Relationship of serum GDF11 levels with bone mineral density and bone turnover markers in postmenopausal Chinese women

Growth differentiation factor 11 （GDF11） is an important circulating factor that regulates aging. However, the role of GDF11 in bone metabolism remains unclear. The present study was undertaken to investigate the relationship between serum GDF11 level, bone mass, and bone turnover markers in postmenopausal Chinese women. Serum GDF11 level, bone turnover biochemical markers, and bone mineral density （BMD） were determined in 169 postmenopausal Chinese women （47-78 years old）. GDF11 serum levels increased with aging. There were negative correlations between GDF11 and BMD at the various skeletal sites. After adjusting for age and body mass index （BMI）, the correlations remained statistically significant. In the multiple linear stepwise regression analysis, age or years since menopause, BMI, GDF11, and estradiol were independent predictors of BMD. A significant negative correlation between GDF11 and bone alkaline phosphatase （BAP） was identified and remained significant after adjusting for age and BMI. No significant correlation was noted between cross-linked N-telopeptides of type I collagen （NTX） and GDF11. In conclusion, GDF11 is an independent negative predictor of BMD and correlates with a biomarker of bone formation, BAP, in postmenopausal Chinese women. GDF11 potentially exerts a negative effect on bone mass by regulating bone formation.

Hair Mercury Levels and Their Relationship with Seafood Consumption among Preschool Children in Shanghai

Mercury is a global pollutant. Children are vulnerable to environmental toxicants. Seafood consumption is a major source of methylmercury exposure. In order to ascertain children’s mercury exposure levels and study their relationship with seafood consumption, we conducted a cross-sectional study among preschool children in Shanghai.

Relationship between glutathione and malonaldehyde levels in erythrocytes and the deformation index of erythrocyte in patients at various periods following acute cerebral infarction

BACKGROUND： Glutathione, as an in vivo free radical scavenger, plays an important role in the anti-oxidation defense mechanism in patients with acute cerebral infarction. OBJECTIVE： To observe the relationship between the levels of glutathione （GSH） and malonaldehyde （MDA）, the metabolite of lipid peroxidation, in erythrocyte and deformation index of erythrocyte in patients at various periods following acute cerebral infarction. DESIGN： Controlled observation.SETTING： Qilu Hospital of Shandong University and Institute of Cerebrovascular Disease of Qingdao Medical College. PARTICIPANTS： We chose 98 inpatients with acute cerebral infarction from Department of Neurology, Qilu Hospital of Shandong University from January to December 2000 , serving as cerebral infarction group, including 50 male and 48 female, with mean age of （62±7）years. There were 23 cases found on the 1^st day after onset; 25 cases on the 3^rd day after onset; 25 cases on the 7^th day after onset; 25 cases on the 14th days after onset, and they were all confirmed by craniocerebral CT or MRI. Another 30 homeochronous inpatients with neurosis, cervical syndrome, lumbar intervertebral disc herniation and motor neuron disease were chosen as control group, including 20 male and 10 female, with mean age of （52±8）years . There was no significant difference in age and gender distribution between two groups （P 〉 0.05）. Patients in the two groups were informed of detected index.METHODS：①Ulnar venous blood was chosen from the patients who were fasted on the 1^st, 3^rd,7^th and 14^th days after onset. Deformation index of erythrocyte was measured with BL88-CKX laser diffraction erythrocyte deformeter and photographing was performed. GSH level in erythrocyte was measured with DTNB assay introduced by Beu-tler. MDA level in erythrocyte was measured with modified thiobarbituric acid colorimetric method.②At each sample collecting , according to the criteria accepted by the Fourth National Conference of Cerebrovascular Disease, intergrant of neurologic impairment 〈 15 points was regarded as mild （n=46）, 15 to 30 points as moderate （n=40）and, 〉 30 points as severe （n=12）. ③ t test was used to compare data between two groups , and linear correlation analysis was used in relationship analysis among indexes. MAIN OUTCOME MEASURES ：① Comparison of erythrocyte GSH and MDA levels and deformation index of erythrocyte at various periods between patients with acute cerebral infarction and controls. ②Correlation of erythrocyte GSH level with erythrocyte MDA level and with deformation index of erythrocyte in patients with cerebral infarction . ③ Relationship between erythrocyte GSH level and severity of disease in patients with acute cerebral infarction. RESULTS： Totally 98 patients with acute cerebral infarction and 30 controls all entered the stage of result analysis. ① Erythrocyte GSH level and deformation index of erythrocyte were lower on the 1^st, 3^rd, 7^th and 14^th days after onset in cerebral infarction group than in control group （P 〈 0.05-0.01）, and erythrocyte MDA level was significantly higher in cerebral infarction group than in control group （P 〈 0.05-0.01）. The three indexes changed most significantly on day 3 after onset in patients, and began to recover or decrease on day 7 after onset and inclined to be normal on day 14 after onset. ② Erythrocyte GSH level was significantly negatively correlated with erythrocyte MDA level in patients with acute cerebral infarction on the 1^st, 3^rd, 7^th and 14^th days after onset （r=-0.534, -0.713, -0.645, -0.656, respectively, P 〈 0.05-0.01 ） ,and significantly positively correlated with erythrocyte deformation index （t-=0.502, 0.560, 0.455, 0.504, respectively, P 〈 0.05）. ③Erythrocyte GSH level was significantly lower in moderate or severe patients with acute cerebral infarction than in mild patients[（0.215±0.088）,（0.192±0.102）, （0.281±0.090） g/L, P〈 0.05]. CONCLUSION：①Erythrocyte GSH and MDA levels and deformation index of erythrocyte change significantly on the 3^rd day following acute cerebral infarction. Index detection results gradually tended to be normal on from the 7^th day to 14^th days day after onset. ② Change of erythrocyte GSH level can reflect the severity of disease of patients with acute cerebral infarction.③Decrease of erythrocyte GSH level in patients with acute cerebral infarction is one of reasons that result in the decrease of deformation ability of erythrocyte.

Mediating role of physical activity in the relationship between psychological distress and intimate relationships among stroke patients

BACKGROUND Stroke patients often experience psychological distress,which can impact their intimate relationships with spouses,subsequently influencing their treatment and recovery.Physical activity is considered a key rehabilitation method for stroke patients.This paper aims to analyze whether psychological distress affects intimate relationship between spouses through physical activity.AIM To explore the mediating effect of physical activity between psychological distress and intimate relationship in stroke patients.METHODS A total of 256 stroke patients who underwent treatment at the First People’s Hospital of Shangqiu between July 2021 and July 2022 were enrolled in this study.The participants completed questionnaires,including the Kessler Psychological Distress Scale(K10),the Quality of Relationship Index(QRI),International Physical Activity Questionnaire,and a general information questionnaire.Data analysis were performed using SPSS 23.0.The Harman test was employed to detect common method deviations,and Spearman correlation was used for correlation analysis.The mediating effect was assessed using Process 3.4.1,with significance testing of the regression coefficients conducted using the bias-corrected percentile Bootstrap method(5000 iterations,95%confidence interval).Statistical significance was set at P<0.05.RESULTS The results showed that patients scored an average of 21.61±6.44 points on the K10,32.40±6.19 points on the QRI;the median physical activity level according to the International Physical Activity Questionnaire was 1861(566,2846)MET·min/w.The level of physical activity(the physical activity intensity of the patients reflected by the Interna-tional Physical Activity Questionnaire-Long Form scale)negatively correlated with psychological distress and intimacy(P<0.05),and positively correlated with each other(P<0.05),with the correlation stronger at lower physical activity levels compared to higher ones.The mediating effect of physical activity between psychological distress and intimate relationship was calculated to be 40.23%.Bootstrap analysis further validated the results.The mediating effect of psychological distress on intimate relationships through physical activity level was-0.284,with a confidence interval of-0.409 to-0.163,excluding 0,confirming a significant mediating effect of psychological distress on intimate relationships.CONCLUSION Physical activity significantly affects relationship between psychological distress and intimate relationships among stroke patients.Addressing the role of physical activity may have implications for improving patient outcomes and rehabilitation strategies.

A PRELIMINARY STUDY ON THE RELATIONSHIP BETWEEN MURINE IgE LEVEL AND 3-METHYL-CHOLANTHRENE INDUCED FIBROSARCOMA

The relationship between murine IgE, IgG, and IgG1 level and birosarcoma induced by 3-Methyl-cholanthrene in NIH mice was studied. The results showed that IgE, IgG or IgGl had no significant effect on tumor incidence; the high IgE level could extend the survival time of 3-Methylcholanthrene injected mice (P<0.05) and survival time of tumor bearing mice (P<0.01), while IgG or IgGl could not. The data from this study did not show that IgE, IgG or IgGl had any significant effect on the tumor size and the tumor growth rate. The probable mechanism involved was discussed.

Relationship between changes of endogenous ABA level and resistance in hybrid rice under temperature stress

We studied the relationship between endogenous ABA and resistance to temperature stress in seedlings of hybrid rice. The hybrid rice Combinations Shanyou 63, Shanyou 287, Weiyou 63, and Weiyou 287 were treated under 2℃ and 42℃ respectively for 48 h. Endogenous ABA concentrations were obtained by gas chromatography with electron capture detector (GC-ECD) and a nickel labelled external standard. Leakage of electrolytes were determined. At optimal temperature (27℃), there was difference between the level of endogenous ABA and the leakage of electrolytes in hybrid rice combinations, which attributed to genetic difference. ABA level in Weiyou system was higher than that in Shanyou, and there were distinctions between Shanyou system itself (see table). At 2℃, the ABA content of rice seedling was increased. ABA level of Weiyou system maintained higher than Shanyou system at 27℃. The leakage quantities of

THE RELATIONSHIP BETWEEN THE ERYTHROCYTE POLYAMINE LEVELS AND THE DIFFERENT TYPES OF LEUKEMIA

In a study on erythrocyte polyamine levels in 20 leukemia patients and 18 healthy individuals, following results were obtained. Putrescine(Pu) in ery-throcytes was nearly undetectable but in 2 AMoL patients; Spermidine(Spd) level in ALL was higher than the control volue (P<0.05), in AML (M1, M2) and APL the Spd level was in the range of control group (P>0.1), while that in AMoL and AMMoL was considerably lower as compared to control (P< 0.001); Spermine (Spm) level in all types of leukemia was increased (P<0.001); Spd/Spm ratio was significantly decreased, showing 1.525 in control group, 0.938 in ALL (P<0.025), 0.779 in AML (M1, M2) P< 0.01), 0.319 in APL (P<0.001) and 0.296 in AMoL & AMMoL (P<0.001), and the differences between the Spd/Spm ratio in AMoL and AMMoL and in ALL were noted (P<0.05). These results suggested that determination of erythrocyte polyamines in leukemia patients may be helpful in diagnosis, differential diagnosis and prognosis.

A Study on the Dose-Response Relationship between Asbestos Exposure Level and Asbestosis among Workers in a Chinese Chrysotile Product Factory

The dose-response relationship for asbestos exposure in a chrysotile product factory was studied. The past gravimetric dust concentration values, obtained from different worksites, were converted into fiber concentration values according to conversion factors that were worked out by simultaneous sampling in this study. The conversions were made so that exposure could be expressed in fiber-years (f-yr). Asbestosis was diagnosed on the basis of chest radiographs and occupational histories. Cumulative dust exposure (f-yr) was calculated up to the date of diagnosis for asbestosis patients, and up to September 1982 for the remaining workers. A dose-response relationship expressed as fiber-years exposed vs cumulative prevalence of asbestosis was established by the life table method on the basis of these data. Predicted 3 and 1% prevalence of asbestosis corresponded to 43 and 22 f-yr exposure, respectively. Considering that a worker can work for 35 years, these doses are commensurate with dust concentrations of 1.22 and 0.63 f/ml, respectively. It is recommended that 1 f/ml be taken as the maximum allowable concentration of airborne asbestos dust for the workplace with an anticipated prevalence of about 2% asbestosis after 35 years of exposure. 1990 Academic Press, Inc.

Relationship between the low density lipoprotein receptor gene polymorphism and serum lipid levels in the Guangxi Bai Ku Yao population

Objectives Bai Ku Yao(White-trousers Yaos)is a special branch of Yao minority in China.They are now living in both Lihu and Baxu villages,Nandan County, Guangxi,China.The population size is about 30,000.The special customs and culture of Bai Ku Yao,including their special clothing,intra-ethnic marriages and alcohol intake are still completely conserved to the present day.In previous epidemiologic studies,we found that the serum lipid levels and the prevalence of hyperlipidaemia were lower in Bai Ku Yao than in Han Chinese from the same region.This ethnic difference in serum lipid profiles is still not well known.We hypothesized that there may be significant differences in some genetic polymorphismsssociation of low density lipoprotein receptor (LDL-R) genepolymorphism and several environmental factors with serum lipid levels in the Guangxi Bai Ku Yao and Han populations.Methods A total of 1024 subjects of Bai Ku Yao and 792 participants of Han Chinese were stud- ied by a stratified randomized cluster sampling.Epidemiological survey was carried out using internationally standardized methods.Information on demographics,socioeconomic status, and lifestyle factors was collected with standardized questionnaires. The height,weight,waist circumference,blood pressure, and serum total cholesterol(TC),triglyceride(TG), high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),apolipoprotein(Apo) A1, and ApoB were measured.Body massindex(BMI,kg/m2) was calculated.Genotyping of the LDL-RAvaⅡwas performed by polymerse chain reaction and restriction fragment length polymorphism combined with gel electrophoresis,and then confirmed by direct sequencing.Results(l)The height,weight,serum TC,HDL-C,LDL-C,ApoAl levels and the ratio of ApoAl to ApoB were lower in Bai Ku Yao than in Han Chinese(P【0.01 for all),whereas the percentage of subjects who consumed alcohol or smoked cigarettes was higher in Bai Ku Yao than in Han Chinese(P【0.01 for each).(2) The frequency of A+ allele in Bai Ku Yao was 34.5%,and the frequencies of A-A-,A-A+ and A+A + genotypes were 42.6%,45.9%and 11.5%;respectively. The frequency of A+ allele in Han Chinese was 19.3%(P【0.001),and the frequencies of A-A-,A-A + and A+A+ genotypes were 64.9%,31.6%and 3.5%(P【0.001);respectively. The frequencies of A-A-,A-A+ and A+A+ genotypes in Bai Ku Yao were significant difference between males and females,between normal TC and high TC subgroup, and between normal LDL-C and high LDL-C subgroup (P【0.05 for all),whereas the frequencies of A- and A+ ? alleles in Han Chinese were significant difference between males and females(P【0.05).(3) Serum LDL-C levels in Bai Ku Yao were significant difference among the A-A-, A-A+ and A+A+ genotypes(P【0.05),the A+ carriers had higher serum LDL-C levels.Serum HDL-C levels in Han Chiese were significant difference among the A-A-,A-A + and A+A+ genotypes(P【0.01),the A+ carriers had higher serum HDL-C levels.(4) After adjusting other factors,the prevalence of LDL-C abnormality was still higher in Han Chiese than in Bai Ku Yao.The prevalence of TC abnormality in Han Chinese was almost twice high as in Bai Ku Yao. The age and diet were common risk factor for TC abnormality. No effect of AvaⅡgenotype or alcohol consumption on the TC abnormality was found,but the combination of geno-type and alcohol consumption can increase the prevalence of TC abnormality[Exp(B) =(1.154)].Age was negatively cor- related with TG level.Conclusions Serum TC and LDL-C levels were lower in Bai Ku Yao than in Han Chinese.There were significant differences in the AvaⅡallele and genotype frequencies between the he A+ carriers in Bai Ku Yao had higher serum LDL-C levels,whereas the A+ carriers in Han had higher serum HDL-C levels.Interactions between alcohol consumption or cigarette smoking and the LDL-R AvaⅡgenotype were also observed.The differences in the serum lipid profiles between the two ethnic groups might partly result from different genotypic frequency of LDL-R AvaⅡpolymorphism or differentgene-enviromental interactions.Bai Ku Yao and Han population,the frequency of A + allele was higher in Bai Ku Yao than in Han.T between the two ethnic groups.Therefore,the aim of the present study was to detect the

Quantitative relationship between surface sedimentary diatoms and water depth in North-Central Bohai Bay,China

To study the quantitative relationship between surface sedimentary diatoms and water depth,67 surface samples were collected for diatom analysis on eight profiles with water depth variation from the muddy intertidal zone to the shallow sea area in North-Central Bohai Bay,China.The results showed that the distribution of diatoms changed significantly in response to the change in water depth.Furthermore,the quantitative relationship between the distribution of dominant diatom species,their assemblages,and the water depth was established.The water depth optima for seven dominant species such as Cyclotella striata/stylorum,Paralia sulcata,and Coscinodiscus perforatus and the water depth indication range of seven diatom assemblages were obtained in the study area above the water depth(elevation)of-10 m.The quantitative relationship between surface sedimentary diatoms and water depth provides a proxy index for diatom-paleo-water depth reconstruction in the strata in Bohai Bay,China.

刈割对滇西北退化高寒草甸植物化学计量特征的影响

为探究环境干扰对退化高寒草甸植物化学计量特征的影响,该研究于2018—2020年对香格里拉市3个退化程度[轻度退化(LD)、中度退化(MD)、重度退化(SD)]的高寒草甸开展刈割试验,进而分析退化高寒草甸植物C、N、P含量、C∶N∶P和N-P幂函数关系在不同刈割年限(0、1、2 a)之间的差异。结果表明:(1)除莎草科P含量外,草甸植物群落、禾本科和杂类草的C、N、P含量在退化程度间无显著差异(P>0.05)。随着刈割年限的增加,退化草甸植物C、N、P含量呈先增后降的趋势(P<0.05)。(2)草甸植物C∶N和C∶P在退化程度间无差异(P>0.05)。从LD到SD,植物群落、莎草科和杂类草的N∶P比先小幅下降再显著上升(P<0.05),禾本科的N∶P未发生显著变化(P>0.05)。(3)随刈割年限增加,草甸植物的C∶N和C∶P呈先降后增、N∶P呈先增后降的趋势。刈割0 a时,莎草科的C∶P和N∶P显著高于杂类草(P<0.05),与植物群落和禾本科无差异(P>0.05);刈割1 a和2 a时,莎草科的C∶P和N∶P高于植物群落和其他功能群(P<0.05);在各刈割年限,植物群落和各功能群植物间的C∶N无差异(P>0.05)。(4)随刈割年限增加,退化草甸植物的N-P幂函数关系由弱变强、幂指数趋于稳定。莎草科的N-P幂指数(小于0.1)与植物群落、禾本科和杂类草的幂指数(稳定在0.19~0.22之间)明显不同。该研究发现,刈割干扰下退化高寒草甸植物生态化学计量特征在退化程度间差异不大,但其随刈割年限增加发生显著变化,这说明滇西北不同退化程度高寒草甸对刈割干扰可能具有相似的响应过程。

我国本科职业教育治理的批判性思考:场域理论的视角

基于场域理论的视角,分析我国本科层次职业教育各场域及其组织间的互动情境,以此探寻不同场域与组织间的关系。立足科层管理、育人定位、职业技能和社会空间四个主要关系场域,思考如何突破科层权力失衡、育人资本缺失、职业惯习固化、社会资源协同不足等困局,进而结合组织与场域理论的适切性,分析路径过程为“入场准备”“中场适应”“出场联动”三个阶段。为应对关系场域形成的困局,提出应从以下三个场域阶段进行治理路径探究:首先是入场的环境建构,考虑权力与文化资本的完善;其次是控场的惯习重塑,重在加深职业行动能力;最后是出场的社会资本联动,关注治理的社会化发展,以期丰富我国本科职业教育治理思路,促进治理多样化发展。

生育水平与女性劳动参与率的动态关系研究

生育水平变动会影响未来劳动年龄人口供给,但生育水平与女性劳动参与率的相关性研究结论尚有争议。基于我国1970—2021年生育率水平和女性劳动参与率时间序列数据,通过平稳性检验、协整检验以及格兰杰因果检验后,建立向量自回归(VAR)模型对两者之间的变动关系进行实证分析和检验,从宏观角度揭示生育水平变动与女性劳动参与率变化的动态关联性。研究发现,我国生育水平与女性劳动参与率的相关性由1979—1990年的负相关转变为1991—2021年的正相关,生育水平与女性劳动参与率存在长期稳定的均衡关系,总和生育率与女性劳动参与率已总体呈现出一定的格兰杰因果关系;1991—2021年我国总和生育率与女性劳动参与率的互动响应关系显著,女性劳动参与率变动对总和生育率变动的冲击影响呈现滞后性,且影响程度没有总和生育率对女性劳动参与率的冲击影响大。因此,在生育政策调整背景下,我国应充分重视生育水平与女性劳动参与率的互动影响和冲击响应关系,有效保障女性生育和劳动权益,推进性别平等的生育支持体系建设,在提振社会生育水平的同时稳定女性劳动参与率。

新时代“枫桥经验”视域下基层综合执法改革的结构张力与路径建构

基层综合执法改革是国家治理现代化的重要环节。近年来,执法重心下移和执法权下沉有效缓解了基层繁重治理任务与有限执法权力之间的实践困境。然而,执法权下沉并不必然转化为执法效能,二者中间存在复杂权变因素。破解基层执法难题可以从“枫桥经验”中寻找答案。“枫桥经验”随着时代变迁不断丰富发展,体现了中国特色的基层治理智慧。将新时代“枫桥经验”推广到基层综合执法改革中,就是要在自上而下的党政统合、由内而外的价值引导、从外到里的数字技术支持、全面兜底的制度支撑下构建边界清晰、结构稳固的“执法共同体”,建立健全系统性、一体化的基层执法体制机制。

共同富裕背景下教育水平对城乡收入差距的影响研究

以新时代推进共同富裕这一历史使命为出发点,在理论回顾的基础上提出问题,利用31个省(区、市)2000-2021年的省际面板数据,就教育水平如何影响城乡收入差距展开实证分析。结果发现,教育水平显著影响城乡收入差距,方向为正,伴随着城乡收入差距水平的提高,教育水平的影响作用更为明显;教育水平和城乡收入差距存在倒U型关系。同时经济开放水平越高,城乡收入差距越大;经济发展和城镇化有助于缩小城乡收入差距;城乡收入差距具有较强的惯性,需采取有效举措控制,以防失控。异质性分析发现东部、中部、西部和东北地区的教育水平对城乡收入差距的作用程度有明显差异,中部最大,西部次之,再次是东部,东北最小;处于不同收入差距分布上的地区对教育水平的依赖程度存在显著差异,教育水平对不同收入差距的地区存在不同的影响作用;不同教育层次对城乡收入差距的影响有明显差异,高中及以下层次的教育对城乡收入差距非常小也不显著,大学及以上教育层次影响较大且显著。

数字化转型与客户关系稳定度

稳定的客户关系是维系供应链安全稳定的重要举措。本文考察数字化转型对客户关系稳定度的影响效应及机制。研究发现,数字化转型可以有效提升客户关系稳定度,增强客户黏性。机制检验表明,数字化转型通过降低供应链企业间信息不对称程度、改善公司治理水平、增强产品与服务的差异化程度来提升客户关系稳定度。异质性检验表明,数字化转型对客户关系稳定度的提升效应主要见诸非国有企业、非高科技企业以及市场竞争更激烈的行业。拓展性研究发现,数字化转型对客户关系稳定度有持续性影响。本文为推动企业数字化转型、构建智能经济新形态和促进供应关系高质量发展具有重要的经验参考和启示意义。

基于GIS的景村协同特征与机制研究——以河南省为例

本研究以河南省为研究案例区,运用空间数量关系和空间质量关系模型定量分析A级景区与特色村镇空间关系,并基于交通通达度、运用核密度分析、缓冲区分析等方法,对河南省A级景区与特色村镇协同发展特征与机制进行探讨.主要结论如下:在数量关系上,河南省特色村镇与A级景区之间的数量空间关系整体较为显著;在质量空间关系上,特色村镇与A级景区质量空间协调度处于基本协调水平,二者质量空间耦合关系处于良好耦合协调发展水平;在协同发展关系上,交通通达度、旅游经济、河流等对特色村镇与A级景区协同发展具有重要的正向影响.

要素流动何以推动县域城乡融合:经验观察与逻辑诠释——以佛山市南海区全域土地综合整治为例

在以“人”为核心的发展理念驱动下,县域城乡融合格局存续和演化的根源与要素流动紧密关联,要素流动、对接与组合构成其基础动力与逻辑起点。本文以佛山市南海区全域土地综合整治为观察样本,将其置于“要素-结构-功能”框架下诠释要素流动与县域城乡融合的内在逻辑。研究发现,县域城乡融合是以土地要素为核心撬动城乡“人”与“业”的复杂动态过程。在土地要素市场化配置的前置情境下,通过建立全周期利益平衡机制与强化政治任务特性促进资本要素流动与组合,借助土地空间整治与土地开发权的再配置推动形成农民非农化的就业结构。进一步立足城乡投资和就业结构变化,通过“工业上楼”与差异性的市民化策略强化城乡系统福利供给能力,最终形成县域城乡融合的整体局面。据此,在“大国大城”基础上推进“大国小城”战略,坚持“在集聚中走向融合”的发展取向,通过充分而全面的要素流动、结构转型与功能整合,整体推进以“人”为核心的县域城乡融合。

融合交互注意力网络的实体和关系联合抽取模型

实体关系三元组的抽取效果直接影响后期知识图谱构建的质量,而传统流水线式和联合式抽取的模型,并没有对句子级别和关系级别的语义特征进行有效建模,从而导致模型性能的缺失。为此,提出一种融合句子级别和关系级别的交互注意力网络的实体和关系联合抽取模型RSIAN,该模型通过交互注意力网络来学习句子级别和关系级别的高阶语义关联,增强句子和关系之间的交互,辅助模型进行抽取决策。在构建的中文旅游数据集(TDDS)的Precision、Recall和F1值分别为0.872、0.760和0.812,其性能均优于其他对比模型;为了进一步验证该模型在英文联合抽取上的性能,在公开英文数据集NYT和Webnlg上进行实验,该模型的F1值相比基线模型RSAN模型分别提高了0.014和0.013,并且该模型在重叠三元组的分析实验也均取得了优于基线模型的性能且更稳定。

维持性血液透析患者希望水平与生存质量的现况及其相互关系调查

目的调查分析维持性血液透析患者希望水平与生存质量的现况及其相互关系。方法应用便利抽样法选取2021年12月至2023年12月中山市人民医院收治的220例维持性血液透析患者进行研究,采用本院自制的一般情况调查表、简明健康状况调查表以及Herth希望量表进行问卷调查,采用单因素χ^(2)检验、多因素Logistic回归分析法分析患者希望水平与生存质量的相关影响因素,并采用Pearson相关分析法分析两者之间的相关性。结果Herth希望量表评分为(25.68±7.50)分,简明健康状况调查表中的生理职能评分为(63.14±5.11)分、情感职能评分为(65.16±4.98)分、生理功能评分为(60.19±5.11)分、社会功能评分为(64.42±5.31)分、精力评分为(63.37±4.75)分、躯体疼痛评分为(62.37±4.62)分、精神健康评分为(62.15±4.71)分、总体健康评分为(61.63±4.58)分。影响维持性血液透析患者希望水平与生存质量的单因素中,家庭月收入>10000元、受教育水平为大学、透析时间为3~24个月患者的希望水平和生存质量均明显更高,差异有统计学意义(P<0.05)。经Logistic回归模型筛查,结果显示,家庭月收入、受教育水平、透析时间是影响维持性血液透析患者希望水平与生存质量的独立危险因素(P<0.05)。经Pearson相关分析结果显示,维持性血液透析患者希望相关维度、总体水平与生存质量各维度均呈正相关(P<0.05)。结论维持性血液透析患者希望水平较低、生存质量较差,家庭收入、受教育程度、透析时间均是影响患者希望水平与生存质量的独立危险因素,且患者希望相关维度、总体水平与生存质量各维度呈正相关,因此临床可对希望水平进行充分评估并给予个体化、针对性护理措施,以提高生存质量。