The Relationships between Serum Concentration of IGF-I and Left Ventricular Function as well as Coronary Collateral Circulation in Patients with Coronary Artery Disease

Objective To investigate therelationships between serum concentration of insulin -like growth factor - I (IGF-I) and left ventricular function as well as coronary collateral circulation in patients with coronary artery disease (CAD) . Methods In 41 patients with CAD and 15 control subjects without CAD, the concentrations of serum IGF - I were measured using radioimmunoassay. The relationships between the concentration of serum IGF - I and Leaman coronary artery score, Rentrop grade of coronary collateral circulation, left ventricular ejection fraction (LVEF) as well as left ventricular wall motion Cortina score were assessed. Results 1. There was no significant difference in the mean level of serum IGF -I between the CAD group and the control group (107. 92±44.74 ng/ml vs 113.05 ±33. 65 ng/ml, P> 0. 05), but the IGF - I concentrations in the subgroup with collateral circulation were significantly greater than that in the control group (147. 33 ±29. 92 ng/ml vs 113. 05±33. 65 ng/ml, P < 0. 01) or in the subgroup without collateral circulation (147. 33 ±29. 92 ng/ml vs 80. 01±29. 75 ng/ml , P < 0. 01). 2. The serum concentration of IGF -I had no significant correlation to the Leaman coronary artery score. 3. The serum level of IGF -I had significantly positive correlation to both LVEF ( r = 0. 45, P < 0. 001) and the Rentrop grade of coronary collateral circulation ( r = 0. 74, P < 0. 001), and was negatively related to the left ventricular wall motion Cortina score (r = -0. 53, P < 0. 001). 4. The Leaman coronary artery score had no significant correlation to the Rentrop grade of coronary collateral circulation. 5. The Leaman coronary artery score was related to neither the LVEF nor the Cortina score in the whole CAD group. In the subgroup without coronary collateral circulation, however, the Leaman score had significantly negative correlation to LVEF ( r = - 0. 46, P < 0. 05) and positive correlation to the Cortina score (r = 0. 47, P < 0. 05) . Conclusions The serum concentration of IGF -I was associated with both left ventricular function and coronary collateral circulation in patients with CAD. IGF -I may play a role in promoting coronary collateral circulation and in protecting left ventricular function in patients with coronary artery disease.

需求导向下农村留守妇女关爱服务体系构建研究--基于3省56个案例的扎根分析

基于对河南、江西和四川3省56个案例的深度访谈资料,采用扎根研究方法,结合社会支持和需求层次理论,通过三级编码,构建起需求导向下农村留守妇女关爱服务体系的构成模型。研究认为,农村留守妇女的需求满足在很大程度上仍停留于匮乏性需求的满足上,较少关注到成长性需求。故亟须建立健全农村留守妇女关爱服务体系,由国家、社会、家庭等多元力量合作参与,为其提供家庭生计、基本生活、卫生医疗、家庭照料、子女教育、劳动生产、情感关爱和文化活动等初级服务,引导其树立先进性别文化观念,强化针对性就业创业服务,重视其自尊和自我实现的需求,帮助其改善身心健康、提高生活质量,并使其成为乡村振兴战略的推动者和受益者。

Effects of aerobic training on serum paraoxonase activity and its relationship with PON1-192 phenotypes in women

Background：Paraoxonase 1（PON1） is an antioxidant enzyme that protects high-density lipoprotein（HDL） and low-density lipoprotein against oxidation.Limited studies have addressed the influenc of exercise on PON1 activity and its relationship with PON1 phenotypes.We investigated relationships between PON1-192 phenotypes,PON1 activity,aerobic exercise,and blood lipid and lipoprotein concentrations in middle-aged women.Methods：An exercise group（n=50） engaging in regular aerobic exercise and a control group（n=41） were selected from a subset of 300 Caucasian women that met the inclusion criteria.Serum PON1,salt-stimulated PON1（SSPON1）,and arylesterase（ARE） activities;cholesterol levels and ARE activities of total HDL and HDL subgroups（HDLs）（supernatants obtained by polyethylene glycol）;and blood lipid and lipoprotein concentrations were determined by standardized enzymatic methods.PON1-192 QQ（low activity）,QR（moderate activity）,and RR（high activity） phenotype groups were define using serum SSPON1/ARE activity ratios.The R-carries（RC） phenotype group consisted of the QR and RR groups combined.Results：All lipid and lipoprotein concentrations were greater in the exercise group than in the control group.Regardless of phenotype,no significan differences were observed between the exercise and control groups in terms of serum PON1,SSPON1,or ARE activity associated with HDLs（p〉 0.05）,whereas PON1 activities in QQ-phenotyped women in the exercise group were significant y higher than those in the control group（p〈0.01）,but not the RC group.A statistically significan interaction between PON1 phenotypes（QQ and RC groups） and exercise（exercise and control groups） on PON1 activity was found.Conclusion：These results showed that a regular aerobic exercise program can improve PON1 activity depending on PON1-192 phenotype,but not on lipid and lipoprotein levels,in middle-aged Turkish women.

Impact of 1,25-(OH)_2D_3 on Left Ventricular Hypertrophy in Type 2 Diabetic Rats

Objective To investigate the impact of 1, 25-(OH)2D3 on left ventricular hypertrophy(LVH) in type 2 diabetic rats. Methods Type 2 diabetic mellitus(DM) model rats were established by intraperitoneally injecting with 30 mg/kg streptozotocin. After 8 weeks, 19 male rats were identified as diabetic with left ventricular hypertrophy(LVH) by ultrasound examination, and randomly assigned into three groups: untreated(DM-LVH, n=7), treated with insulin(DM-LVH+INS, n=6), and treated with 1, 25-(OH)2D3(DM-LVH+VD, n=6). Healthy male rats were used as the controls group(n=6). The fasting blood glucose and the insulin level were determined weekly. The left ventricular mass index, myocardial collagen content, collagen volume fraction, and 1, 25-(OH)2D3-receptor level were determined by 4 weeks later. Results In the DM-LVH model group, the insulin level was significantly decreased compared with the non-diabetic control group(P<0.05), whereas the blood glucose, left ventricular mass index, myocardial collagen content, collagen volume fraction, and 1, 25-(OH)2D3-receptor expression were significantly increased(all P<0.05). In the DM-LVH+INS and DM-LVH+VD groups, the insulin levels were significantly increased compared with the DM-LVH model group(P<0.05), whereas the other parameters were significantly decreased(all P<0.05). Conclusion 1, 25-(OH)2D3 could reverse LVH in diabetic rats and that the mechanism may involve stimulating insulin secretion and reducing blood glucose via direct up-regulation of 1, 25-(OH)2D3-receptor expression.

Association between eNOS gene promoter polymorphism (-786T>C) and idiopathic recurrent pregnancy loss in Iranian women

Objective:To investigate the frequency of-786T>C variant in endothelial nitric oxide synthase(eNOS)gene promoter in Iranian women with recurrent pregnancy loss.Methods:Blood samples were obtained from 100 unrelated women affected by recurrent pregnancy loss and 100 unaffected women as the controls.Genomic DNA was extracted and-786T>C polymorphism in eNOS gene promoter was investigated by PCR-RFLP method.Statistical analyses and Hardy-Weinberg equilibrium in the groups of patients and controls were performed by Chi-square test and SPSS standard software(Version 21).Results:The frequency of homozygous TT was 40%in cases and 46%in the control group;the frequency of CC was 7%in cases and 5%in the control group;frequency heterozygote TC was 53%in cases and 49%in the control group.Genotype frequencies between the two groups showed no significant differences(P>0.05).Conclusions:The-786T>C polymorphism is not more frequent in recurrent pregnancy loss in this population.

Prevelance of Pregnancy Complications among Women Aged 15 - 49 in Oğuzeli, Turkey

As maternal deaths have decreased worldwide, increasing attention has been placed on the study of severe obstetric complications, such as hemorrhage, eclampsia, and obstructed labor, to identify where improvements can be made in maternal health. The objective of this study was to determine pregnancy complications and prenatal care among women aged 15 - 49 in O&#287;uzeli, Turkey, and to provide data for prevention in the field. This descriptive, cross-sectional study was conducted between February and May 2013 in O&#287;uzeli distinct, Turkey. The total women registered to family doctors in O&#287;uzeli was listed and, 470 women were selected using a stratified and simple random sampling technique. Pregnancy complications were asked for the last pregnancy of each women. Of the women, 23.9% (n = 109) declared that they experienced pregnancy complications during their pregnancies. The most frequent problems were anemia (11.1%) hypertension (3.7%) and diabetes mellitus (2.4%) respectively. Women having chronic diseases before their pregnancy were more likely to have pregnancy complications compared to healthy women (p = 0.005). The mean number of prenatal care among women having pregnancy complications was 5.47 ± 3.57, while it was 3.84 ± 3.00 among healthy women (p = 0.000). Women having chronic diseases should be handled carefully and, pregnancy should be delayed until the chronic disease’s remission. Family planning in primary care is the key measure to archive this. Early diagnosis of hypertension among young women is highly important for the women’s and infants’s health during pregnancy, and for the women’s future heath. During prenatal care, women should be trained about correct eating habits and activity.

The Programme for the Development of Chinese Women 1995-2000 Eleven Goals

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实时三维超声心动图结合二维斑点追踪技术评价高龄孕晚期孕妇左心室收缩功能

目的:运用实时三维超声心动图(RT-3DE)和二维斑点追踪技术(2D-STI)评估高龄孕晚期孕妇左心室收缩功能。方法:选取20~45岁孕晚期孕妇为研究对象,另纳入年龄匹配的健康查体女性102例作为对照组。对所有纳入对象用辛普森双平面法、2D-STI及RT-3DE进行检查分析,采用t检验或Mann-Whitney U检验对比高龄孕妇与对照组受试者左室收缩功能的差异。结果:三种方法测量的左室射血分数(LVEF)组间均无统计学差异(P>0.05)。高龄孕妇较高龄对照受试者左室LSapi减低,Tmsv-16-SD%及Tmsv-16-Dif%增高(P<0.05),高龄孕妇较适龄孕妇LSbas增加(P<0.05)。结论:高龄孕妇孕晚期LVEF处于正常水平,但可能已经存在左室壁局部纵向应变减低和心肌运动同步性减低,RT-3DE及2D-STI均可早期评价左室收缩功能改变,提示临床给予早期干预。

The Commutativity of a *-Ring with Generalized Left *-α-Derivation

In this paper, it is defined that left *-α-derivation, generalized left *-α-derivation and *-α-derivation, generalized *-α-derivation of a *-ring where α is a homomorphism. The results which proved for generalized left *-derivation of R in [1] are extended by using generalized left *-α-derivation. The commutativity of a *-ring with generalized left *-α-derivation is investigated and some results are given for generalized *-α-derivation.

温州丽岙侨乡留守妇女规模变迁的研究

侨乡留守妇女研究是中国侨乡女性史研究的重要内容之一,对温州著名侨乡丽岙街道跨国移民引起的留守妇女的研究,有助于了解侨乡留守妇女规模变迁的阶段及特征,即20世纪70年代前,男性出国人员较少、与海外女子婚配等原因形成留守妇女产生的萌芽期;改革开放后,大批男性前往海外谋生引发留守妇女规模的爆发期;男性取得海外合法身份及立业后,以家庭团聚方式的人口“大迁徙”形成留守妇女规模的锐减期;由于出境手续办理繁琐、海外婚配增加等原因造成留守妇女规模的停滞期;2015年后,在国外生活的妇女,由于生活压力大、语言交流障碍等原因回国,促成留守妇女规模的反弹期。在经历各阶段的起伏后,现今温州丽岙侨乡留守妇女总体规模较小,并趋于稳定。

桂滇黔民族地区乡村旅游促进留守妇女可持续生计演进与影响因素研究

随着桂滇黔民族地区乡村旅游的蓬勃发展,受其影响,当地留守妇女重构了该地区土地资源、劳动供给、劳动技能技术和资本等生产要素配置,进而促进了桂滇黔民族地区留守妇女生计的转型。文章通过分析桂滇黔民族地区旅游发展的不同阶段特点,剖析了该地区留守妇女生计演进的过程,可划分为农业主导型生计模式、混合兼业型生计模式和旅游主导型生计模式等3个阶段。结合旅游可持续生计分析研究框架,桂滇黔民族地区留守妇女可持续生计由外在因素和内在因素共同作用。桂滇黔民族地区留守妇女获得经济收入、提升技能和增强社会参与度,有助于文化传承和家庭关系的改善,提升了桂滇黔民族地区留守妇女可持续生计潜力。梳理桂滇黔民族地区乡村旅游对留守妇女生计演变过程与影响因素,不仅有助于深化对生计转型机制的理解、丰富乡村经济与社会发展理论和促进性别与发展研究的深化,还能为政策制定提供理论借鉴和参考。

媒介依赖视角下农村留守妇女短视频使用行为分析——以江苏东部X村为例

农村互联网和短视频的快速发展为农村留守妇女的信息接触和社交互动提供便利。本研究深入江苏省东部X村,采用质性研究方法,从媒介依赖理论角度探析农村留守妇女使用短视频过程中的行为表征和心理诉求。研究发现,社会环境变化中农村留守妇女的“有闲”状态相对延长,劳动压力的增加和文化活动的转变对其短视频使用行为产生一定影响。从信息、心理以及娱乐三方面的目标和需求出发,农村留守妇女使用短视频增强自我认知,调整个人情感,从而改善日常生活,形成信息理解、心理定向和个体娱乐的特点。呈现出新特点与新问题的农村留守妇女通过“刷”短视频了解自我和社会信息,缓解心理压力,并在短视频互动中丰富农村文化生活。

青年留守妇女参与乡村电商建设困境与超越——基于X村的实地研究

青年留守妇女是乡村数字经济建设的重要人力支持。从增能视角审视X村留守妇女参与电商能力现状发现,当前既存在赋权不够,又存在增能不足,具体表现在“自我效能感低下”“主体性建设不足”“多元环境排斥”。本文从“个体—人际—环境”三个维度出发,结合X村进行实地分析,提出“提升主体能力”“融入式微观合作”“开放型政策环境”的对策,旨在探究青年留守妇女参与数字乡村的新模式,增强其主体意识,提高电商参与能力,进而缓解数字人才瓶颈。

论中国左翼电影中的女性婚恋观(1932−1937)

20世纪30年代的左翼电影运动,以现实主义的创作在时代的诉求中掀起了中国电影发展的革新运动,改变了中国电影业的总体面貌。本文回溯历史,选取1932年−1937年的部分左翼电影作品,依托其中不同的女性镜像,旨在探析传统社会女性不平等婚恋状况的根源、其主体意识觉醒下的新婚恋观的萌生以及在革命意识形态询唤下轻爱情重革命的感召形象,以此发掘左翼电影运动及电影文本的现实美学意义与时代蕴涵。

乡村文化振兴的主体再造与路径创新--以“赣南新妇女”运动为例

当前中西部农村的乡村文化建设面临诸多困境,严重阻碍了乡村社会发展的步伐。基于推动乡村振兴和基层治理的现实需求,江西省赣州市的“新妇女”运动开创了以家庭为组织载体的乡村文化建设实践,在留守群体日益成为乡村社会主体的背景下,通过赋予留守妇女群体以合法的体制性身份,实现社会的再组织化,再造了乡村文化建设的治理主体。在具体实践中,行政力量的外部引导、家庭事务的公共治理和村庄舆论的内部激活,可有效拓展村庄社会的自治实践,促进乡村文化建设的路径创新。“新妇女”运动不仅实现了乡村社会的内部动员,还推动了村庄治理主体的内部供给,激活了村庄内部活力和村庄发展动力,提升了自治水平,为基层社会有效治理和乡村社会发展提供了新的路径思考。

Ideas from the Women's Liberation Movement during the Period of the Central Soviet Area

During the period of the Central Soviet Area,the women's liberation movement flourished,greatly improving the living environment and space for women in the Soviet Area,and providing important implication for resolving issues concerning the development of women left behind in the current rural areas. Based on the useful exploration in the women's liberation movement during the period of the Central Soviet Area, and the field research data concerning the Gannan area,we conduct research on the women's liberation movement during the period of the Central Soviet Area from two dimensions ( family and society) . At the same time,we conduct analysis on current issues concerning the women left behind: in terms of family dimension,the patriarchal tendency of family interests is the core issue shackling the development of women left behind,extension of the family division of labor further restricts the space for the development of women left behind,and the weakening of family function is the key factor influencing the development of women left behind; in terms of social dimension,system isolation is the direct reason for restricted development of women left behind,weak economic foundation is the root cause of restricted development of women left behind, and the existence of discriminatory attitudes is the deep-seated reason for restricted development of women left behind. From the level of human development,we point out that the first step for the development of women left behind lies in the transformation of ideas. In order to solve issues concerning the women left behind,it is necessary to eliminate the property of individual family as the economic unit of society,and make all the women back to the common cause again.

三维斑点追踪技术评估高龄孕妇左心功能

目的应用三维斑点追踪(3D-STI)技术评估高龄孕妇左心功能。方法选取于我院产检的高龄单胎孕妇40例(妊娠年龄≥35岁,高龄组)和同期适龄单胎孕妇35例(妊娠年龄25~29岁,适龄组),分别于早孕期(妊娠第12~14周)、中孕期(妊娠第24~27周)、晚孕期(妊娠第36~39周)采集超声心动图,获取两组各孕期常规超声心动图参数即室间隔舒张末期厚度(IVSd)、左室后壁舒张末期厚度(LVPWd)、左房内径(LAD)、左室射血分数(LVEF)、每搏输出量(SV)、心输出量(CO)、二尖瓣舒张早期和晚期峰值血流速度(E、A)、E/A、室间隔侧二尖瓣环舒张早期运动速度(e’)、左室侧壁e’、平均E/e’、三尖瓣环收缩期位移(TAPSE),以及3D-STI参数即左室整体纵向应变(GLS)、左室整体环向应变(GCS)、左室同步性指数(SDI)、左室舒张末期容积(LVEDV)、左室收缩末期容积(LVESV)、LVEF,比较两组各孕期上述参数的差异。结果适龄组晚孕期LAD、SV、CO、LVEDV均较早、中孕期增大,差异均有统计学意义(均P<0.05);高龄组中、晚孕期LAD、SV、CO、LVEDV均较早孕期增大,差异均有统计学意义(均P<0.05);高龄组各孕期GLS、GCS均降低,SDI均增高,与适龄组同孕期比较差异均有统计学意义(均P<0.05)。两组各孕期IVSd、LVPWd、LVEF、E、A、E/A、室间隔侧e’、左室侧壁e’、平均E/e’、TAPSE、LVESV比较差异均无统计学意义。结论应用3D-STI技术可早期发现高龄孕妇的亚临床左心功能损伤,是监测其妊娠期心功能变化的可靠手段。

VENTRICUAL ECTOPY IN PATIENTS WITH HYPERTENSIVE LEFT VENTRICULAR HYPERTOPHY

It has been noticed that patients with essential hypertension and left ventricular hypertrophy on EKG, are highly exposed to a risk of sudden death. LVH in arterial hypertension has repeatedly been documented to trigger or aggravate ventricular ectory. So we investigated the frequency of complex ventricular arrhythmia by means of 24-hour holter monitoring in 120 patients divided into 3 groups, the first group are 40 patients of essential hypetrtension with LVH, the second group are 40 patients with essential hypertension without LVH, and the third group are 40 normotensives without LVH as a control group. The three groups have been matched for age, sex and smoking habit, and the two hypertensive groups matched for blood pressure before and after antihypertensive therapy and duration of hypertension. Thirty hypertensive patients were examined for plasma norepinephrive on the day of holter monitoring, fifteen of those with LVH and the other fifteen without LVH. Nonsustained ventricular tahycardia, had been seen on five (12.5%)of the 40 patients with echocardiographic patten of LVH, and in no one of the 40 hypertensive patients without hyperophy and the 40 normotgnsive control group. Ninteen patients (47. 5%) with LVH had episodes of less than 30 premature ventricular contraction/hour. One patient (2.5%) with LVH has episodes of >30 premature ventricual contraction/hour, higher grade of ventricular ectopic activity such as coupled premature ventricular contractions was seen in two patiens (5%) and multifocal premature ventricular contractions in 11 patiens (27.5%) of the group with LVH. In this study all the data suggest that complex ventricular arrhythmia occur commonly in hypertensive patients with LVH, and map contribute the higher incidence of sudden death in these patients.

双腔起搏器术后应激性心肌病一例

应激性心肌病的发生多与情绪激动或精神压力有关,多发生于绝经期女性。主要表现为一过性左心室功能受损,数周或数月后可恢复,预后好。本例患者为75岁女性,在起搏器术后出现急性心功能不全,冠状动脉造影未见狭窄病变,超声心动图及心脏磁共振成像提示心尖部运动消失,左心室射血分数下降,初步诊断为应激性心肌病,给予改善心功能治疗后3周复查,患者左心功能完全恢复,复查超声心动图提示心尖部室壁运动正常,应激性心肌病诊断明确。应激性心肌病虽然罕见,但可为绝经后女性起搏器植入后出现左心衰竭的潜在并发症。

文学里的留守世界--城市化进程中乡村留守女性生存图景

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