Design of N-11-Azaartemisinins Potentially Active against Plasmodium falciparum by Combined Molecular Electrostatic Potential, Ligand-Receptor Interaction and Models Built with Supervised Machine Learning Methods

N-11-azaartemisinins potentially active against Plasmodium falciparum are designed by combining molecular electrostatic potential (MEP), ligand-receptor interaction, and models built with supervised machine learning methods (PCA, HCA, KNN, SIMCA, and SDA). The optimization of molecular structures was performed using the B3LYP/6-31G* approach. MEP maps and ligand-receptor interactions were used to investigate key structural features required for biological activities and likely interactions between N-11-azaartemisinins and heme, respectively. The supervised machine learning methods allowed the separation of the investigated compounds into two classes: cha and cla, with the properties εLUMO+1 (one level above lowest unoccupied molecular orbital energy), d(C6-C5) (distance between C6 and C5 atoms in ligands), and TSA (total surface area) responsible for the classification. The insights extracted from the investigation developed and the chemical intuition enabled the design of sixteen new N-11-azaartemisinins (prediction set), moreover, models built with supervised machine learning methods were applied to this prediction set. The result of this application showed twelve new promising N-11-azaartemisinins for synthesis and biological evaluation.

The State-of-the-Art Review on Applications of Intrusive Sensing,Image Processing Techniques,and Machine Learning Methods in Pavement Monitoring and Analysis

In modern transportation,pavement is one of the most important civil infrastructures for the movement of vehicles and pedestrians.Pavement service quality and service life are of great importance for civil engineers as they directly affect the regular service for the users.Therefore,monitoring the health status of pavement before irreversible damage occurs is essential for timely maintenance,which in turn ensures public transportation safety.Many pavement damages can be detected and analyzed by monitoring the structure dynamic responses and evaluating road surface conditions.Advanced technologies can be employed for the collection and analysis of such data,including various intrusive sensing techniques,image processing techniques,and machine learning methods.This review summarizes the state-ofthe-art of these three technologies in pavement engineering in recent years and suggests possible developments for future pavement monitoring and analysis based on these approaches.

Case Study of a Chinese Girl's English Learning Methods in the American Elementary School

The goal of this research is to explore a more successful method for Mainland Chinese students to learn English.This newmethod will be illustrated by using the experiences of my daughter while a student in an elementary school in the United States for oneyear.From the analysis of her learning experiences,the following conclusions were drawn:1) Immerse language learning is important tolanguage input.2) Phonics is an effective tool to improve reading for Chinese English

Vibration properties of Paulownia wood for Ruan sound quality using machine learning methods

As an important material for manufacturing resonant components of musical instruments,Paulownia has an important influence on the sound quality of Ruan.In this paper,a model for evaluating the sound quality of Ruan based on the vibration characteristics of wood is developed using machine learning methods.Generally,the selection of materials for Ruan manufacturing relies primarily on manually weighing,observing,striking,and listening by the instrument technician.Deficiencies in scientific theory have hindered the quality of the finished Ruan.In this study,nine Ruans were manufactured,and a prediction model of Ruan sound quality was proposed based on the raw material information of Ruans.Out of a total of 180 data sets,145 and 45 sets were chosen for training and validation,respec-tively.In this paper,typical correlation analysis was used to determine the correlation between two single indicators in two adjacent pairwise combinations of the measured objects in each stage of the production process in Ruan.The vibra-tion characteristics of the wood were tested,and a model for predicting the evaluation of Ruan’s acoustic qualities was developed by measuring the vibration characteristics of the resonating plate material.The acoustic quality of the Ruan sound board wood was evaluated and predicted using machine learning model generalized regression neural net-work.The results show that the prediction of Ruan sound quality can be achieved using Matlab simulation based on the vibration characteristics of the soundboard wood.When the model-predicted values were compared with the tradi-tional predicted results,it was found that the generalized regression neural network had good performance,achieving an accuracy of 93.8%which was highly consistent with the experimental results.It was concluded that the model can accurately predict the acoustic quality of the Ruan based on the vibration performance of the soundboards.

Feedback on a shared big dataset for intelligent TBM PartⅠ:Feature extraction and machine learning methods

This review summarizes the research outcomes and findings documented in 45 journal papers using a shared tunnel boring machine(TBM)dataset for performance prediction and boring efficiency optimization using machine learning methods.The big dataset was col-lected during the Yinsong water diversion project construction in China,covering the tunnel excavation of a 20 km-section with 199 items of monitoring metrics taken with an interval of one second.The research papers were the result of a call for contributions during a TBM machine learning contest in 2019 and covered a variety of topics related to the intelligent construction of TBM.This review com-prises two parts.Part I is concerned with the data processing,feature extraction,and machine learning methods applied by the contrib-utors.The review finds that the data-driven and knowledge-driven approaches in extracting important features applied by various authors are diversified,requiring further studies to achieve commonly accepted criteria.The techniques for cleaning and amending the raw data adopted by the contributors were summarized,indicating some highlights such as the importance of sufficiently high fre-quency of data acquisition(higher than 1 second),classification and standardization for the data preprocessing process,and the appro-priate selections of features in a boring cycle.The review finds that both supervised and unsupervised machine learning methods have been utilized by various researchers.The ensemble and deep learning methods have found wide applications.Part I highlights the impor-tant features of the individual methods applied by the contributors,including the structures of the algorithm,selection of hyperparam-eters,and model validation approaches.

The Effectiveness of Group Cooperative Learning Method in Badminton Teaching in Colleges and Universities

In college badminton teaching,teachers utilize the group cooperative learning method,which not only helps to improve students’badminton skill level but also cultivates their teamwork spirit,communication skills,and self-management ability unconsciously.In view of this,this paper mainly describes the significance of applying the group cooperative learning method in college badminton teaching,analyzes the current problems in college badminton teaching,and aims to discover effective development strategies for group cooperative learning method in college badminton teaching in order to improve the effectiveness of college badminton teaching.

Research and Discussion on Flipped Classroom Combined with Case-Based Learning in Pharmacoeconomics Teaching

Objective:To explore the application effect of flipped classroom combined with case-based learning teaching methods in pharmacoeconomics teaching.Methods:The students majoring in clinical pharmacy in 2019 were selected as the study subjects,and the cost-effectiveness analysis of different dosage forms of Yinzhihuang in the treatment of neonatal jaundice was selected as the teaching case.The flipped classroom combined with case-based learning teaching method was used to carry out theoretical teaching to the students.After the course,questionnaires were distributed through the Sojump platform to evaluate the teaching effect.Results:The results of the questionnaire showed that 85.71%of the students believed that the flipped classroom combined with case-based learning teaching method was helpful in mobilizing the learning enthusiasm and initiative,and improving the comprehensive application ability of the knowledge of pharmacoeconomics.92.86%of the students think that it is conducive to the understanding and memorization of learning content,as well as the cultivation of teamwork,communication,etc.Conclusion:Flipped classroom combined with case-based learning teaching method can improve students’knowledge mastery,thinking skills,and practical application skills,as well as optimize and improve teachers’teaching levels.

Survey on Deep Learning Approaches for Detection of Email Security Threat

Emailing is among the cheapest and most easily accessible platforms,and covers every idea of the present century like banking,personal login database,academic information,invitation,marketing,advertisement,social engineering,model creation on cyber-based technologies,etc.The uncontrolled development and easy access to the internet are the reasons for the increased insecurity in email communication.Therefore,this review paper aims to investigate deep learning approaches for detecting the threats associated with e-mail security.This study compiles the literature related to the deep learning methodologies,which are applicable for providing safety in the field of cyber security of email in different organizations.Relevant data were extracted from different research depositories.The paper discusses various solutions for handling these threats.Different challenges and issues are also investigated for e-mail security threats including social engineering,malware,spam,and phishing in the existing solutions to identify the core current problem and set the road for future studies.The review analysis showed that communication media is the common platform for attackers to conduct fraudulent activities via spoofed e-mails and fake websites and this research has combined the merit and demerits of the deep learning approaches adaption in email security threat by the usage of models and technologies.The study highlighted the contrasts of deep learning approaches in detecting email security threats.This review study has set criteria to include studies that deal with at least one of the six machine models in cyber security.

Exploring the Application Effect of Flipped Classroom Combined with Problem-Based Learning Teaching Method in Clinical Skills Teaching of Standardized Training for Resident Doctors of Traditional Chinese Medicine

Objective: To explore the application effect of flipped classroom combined with problem-based learning teaching method in clinical skills teaching of standardized training for resident doctors of traditional Chinese Medicine. Methods: The study used the experimental control method. The study lasted from September to November 2022. The subjects of this study were 49 students of standardized training for resident doctors of traditional Chinese Medicine from grades 2020, 2021 and 2022 of Dazhou integrated TCM & Western Medicine Hospital. They were randomly divided into experiment group (25) and control group (24). The experiment group adopted flipped classroom combined with problem-based learning teaching method, and the control group adopted traditional teaching method. The teaching content was 4 basic clinical skill projects, including four diagnoses of traditional Chinese Medicine, cardiopulmonary resuscitation, dressing change procedure, acupuncture and massage. The evaluation method was carried out by comparing the students’ performance and a self-designed questionnaire was used to investigate the students’ evaluation of the teaching method. Results: The test scores of total scores in the experimental group (90.12 ± 5.89) were all higher than those in the control group (81.47 ± 7.96) (t = 4.53, P P Conclusions: The teaching process of the flipped classroom combined with problem-based learning teaching method is conducive to improving the efficiency of classroom teaching, cultivating students’ self-learning ability, and enhancing students’ willingness to learn.

LexDeep:Hybrid Lexicon and Deep Learning Sentiment Analysis Using Twitter for Unemployment-Related Discussions During COVID-19

The COVID-19 pandemic has spread globally,resulting in financialinstability in many countries and reductions in the per capita grossdomestic product.Sentiment analysis is a cost-effective method for acquiringsentiments based on household income loss,as expressed on social media.However,limited research has been conducted in this domain using theLexDeep approach.This study aimed to explore social trend analytics usingLexDeep,which is a hybrid sentiment analysis technique,on Twitter to capturethe risk of household income loss during the COVID-19 pandemic.First,tweet data were collected using Twint with relevant keywords before(9 March2019 to 17 March 2020)and during(18 March 2020 to 21 August 2021)thepandemic.Subsequently,the tweets were annotated using VADER(lexiconbased)and fed into deep learning classifiers,and experiments were conductedusing several embeddings,namely simple embedding,Global Vectors,andWord2Vec,to classify the sentiments expressed in the tweets.The performanceof each LexDeep model was evaluated and compared with that of a supportvector machine(SVM).Finally,the unemployment rates before and duringCOVID-19 were analysed to gain insights into the differences in unemploymentpercentages through social media input and analysis.The resultsdemonstrated that all LexDeep models with simple embedding outperformedthe SVM.This confirmed the superiority of the proposed LexDeep modelover a classical machine learning classifier in performing sentiment analysistasks for domain-specific sentiments.In terms of the risk of income loss,the unemployment issue is highly politicised on both the regional and globalscales;thus,if a country cannot combat this issue,the global economy will alsobe affected.Future research should develop a utility maximisation algorithmfor household welfare evaluation,given the percentage risk of income lossowing to COVID-19.

Automatic recognition of tweek atmospherics and plasma diagnostics in the lower ionosphere with the machine learning method

Tweek atmospherics are extremely low frequency and very low frequency pulse signals with frequency dispersion characteristics that originate from lightning discharges and that propagate in the Earth–ionosphere waveguide over long distances.In this study,we developed an automatic method to recognize tweek atmospherics and diagnose the lower ionosphere based on the machine learning method.The differences(automatic−manual)in each ionosphere parameter between the automatic method and the manual method were−0.07±2.73 km,0.03±0.92 cm^(−3),and 91±1,068 km for the ionospheric reflection height(h),equivalent electron densities at reflection heights(Ne),and propagation distance(d),respectively.Moreover,the automatic method is capable of recognizing higher harmonic tweek sferics.The evaluation results of the model suggest that the automatic method is a powerful tool for investigating the long-term variations in the lower ionosphere.

Efficient People Detection with Infrared Images

This work focuses on the problem of monitoring the coastline, which in Portugal’s case means monitoring 3007 kilometers, including 1793 maritime borders with the Atlantic Ocean to the south and west. The human burden on the coast becomes a problem, both because erosion makes the cliffs unstable and because pollution increases, making the fragile dune ecosystem difficult to preserve. It is becoming necessary to increase the control of access to beaches, even if it is not a popular measure for internal and external tourism. The methodology described can also be used to monitor maritime borders. The use of images acquired in the infrared range guarantees active surveillance both day and night, the main objective being to mimic the infrared cameras already installed in some critical areas along the coastline. Using a series of infrared photographs taken at low angles with a modified camera and appropriate filter, a recent deep learning algorithm with the right training can simultaneously detect and count whole people at close range and people almost completely submerged in the water, including partially visible targets, achieving a performance with F1 score of 0.945, with 97% of targets correctly identified. This implementation is possible with ordinary laptop computers and could contribute to more frequent and more extensive coverage in beach/border surveillance, using infrared cameras at regular intervals. It can be partially automated to send alerts to the authorities and/or the nearest lifeguards, thus increasing monitoring without relying on human resources.

Deep Learning Applied to Computational Mechanics:A Comprehensive Review,State of the Art,and the Classics

Three recent breakthroughs due to AI in arts and science serve as motivation:An award winning digital image,protein folding,fast matrix multiplication.Many recent developments in artificial neural networks,particularly deep learning(DL),applied and relevant to computational mechanics(solid,fluids,finite-element technology)are reviewed in detail.Both hybrid and pure machine learning(ML)methods are discussed.Hybrid methods combine traditional PDE discretizations with ML methods either(1)to help model complex nonlinear constitutive relations,(2)to nonlinearly reduce the model order for efficient simulation(turbulence),or(3)to accelerate the simulation by predicting certain components in the traditional integration methods.Here,methods(1)and(2)relied on Long-Short-Term Memory(LSTM)architecture,with method(3)relying on convolutional neural networks.Pure ML methods to solve(nonlinear)PDEs are represented by Physics-Informed Neural network(PINN)methods,which could be combined with attention mechanism to address discontinuous solutions.Both LSTM and attention architectures,together with modern and generalized classic optimizers to include stochasticity for DL networks,are extensively reviewed.Kernel machines,including Gaussian processes,are provided to sufficient depth for more advanced works such as shallow networks with infinite width.Not only addressing experts,readers are assumed familiar with computational mechanics,but not with DL,whose concepts and applications are built up from the basics,aiming at bringing first-time learners quickly to the forefront of research.History and limitations of AI are recounted and discussed,with particular attention at pointing out misstatements or misconceptions of the classics,even in well-known references.Positioning and pointing control of a large-deformable beam is given as an example.

Weighted Forwarding in Graph Convolution Networks for Recommendation Information Systems

Recommendation Information Systems(RIS)are pivotal in helping users in swiftly locating desired content from the vast amount of information available on the Internet.Graph Convolution Network(GCN)algorithms have been employed to implement the RIS efficiently.However,the GCN algorithm faces limitations in terms of performance enhancement owing to the due to the embedding value-vanishing problem that occurs during the learning process.To address this issue,we propose a Weighted Forwarding method using the GCN(WF-GCN)algorithm.The proposed method involves multiplying the embedding results with different weights for each hop layer during graph learning.By applying the WF-GCN algorithm,which adjusts weights for each hop layer before forwarding to the next,nodes with many neighbors achieve higher embedding values.This approach facilitates the learning of more hop layers within the GCN framework.The efficacy of the WF-GCN was demonstrated through its application to various datasets.In the MovieLens dataset,the implementation of WF-GCN in LightGCN resulted in significant performance improvements,with recall and NDCG increasing by up to+163.64%and+132.04%,respectively.Similarly,in the Last.FM dataset,LightGCN using WF-GCN enhanced with WF-GCN showed substantial improvements,with the recall and NDCG metrics rising by up to+174.40%and+169.95%,respectively.Furthermore,the application of WF-GCN to Self-supervised Graph Learning(SGL)and Simple Graph Contrastive Learning(SimGCL)also demonstrated notable enhancements in both recall and NDCG across these datasets.

English Learning under the Context of Globalization

In contemporary,globalization is advancing at an unprecedented rate in multitude arenas.Globalization has brought us to contact with the culture,customs and thinking of countries around the world.English learning under the context of globalization has been changed to some extent.Globalization is exuberant,specific learning instead of systematic learning is what is necessitated.

A Study on the Effect of Creative Chinese Characters Learning on the Ability to Learn Chinese Old Sayings and Idioms Using K-Pop Music Video

Music is an extraordinary bridge between people all over the world so much as to be called a universal language. Idols and B-boys stages are fun, touching, and fantastic. Today, South Korean students are excited and enthusiastic about their colorful dance moves. The study is about creative educational methods that use K-pop music videos to learn the proverbs and old words that our ancestors learned to keep in mind and teach. K-pop lyrics are a rich reflection of the experiences of life and the world in which people are living today. Accordingly, this study can present new teaching and learning method examples that are used in class related to the old language associated with K-pop lyrics and can also introduce interesting class materials.

The Impact of Online Courses towards Students in Autonomous Learning Based on New Media Technologies

In the 21st century,the rapid development of online technology has dramatically transformed people’s way of lives.The emergence of high-tech products has also boosted modern education to embrace informationization and virtualization.With the promotion and development of online courses,autonomous learning is now emerging among students in colleges and universities.If they want to learn relevant professional knowledge,they could use networking and information technology with relevant devices.This learning method could not only impact traditional education but also facilitate students to explore new ways to learn autonomously.This paper is to discuss the impact of online courses towards students in autonomous learning by analyzing its current learning situation,the feature of this new form and its effects towards students.

Soliton, breather, and rogue wave solutions for solving the nonlinear Schrodinger equation using a deep learning method with physical constraints

The nonlinear Schrodinger equation is a classical integrable equation which contains plenty of significant properties and occurs in many physical areas.However,due to the difficulty of solving this equation,in particular in high dimensions,lots of methods are proposed to effectively obtain different kinds of solutions,such as neural networks among others.Recently,a method where some underlying physical laws are embeded into a conventional neural network is proposed to uncover the equation’s dynamical behaviors from spatiotemporal data directly.Compared with traditional neural networks,this method can obtain remarkably accurate solution with extraordinarily less data.Meanwhile,this method also provides a better physical explanation and generalization.In this paper,based on the above method,we present an improved deep learning method to recover the soliton solutions,breather solution,and rogue wave solutions of the nonlinear Schrodinger equation.In particular,the dynamical behaviors and error analysis about the one-order and two-order rogue waves of nonlinear integrable equations are revealed by the deep neural network with physical constraints for the first time.Moreover,the effects of different numbers of initial points sampled,collocation points sampled,network layers,neurons per hidden layer on the one-order rogue wave dynamics of this equation have been considered with the help of the control variable way under the same initial and boundary conditions.Numerical experiments show that the dynamical behaviors of soliton solutions,breather solution,and rogue wave solutions of the integrable nonlinear Schrodinger equation can be well reconstructed by utilizing this physically-constrained deep learning method.

Real-time determination of sandy soil stiffness during vibratory compaction incorporating machine learning method for intelligent compaction

An emerging real-time ground compaction and quality control, known as intelligent compaction(IC), has been applied for efficiently optimising the full-area compaction. Although IC technology can provide real-time assessment of uniformity of the compacted area, accurate determination of the soil stiffness required for quality control and design remains challenging. In this paper, a novel and advanced numerical model simulating the interaction of vibratory drum and soil beneath is developed. The model is capable of evaluating the nonlinear behaviour of underlying soil subjected to dynamic loading by capturing the variations of damping with the cyclic shear strains and degradation of soil modulus. The interaction of the drum and the soil is simulated via the finite element method to develop a comprehensive dataset capturing the dynamic responses of the drum and the soil. Indeed, more than a thousand three-dimensional(3D) numerical models covering various soil characteristics, roller weights, vibration amplitudes and frequencies were adopted. The developed dataset is then used to train the inverse solver using an innovative machine learning approach, i.e. the extended support vector regression, to simulate the stiffness of the compacted soil by adopting drum acceleration records. Furthermore, the impacts of the amplitude and frequency of the vibration on the level of underlying soil compaction are discussed.The proposed machine learning approach is promising for real-time extraction of actual soil stiffness during compaction. Results of the study can be employed by practising engineers to interpret roller drum acceleration data to estimate the level of compaction and ground stiffness during compaction.

Prediction of Seaward Slope Recession in Berm Breakwaters Using M5＇ Machine Learning Approach

In the design process of berm breakwaters, their front slope recession has an inevitable rule in large number of model tests, and this parameter being studied. This research draws its data from Moghim＇s and Shekari＇s experiment results. These experiments consist of two different 2D model tests in two wave flumes, in which the berm recession to different sea state and structural parameters have been studied. Irregular waves with a JONSWAP spectrum were used in both test series. A total of 412 test results were used to cover the impact of sea state conditions such as wave height, wave period, storm duration and water depth at the toe of the structure, and structural parameters such as berm elevation from still water level, berm width and stone diameter on berm recession parameters. In this paper, a new set of equations for berm recession is derived using the M5＇ model tree as a machine learning approach. A comparison is made between the estimations by the new formula and the formulae recently given by other researchers to show the preference of new M5＇ approach.