The shift towards online intelligent learning has become the norm in education and is now a fundamental part of modern educational activities.However,this new model can influence students’learning behavior and lead t...The shift towards online intelligent learning has become the norm in education and is now a fundamental part of modern educational activities.However,this new model can influence students’learning behavior and lead to changes in their approach to learning.Based on online intelligent learning,we investigated how the academic self-efficacy of nursing students affects their engagement with learning and explored the role of academic attribution as a mediator.Five hundred fifty-three nursing college students from Hebei and Hunan provinces in China participated in the online questionnaire.The results revealed that effort plays a mediating role in the relationship between academic self-efficacy and learning engagement.展开更多
Blended learning(BL)has been widely adopted to improve students’academic achievements in higher education.However,its success relies mainly on student engagement,which plays an essential role in active learning and p...Blended learning(BL)has been widely adopted to improve students’academic achievements in higher education.However,its success relies mainly on student engagement,which plays an essential role in active learning and provides a rich understanding of students’experiences.The study utilized three self-designed scales-the Teacher Support Scale,Student Engagement Scale,and Student Learning Experience Scale-to gauge and examine the impact and relationship between perceived teacher support,student behavioral engagement,and the intermediary role of learning experiences.A cohort of 899 college students undertaking the obligatory College English course through BL modes across five Chinese universities actively participated by completing a comprehensive questionnaire.The results showed significant correlations between perceived teacher support,learning experience,and behavioral engagement.Perceived teacher support significantly predicted students’behavioral engagement,with socio-affective support exerting the most substantial predictive effects.All predictive effects were partially mediated by learning experience(learning mode,online resources,overall LMS-based learning,interaction with their instructor and peers,and learning outcome).The influence of perceived teacher support on behavioral engagement differed between students who reported the most positive(vs.negative)learning experiences.Suggestions for further research are offered for consideration.展开更多
Artificial neural networks are capable of machine learning by simulating the hiera rchical structure of the human brain.To enable learning by brain and machine,it is essential to accurately identify and correct the pr...Artificial neural networks are capable of machine learning by simulating the hiera rchical structure of the human brain.To enable learning by brain and machine,it is essential to accurately identify and correct the prediction errors,referred to as credit assignment(Lillicrap et al.,2020).It is critical to develop artificial intelligence by understanding how the brain deals with credit assignment in neuroscience.展开更多
Early identification and treatment of stroke can greatly improve patient outcomes and quality of life.Although clinical tests such as the Cincinnati Pre-hospital Stroke Scale(CPSS)and the Face Arm Speech Test(FAST)are...Early identification and treatment of stroke can greatly improve patient outcomes and quality of life.Although clinical tests such as the Cincinnati Pre-hospital Stroke Scale(CPSS)and the Face Arm Speech Test(FAST)are commonly used for stroke screening,accurate administration is dependent on specialized training.In this study,we proposed a novel multimodal deep learning approach,based on the FAST,for assessing suspected stroke patients exhibiting symptoms such as limb weakness,facial paresis,and speech disorders in acute settings.We collected a dataset comprising videos and audio recordings of emergency room patients performing designated limb movements,facial expressions,and speech tests based on the FAST.We compared the constructed deep learning model,which was designed to process multi-modal datasets,with six prior models that achieved good action classification performance,including the I3D,SlowFast,X3D,TPN,TimeSformer,and MViT.We found that the findings of our deep learning model had a higher clinical value compared with the other approaches.Moreover,the multi-modal model outperformed its single-module variants,highlighting the benefit of utilizing multiple types of patient data,such as action videos and speech audio.These results indicate that a multi-modal deep learning model combined with the FAST could greatly improve the accuracy and sensitivity of early stroke identification of stroke,thus providing a practical and powerful tool for assessing stroke patients in an emergency clinical setting.展开更多
Machine learning(ML)is a type of artificial intelligence that assists computers in the acquisition of knowledge through data analysis,thus creating machines that can complete tasks otherwise requiring human intelligen...Machine learning(ML)is a type of artificial intelligence that assists computers in the acquisition of knowledge through data analysis,thus creating machines that can complete tasks otherwise requiring human intelligence.Among its various applications,it has proven groundbreaking in healthcare as well,both in clinical practice and research.In this editorial,we succinctly introduce ML applications and present a study,featured in the latest issue of the World Journal of Clinical Cases.The authors of this study conducted an analysis using both multiple linear regression(MLR)and ML methods to investigate the significant factors that may impact the estimated glomerular filtration rate in healthy women with and without non-alcoholic fatty liver disease(NAFLD).Their results implicated age as the most important determining factor in both groups,followed by lactic dehydrogenase,uric acid,forced expiratory volume in one second,and albumin.In addition,for the NAFLD-group,the 5th and 6th most important impact factors were thyroid-stimulating hormone and systolic blood pressure,as compared to plasma calcium and body fat for the NAFLD+group.However,the study's distinctive contribution lies in its adoption of ML methodologies,showcasing their superiority over traditional statistical approaches(herein MLR),thereby highlighting the potential of ML to represent an invaluable advanced adjunct tool in clinical practice and research.展开更多
Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life ...Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life of patients.To date,there are no viable treatment options for postoperative cognitive dysfunction.The identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future research.To identify the signaling mechanisms contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the Gene Expression Omnibus GSE95426 dataset,which consists of mRNAs and long non-coding RNAs differentially expressed in mouse hippocampus3 days after tibial fracture.The dataset was enriched in genes associated with the biological process"regulation of immune cells,"of which Chill was identified as a hub gene.Therefore,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the mouse model of tibial fractu re surgery.Mice were intraperitoneally injected with vehicle or recombinant chitinase-3-like protein 124 hours post-surgery,and the injection groups were compared with untreated control mice for learning and memory capacities using the Y-maze and fear conditioning tests.In addition,protein expression levels of proinflammatory factors(interleukin-1βand inducible nitric oxide synthase),M2-type macrophage markers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated NMDA receptor subunit NR2B)were measured in hippocampus by western blotting.Treatment with recombinant chitinase-3-like protein 1 prevented surgery-induced cognitive impairment,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expression compared with vehicle treatment.Intraperitoneal administration of the specific ERK inhibitor PD98059 diminished the effects of recombinant chitinase-3-like protein 1.Collectively,our findings suggest that recombinant chitinase-3-like protein 1 ameliorates surgery-induced cognitive decline by attenuating neuroinflammation via M2 microglial polarization in the hippocampus.Therefore,recombinant chitinase-3-like protein1 may have therapeutic potential fo r postoperative cognitive dysfunction.展开更多
Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s disease.Adult hippocampal neurogenesis is reduced in patients with Alzheimer’s disease.Exercise stimulates adult hippocampal neurogenesis in rode...Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s disease.Adult hippocampal neurogenesis is reduced in patients with Alzheimer’s disease.Exercise stimulates adult hippocampal neurogenesis in rodents and improves memory and slows cognitive decline in patients with Alzheimer’s disease.However,the molecular pathways for exercise-induced adult hippocampal neurogenesis and improved cognition in Alzheimer’s disease are poorly understood.Recently,regulator of G protein signaling 6(RGS6)was identified as the mediator of voluntary running-induced adult hippocampal neurogenesis in mice.Here,we generated novel RGS6fl/fl;APP_(SWE) mice and used retroviral approaches to examine the impact of RGS6 deletion from dentate gyrus neuronal progenitor cells on voluntary running-induced adult hippocampal neurogenesis and cognition in an amyloid-based Alzheimer’s disease mouse model.We found that voluntary running in APP_(SWE) mice restored their hippocampal cognitive impairments to that of control mice.This cognitive rescue was abolished by RGS6 deletion in dentate gyrus neuronal progenitor cells,which also abolished running-mediated increases in adult hippocampal neurogenesis.Adult hippocampal neurogenesis was reduced in sedentary APP_(SWE) mice versus control mice,with basal adult hippocampal neurogenesis reduced by RGS6 deletion in dentate gyrus neural precursor cells.RGS6 was expressed in neurons within the dentate gyrus of patients with Alzheimer’s disease with significant loss of these RGS6-expressing neurons.Thus,RGS6 mediated voluntary running-induced rescue of impaired cognition and adult hippocampal neurogenesis in APP_(SWE) mice,identifying RGS6 in dentate gyrus neural precursor cells as a possible therapeutic target in Alzheimer’s disease.展开更多
Student engagement in a clinical learning environment is a vital component in the curricula of pre-licensure nursing students, providing an opportunity to combine cognitive, psychomotor, and affective skills. This pap...Student engagement in a clinical learning environment is a vital component in the curricula of pre-licensure nursing students, providing an opportunity to combine cognitive, psychomotor, and affective skills. This paper is significant in Arab world as there is a lack of knowledge, attitude and practice of student involvement in the new clinical learning environment. The purpose of this review article is to describe the experiences and perspectives of the nurse educator in facilitating pre-licensure nursing students’ engagement in the new clinical learning environment. The review suggests that novice students prefer actual engagement in clinical learning facilitated through diversity experiences, shared learning opportunities, student-faculty interaction and active learning. They expressed continuous supervision, ongoing feedback, interpersonal relationship and personal support from nurse educators useful in the clinical practice. However, the value of this review lies in a better understanding of what constitutes quality clinical learning environment from the students’ perspective of engagement in evidence-based nursing, reflective practice, e-learning and simulated case scenarios facilitated by the nurse educators. This review is valuable in planning and implementing innovative clinical and educational experiences for improving the quality of the clinical teaching-learning environment.展开更多
This paper proposes an autonomous maneuver decision method using transfer learning pigeon-inspired optimization(TLPIO)for unmanned combat aerial vehicles(UCAVs)in dogfight engagements.Firstly,a nonlinear F-16 aircraft...This paper proposes an autonomous maneuver decision method using transfer learning pigeon-inspired optimization(TLPIO)for unmanned combat aerial vehicles(UCAVs)in dogfight engagements.Firstly,a nonlinear F-16 aircraft model and automatic control system are constructed by a MATLAB/Simulink platform.Secondly,a 3-degrees-of-freedom(3-DOF)aircraft model is used as a maneuvering command generator,and the expanded elemental maneuver library is designed,so that the aircraft state reachable set can be obtained.Then,the game matrix is composed with the air combat situation evaluation function calculated according to the angle and range threats.Finally,a key point is that the objective function to be optimized is designed using the game mixed strategy,and the optimal mixed strategy is obtained by TLPIO.Significantly,the proposed TLPIO does not initialize the population randomly,but adopts the transfer learning method based on Kullback-Leibler(KL)divergence to initialize the population,which improves the search accuracy of the optimization algorithm.Besides,the convergence and time complexity of TLPIO are discussed.Comparison analysis with other classical optimization algorithms highlights the advantage of TLPIO.In the simulation of air combat,three initial scenarios are set,namely,opposite,offensive and defensive conditions.The effectiveness performance of the proposed autonomous maneuver decision method is verified by simulation results.展开更多
Training can now be delivered on a large scale through mobile and web-based platforms in which the learner is often distanced from the instructor and their peers. In order to optimize learner engagement and maximize l...Training can now be delivered on a large scale through mobile and web-based platforms in which the learner is often distanced from the instructor and their peers. In order to optimize learner engagement and maximize learning in these contexts, instructional content and strategies must be engaging. Key to the development and study of such content and strategies, and adaptation of instructional techniques when learners become disengaged, is the ability to objectively assess engagement in real-time. Previous self-reported metrics, or expensive EEG-based engagement measures are not appropriate for large-scale platforms due to their complexity and cost. Here we describe the development and testing of a measurement and classification technique that utilizes non-invasive physiological and behavioral monitoring technology to directly assess engagement in classroom, simulation, and live training environments. An experimental study was conducted with 45 students and first responders in a unmanned aircraft systems (UAS) training program to assess the ability to accurately assess learner engagement and discriminate between levels of learner engagement within classroom, simulation and live environments via physiological and behavioral inputs. A series of engagement classifiers were developed using cardiovascular, respiratory, electrodermal, movement, and eye-tracking features that were able to successfully classify engagement levels at an accuracy level of 85% with eye-tracking features included or 81% without eye-tracking features. This approach is capable of monitoring, assessing, and tracking learner engagement across learning situations and contexts, and providing real-time and after action feedback to support instructors in modulating learner engagement.展开更多
Monitoring students’ level of engagement during learning activities is an important challenge in the development of tutoring interventions. In this paper, we explore the feasibility of using electroencephalographic s...Monitoring students’ level of engagement during learning activities is an important challenge in the development of tutoring interventions. In this paper, we explore the feasibility of using electroencephalographic signals (EEG) as a tool to monitor the mental engagement index of novice medicine students during a reasoning process. More precisely, the objectives were first, to track students’ mental engagement evolution in order to investigate whether there were particular sections within the learning environment that aroused the highest engagement level among the students, and, if so, did these sections have an impact on learners’ performance. Experimental analyses showed the same trends in the different resolution phases as well as across the different regions of the environments. However, we noticed a higher engagement index during the treatment identification phase since it aroused more mental effort. Moreover statistically significant effects were found between mental engagement and students’ performance.展开更多
Stroke is a leading cause of disability and mortality worldwide,necessitating the development of advanced technologies to improve its diagnosis,treatment,and patient outcomes.In recent years,machine learning technique...Stroke is a leading cause of disability and mortality worldwide,necessitating the development of advanced technologies to improve its diagnosis,treatment,and patient outcomes.In recent years,machine learning techniques have emerged as promising tools in stroke medicine,enabling efficient analysis of large-scale datasets and facilitating personalized and precision medicine approaches.This abstract provides a comprehensive overview of machine learning’s applications,challenges,and future directions in stroke medicine.Recently introduced machine learning algorithms have been extensively employed in all the fields of stroke medicine.Machine learning models have demonstrated remarkable accuracy in imaging analysis,diagnosing stroke subtypes,risk stratifications,guiding medical treatment,and predicting patient prognosis.Despite the tremendous potential of machine learning in stroke medicine,several challenges must be addressed.These include the need for standardized and interoperable data collection,robust model validation and generalization,and the ethical considerations surrounding privacy and bias.In addition,integrating machine learning models into clinical workflows and establishing regulatory frameworks are critical for ensuring their widespread adoption and impact in routine stroke care.Machine learning promises to revolutionize stroke medicine by enabling precise diagnosis,tailored treatment selection,and improved prognostication.Continued research and collaboration among clinicians,researchers,and technologists are essential for overcoming challenges and realizing the full potential of machine learning in stroke care,ultimately leading to enhanced patient outcomes and quality of life.This review aims to summarize all the current implications of machine learning in stroke diagnosis,treatment,and prognostic evaluation.At the same time,another purpose of this paper is to explore all the future perspectives these techniques can provide in combating this disabling disease.展开更多
As the field of artificial intelligence continues to evolve,so too does the application of multimodal learning analysis and intelligent adaptive learning systems.This trend has the potential to promote the equalizatio...As the field of artificial intelligence continues to evolve,so too does the application of multimodal learning analysis and intelligent adaptive learning systems.This trend has the potential to promote the equalization of educational resources,the intellectualization of educational methods,and the modernization of educational reform,among other benefits.This study proposes a construction framework for an intelligent adaptive learning system that is supported by multimodal data.It provides a detailed explanation of the system’s working principles and patterns,which aim to enhance learners’online engagement in behavior,emotion,and cognition.The study seeks to address the issue of intelligent adaptive learning systems diagnosing learners’learning behavior based solely on learning achievement,to improve learners’online engagement,enable them to master more required knowledge,and ultimately achieve better learning outcomes.展开更多
Learning analytics is an emerging technique of analysing student par-ticipation and engagement.The recent COVID-19 pandemic has significantly increased the role of learning management systems(LMSs).LMSs previously only...Learning analytics is an emerging technique of analysing student par-ticipation and engagement.The recent COVID-19 pandemic has significantly increased the role of learning management systems(LMSs).LMSs previously only complemented face-to-face teaching,something which has not been possible between 2019 to 2020.To date,the existing body of literature on LMSs has not analysed learning in the context of the pandemic,where an LMS serves as the only interface between students and instructors.Consequently,productive results will remain elusive if the key factors that contribute towards engaging students in learning are notfirst identified.Therefore,this study aimed to perform an exten-sive literature review with which to design and develop a student engagement model for holistic involvement in an LMS.The required data was collected from an LMS that is currently utilised by a local Malaysian university.The model was validated by a panel of experts as well as discussions with students.It is our hope that the result of this study will help other institutions of higher learning determine factors of low engagement in their respective LMSs.展开更多
Learning analytics is a rapidly evolving research discipline that uses theinsights generated from data analysis to support learners as well as optimize boththe learning process and environment. This paper studied stud...Learning analytics is a rapidly evolving research discipline that uses theinsights generated from data analysis to support learners as well as optimize boththe learning process and environment. This paper studied students’ engagementlevel of the Learning Management System (LMS) via a learning analytics tool,student’s approach in managing their studies and possible learning analytic methods to analyze student data. Moreover, extensive systematic literature review(SLR) was employed for the selection, sorting and exclusion of articles fromdiverse renowned sources. The findings show that most of the engagement inLMS are driven by educators. Additionally, we have discussed the factors inLMS, causes of low engagement and ways of increasing engagement factorsvia the Learning Analytics approach. Nevertheless, apart from recognizing theLearning Analytics approach as being a successful method and technique for analyzing the LMS data, this research further highlighted the possibility of mergingthe learning analytics technique with the LMS engagement in every institution asbeing a direction for future research.展开更多
针对大规模无人机自组网面临的任务需求多样性、电磁环境复杂性、节点高机动性等问题,充分考虑无人机节点高速移动的特点,基于无人机拓扑稳定度和链路通信容量指标设计了一种无人机多点中继(multi-point relay,MPR)选择方法;为了减少网...针对大规模无人机自组网面临的任务需求多样性、电磁环境复杂性、节点高机动性等问题,充分考虑无人机节点高速移动的特点,基于无人机拓扑稳定度和链路通信容量指标设计了一种无人机多点中继(multi-point relay,MPR)选择方法;为了减少网络路由更新时间,增加无人机自组网路由策略的稳定性和可靠性,提出了一种基于Q-learning的自适应链路状态路由协议(Q-learning based adaptive link state routing,QALSR)。仿真结果表明,所提算法性能指标优于现有的主动路由协议。展开更多
基金Research Project on Education and Teaching Reform at Hebei University of Chinese Medicine(22yb-45)Hebei Province Higher Education Teaching Reform Research and Practice Project(2021GJJG278)。
文摘The shift towards online intelligent learning has become the norm in education and is now a fundamental part of modern educational activities.However,this new model can influence students’learning behavior and lead to changes in their approach to learning.Based on online intelligent learning,we investigated how the academic self-efficacy of nursing students affects their engagement with learning and explored the role of academic attribution as a mediator.Five hundred fifty-three nursing college students from Hebei and Hunan provinces in China participated in the online questionnaire.The results revealed that effort plays a mediating role in the relationship between academic self-efficacy and learning engagement.
基金Zhejiang Provincial Philosophy and Social Sciences Planning Project from Zhejiang Office of Philosophy and Social Science(21NDJC092YB)Zhejiang Provincial Educational Science Plan Project(2021SCG166)。
文摘Blended learning(BL)has been widely adopted to improve students’academic achievements in higher education.However,its success relies mainly on student engagement,which plays an essential role in active learning and provides a rich understanding of students’experiences.The study utilized three self-designed scales-the Teacher Support Scale,Student Engagement Scale,and Student Learning Experience Scale-to gauge and examine the impact and relationship between perceived teacher support,student behavioral engagement,and the intermediary role of learning experiences.A cohort of 899 college students undertaking the obligatory College English course through BL modes across five Chinese universities actively participated by completing a comprehensive questionnaire.The results showed significant correlations between perceived teacher support,learning experience,and behavioral engagement.Perceived teacher support significantly predicted students’behavioral engagement,with socio-affective support exerting the most substantial predictive effects.All predictive effects were partially mediated by learning experience(learning mode,online resources,overall LMS-based learning,interaction with their instructor and peers,and learning outcome).The influence of perceived teacher support on behavioral engagement differed between students who reported the most positive(vs.negative)learning experiences.Suggestions for further research are offered for consideration.
基金supported by the National Natural Science Foundation of China,No.62276089。
文摘Artificial neural networks are capable of machine learning by simulating the hiera rchical structure of the human brain.To enable learning by brain and machine,it is essential to accurately identify and correct the prediction errors,referred to as credit assignment(Lillicrap et al.,2020).It is critical to develop artificial intelligence by understanding how the brain deals with credit assignment in neuroscience.
基金supported by the Ministry of Science and Technology of China,No.2020AAA0109605(to XL)Meizhou Major Scientific and Technological Innovation PlatformsProjects of Guangdong Provincial Science & Technology Plan Projects,No.2019A0102005(to HW).
文摘Early identification and treatment of stroke can greatly improve patient outcomes and quality of life.Although clinical tests such as the Cincinnati Pre-hospital Stroke Scale(CPSS)and the Face Arm Speech Test(FAST)are commonly used for stroke screening,accurate administration is dependent on specialized training.In this study,we proposed a novel multimodal deep learning approach,based on the FAST,for assessing suspected stroke patients exhibiting symptoms such as limb weakness,facial paresis,and speech disorders in acute settings.We collected a dataset comprising videos and audio recordings of emergency room patients performing designated limb movements,facial expressions,and speech tests based on the FAST.We compared the constructed deep learning model,which was designed to process multi-modal datasets,with six prior models that achieved good action classification performance,including the I3D,SlowFast,X3D,TPN,TimeSformer,and MViT.We found that the findings of our deep learning model had a higher clinical value compared with the other approaches.Moreover,the multi-modal model outperformed its single-module variants,highlighting the benefit of utilizing multiple types of patient data,such as action videos and speech audio.These results indicate that a multi-modal deep learning model combined with the FAST could greatly improve the accuracy and sensitivity of early stroke identification of stroke,thus providing a practical and powerful tool for assessing stroke patients in an emergency clinical setting.
文摘Machine learning(ML)is a type of artificial intelligence that assists computers in the acquisition of knowledge through data analysis,thus creating machines that can complete tasks otherwise requiring human intelligence.Among its various applications,it has proven groundbreaking in healthcare as well,both in clinical practice and research.In this editorial,we succinctly introduce ML applications and present a study,featured in the latest issue of the World Journal of Clinical Cases.The authors of this study conducted an analysis using both multiple linear regression(MLR)and ML methods to investigate the significant factors that may impact the estimated glomerular filtration rate in healthy women with and without non-alcoholic fatty liver disease(NAFLD).Their results implicated age as the most important determining factor in both groups,followed by lactic dehydrogenase,uric acid,forced expiratory volume in one second,and albumin.In addition,for the NAFLD-group,the 5th and 6th most important impact factors were thyroid-stimulating hormone and systolic blood pressure,as compared to plasma calcium and body fat for the NAFLD+group.However,the study's distinctive contribution lies in its adoption of ML methodologies,showcasing their superiority over traditional statistical approaches(herein MLR),thereby highlighting the potential of ML to represent an invaluable advanced adjunct tool in clinical practice and research.
基金supported by the National Natural Science Foundation of China,Nos.81730033,82171193(to XG)the Key Talent Project for Strengthening Health during the 13^(th)Five-Year Plan Period,No.ZDRCA2016069(to XG)+1 种基金the National Key R&D Program of China,No.2018YFC2001901(to XG)Jiangsu Provincial Medical Key Discipline,No.ZDXK202232(to XG)。
文摘Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life of patients.To date,there are no viable treatment options for postoperative cognitive dysfunction.The identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future research.To identify the signaling mechanisms contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the Gene Expression Omnibus GSE95426 dataset,which consists of mRNAs and long non-coding RNAs differentially expressed in mouse hippocampus3 days after tibial fracture.The dataset was enriched in genes associated with the biological process"regulation of immune cells,"of which Chill was identified as a hub gene.Therefore,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the mouse model of tibial fractu re surgery.Mice were intraperitoneally injected with vehicle or recombinant chitinase-3-like protein 124 hours post-surgery,and the injection groups were compared with untreated control mice for learning and memory capacities using the Y-maze and fear conditioning tests.In addition,protein expression levels of proinflammatory factors(interleukin-1βand inducible nitric oxide synthase),M2-type macrophage markers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated NMDA receptor subunit NR2B)were measured in hippocampus by western blotting.Treatment with recombinant chitinase-3-like protein 1 prevented surgery-induced cognitive impairment,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expression compared with vehicle treatment.Intraperitoneal administration of the specific ERK inhibitor PD98059 diminished the effects of recombinant chitinase-3-like protein 1.Collectively,our findings suggest that recombinant chitinase-3-like protein 1 ameliorates surgery-induced cognitive decline by attenuating neuroinflammation via M2 microglial polarization in the hippocampus.Therefore,recombinant chitinase-3-like protein1 may have therapeutic potential fo r postoperative cognitive dysfunction.
基金supported by the National Institutes of Health,Nos.AA025919,AA025919-03S1,and AA025919-05S1(all to RAF).
文摘Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s disease.Adult hippocampal neurogenesis is reduced in patients with Alzheimer’s disease.Exercise stimulates adult hippocampal neurogenesis in rodents and improves memory and slows cognitive decline in patients with Alzheimer’s disease.However,the molecular pathways for exercise-induced adult hippocampal neurogenesis and improved cognition in Alzheimer’s disease are poorly understood.Recently,regulator of G protein signaling 6(RGS6)was identified as the mediator of voluntary running-induced adult hippocampal neurogenesis in mice.Here,we generated novel RGS6fl/fl;APP_(SWE) mice and used retroviral approaches to examine the impact of RGS6 deletion from dentate gyrus neuronal progenitor cells on voluntary running-induced adult hippocampal neurogenesis and cognition in an amyloid-based Alzheimer’s disease mouse model.We found that voluntary running in APP_(SWE) mice restored their hippocampal cognitive impairments to that of control mice.This cognitive rescue was abolished by RGS6 deletion in dentate gyrus neuronal progenitor cells,which also abolished running-mediated increases in adult hippocampal neurogenesis.Adult hippocampal neurogenesis was reduced in sedentary APP_(SWE) mice versus control mice,with basal adult hippocampal neurogenesis reduced by RGS6 deletion in dentate gyrus neural precursor cells.RGS6 was expressed in neurons within the dentate gyrus of patients with Alzheimer’s disease with significant loss of these RGS6-expressing neurons.Thus,RGS6 mediated voluntary running-induced rescue of impaired cognition and adult hippocampal neurogenesis in APP_(SWE) mice,identifying RGS6 in dentate gyrus neural precursor cells as a possible therapeutic target in Alzheimer’s disease.
文摘Student engagement in a clinical learning environment is a vital component in the curricula of pre-licensure nursing students, providing an opportunity to combine cognitive, psychomotor, and affective skills. This paper is significant in Arab world as there is a lack of knowledge, attitude and practice of student involvement in the new clinical learning environment. The purpose of this review article is to describe the experiences and perspectives of the nurse educator in facilitating pre-licensure nursing students’ engagement in the new clinical learning environment. The review suggests that novice students prefer actual engagement in clinical learning facilitated through diversity experiences, shared learning opportunities, student-faculty interaction and active learning. They expressed continuous supervision, ongoing feedback, interpersonal relationship and personal support from nurse educators useful in the clinical practice. However, the value of this review lies in a better understanding of what constitutes quality clinical learning environment from the students’ perspective of engagement in evidence-based nursing, reflective practice, e-learning and simulated case scenarios facilitated by the nurse educators. This review is valuable in planning and implementing innovative clinical and educational experiences for improving the quality of the clinical teaching-learning environment.
基金the Science and Technology Innovation 2030-Key Project of“New Generation Artificial Intelligence”(2018AAA0100803)the National Natural Science Foundation of China(U20B2071,91948204,T2121003,U1913602)。
文摘This paper proposes an autonomous maneuver decision method using transfer learning pigeon-inspired optimization(TLPIO)for unmanned combat aerial vehicles(UCAVs)in dogfight engagements.Firstly,a nonlinear F-16 aircraft model and automatic control system are constructed by a MATLAB/Simulink platform.Secondly,a 3-degrees-of-freedom(3-DOF)aircraft model is used as a maneuvering command generator,and the expanded elemental maneuver library is designed,so that the aircraft state reachable set can be obtained.Then,the game matrix is composed with the air combat situation evaluation function calculated according to the angle and range threats.Finally,a key point is that the objective function to be optimized is designed using the game mixed strategy,and the optimal mixed strategy is obtained by TLPIO.Significantly,the proposed TLPIO does not initialize the population randomly,but adopts the transfer learning method based on Kullback-Leibler(KL)divergence to initialize the population,which improves the search accuracy of the optimization algorithm.Besides,the convergence and time complexity of TLPIO are discussed.Comparison analysis with other classical optimization algorithms highlights the advantage of TLPIO.In the simulation of air combat,three initial scenarios are set,namely,opposite,offensive and defensive conditions.The effectiveness performance of the proposed autonomous maneuver decision method is verified by simulation results.
文摘Training can now be delivered on a large scale through mobile and web-based platforms in which the learner is often distanced from the instructor and their peers. In order to optimize learner engagement and maximize learning in these contexts, instructional content and strategies must be engaging. Key to the development and study of such content and strategies, and adaptation of instructional techniques when learners become disengaged, is the ability to objectively assess engagement in real-time. Previous self-reported metrics, or expensive EEG-based engagement measures are not appropriate for large-scale platforms due to their complexity and cost. Here we describe the development and testing of a measurement and classification technique that utilizes non-invasive physiological and behavioral monitoring technology to directly assess engagement in classroom, simulation, and live training environments. An experimental study was conducted with 45 students and first responders in a unmanned aircraft systems (UAS) training program to assess the ability to accurately assess learner engagement and discriminate between levels of learner engagement within classroom, simulation and live environments via physiological and behavioral inputs. A series of engagement classifiers were developed using cardiovascular, respiratory, electrodermal, movement, and eye-tracking features that were able to successfully classify engagement levels at an accuracy level of 85% with eye-tracking features included or 81% without eye-tracking features. This approach is capable of monitoring, assessing, and tracking learner engagement across learning situations and contexts, and providing real-time and after action feedback to support instructors in modulating learner engagement.
文摘Monitoring students’ level of engagement during learning activities is an important challenge in the development of tutoring interventions. In this paper, we explore the feasibility of using electroencephalographic signals (EEG) as a tool to monitor the mental engagement index of novice medicine students during a reasoning process. More precisely, the objectives were first, to track students’ mental engagement evolution in order to investigate whether there were particular sections within the learning environment that aroused the highest engagement level among the students, and, if so, did these sections have an impact on learners’ performance. Experimental analyses showed the same trends in the different resolution phases as well as across the different regions of the environments. However, we noticed a higher engagement index during the treatment identification phase since it aroused more mental effort. Moreover statistically significant effects were found between mental engagement and students’ performance.
文摘Stroke is a leading cause of disability and mortality worldwide,necessitating the development of advanced technologies to improve its diagnosis,treatment,and patient outcomes.In recent years,machine learning techniques have emerged as promising tools in stroke medicine,enabling efficient analysis of large-scale datasets and facilitating personalized and precision medicine approaches.This abstract provides a comprehensive overview of machine learning’s applications,challenges,and future directions in stroke medicine.Recently introduced machine learning algorithms have been extensively employed in all the fields of stroke medicine.Machine learning models have demonstrated remarkable accuracy in imaging analysis,diagnosing stroke subtypes,risk stratifications,guiding medical treatment,and predicting patient prognosis.Despite the tremendous potential of machine learning in stroke medicine,several challenges must be addressed.These include the need for standardized and interoperable data collection,robust model validation and generalization,and the ethical considerations surrounding privacy and bias.In addition,integrating machine learning models into clinical workflows and establishing regulatory frameworks are critical for ensuring their widespread adoption and impact in routine stroke care.Machine learning promises to revolutionize stroke medicine by enabling precise diagnosis,tailored treatment selection,and improved prognostication.Continued research and collaboration among clinicians,researchers,and technologists are essential for overcoming challenges and realizing the full potential of machine learning in stroke care,ultimately leading to enhanced patient outcomes and quality of life.This review aims to summarize all the current implications of machine learning in stroke diagnosis,treatment,and prognostic evaluation.At the same time,another purpose of this paper is to explore all the future perspectives these techniques can provide in combating this disabling disease.
文摘As the field of artificial intelligence continues to evolve,so too does the application of multimodal learning analysis and intelligent adaptive learning systems.This trend has the potential to promote the equalization of educational resources,the intellectualization of educational methods,and the modernization of educational reform,among other benefits.This study proposes a construction framework for an intelligent adaptive learning system that is supported by multimodal data.It provides a detailed explanation of the system’s working principles and patterns,which aim to enhance learners’online engagement in behavior,emotion,and cognition.The study seeks to address the issue of intelligent adaptive learning systems diagnosing learners’learning behavior based solely on learning achievement,to improve learners’online engagement,enable them to master more required knowledge,and ultimately achieve better learning outcomes.
文摘Learning analytics is an emerging technique of analysing student par-ticipation and engagement.The recent COVID-19 pandemic has significantly increased the role of learning management systems(LMSs).LMSs previously only complemented face-to-face teaching,something which has not been possible between 2019 to 2020.To date,the existing body of literature on LMSs has not analysed learning in the context of the pandemic,where an LMS serves as the only interface between students and instructors.Consequently,productive results will remain elusive if the key factors that contribute towards engaging students in learning are notfirst identified.Therefore,this study aimed to perform an exten-sive literature review with which to design and develop a student engagement model for holistic involvement in an LMS.The required data was collected from an LMS that is currently utilised by a local Malaysian university.The model was validated by a panel of experts as well as discussions with students.It is our hope that the result of this study will help other institutions of higher learning determine factors of low engagement in their respective LMSs.
基金supported by the University of Malaya,Bantuan Khas Penyelidikan under the research grant of BKS083-2017Fundamental Research Grant Scheme(FRGS)under Grant number FP112-2018A from the Ministry of Education Malaysia,Higher Education.
文摘Learning analytics is a rapidly evolving research discipline that uses theinsights generated from data analysis to support learners as well as optimize boththe learning process and environment. This paper studied students’ engagementlevel of the Learning Management System (LMS) via a learning analytics tool,student’s approach in managing their studies and possible learning analytic methods to analyze student data. Moreover, extensive systematic literature review(SLR) was employed for the selection, sorting and exclusion of articles fromdiverse renowned sources. The findings show that most of the engagement inLMS are driven by educators. Additionally, we have discussed the factors inLMS, causes of low engagement and ways of increasing engagement factorsvia the Learning Analytics approach. Nevertheless, apart from recognizing theLearning Analytics approach as being a successful method and technique for analyzing the LMS data, this research further highlighted the possibility of mergingthe learning analytics technique with the LMS engagement in every institution asbeing a direction for future research.
文摘针对大规模无人机自组网面临的任务需求多样性、电磁环境复杂性、节点高机动性等问题,充分考虑无人机节点高速移动的特点,基于无人机拓扑稳定度和链路通信容量指标设计了一种无人机多点中继(multi-point relay,MPR)选择方法;为了减少网络路由更新时间,增加无人机自组网路由策略的稳定性和可靠性,提出了一种基于Q-learning的自适应链路状态路由协议(Q-learning based adaptive link state routing,QALSR)。仿真结果表明,所提算法性能指标优于现有的主动路由协议。