Introduction: Leukocoria, a whitish pupillary reflection, is a common warning sign of various pediatric ocular pathologies, including Persistent hyperplastic primary vitreous (PHVP). This case report describes the obs...Introduction: Leukocoria, a whitish pupillary reflection, is a common warning sign of various pediatric ocular pathologies, including Persistent hyperplastic primary vitreous (PHVP). This case report describes the observation of a 3-year-old child with melanoderma, presenting with a white spot in the left eye since birth. Observation: Uncorrected distance visual acuity was 2/10 in the right eye and hand movements were perceived at 2 meters in the left eye. Examination of the anterior segment in the left eye revealed leukocoria and microphthalmia. The fundus examination was normal in the right eye but revealed a white mass extending from the center of the optic disc towards the temporal region in the left eye. Ocular imaging, including ocular ultrasound and optical coherence tomography, confirmed the diagnosis of PHVP, illustrated by a residual white mass at the center of the optic disc in the left eye. Conclusion: PHVP should be considered in the presence of leukocoria in a child, with urgent exclusion of retinoblastoma. This observation underscores the importance of early diagnosis for appropriate management. .展开更多
·Retinoblastoma (RB) is the most common intraocular cancer of infancy and childhood. This cancer is initiated by mutation on , the tumor suppressor gene that is responsible for the regulation of both cell cycle a...·Retinoblastoma (RB) is the most common intraocular cancer of infancy and childhood. This cancer is initiated by mutation on , the tumor suppressor gene that is responsible for the regulation of both cell cycle and gnome stability in retinal cells. Patients with a constitutional mutation on can be inherited. RB occurs approximately 1 in every 15 000-20 000 live births. The worldwide mortality for this cancer is about 5%-11%. However, this rate rises to about 40%-70% in developing countries due to a delay in diagnosis. A wide variety of options are available for the treatment, but often a combination of therapies is adopted to optimize individualized care. ·展开更多
·AIM: To collect and present updated evidence about epidemiological aspects of retinoblastoma(Rb) in the world.·METHODS: A comprehensive search without the time and language restrictions was conducted in int...·AIM: To collect and present updated evidence about epidemiological aspects of retinoblastoma(Rb) in the world.·METHODS: A comprehensive search without the time and language restrictions was conducted in international databases, including MEDLINE, Scopus, Web of Science, and Pub Med. The search keywords were “retinoblastoma” OR “retinal Neuroblastoma” OR “retinal glioma” OR “retinoblastoma eye cancer” OR “retinal glioblastoma”.·RESULTS: The worldwide incidence of Rb is 1 in 16 000-28 000 live births, but was higher in developing compared to developed countries. Several attempts for improving early detection and treatment had increased the Rb survival rate from 5% to 90% in developed countries over the past decade, but its survival was lower in developing countries(about 40% in low-income countries) and the majority of mortalities occurred in developing countries. The etiology of Rb could be viewed as genetics in the heritable form and environmental and lifestyle factors in the sporadic form. Some environmental risk factors such as in vitro fertilization;insect sprays;father’s occupational exposure to oil mists in metal working, and poor living conditions might play a role in the occurrence of the disease. Although ethnicity might affect Rb incidence, sex has no documented effect and the best treatment approaches were now ophthalmic artery chemosurgery and intravitreal chemotherapy.·CONCLUSION: Determining the role of genetics and environmental factors helps to accurately predict the prognosis and identify the mechanism of the disease, which can reduce the risk of tumor development.展开更多
<strong>Introduction:</strong><span style="font-family:""><span style="font-family:Verdana;"> Retinoblastoma is one of the pediatric malignancies and its treatment is s...<strong>Introduction:</strong><span style="font-family:""><span style="font-family:Verdana;"> Retinoblastoma is one of the pediatric malignancies and its treatment is still challenging. The objective of this study was to highlight the sociodemographic, clinical, and therapeutic aspects of retinoblastoma at the Donka Paediatric Haematology/Oncology unit in Donka university hospital, Guinea, and thereby highlight the conditions of this malignancy in this country. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> This was a retrospective study over 3 years (January 1, 2017 to December 31, 2019). The study population was all retinoblastoma patients who were treated in this unit. Socio-demographic, clinical, and therapeutic data were analyzed. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> Out of 210 pediatric patients followed up for cancer in this unit during the period, retinoblastoma accounted for 46 (22%). The patient age at diagnosis was 35.17 months (range: 3 - 132 months). At admission, metastases were observed in 16 patients (35%): 14 with brain metastases and 2 with lymph node metastases. Preoperative chemotherapy was employed in 38 (83%), tumor resection was performed in 20 patients (43%), and postoperative chemotherapy was performed in 19 patients. As for the prognosis, remission in 9, death in 14, and treatment discontinuation in 15. Only one patient had health insurance (2%). </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> In this region of Guinea, retinoblastoma is the most common ocular tumor in children. Its diagnosis is easy: strabismus and leukocoria are the early signs of retinoblastoma. The prognosis depends on how early the diagnosis is made. Physicians, care-givers, and family members should be aware of the nature of this malignancy and social education/message as such is necessary.</span></span>展开更多
BACKGROUND Red reflex test(RRT)is a simple,non-invasive method that can be performed easily by pediatricians during the clinical examination in neonatal period,infancy and childhood.Abnormal reflexes can lead to promp...BACKGROUND Red reflex test(RRT)is a simple,non-invasive method that can be performed easily by pediatricians during the clinical examination in neonatal period,infancy and childhood.Abnormal reflexes can lead to prompt diagnosis of several ocular disorders,with potentially severe consequences on patient’s vision,cognitive function and even life.AIM To underline the contribution of pediatricians to early detection of vision and life threatening diseases by using RRT effectively.METHODS For the present systematic review,PubMed searches were performed using the key words“red reflex and newborn”;“red reflex and neonate”;“red reflex and complications”;“red reflex and necessity”;“red reflex and retinoblastoma”;“red reflex and congenital cataract”;“red reflex and glaucoma”;“red reflex and prematurity”;“red reflex and leukocoria”;“red reflex and blindness”;“red reflex sensitivity and specificity”;“red reflex and differential diagnosis”;“red reflex and guidelines”.The relevant articles were selected without language restrictions.When a full-text publication was not available,their English abstracts were used.In some cases,studies from the reference lists of the selected articles provided useful information.The research took place in September 2020,in the Ophthalmology Department of University Hospital of Alexandroupolis.RESULTS A total of 45 articles were selected according to the used key words.After reviewing data from these articles,it is supported that red reflex remains an effective tool of undeniable importance for early detection of severe eye conditions,such as cataract,retinoblastoma,retinopathy of prematurity and glaucoma.Although literature reports some limitations of RRT,including a notable percentage of false positive tests,the inability to detect small,peripheral retinoblastomas and the lower sensitivity for posterior segment pathology,it is widely accepted that the benefits from the regular evaluation of the test on public health are significant.Therefore,RRT has been established by international guidelines and should be an essential component of pediatricians clinical practice.Red reflex implementation should be incorporated in pediatricians educational programs,so that they would be able to provide quality services and safe diagnoses.CONCLUSION The implementation of RRT should be encouraged in all neonatal/pediatric departments.Prompt education of pediatricians should be empowered in order to achieve careful vision screening,according to current guidelines.展开更多
We aim to report an uncommon presentation of retinoblastoma and its management.A 4-year-old boy presented with left eye pain for 1 week with eye redness after being hit by a ball.On examination,the visual acuity in hi...We aim to report an uncommon presentation of retinoblastoma and its management.A 4-year-old boy presented with left eye pain for 1 week with eye redness after being hit by a ball.On examination,the visual acuity in his right eye was 6/6 and left eye was no perception to light.The conjunctiva in his left eye was injected and cornea was edematous.There was pseudohypopyon inferiorly.Lens was opaque and there was no fundus view.Intraocular pressure was 50 mmHg.Patient was initially treated as phacolytic glaucoma with severe inflammation.B scan showed intralesional calcification with retinal detachment.CT orbit showed left intraocular mass with calcification and optic nerve involvement.Thus,our final diagnosis was left eye retinoblastoma.Patient was performed a enucleation with chemotherapy in left eye.One year after the treatment,there was no local and distant invasion of the tumor.Anterior inflammation is a rare form of masquerade syndrome associated with retinoblastoma.展开更多
文摘Introduction: Leukocoria, a whitish pupillary reflection, is a common warning sign of various pediatric ocular pathologies, including Persistent hyperplastic primary vitreous (PHVP). This case report describes the observation of a 3-year-old child with melanoderma, presenting with a white spot in the left eye since birth. Observation: Uncorrected distance visual acuity was 2/10 in the right eye and hand movements were perceived at 2 meters in the left eye. Examination of the anterior segment in the left eye revealed leukocoria and microphthalmia. The fundus examination was normal in the right eye but revealed a white mass extending from the center of the optic disc towards the temporal region in the left eye. Ocular imaging, including ocular ultrasound and optical coherence tomography, confirmed the diagnosis of PHVP, illustrated by a residual white mass at the center of the optic disc in the left eye. Conclusion: PHVP should be considered in the presence of leukocoria in a child, with urgent exclusion of retinoblastoma. This observation underscores the importance of early diagnosis for appropriate management. .
文摘·Retinoblastoma (RB) is the most common intraocular cancer of infancy and childhood. This cancer is initiated by mutation on , the tumor suppressor gene that is responsible for the regulation of both cell cycle and gnome stability in retinal cells. Patients with a constitutional mutation on can be inherited. RB occurs approximately 1 in every 15 000-20 000 live births. The worldwide mortality for this cancer is about 5%-11%. However, this rate rises to about 40%-70% in developing countries due to a delay in diagnosis. A wide variety of options are available for the treatment, but often a combination of therapies is adopted to optimize individualized care. ·
文摘·AIM: To collect and present updated evidence about epidemiological aspects of retinoblastoma(Rb) in the world.·METHODS: A comprehensive search without the time and language restrictions was conducted in international databases, including MEDLINE, Scopus, Web of Science, and Pub Med. The search keywords were “retinoblastoma” OR “retinal Neuroblastoma” OR “retinal glioma” OR “retinoblastoma eye cancer” OR “retinal glioblastoma”.·RESULTS: The worldwide incidence of Rb is 1 in 16 000-28 000 live births, but was higher in developing compared to developed countries. Several attempts for improving early detection and treatment had increased the Rb survival rate from 5% to 90% in developed countries over the past decade, but its survival was lower in developing countries(about 40% in low-income countries) and the majority of mortalities occurred in developing countries. The etiology of Rb could be viewed as genetics in the heritable form and environmental and lifestyle factors in the sporadic form. Some environmental risk factors such as in vitro fertilization;insect sprays;father’s occupational exposure to oil mists in metal working, and poor living conditions might play a role in the occurrence of the disease. Although ethnicity might affect Rb incidence, sex has no documented effect and the best treatment approaches were now ophthalmic artery chemosurgery and intravitreal chemotherapy.·CONCLUSION: Determining the role of genetics and environmental factors helps to accurately predict the prognosis and identify the mechanism of the disease, which can reduce the risk of tumor development.
文摘<strong>Introduction:</strong><span style="font-family:""><span style="font-family:Verdana;"> Retinoblastoma is one of the pediatric malignancies and its treatment is still challenging. The objective of this study was to highlight the sociodemographic, clinical, and therapeutic aspects of retinoblastoma at the Donka Paediatric Haematology/Oncology unit in Donka university hospital, Guinea, and thereby highlight the conditions of this malignancy in this country. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> This was a retrospective study over 3 years (January 1, 2017 to December 31, 2019). The study population was all retinoblastoma patients who were treated in this unit. Socio-demographic, clinical, and therapeutic data were analyzed. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> Out of 210 pediatric patients followed up for cancer in this unit during the period, retinoblastoma accounted for 46 (22%). The patient age at diagnosis was 35.17 months (range: 3 - 132 months). At admission, metastases were observed in 16 patients (35%): 14 with brain metastases and 2 with lymph node metastases. Preoperative chemotherapy was employed in 38 (83%), tumor resection was performed in 20 patients (43%), and postoperative chemotherapy was performed in 19 patients. As for the prognosis, remission in 9, death in 14, and treatment discontinuation in 15. Only one patient had health insurance (2%). </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> In this region of Guinea, retinoblastoma is the most common ocular tumor in children. Its diagnosis is easy: strabismus and leukocoria are the early signs of retinoblastoma. The prognosis depends on how early the diagnosis is made. Physicians, care-givers, and family members should be aware of the nature of this malignancy and social education/message as such is necessary.</span></span>
文摘BACKGROUND Red reflex test(RRT)is a simple,non-invasive method that can be performed easily by pediatricians during the clinical examination in neonatal period,infancy and childhood.Abnormal reflexes can lead to prompt diagnosis of several ocular disorders,with potentially severe consequences on patient’s vision,cognitive function and even life.AIM To underline the contribution of pediatricians to early detection of vision and life threatening diseases by using RRT effectively.METHODS For the present systematic review,PubMed searches were performed using the key words“red reflex and newborn”;“red reflex and neonate”;“red reflex and complications”;“red reflex and necessity”;“red reflex and retinoblastoma”;“red reflex and congenital cataract”;“red reflex and glaucoma”;“red reflex and prematurity”;“red reflex and leukocoria”;“red reflex and blindness”;“red reflex sensitivity and specificity”;“red reflex and differential diagnosis”;“red reflex and guidelines”.The relevant articles were selected without language restrictions.When a full-text publication was not available,their English abstracts were used.In some cases,studies from the reference lists of the selected articles provided useful information.The research took place in September 2020,in the Ophthalmology Department of University Hospital of Alexandroupolis.RESULTS A total of 45 articles were selected according to the used key words.After reviewing data from these articles,it is supported that red reflex remains an effective tool of undeniable importance for early detection of severe eye conditions,such as cataract,retinoblastoma,retinopathy of prematurity and glaucoma.Although literature reports some limitations of RRT,including a notable percentage of false positive tests,the inability to detect small,peripheral retinoblastomas and the lower sensitivity for posterior segment pathology,it is widely accepted that the benefits from the regular evaluation of the test on public health are significant.Therefore,RRT has been established by international guidelines and should be an essential component of pediatricians clinical practice.Red reflex implementation should be incorporated in pediatricians educational programs,so that they would be able to provide quality services and safe diagnoses.CONCLUSION The implementation of RRT should be encouraged in all neonatal/pediatric departments.Prompt education of pediatricians should be empowered in order to achieve careful vision screening,according to current guidelines.
文摘We aim to report an uncommon presentation of retinoblastoma and its management.A 4-year-old boy presented with left eye pain for 1 week with eye redness after being hit by a ball.On examination,the visual acuity in his right eye was 6/6 and left eye was no perception to light.The conjunctiva in his left eye was injected and cornea was edematous.There was pseudohypopyon inferiorly.Lens was opaque and there was no fundus view.Intraocular pressure was 50 mmHg.Patient was initially treated as phacolytic glaucoma with severe inflammation.B scan showed intralesional calcification with retinal detachment.CT orbit showed left intraocular mass with calcification and optic nerve involvement.Thus,our final diagnosis was left eye retinoblastoma.Patient was performed a enucleation with chemotherapy in left eye.One year after the treatment,there was no local and distant invasion of the tumor.Anterior inflammation is a rare form of masquerade syndrome associated with retinoblastoma.
