Background: The etiology of ovarian cancer is not well-understood;numerous metabolomics profiling, epidemiological, and hospital-based case control studies have associated abnormal levels of blood glucose and serum li...Background: The etiology of ovarian cancer is not well-understood;numerous metabolomics profiling, epidemiological, and hospital-based case control studies have associated abnormal levels of blood glucose and serum lipids with the risk and the prognosis of various types of cancers including ovarian cancer. The association between the risk of the incidence of ovarian cancer and the alterations in the levels of blood glucose and serum lipids is not well defined. Objective: In this study we aimed to compare the levels of blood glucose, triacylglycerols, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol in patients with different stages of ovarian cancer and healthy controls to determine how they relate to the risk and prognosis of ovarian cancer. Methodology: In a case-control cross sectional study, we enrolled ninety-nine Sudanese women, diagnosed with ovarian cancer but had not received any kind of treatment as the study group, and a control group of forty-one age-matched, apparently healthy women. The patients were classified according to the International Federation of Obstetricians and Gynecologists staging system into two groups: early stages (stage I & II) and late stages (stages III & IV). Blood glucose and serum lipids;triacylglycerols, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol were determined by enzymatic colorimetric methods using commercially available analytical kits. The IBM SPSS version 20 software was used for statistical analysis. A Mann-Whitney U test was used for comparison of the median concentrations of blood glucose, triacylglycerols, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol in the study groups. Logistic regression model was used to estimate the relative risk of ovarian cancer in relation to levels of blood glucose and serum lipids. P value of 0.05 was considered significant. Results: Our data indicated significantly higher levels of blood glucose (p < 0.001), triacylglycerols (p = 0.002), and low-density lipoprotein cholesterol (p < 0.001), and lower levels of high-density lipoprotein cholesterol (p = 0.023), in ovarian cancer patients compared to the control subjects. No significant difference was found in the levels of blood glucose or any of the serum lipids between patients in the early stages (stage I & II) and those in late stages (stage III & IV) of ovarian cancer. The logistic regression analysis indicated significant association between the elevated levels of the blood glucose, triacylglycerols and low-density lipoprotein cholesterol and the risk of the ovarian cancer. Conclusion: We conclude that the levels of blood glucose, triacylglycerols, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol differ significantly between ovarian cancer patients and the healthy control subjects. The risk of ovarian cancer was positively associated with the levels of blood glucose, triacylglycerols and low-density lipoprotein cholesterol, and negatively associated with levels of high-density lipoprotein cholesterol. Therefore, determination of blood glucose and serum lipids, particularly, triacylglycerols, low-density lipoprotein cholesterol may be helpful as diagnostic indicators of ovarian cancer (OC).展开更多
To study the relationship of the polymorphism of endothelial nitric oxide synthase(eNOS)gene and blood pressure,lipid profiles and blood glucose level.By using PCR-RFLP,the eNOS Glu298Asp gene polymorphism was detecte...To study the relationship of the polymorphism of endothelial nitric oxide synthase(eNOS)gene and blood pressure,lipid profiles and blood glucose level.By using PCR-RFLP,the eNOS Glu298Asp gene polymorphism was detected in 184 patients with essential hypertension and 196 matched healthy individuals with normal blood pressure.Taking into account eNOS Glu298Asp poly-morphisms,the relationship of blood pressure with trigly-cerides(TG),total cholesterol(TC),high density lipoprotein(HDL),low density lipoprotein(LDL)and blood glucose level was analyzed.The distribution of eNOS Glu298Asp polymorphism had no significant differ-ence between different blood pressure groups and gender groups,but there was a significant difference between dif-ferent age groups,diastolic blood pressure groups or BMI groups(P<0.05).Asp/Asp genotype significantly increased the risk of hypertension in individuals with serum TC above 5.4 mmol/L(P=0.03,OR=52.65).eNOS Glu298Asp polymorphism and serum lipid could synergis-tically modulate the blood pressure.eNOS Asp/Asp geno-type could significantly increase the risk of hypertension in individuals with serum TC over 5.4 mmol/L.eNOS Glu298Asp in combination with serum TC could be used to predict the risk of hypertension.展开更多
目的分析2型糖尿病(T2DM)患者采取达格列净联合二甲双胍治疗对其代谢指标的影响。方法100例T2DM患者,随机分为观察组和对照组,每组50例。对照组给予二甲双胍治疗,观察组给予二甲双胍联合达格列净治疗。比较两组患者不良反应(厌食、呕吐...目的分析2型糖尿病(T2DM)患者采取达格列净联合二甲双胍治疗对其代谢指标的影响。方法100例T2DM患者,随机分为观察组和对照组,每组50例。对照组给予二甲双胍治疗,观察组给予二甲双胍联合达格列净治疗。比较两组患者不良反应(厌食、呕吐、便秘、尿路感染)发生情况以及治疗前后血脂[低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯(TG)、总胆固醇(TC)]、血糖[餐后2 h血糖(2 h PG)、空腹血糖(FPG)、糖化血红蛋白(HbA1c)]、血清指标[同型半胱氨酸(Hcy)、C反应蛋白(CRP)、尿微量白蛋白与肌酐比值(ACR)、胱抑素C(Cys-C)]水平。结果观察组不良反应发生率为6.00%,与对照组的16.00%比较,差异无统计学意义(P>0.05)。治疗后,观察组LDL-C(2.60±0.30)mmol/L、TG(1.44±0.53)mmol/L、TC(4.02±0.77)mmol/L低于对照组的(3.79±0.47)、(2.38±0.66)、(5.74±0.84)mmol/L,HDL-C(1.37±0.16)mmol/L高于对照组的(1.22±0.10)mmol/L,差异具有统计学意义(P<0.05)。治疗后,观察组2 h PG(6.10±1.08)mmol/L、FPG(5.13±1.31)mmol/L、HbA1c(6.20±0.85)%均低于对照组的(7.57±1.14)mmol/L、(6.68±1.42)mmol/L、(7.88±1.21)%,差异具有统计学意义(P<0.05)。治疗后,观察组Hcy(9.35±1.01)μmol/L、CRP(1.51±0.34)mg/L、ACR(19.81±2.74)mg/g、Cys-C(0.81±0.10)mg/L均低于对照组的(11.11±1.88)μmol/L、(2.00±0.43)mg/L、(21.32±2.76)mg/g、(0.87±0.12)mg/L,差异具有统计学意义(P<0.05)。结论T2DM患者使用二甲双胍+达格列净治疗可对血糖控制效果进一步提升,使机体微炎症状态有效减轻,使血脂水平有效改善,同时存在良好的安全性,在对适应证严格掌握的状态下可将其作为提升降糖效果的理想措施。展开更多
文摘Background: The etiology of ovarian cancer is not well-understood;numerous metabolomics profiling, epidemiological, and hospital-based case control studies have associated abnormal levels of blood glucose and serum lipids with the risk and the prognosis of various types of cancers including ovarian cancer. The association between the risk of the incidence of ovarian cancer and the alterations in the levels of blood glucose and serum lipids is not well defined. Objective: In this study we aimed to compare the levels of blood glucose, triacylglycerols, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol in patients with different stages of ovarian cancer and healthy controls to determine how they relate to the risk and prognosis of ovarian cancer. Methodology: In a case-control cross sectional study, we enrolled ninety-nine Sudanese women, diagnosed with ovarian cancer but had not received any kind of treatment as the study group, and a control group of forty-one age-matched, apparently healthy women. The patients were classified according to the International Federation of Obstetricians and Gynecologists staging system into two groups: early stages (stage I & II) and late stages (stages III & IV). Blood glucose and serum lipids;triacylglycerols, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol were determined by enzymatic colorimetric methods using commercially available analytical kits. The IBM SPSS version 20 software was used for statistical analysis. A Mann-Whitney U test was used for comparison of the median concentrations of blood glucose, triacylglycerols, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol in the study groups. Logistic regression model was used to estimate the relative risk of ovarian cancer in relation to levels of blood glucose and serum lipids. P value of 0.05 was considered significant. Results: Our data indicated significantly higher levels of blood glucose (p < 0.001), triacylglycerols (p = 0.002), and low-density lipoprotein cholesterol (p < 0.001), and lower levels of high-density lipoprotein cholesterol (p = 0.023), in ovarian cancer patients compared to the control subjects. No significant difference was found in the levels of blood glucose or any of the serum lipids between patients in the early stages (stage I & II) and those in late stages (stage III & IV) of ovarian cancer. The logistic regression analysis indicated significant association between the elevated levels of the blood glucose, triacylglycerols and low-density lipoprotein cholesterol and the risk of the ovarian cancer. Conclusion: We conclude that the levels of blood glucose, triacylglycerols, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol differ significantly between ovarian cancer patients and the healthy control subjects. The risk of ovarian cancer was positively associated with the levels of blood glucose, triacylglycerols and low-density lipoprotein cholesterol, and negatively associated with levels of high-density lipoprotein cholesterol. Therefore, determination of blood glucose and serum lipids, particularly, triacylglycerols, low-density lipoprotein cholesterol may be helpful as diagnostic indicators of ovarian cancer (OC).
基金supported by a Grant from the Sci&Tech Research Project Foundation of Public Health Department of Hubei Province(No.NX200421)。
文摘To study the relationship of the polymorphism of endothelial nitric oxide synthase(eNOS)gene and blood pressure,lipid profiles and blood glucose level.By using PCR-RFLP,the eNOS Glu298Asp gene polymorphism was detected in 184 patients with essential hypertension and 196 matched healthy individuals with normal blood pressure.Taking into account eNOS Glu298Asp poly-morphisms,the relationship of blood pressure with trigly-cerides(TG),total cholesterol(TC),high density lipoprotein(HDL),low density lipoprotein(LDL)and blood glucose level was analyzed.The distribution of eNOS Glu298Asp polymorphism had no significant differ-ence between different blood pressure groups and gender groups,but there was a significant difference between dif-ferent age groups,diastolic blood pressure groups or BMI groups(P<0.05).Asp/Asp genotype significantly increased the risk of hypertension in individuals with serum TC above 5.4 mmol/L(P=0.03,OR=52.65).eNOS Glu298Asp polymorphism and serum lipid could synergis-tically modulate the blood pressure.eNOS Asp/Asp geno-type could significantly increase the risk of hypertension in individuals with serum TC over 5.4 mmol/L.eNOS Glu298Asp in combination with serum TC could be used to predict the risk of hypertension.
文摘目的分析2型糖尿病(T2DM)患者采取达格列净联合二甲双胍治疗对其代谢指标的影响。方法100例T2DM患者,随机分为观察组和对照组,每组50例。对照组给予二甲双胍治疗,观察组给予二甲双胍联合达格列净治疗。比较两组患者不良反应(厌食、呕吐、便秘、尿路感染)发生情况以及治疗前后血脂[低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯(TG)、总胆固醇(TC)]、血糖[餐后2 h血糖(2 h PG)、空腹血糖(FPG)、糖化血红蛋白(HbA1c)]、血清指标[同型半胱氨酸(Hcy)、C反应蛋白(CRP)、尿微量白蛋白与肌酐比值(ACR)、胱抑素C(Cys-C)]水平。结果观察组不良反应发生率为6.00%,与对照组的16.00%比较,差异无统计学意义(P>0.05)。治疗后,观察组LDL-C(2.60±0.30)mmol/L、TG(1.44±0.53)mmol/L、TC(4.02±0.77)mmol/L低于对照组的(3.79±0.47)、(2.38±0.66)、(5.74±0.84)mmol/L,HDL-C(1.37±0.16)mmol/L高于对照组的(1.22±0.10)mmol/L,差异具有统计学意义(P<0.05)。治疗后,观察组2 h PG(6.10±1.08)mmol/L、FPG(5.13±1.31)mmol/L、HbA1c(6.20±0.85)%均低于对照组的(7.57±1.14)mmol/L、(6.68±1.42)mmol/L、(7.88±1.21)%,差异具有统计学意义(P<0.05)。治疗后,观察组Hcy(9.35±1.01)μmol/L、CRP(1.51±0.34)mg/L、ACR(19.81±2.74)mg/g、Cys-C(0.81±0.10)mg/L均低于对照组的(11.11±1.88)μmol/L、(2.00±0.43)mg/L、(21.32±2.76)mg/g、(0.87±0.12)mg/L,差异具有统计学意义(P<0.05)。结论T2DM患者使用二甲双胍+达格列净治疗可对血糖控制效果进一步提升,使机体微炎症状态有效减轻,使血脂水平有效改善,同时存在良好的安全性,在对适应证严格掌握的状态下可将其作为提升降糖效果的理想措施。
