univariate and multivariate logistic regression analyses. Results: Over the 9-month study duration there were 269 lung resections, of which 31 (11.52%) had an air leak lasting longer than 5 days. Mean length of stay in hospital was significantly longer in patients with PAL compared to the control group (13 vs 5 days, P P = 0.009), right upper lobectomy (P = 0.001), and unplanned conversion from video-assisted thoracoscopic surgery (VATS) to thoracotomy (P = 0.023). Conclusion: The incidence of PAL in our study population is similar to that found in previous studies. PAL prolongs hospital length of stay. Normal BMI, right upper lobectomy, and unplanned conversion from VATS to thoracotomy are risk factors for PAL.
文摘目的:长时间漏气(prolonged air leak,PAL)是肺手术后最常见的术后并发症之一。这项研究旨在确定肺切除后PAL的风险因素,并构建一个术前预测模型,以估计其对单个患者的风险。方法:回顾性分析2017年01月至2021年06月期间接受解剖性肺切除的肺恶性肿瘤患者。PAL被定义为手术后7天以上的空气泄漏,并分析了风险因素。通过多因素Logistic回归模型,以识别独立的风险因素,并构建了列线图模型。采用重复抽样1000次的Bootstrap检验对列线图模型进行内部验证。采用一致性指数(concordance index,C-index)和校准曲线来表示模型的预测性能和预测准确度。决策曲线分析(decision curve analysis,DCA)评价该列线图模型的临床应用价值。结果:共有738名符合研究标准的患者纳入了这项研究。PAL的总体发病率为8.3%(61/738)。最终模型中包括身体质量指数(body mass index,BMI)、吸烟状况、手术时间、胸腔粘连和晚期肺癌炎症指数(advanced lung cancer inflammation index,ALI)。校准曲线表明该模型拟合较好;ROC曲线下面积(area under curve,AUC)为0.784(95%CI:0.720~0.848);DCA结果表明该模型具有较高的净获益水平。结论:本研究建立了列线图模型,对肺癌患者解剖性肺切除术后PAL的发生有较好的预测能力及良好的临床应用价值。
