AIM:To describe the clinical characteristics of eyes using multimodal imaging features with acute macular neuroretinopathy(AMN)lesions following severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection.MET...AIM:To describe the clinical characteristics of eyes using multimodal imaging features with acute macular neuroretinopathy(AMN)lesions following severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection.METHODS:Retrospective case series study.From December 18,2022 to February 14,2023,previously healthy cases within 1-week infection with SARS-CoV-2 and examined at Tianjin Eye Hospital to confirm the diagnosis of AMN were included in the study.Totally 5 males and 9 females[mean age:29.93±10.32(16-49)y]were presented for reduced vision,with or without blurred vision.All patients underwent best corrected visual acuity(BCVA),intraocular pressure,slit lamp microscopy,indirect fundoscopy.Simultaneously,multimodal imagings fundus photography(45°or 200°field of view)was performed in 7 cases(14 eyes).Near infrared(NIR)fundus photography was performed in 9 cases(18 eyes),optical coherence tomography(OCT)in 5 cases(10 eyes),optical coherence tomography angiography(OCTA)in 9 cases(18 eyes),and fundus fluorescence angiography(FFA)in 3 cases(6 eyes).Visual field was performed in 1 case(2 eyes).RESULTS:Multimodal imaging findings data from 14 patients with AMN were reviewed.All eyes demonstrated different extent hyperreflective lesions at the level of the inner nuclear layer and/or outer plexus layer on OCT or OCTA.Fundus photography(45°or 200°field of view)showed irregular hypo-reflective lesion around the fovea in 7 cases(14 eyes).OCTA demonstrated that the superficial retinal capillary plexus(SCP)vascular density,deep capillary plexus(DCP)vascular density and choriocapillaris(CC)vascular density was reduced in 9 case(18 eyes).Among the follow-up cases(2 cases),vascular density increased in 1 case with elevated BCVA;another case has vascular density decrease in one eye and basically unchanged in other eye.En face images of the ellipsoidal zone and interdigitation zone injury showed a low wedge-shaped reflection contour appearance.NIR image mainly show the absence of the outer retinal interdigitation zone in AMN.No abnormal fluorescence was observed in FFA.Corresponding partial defect of the visual field were visualized via perimeter in one case.CONCLUSION:The morbidity of SARS-CoV-2 infection with AMN is increased.Ophthalmologists should be aware of the possible,albeit rare,AMN after SARS-CoV-2 infection and focus on multimodal imaging features.OCT,OCTA,and infrared fundus phase are proved to be valuable tools for detection of AMN in patients with SARS-CoV-2.展开更多
Ratoon rice,which refers to a second harvest of rice obtained from the regenerated tillers originating from the stubble of the first harvested crop,plays an important role in both food security and agroecology while r...Ratoon rice,which refers to a second harvest of rice obtained from the regenerated tillers originating from the stubble of the first harvested crop,plays an important role in both food security and agroecology while requiring minimal agricultural inputs.However,accurately identifying ratoon rice crops is challenging due to the similarity of its spectral features with other rice cropping systems(e.g.,double rice).Moreover,images with a high spatiotemporal resolution are essential since ratoon rice is generally cultivated in fragmented croplands within regions that frequently exhibit cloudy and rainy weather.In this study,taking Qichun County in Hubei Province,China as an example,we developed a new phenology-based ratoon rice vegetation index(PRVI)for the purpose of ratoon rice mapping at a 30 m spatial resolution using a robust time series generated from Harmonized Landsat and Sentinel-2(HLS)images.The PRVI that incorporated the red,near-infrared,and shortwave infrared 1 bands was developed based on the analysis of spectro-phenological separability and feature selection.Based on actual field samples,the performance of the PRVI for ratoon rice mapping was carefully evaluated by comparing it to several vegetation indices,including normalized difference vegetation index(NDVI),enhanced vegetation index(EVI)and land surface water index(LSWI).The results suggested that the PRVI could sufficiently capture the specific characteristics of ratoon rice,leading to a favorable separability between ratoon rice and other land cover types.Furthermore,the PRVI showed the best performance for identifying ratoon rice in the phenological phases characterized by grain filling and harvesting to tillering of the ratoon crop(GHS-TS2),indicating that only several images are required to obtain an accurate ratoon rice map.Finally,the PRVI performed better than NDVI,EVI,LSWI and their combination at the GHS-TS2 stages,with producer's accuracy and user's accuracy of 92.22 and 89.30%,respectively.These results demonstrate that the proposed PRVI based on HLS data can effectively identify ratoon rice in fragmented croplands at crucial phenological stages,which is promising for identifying the earliest timing of ratoon rice planting and can provide a fundamental dataset for crop management activities.展开更多
BACKGROUND Since the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)epidemic,numerous studies have been published on SARS-CoV-2-related encephalitis/meningitis,but it has not been established if there are ...BACKGROUND Since the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)epidemic,numerous studies have been published on SARS-CoV-2-related encephalitis/meningitis,but it has not been established if there are specific clinical characteristics of encephalitis/meningitis associated with SARS-CoV-2 infection.AIM To identify the specific clinical features of cases of encephalitis/meningitis associated with SARS-CoV-2 infection in the context of this virus infection pandemic and investigate their relationship with SARS-CoV-2 infection.METHODS We searched PubMed,and included single case reports and case series with full text in English,reporting original data of coronavirus disease-19(COVID-19)patients with encephalitis/meningitis and a confirmed recent SARS-CoV-2 infection.Clinical data were extracted.RESULTS We identified 22 articles(18 single case reports and 4 case series)reporting on a total of 32 encephalitis/meningitis patients with confirmed SARS-CoV-2 infection.SARS-CoV-2 infection was confirmed through reverse transcriptase-polymerasechain-reaction(RT-PCR)in 96.88%of cases.A total of 22(68.75%)patients had symptoms of SARS-CoV-2 infection in about 1 wk(7.91 d)preceding the onset of neurologic symptoms.The most common neurological symptoms were consciousness disturbance(59.38%),seizure(21.88%),delirium(18.75%),and headache(18.75%).Four cases were confirmed by positive RT-PCR results in cerebrospinal fluid(CSF),one was confirmed by positive RT-PCR results in postoperative brain tissue,and one by the presence of SARS-CoV-2 antibodies in CSF.The mainly damaged targets identified by neuroimaging included the temporal lobe(15.63%),white matter(12.5%),frontal lobe(9.38%),corpus callosum(9.38%),and cervical spinal cord(9.38%).Eighty percent of patients had electroencephalograms that showed a diffuse slow wave.Twenty-eight(87.5%)patients were administered with specific treatment.The majority(65.63%)of patients improved following systemic therapy.CONCLUSION Encephalitis/meningitis is the common neurological complication in patients with COVID-19.The appropriate use of definitions and exclusion of potential similar diseases are important to reduce over-diagnosis of SARS-CoV-2 associated encephalitis or meningitis.展开更多
Background:Accurate mapping of tree species is highly desired in the management and research of plantation forests,whose ecosystem services are currently under threats.Time-series multispectral satellite images,e.g.,f...Background:Accurate mapping of tree species is highly desired in the management and research of plantation forests,whose ecosystem services are currently under threats.Time-series multispectral satellite images,e.g.,from Landsat-8(L8)and Sentinel-2(S2),have been proven useful in mapping general forest types,yet we do not know quantitatively how their spectral features(e.g.,red-edge)and temporal frequency of data acquisitions(e.g.,16-day vs.5-day)contribute to plantation forest mapping to the species level.Moreover,it is unclear to what extent the fusion of L8 and S2 will result in improvements in tree species mapping of northern plantation forests in China.Methods:We designed three sets of classification experiments(i.e.,single-date,multi-date,and spectral-temporal)to evaluate the performances of L8 and S2 data for mapping keystone timber tree species in northern China.We first used seven pairs of L8 and S2 images to evaluate the performances of L8 and S2 key spectral features for separating these tree species across key growing stages.Then we extracted the spectral-temporal features from all available images of different temporal frequency of data acquisition(i.e.,L8 time series,S2 time series,and fusion of L8 and S2)to assess the contribution of image temporal frequency on the accuracy of tree species mapping in the study area.Results:1)S2 outperformed L8 images in all classification experiments,with or without the red edge bands(0.4%–3.4%and 0.2%–4.4%higher for overall accuracy and macro-F1,respectively);2)NDTI(the ratio of SWIR1 minus SWIR2 to SWIR1 plus SWIR2)and Tasseled Cap coefficients were most important features in all the classifications,and for time-series experiments,the spectral-temporal features of red band-related vegetation indices were most useful;3)increasing the temporal frequency of data acquisition can improve overall accuracy of tree species mapping for up to 3.2%(from 90.1%using single-date imagery to 93.3%using S2 time-series),yet similar overall accuracies were achieved using S2 time-series(93.3%)and the fusion of S2 and L8(93.2%).Conclusions:This study quantifies the contributions of L8 and S2 spectral and temporal features in mapping keystone tree species of northern plantation forests in China and suggests that for mapping tree species in China's northern plantation forests,the effects of increasing the temporal frequency of data acquisition could saturate quickly after using only two images from key phenological stages.展开更多
噪声的包络调制检测(Detection of Envelope Modulation on Noise,DEMON)谱分析技术已被广泛应用于特征提取领域,但经典DEMON谱提取中高频信号频段的选取会影响DEMON谱的提取效果。针对这一问题,文中首先运用经验模态分解(Empirical Mod...噪声的包络调制检测(Detection of Envelope Modulation on Noise,DEMON)谱分析技术已被广泛应用于特征提取领域,但经典DEMON谱提取中高频信号频段的选取会影响DEMON谱的提取效果。针对这一问题,文中首先运用经验模态分解(Empirical Mode Decomposition,EMD)方法获得一系列固有模态函数(Intrinsic Mode Function,IMF),依据各阶模态函数与原信号的相关程度,筛选出更具代表性的几阶固有模态函数进行解调,再对解调的结果运用11/2维谱分析方法进行谱分析以抑制高斯噪声,通过这种方法获得的DEMON谱信噪比优于传统方法。实测湖试数据分析结果表明,该改进方法可以有效地进行特征提取,结果优于经典DEMON谱分析方法;该改进方法具有一定的实用性,有利于进行后续目标分类识别。展开更多
A new feature extraction method based on 2D-hidden Markov model（HMM） is proposed. Meanwhile the time index and frequency index are introduced to represent the new features. The new feature extraction strategy is tes...A new feature extraction method based on 2D-hidden Markov model（HMM） is proposed. Meanwhile the time index and frequency index are introduced to represent the new features. The new feature extraction strategy is tested by the experimental data that collected from Bently rotor experiment system. The results show that this methodology is very effective to extract the feature of vibration signals in the rotor speed-up course and can be extended to other non-stationary signal analysis fields in the future.展开更多
目的基于真实世界研究探讨全国名中医庞国明教授纯中医缓解2型糖尿病(T2DM)临床特征,为临床实践提供借鉴和参考。方法采集2020年1月—2022年10月开封市中医院庞国明教授工作室就诊的符合T2DM诊断,并采用纯中医“三辨诊疗模式”“序贯三...目的基于真实世界研究探讨全国名中医庞国明教授纯中医缓解2型糖尿病(T2DM)临床特征,为临床实践提供借鉴和参考。方法采集2020年1月—2022年10月开封市中医院庞国明教授工作室就诊的符合T2DM诊断,并采用纯中医“三辨诊疗模式”“序贯三法”治疗方案且达到缓解标准的T2DM患者共计30例。采集患者的人口学资料、中医证型及纯中医治疗前、治疗达标停药时、缓解时患者的体质量指数、血生化检验指标,计算纯中医治疗时长,使用稳态模型评估法评估胰岛素抵抗指数和胰岛β细胞功能指数。分析患者的临床特征、中医证型分布,比较纯中医治疗前与治疗达标停药时、缓解时各项指标的差异。结果患者平均年龄(50.77±9.77)岁;平均病程中位数22(10.5,39.0)个月;平均体质量指数中位数27.75(25.87,28.80)kg/m^(2),中医证型分布情况:痰浊中阻证频率最高,其次气阴两虚证。与治疗前比较,患者停药时空腹血糖(FPG)、餐后1 h血糖(1 h PG)、2 h PG、3 h PG、空腹胰高血糖素(FGC)、1 h GC、2 h GC、3 h GC、糖化血红蛋白(HbA1c)、果糖胺(FMN)、胰岛素抵抗指数(HOMA-IR)、体质量指数(BMI)、总胆固醇(TC)水平明显下降,差异有统计学意义(P<0.05),1 h C肽(CP)、胰岛β细胞功能指数(HOMA-β)水平较前升高,差异有统计学意义(P<0.05),与治疗前比较,缓解时FPG、1 h PG、2 h PG、1 h GC、2 h GC、HbA1c、BMI、3 h PG、FGC、3 h GC、TC、HOMA-IR水平明显下降,差异有统计学意义(P<0.05),HOMA-β、1 h CP、高密度脂蛋白胆固醇(HDL-C)水平较前升高,差异有统计学意义(P<0.05)。结论纯中医缓解T2DM患者以糖尿病病程<5年,超重或肥胖为主,纯中医治疗时长多集中在3~12个月,中医证型以痰浊中阻证为主。纯中医可能通过降低体质量,改善胰岛素抵抗,改善胰岛β细胞功能,降低胰高血糖素等途径实现缓解T2DM。展开更多
文摘AIM:To describe the clinical characteristics of eyes using multimodal imaging features with acute macular neuroretinopathy(AMN)lesions following severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection.METHODS:Retrospective case series study.From December 18,2022 to February 14,2023,previously healthy cases within 1-week infection with SARS-CoV-2 and examined at Tianjin Eye Hospital to confirm the diagnosis of AMN were included in the study.Totally 5 males and 9 females[mean age:29.93±10.32(16-49)y]were presented for reduced vision,with or without blurred vision.All patients underwent best corrected visual acuity(BCVA),intraocular pressure,slit lamp microscopy,indirect fundoscopy.Simultaneously,multimodal imagings fundus photography(45°or 200°field of view)was performed in 7 cases(14 eyes).Near infrared(NIR)fundus photography was performed in 9 cases(18 eyes),optical coherence tomography(OCT)in 5 cases(10 eyes),optical coherence tomography angiography(OCTA)in 9 cases(18 eyes),and fundus fluorescence angiography(FFA)in 3 cases(6 eyes).Visual field was performed in 1 case(2 eyes).RESULTS:Multimodal imaging findings data from 14 patients with AMN were reviewed.All eyes demonstrated different extent hyperreflective lesions at the level of the inner nuclear layer and/or outer plexus layer on OCT or OCTA.Fundus photography(45°or 200°field of view)showed irregular hypo-reflective lesion around the fovea in 7 cases(14 eyes).OCTA demonstrated that the superficial retinal capillary plexus(SCP)vascular density,deep capillary plexus(DCP)vascular density and choriocapillaris(CC)vascular density was reduced in 9 case(18 eyes).Among the follow-up cases(2 cases),vascular density increased in 1 case with elevated BCVA;another case has vascular density decrease in one eye and basically unchanged in other eye.En face images of the ellipsoidal zone and interdigitation zone injury showed a low wedge-shaped reflection contour appearance.NIR image mainly show the absence of the outer retinal interdigitation zone in AMN.No abnormal fluorescence was observed in FFA.Corresponding partial defect of the visual field were visualized via perimeter in one case.CONCLUSION:The morbidity of SARS-CoV-2 infection with AMN is increased.Ophthalmologists should be aware of the possible,albeit rare,AMN after SARS-CoV-2 infection and focus on multimodal imaging features.OCT,OCTA,and infrared fundus phase are proved to be valuable tools for detection of AMN in patients with SARS-CoV-2.
基金supported by the National Natural Science Foundation of China(42271360 and 42271399)the Young Elite Scientists Sponsorship Program by China Association for Science and Technology(CAST)(2020QNRC001)the Fundamental Research Funds for the Central Universities,China(2662021JC013,CCNU22QN018)。
文摘Ratoon rice,which refers to a second harvest of rice obtained from the regenerated tillers originating from the stubble of the first harvested crop,plays an important role in both food security and agroecology while requiring minimal agricultural inputs.However,accurately identifying ratoon rice crops is challenging due to the similarity of its spectral features with other rice cropping systems(e.g.,double rice).Moreover,images with a high spatiotemporal resolution are essential since ratoon rice is generally cultivated in fragmented croplands within regions that frequently exhibit cloudy and rainy weather.In this study,taking Qichun County in Hubei Province,China as an example,we developed a new phenology-based ratoon rice vegetation index(PRVI)for the purpose of ratoon rice mapping at a 30 m spatial resolution using a robust time series generated from Harmonized Landsat and Sentinel-2(HLS)images.The PRVI that incorporated the red,near-infrared,and shortwave infrared 1 bands was developed based on the analysis of spectro-phenological separability and feature selection.Based on actual field samples,the performance of the PRVI for ratoon rice mapping was carefully evaluated by comparing it to several vegetation indices,including normalized difference vegetation index(NDVI),enhanced vegetation index(EVI)and land surface water index(LSWI).The results suggested that the PRVI could sufficiently capture the specific characteristics of ratoon rice,leading to a favorable separability between ratoon rice and other land cover types.Furthermore,the PRVI showed the best performance for identifying ratoon rice in the phenological phases characterized by grain filling and harvesting to tillering of the ratoon crop(GHS-TS2),indicating that only several images are required to obtain an accurate ratoon rice map.Finally,the PRVI performed better than NDVI,EVI,LSWI and their combination at the GHS-TS2 stages,with producer's accuracy and user's accuracy of 92.22 and 89.30%,respectively.These results demonstrate that the proposed PRVI based on HLS data can effectively identify ratoon rice in fragmented croplands at crucial phenological stages,which is promising for identifying the earliest timing of ratoon rice planting and can provide a fundamental dataset for crop management activities.
基金Supported by Liaoning Provincial Department of Education Scientific Research Project,No.QNZR2020012Henan Neural Development Engineering Research Center for Children Foundation,No.SG201905and the National Key Research and Development Program of China,No.2016YFC1306203.
文摘BACKGROUND Since the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)epidemic,numerous studies have been published on SARS-CoV-2-related encephalitis/meningitis,but it has not been established if there are specific clinical characteristics of encephalitis/meningitis associated with SARS-CoV-2 infection.AIM To identify the specific clinical features of cases of encephalitis/meningitis associated with SARS-CoV-2 infection in the context of this virus infection pandemic and investigate their relationship with SARS-CoV-2 infection.METHODS We searched PubMed,and included single case reports and case series with full text in English,reporting original data of coronavirus disease-19(COVID-19)patients with encephalitis/meningitis and a confirmed recent SARS-CoV-2 infection.Clinical data were extracted.RESULTS We identified 22 articles(18 single case reports and 4 case series)reporting on a total of 32 encephalitis/meningitis patients with confirmed SARS-CoV-2 infection.SARS-CoV-2 infection was confirmed through reverse transcriptase-polymerasechain-reaction(RT-PCR)in 96.88%of cases.A total of 22(68.75%)patients had symptoms of SARS-CoV-2 infection in about 1 wk(7.91 d)preceding the onset of neurologic symptoms.The most common neurological symptoms were consciousness disturbance(59.38%),seizure(21.88%),delirium(18.75%),and headache(18.75%).Four cases were confirmed by positive RT-PCR results in cerebrospinal fluid(CSF),one was confirmed by positive RT-PCR results in postoperative brain tissue,and one by the presence of SARS-CoV-2 antibodies in CSF.The mainly damaged targets identified by neuroimaging included the temporal lobe(15.63%),white matter(12.5%),frontal lobe(9.38%),corpus callosum(9.38%),and cervical spinal cord(9.38%).Eighty percent of patients had electroencephalograms that showed a diffuse slow wave.Twenty-eight(87.5%)patients were administered with specific treatment.The majority(65.63%)of patients improved following systemic therapy.CONCLUSION Encephalitis/meningitis is the common neurological complication in patients with COVID-19.The appropriate use of definitions and exclusion of potential similar diseases are important to reduce over-diagnosis of SARS-CoV-2 associated encephalitis or meningitis.
基金supported by National Natural Science Foundation of China(Grant No.41901382)Open Fund of State Key Laboratory of Remote Sensing Science(Grant No.OFSLRSS201917)the HZAU research startup fund(No.11041810340,No.11041810341).
文摘Background:Accurate mapping of tree species is highly desired in the management and research of plantation forests,whose ecosystem services are currently under threats.Time-series multispectral satellite images,e.g.,from Landsat-8(L8)and Sentinel-2(S2),have been proven useful in mapping general forest types,yet we do not know quantitatively how their spectral features(e.g.,red-edge)and temporal frequency of data acquisitions(e.g.,16-day vs.5-day)contribute to plantation forest mapping to the species level.Moreover,it is unclear to what extent the fusion of L8 and S2 will result in improvements in tree species mapping of northern plantation forests in China.Methods:We designed three sets of classification experiments(i.e.,single-date,multi-date,and spectral-temporal)to evaluate the performances of L8 and S2 data for mapping keystone timber tree species in northern China.We first used seven pairs of L8 and S2 images to evaluate the performances of L8 and S2 key spectral features for separating these tree species across key growing stages.Then we extracted the spectral-temporal features from all available images of different temporal frequency of data acquisition(i.e.,L8 time series,S2 time series,and fusion of L8 and S2)to assess the contribution of image temporal frequency on the accuracy of tree species mapping in the study area.Results:1)S2 outperformed L8 images in all classification experiments,with or without the red edge bands(0.4%–3.4%and 0.2%–4.4%higher for overall accuracy and macro-F1,respectively);2)NDTI(the ratio of SWIR1 minus SWIR2 to SWIR1 plus SWIR2)and Tasseled Cap coefficients were most important features in all the classifications,and for time-series experiments,the spectral-temporal features of red band-related vegetation indices were most useful;3)increasing the temporal frequency of data acquisition can improve overall accuracy of tree species mapping for up to 3.2%(from 90.1%using single-date imagery to 93.3%using S2 time-series),yet similar overall accuracies were achieved using S2 time-series(93.3%)and the fusion of S2 and L8(93.2%).Conclusions:This study quantifies the contributions of L8 and S2 spectral and temporal features in mapping keystone tree species of northern plantation forests in China and suggests that for mapping tree species in China's northern plantation forests,the effects of increasing the temporal frequency of data acquisition could saturate quickly after using only two images from key phenological stages.
文摘噪声的包络调制检测(Detection of Envelope Modulation on Noise,DEMON)谱分析技术已被广泛应用于特征提取领域,但经典DEMON谱提取中高频信号频段的选取会影响DEMON谱的提取效果。针对这一问题,文中首先运用经验模态分解(Empirical Mode Decomposition,EMD)方法获得一系列固有模态函数(Intrinsic Mode Function,IMF),依据各阶模态函数与原信号的相关程度,筛选出更具代表性的几阶固有模态函数进行解调,再对解调的结果运用11/2维谱分析方法进行谱分析以抑制高斯噪声,通过这种方法获得的DEMON谱信噪比优于传统方法。实测湖试数据分析结果表明,该改进方法可以有效地进行特征提取,结果优于经典DEMON谱分析方法;该改进方法具有一定的实用性,有利于进行后续目标分类识别。
基金This project is supported by National Natural Science Foundation of China(No.50075079).
文摘A new feature extraction method based on 2D-hidden Markov model（HMM） is proposed. Meanwhile the time index and frequency index are introduced to represent the new features. The new feature extraction strategy is tested by the experimental data that collected from Bently rotor experiment system. The results show that this methodology is very effective to extract the feature of vibration signals in the rotor speed-up course and can be extended to other non-stationary signal analysis fields in the future.
文摘目的基于真实世界研究探讨全国名中医庞国明教授纯中医缓解2型糖尿病(T2DM)临床特征,为临床实践提供借鉴和参考。方法采集2020年1月—2022年10月开封市中医院庞国明教授工作室就诊的符合T2DM诊断,并采用纯中医“三辨诊疗模式”“序贯三法”治疗方案且达到缓解标准的T2DM患者共计30例。采集患者的人口学资料、中医证型及纯中医治疗前、治疗达标停药时、缓解时患者的体质量指数、血生化检验指标,计算纯中医治疗时长,使用稳态模型评估法评估胰岛素抵抗指数和胰岛β细胞功能指数。分析患者的临床特征、中医证型分布,比较纯中医治疗前与治疗达标停药时、缓解时各项指标的差异。结果患者平均年龄(50.77±9.77)岁;平均病程中位数22(10.5,39.0)个月;平均体质量指数中位数27.75(25.87,28.80)kg/m^(2),中医证型分布情况:痰浊中阻证频率最高,其次气阴两虚证。与治疗前比较,患者停药时空腹血糖(FPG)、餐后1 h血糖(1 h PG)、2 h PG、3 h PG、空腹胰高血糖素(FGC)、1 h GC、2 h GC、3 h GC、糖化血红蛋白(HbA1c)、果糖胺(FMN)、胰岛素抵抗指数(HOMA-IR)、体质量指数(BMI)、总胆固醇(TC)水平明显下降,差异有统计学意义(P<0.05),1 h C肽(CP)、胰岛β细胞功能指数(HOMA-β)水平较前升高,差异有统计学意义(P<0.05),与治疗前比较,缓解时FPG、1 h PG、2 h PG、1 h GC、2 h GC、HbA1c、BMI、3 h PG、FGC、3 h GC、TC、HOMA-IR水平明显下降,差异有统计学意义(P<0.05),HOMA-β、1 h CP、高密度脂蛋白胆固醇(HDL-C)水平较前升高,差异有统计学意义(P<0.05)。结论纯中医缓解T2DM患者以糖尿病病程<5年,超重或肥胖为主,纯中医治疗时长多集中在3~12个月,中医证型以痰浊中阻证为主。纯中医可能通过降低体质量,改善胰岛素抵抗,改善胰岛β细胞功能,降低胰高血糖素等途径实现缓解T2DM。
