Production and Characterization of a Composite Based on Plaster and Juncus Maritimus Plant Fibers

Nowadays,materials with a limited impact on the environment are required in the construction sector.Considering the interesting properties of natural elements such as natural fibers,it seems advantageous to use them to reinforce materials while protecting the environment and guaranteeing economic gain.Along these lines,this research was devoted to studying the effect of untreated natural fibers extracted from the Juncus maritimus plant(from Southern Morocco)on plaster.First,the effect of the percentage of added fibers on the fluidity of the plaster was evaluated by means of the Marsh’s cone method,that is,by measuring the time taken by a known volume of plaster to flow from a cone through a short tube.Then,the highly porous microstructure of the plaster was observed using a scanning electron microscope(SEM).The diffractogram of Juncus maritimus fibers was built by means of a X-ray diffraction(XRD)method.The values obtained for the wet thermal conductivity of the composites decreased from 0.4853 W/m.K for the reference specimen to 0.4324 W/m K for a fiber volume content of 40%.The densities were calculated to determine the lightness of each composite.The mechanical strengths[flexural and compressive]were evaluated for different percentages of rush fibers.The addition of 20%volume fiber was found to improve the flexural strength to 3.63 MPa compared to the sample without fiber(3.36 MPa),thereby ensuring good toughness of the considered material.Nevertheless,a reduction in compressive strength was observed,due to the poor adhesion between the fibers and the plaster matrix.

Study on the effect of Shixiang plaster on the expression of CD31,serum FN,and VEGF in a rat model with chronic wounds

Background:Chronic wounds pose a significant surgical challenge,often requiring traditional treatments with limited efficacy.This study explores the promising impact of Shixiang plaster,a classic Chinese ointment,on wound healing.We investigated the cluster of differentiation 31(CD31)expression,serum fibronectin(FN),and vascular endothelial growth factor(VEGF)levels in SPF rats with induced wounds to elucidate the mechanism behind Shixiang plaster’s effectiveness.We investigated the effect and explored the role of Shixiang plaster on the expression of CD31,serum FN,and VEGF in chronic wounds.Methods:The study involved 36 SPF rats divided into model,rb-bFGF,and Shixiang plaster groups.Penicillin was injected into the rats before modelling for 3 days to prevent infection.The skin was excised 2 cm below the horizontal line of the inferior border of the shoulder bone in the middle of the rat column up to the deep fascial layer and inoculated with a certain concentration of Staphylococcus aureus;the wound was covered aseptically for 3 days.The trauma area of the rats was observed at 3,7,and 14 days,respectively.Histopathology was observed using haematoxylin eosin and Masson staining.CD31 expression was detected using immunohistochemistry staining.FN and VEGF expression was detected using serum ELISA.Statistical analyses were carried out by the method of SPSS.Results:Regarding wound morphology,at 3 days,the recovery area of the Shixiang plaster group was larger than that of the other two groups,at 7 days,the wound healing rate of the Shixiang plaster group was significantly higher,and at 14 days,the wounds of the Shixiang plaster group had been mostly healed,with a healing rate of 98.3%.Haematoxylin eosin staining revealed a large amount of granulation tissue at 3 days in the Shixiang plaster group,and the epidermal scales disappeared at 14 days,with thinner epidermal thickness at 1 lesion and a large reduction in inflammatory cell infiltration.Masson staining showed that at 3,7,and 14 days,blue staining was the most abundant and deeper in the Shixiang plaster group,with richer collagen and a compact tissue matrix.Immunohistochemical testing showed strong positive expression of CD31 in the Shixiang plaster group,with abundant neovascularisation and large official lumens extending towards the surface of the wound.Statistically significant elevated expression of FN at 7 and 14 days was determined by ELISA in the Shixiang plaster group,and VEGF expression was significantly increased at 7 days,but expression had been expressed at a low level at 14 days.Conclusion:Shixiang plaster exhibits remarkable efficacy in healing chronic wounds.The proposed mechanism involves FN’s promotion of angiogenesis and cell proliferation,VEGF’s impact on angiogenesis and inflammation,and CD31’s regulatory role in inhibiting inflammation while promoting angiogenesis.

Investigation of the Fermentation Mode of Rice Husk for the Stabilization of Earth Plaster

Despite its low resistance to humidity, adobe remains the most widely used material for housing construction, particularly in developing countries. The present study aims to assess different modes of use of fermented RH and to evaluate their influence on the behavior of raw earth for application in plaster. The influences of two types of RH are evaluated: granular rice husk (RHg) and powdered RH (RHp). The clay mainly consists of clay (40%), silt (22%), and sand (38.4%), with a small proportion of gravel (0.24%). Its liquidity limit is 40% and the plasticity index is 26.5%. The mixtures were designed using earth and each of the two rice husks at the volumetric content of 10%, 15% and 20% of the total volume mixed with water 36.5%, 38.5% and 40.3% and fermented for three weeks. Each fermented mixture was added to the soil to form the paste, and 40 × 40 × 160 mm3 test speciments were made for characterization. The results generally show an improvement in the physico-mechanical properties and water resistance of the mortars containing fermented RH, with an optimal content between 10% and 15%. The powdered RH improved the performance of the mortar better than granular RH.

Thermal Performance Analysis of Plaster Reinforced with Raffia Vinifera Particles for Use as Insulating Materials in Building

The present study focuses on the formulation of new composite consisting of plaster and raffia vinifera particle (RVP) with the purpose to reducing energy consumption. The aim of this study is to test this new compound as an insulating eco-material in building in a tropical climate. The composites samples were developed by mixing plaster with raffia vinifera particles (RVP) using three different sizes (1.6 mm, 2.5 mm and 4 mm). The effects of four different RVP incorporations rates (i.e., 0wt%, 5wt%;10wt%;15wt%) on physical, thermal, mechanicals properties of the composites were investigated. In addition, the use of the raffia vinifera particles and plaster based composite material as building envelopes thermal insulation material is studied by the habitable cell thermal behavior instrumentation. The results indicate that the incorporation of raffia vinifera particle leads to improve the new composite physical, mechanical and thermal properties. And the parametric analysis reveals that the sampling rate and the size of raffia vinifera particles are the most decisive factor to impact these properties, and to decreases in the thermal conductivity which leads to an improvement to the thermal resistance and energy savings. The best improvement of plaster composite was obtained at the raffia vinifera particles size between 2.5 and 4.0 mm loading of 5wt% (C95P5R) with a good ratio of thermo-physical-mechanical properties. Additionally, the habitable cell experimental thermal behavior, with the new raffia vinifera particles and plaster-based composite as thermal insulating material for building walls, gives an average damping of 4°C and 5.8°C in the insulated house interior environment respectively for cold and hot cases compared to the outside environment and the uninsulated house interior environment. The current study highlights that this mixture gives the new composite thermal insulation properties applicable in the eco-construction of habitats in tropical environments.

Effect of Head Meridian Massage Combined with Auricular Acupoint Plaster on Patients with Insomnia

Objective:To study the effect of head meridian massage combined with auricular acupoint plasters on patients with insomnia.Methods:The sample consisted of 50 cases,and all of them were admitted to Yixing Hospital of Traditional Chinese Medicine from January 2022 to December 2023.The patients were divided into an observation group and a control group,with 25 cases in each group.The observation group was treated with a combination of head meridian massage and auricular acupoint plaster while the control group underwent conventional nursing care.The improvement of sleep quality and nursing effect were used as evaluation criteria to compare the clinical effects of the nursing programs.Results:After nursing intervention,the Pittsburgh sleep quality index(PSQI)score of the observation group,which was 7.17±1.41 points was lower than that of the control group(9.04±1.96 points),(t=3.8724,P<0.05).The total efficacy was 96.00%for the observation group and 76.00%for the control group(2=4.1528,P<0.05).Conclusion:Head meridian massage combined with auricular acupoint can improve the sleep quality of patients with insomnia.

Yinqiao Sanhuang Paste Combined with Traditional Chinese Medicine Plaster for the Intervention of Drug Rash Induced by Targeted Therapy in Lung Cancer

Objective:To observe the efficacy and safety of Yinqiao Sanhuang Paste combined with traditional Chinese medicine plaster in treating drug rash caused by targeted therapy in lung cancer.Methods:A total of 100 lung cancer patients treated at our hospital from January 2021 to December 2023 were selected and randomly divided into an observation group and a control group,with 50 patients in each group.The control group received conventional medication,while the observation group was treated with Yinqiao Sanhuang Paste combined with traditional Chinese medicine plaster.The clinical symptom improvement and adverse reactions in both groups were observed.Results:The effective rate in the control group was 80.00%,while in the observation group,it was 96.00%,with a statistically significant difference between the two groups(P<0.05).The onset time,duration,and significant effect time in the control group were(2.41±0.29)days,(4.42±1.21)days,and(5.45±0.29)days,respectively;in the observation group,they were(2.44±0.21)days,(4.28±1.11)days,and(5.57±1.01)days,respectively.There was no statistically significant difference in the total onset time and total duration between the two groups(P>0.05).The incidence of adverse reactions in the control group was 28.00%,higher than the observation group’s 10.00%(P<0.05).Conclusion:Yinqiao Sanhuang Paste combined with traditional Chinese medicine plaster can effectively reduce the symptoms of drug rash induced by targeted therapy in lung cancer and lower the incidence of adverse reactions,indicating good clinical application value.

Study on the Application of Non-Plastering Technology of BM Lightweight Aggregate Interlocking Block

Benchmark(BM)lightweight aggregate interlocking block has the characteristics of energy saving,no plastering,convenient construction,etc.,which can be used for internal infilled walls at all parts(240 mm thick block can also be used for external infilled walls).The U-shaped bricks are used in building ring beams,structural columns and lintel formwork.It eases the formwork construction process,saves energy consumption,shortens the construction period,and reduces the materials used,achieving the purpose of ensuring a high-quality building at minimum construction cost.Taking the practical project as an example,this paper studies the performance and characteristics of BM light aggregate interlocking block,and introduces the key construction technologies,aiming to provide relevant reference for the application of BM light aggregate interlocking block in practical projects.

Clinical Study on Treatment of Chronic Prostatitis with Lingze Tablets Combined with TCM Herbal Acupoint Plasters

Objective:To study the therapeutic effect of Lingze tablets combined with traditional Chinese medicine herbal acupoint plasters on chronic prostatitis.Methods:A total of 64 patients with chronic prostatitis who were admitted to the Andrology Clinic of Shuyang County Hospital of Traditional Chinese Medicine from March 2021 to March 2023 were randomly divided into a treatment group and a control group,with 32 cases in each group.The control group took Lingze tablets orally,4 tablets/time,3 times/d;the treatment group took the same medication along with traditional Chinese medicine acupoint herbal plasters.The two groups of patients were treated continuously for 6 weeks,and the differences in the relevant indexes of the curative effect were observed.Results:The NIH-Chronic Prostatitis Symptom Index(NIH-CPSI)scores of the two groups significantly reduced after treatment(P<0.05),and the scores of the patients in the treatment group were lower than those in the control group(P<0.05).The treatment received in the treatment group achieved and efficacy of 96.88%,which was significantly higher than that of the group,which was 81.25%(P<0.05).The maximum flow rate(MFR),average flow rate AFR,and urine output of the patients of both groups improved significantly after treatment(P<0.05).However,the experimental group showed better improvements in these indicators(P<0.05).Conclusion:Lingze tablets combined with traditional Chinese medicine acupoint herbal plasters can significantly improve the symptoms and urodynamic function of patients with chronic prostatitis.

Analysis of the Effect of Shenghua Zhuyu Herbal Acupoint Plaster in the Treatment of Postpartum Malodor

Objective:To assess the clinical effect of Shenghua Zhuyu ointment,which was applied onto the Zhongji,Qihai,and Guanyuan acupoints,on postpartum lochia.Methods:We randomly divided 166 patients who were admitted in 2018-2021 into an observation group and a control group.The control group was treated with conventional clinical methods,whereas the observation group was treated by applying Shenghua Zhuyu ointment on the Zhongji,Qihai,and Guanyuan acupoints.The amount and duration of lochia,abdominal pain,hospitalization time were observed;B-scan ultrasonography was performed to check whether the placenta was discharged.Results:The treatment received by the observation group of patients was shown to be more effective than that of the control group.Besides,the experimental group had less lochia than that of the control group.The observation group also had shorter duration of lochia and hospital stay than those of the control group(P<0.05).The placenta excretion was better,and the degree of abdominal pain was lower in the observation group than those of the control group(P<0.05).Conclusion:The acupoint application of Shenghua Zhuyu herbal acupoint plaster has a significant impact on retained placenta,in which it can aid the discharge of residual placenta and improve the patients’physical functions and symptoms.

消瘀散精简方贴膏治疗膝骨关节炎临床研究

目的观察探讨消瘀散精简方贴膏治疗膝骨关节炎的临床疗效及对软骨代谢干预的意义。方法采用随机数字表法将105例膝骨关节炎病例随机分为消瘀散精简方组、消瘀散组和双氯芬酸二乙胺组各35例。消瘀散精简方组在肿胀疼痛部位贴敷消瘀散精简方,消瘀散组在肿胀疼痛部位贴敷消瘀散方,以覆盖整个病变部位为宜,24 h换药1次;双氯芬酸二乙胺组在肿胀疼痛部位均匀涂抹双氯芬酸二乙胺乳胶剂,每日3次;3组均2周为1个疗程,连续治疗2个疗程。观察3组临床疗效,比较3组治疗前后视觉模拟量表(VAS)评分、西安大略和麦克马斯特大学骨关节炎指数(WOMAC)评分、膝关节活动度及软骨代谢指标血清透明质酸(HA)、Ⅱ型胶原、血清人软骨寡聚基质蛋白(COMP)、尿Ⅱ型胶原C端肽(CTX-Ⅱ)的含量改变。监测3组安全性指标。结果消瘀散精简方组、消瘀散组总有效率均为97.1%(33/34),优于双氯芬酸二乙胺组的81.8%(27/33),3组比较差异有统计学意义(P<0.05)。消瘀散精简方组和消瘀散组患者治疗后VAS评分、WOMAC评分、坐-立5次时间明显低于双氯芬酸二乙胺组(P<0.05);消瘀散精简方组和消瘀散组在延缓HA含量降低程度及COMP含量升高程度上优于双氯芬酸二乙胺组(P<0.05);消瘀散精简方组和消瘀散组治疗4周VAS评分、WOMAC评分、膝关节活动度及骨代谢指标含量差异无统计学意义(P>0.05)。3组治疗前后血尿常规、肝肾功能及心电图检查无异常。结论消瘀散精简方与消瘀散功效相当,能减少膝骨关节炎患者疼痛,增加患者膝关节活动度及日常生活能力,延缓软骨组织的损伤代谢。

石墨粉吸波剂对抹灰石膏性能的影响

【目的】为了低成本制备民用建筑吸波材料,研究不同种类石墨粉对抹灰石膏性能的影响。【方法】以新型墙体抹灰砂浆抹灰石膏作为研究对象,掺入包括自制的膨胀破碎石墨在内的不同种类的低成本石墨粉作为吸波剂,制备石墨-抹灰石膏复合材料;使用X射线衍射仪、扫描电子显微镜、网络分析仪等设备对复合材料的结构、物性、强度和吸波性能进行测试和表征。【结果】在抹灰石膏中掺入石墨粉,导致标准扩散度用水量增加,凝结时间缩短,体积密度减小,力学性能降低,吸波性能提高;相比于天然鳞片石墨和石墨微片,抹灰石膏中掺入质量分数为8%的膨胀破碎石墨粉可获得最好的吸波性能,在频率为2~18 GHz时,反射损耗(reflection loss,R_(L))小于-5 dB的带宽可达10.8 GHz,至少有68.38%的电磁波被吸收,且凝结时间、体积密度和力学性能均可达到国标中对轻质底层抹灰石膏的要求。【结论】膨胀破碎石墨粉是几种石墨粉中最适合用于民用建筑的低成本吸波剂。

滋阴疏肝颗粒配合耳穴贴压法治疗女童性早熟的疗效及对其性激素、性腺体积的影响

目的 观察滋阴疏肝颗粒配合耳穴贴压法治疗女童性早熟的疗效及对其性激素、性腺体积的影响。方法 选取2021年1月—2022年10月期间荆州市第一人民医院收治的性早熟女童98例,按随机数字表法分为对照组和观察组,每组各49例。对照组患儿给予亮丙瑞林治疗,观察组给予滋阴疏肝颗粒配合耳穴贴压法治疗,疗程3个月。观察比较两组患儿临床疗效、不良反应情况,治疗前后中医证候积分,性激素[血清孕酮(Progesterone,P)、睾酮(Testosterone,T)、雌二醇(Estradiol,E_(2))、黄体生成素(Luteinizing hormone,LH)、促卵泡激素(Follicle-stimulating hormone,FSH)和催乳素(Prolactin,PRL)]、乳核指数、子宫体积、卵巢体积和骨龄(Bone age,BA)/生活年龄(Chronological age,CA)比值。结果 治疗后两组患儿中医证候积分较治疗前降低,差异有统计学意义(P<0.05);且观察组中医证候积分明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患儿血清性激素P、LH、FSH、E_(2)和PRL水平均较治疗前降低,差异有统计学意义(P<0.05),T水平与治疗前比较,差异无统计学意义(P>0.05);且观察组血清性激素P、LH、FSH、E_(2)和PRL水平均明显低于对照组,差异有统计学意义(P<0.05),T水平与对照组比较,差异无统计学意义(P>0.05)。治疗后两组患儿子宫体积、卵巢体积、乳核指数及BA/CA值均较治疗前降低,差异有统计学意义(P<0.05);且观察组子宫体积、卵巢体积、乳核指数及BA/CA值均明显低于对照组,差异有统计学意义(P<0.05)。治疗后观察组的临床总有效率87.50%(42/48)明显高于对照组72.34%(34/47),差异有统计学意义(χ^(2)=6.247,P=0.012)。治疗期间,两组患儿不良反应发生率比较,差异无统计学意义(χ^(2)=0.146,P=0.702)。结论 滋阴疏肝颗粒配合耳穴贴压法治疗女童性早熟可调节性激素水平,缩小性腺体积,抑制第二性征提前发育,提高临床疗效。

三黄膏质量标准提升研究

目的:提升三黄膏的质量标准。方法:制备三黄膏,进行性状观察和粒度检查,采用薄层色谱法对该制剂中的黄连药材进行定性鉴别,采用高效液相色谱法测定该制剂中的小檗碱、表小檗碱、黄连碱、巴马汀含量并规定其总含量限度。结果:本研究所制得的三黄膏为黄色至棕黄色的软膏;粒度检查符合相关规定;建立的薄层色谱法专属性强,可准确鉴别黄连药材;小檗碱、表小檗碱、黄连碱、巴马汀的平均总含量为4.01 mg/g,其含量限度不得少于3.21 mg/g。结论:本研究建立的三黄膏质量标准稳定、可行,可有效控制该制剂的质量。

“关节粘连外洗方”凝胶贴膏的基质配比研究

目的 探索将关节粘连外洗方的外用洗剂剂型转变为凝胶贴膏,优选凝胶贴膏的最佳基质处方。方法 初步拟定凝胶贴膏的5种关键基质,对聚丙烯酸钠NP700、甘羟铝、羧甲基纤维素钠(CMC-Na)、聚乙烯醇(PVA)、甘油这5种用量,进行单因素分析,并以成型贴膏的初黏力、持黏力、剥离强度等为考察指标进行判定。结果 从单因素考察中发现,当NP700合理用量范围在2%~15%,用量过低则膏体过软难以成型,无法涂布。当甘羟铝合理用量范围在0.03%~0.25%,用量增高则导致贴膏的初黏力和内聚力增高、剥离强度减少。当CMC-Na合理用量范围在0.5%~10%,随用量水平提高,则导致贴膏的初黏力明显增加和内聚力剥离强度减弱。当PVA合理用量范围在1%~6%,用量减少时贴膏不能成型,用量增多时贴膏初黏力增加、内聚力减弱。当甘油合理用量范围在28%~33%,用量过低则膏体偏硬,涂布出现硬块,用量过高则膏体过软,出现溢膏。结论 5种基质辅料均会对贴膏的各项指标造成明显影响,且作用并不相同,用量范围最终确定为:NP700(2%~15%)、甘羟铝(0.07%~0.25%)、CMC-Na(0.5%~10%)、PVA(1%~6%)、甘油(23%~33%)。

两种治疗方案对老年人桡骨远端骨折的疗效比较

目的:探讨采用保守治疗和切开复位内固定两种方案对65岁以上老年人桡骨远端骨折(DRF)的疗效。方法:选择我院于2020年6月—2022年2月收治的DRF患者81例,分为手法组(46例)与切开组(35例)。手法组采用骨折手法复位高分子聚酯绷带固定治疗;切开组采用切开复位内固定手术治疗。使用X线片对比患者治疗前后的尺偏角、掌偏角和桡骨高度,以评估治疗情况。统计患者末次随访的改良Mayo腕关节评分(MMWS)、DASH-Chinese上肢功能评分以及并发症,对患者预后评价。结果:两组治疗后尺偏角、掌偏角和桡骨高度较治疗前增加(P<0.05);切开组治疗后尺偏角、掌偏角和桡骨高度高于手法组(P<0.05)。两组治疗后MMWS较治疗前增加,而DASH-Chinese上肢功能评分较治疗前降低(P<0.05);切开组治疗后MMWS高于手法组,而DASH-Chinese上肢功能评分低于手法组(P<0.05)。切开组并发症发生率低于手法组(P<0.05)。结论:切开复位内固定术治疗老年人DRF有明显的临床优势,可以促进患者腕关节和上肢功能恢复。

三黄膏制备工艺改进对其体外药物释放特性的影响

目的:考察三黄膏制备工艺改进对其体外药物释放特性的影响。方法:用人工尼龙膜作为半透膜,采用Franz直立式扩散池考察三黄膏的释放特性,应用HPLC测定接收液介质中小檗碱的含量,以美国FDA与欧盟体外释放指南考察三黄膏变更前后质量一致性,并对变更后的三黄膏释放动力学进行拟合。结果:变更前三黄膏(即参比制剂)单位面积累积渗透量(A total)为(556.35±28.65)μg/cm 2,变更后三黄膏(即试验制剂)单位面积累积渗透量(A total)为(507.54±25.07)μg/cm 2。试验制剂与参比制剂的中位体外释放率比值、体外释放率平均值比率、单位面积渗透总量(A total)平均值比率均符合美国FDA与欧盟的体外释放指南要求。释放动力学过程符合零级和Hixson-Crowell释放模型,Hixson-Crowell方程表明小檗碱释放符合被动扩散机制。结论:试验制剂与参比制剂的体外释放具有一致性,三黄膏工艺变更符合预期。

罗浮山风湿膏药在膝骨关节炎患者中的应用分析

目的探讨罗浮山风湿膏药治疗对膝骨关节炎(knee osteoarthritis,KOA)患者的应用效果。方法选取该院2020年1月—2021年1月治疗的200例KOA患者,随机分为对照组和观察组各100例。对照组口服艾瑞昔布片,0.1 g/次,2次/d;观察组在对照组的基础上外敷罗浮山风湿膏药,1次/d;两组患者均治疗3周。观察两组临床疗效,比较两组运动功能指标、关节疼痛情况。结果治疗后,观察组临床有效率高于对照组(P<0.05)。治疗后,观察组Lysholm膝关节评分(lysholm knee society score,LKSS)和美国膝关节协会评分量表(american knee association,AKS)功能评分显著高于对照组(P<0.05);且观察组视觉模拟评分法(visual analogue scale,VAS)评分在静息状态下、行走时、上下楼时均低于对照组(P<0.05)。结论罗浮山风湿膏药联合艾瑞昔布片治疗可以显著缓解KOA患者疼痛,改善膝关节功能,促进运动功能恢复,提高临床疗效。

芳香疗法及耳穴贴压在脑卒中失眠患者中应用效果的研究

目的:研究芳香疗法及耳穴贴压治疗脑卒中失眠患者的临床效果。方法:采用便利抽样法,选取天津市某三级甲等神经专科医院脑卒中失眠住院患者120例为研究对象。采用随机数字表将研究对象分为对照组、芳香组、耳穴组和联合组,每组30例。比较四组患者入院时、干预7天、干预1个月睡眠质量[匹兹堡睡眠质量评估表(Pittsburgh Sleep Quality Index,PSQI)]以及抑郁情绪[汉密尔顿抑郁量表(Hamilton Depression Scale,HAMD)]的变化,并比较各组住院时间及护理服务总体满意情况的差异。结果:干预7天后,芳香组、联合组PSQI得分均低于对照组(P<0.05),耳穴组与其他三组间PSQI得分差异无统计学意义(P>0.05);而HAMD得分四组间差异无统计学意义(F=2.462,P>0.05)。干预1个月后,芳香组、耳穴组、联合组PSQI得分均低于对照组(P<0.05);芳香组、联合组HAMD得分低于对照组(P<0.05),但耳穴组与对照组相比差异无统计学意义(P>0.05)。住院时间方面联合组住院时间短于其他三组(F=3.213,P<0.05);住院患者满意度方面组间比较差异无统计学意义(H=6.629,P>0.05)。结论:芳香疗法在短期内(7天)使用即可改善脑卒中后失眠患者的睡眠质量,持续使用还可改善其抑郁情绪;耳穴贴压需要经长时间(>1月)持续治疗方可对脑卒中后失眠患者睡眠有改善作用;芳香疗法联合耳穴贴压有助于缩短住院时间,有利于维持良好的护患关系。

“针-药-模”结合治疗粉刺病肺胃热蕴证的临床效应评价

目的:探究“针-药-模”结合治疗粉刺病肺胃热蕴证的临床效果。方法:收集2020年10月—2022年9月上海市嘉定区中医医院皮肤科门诊收治的粉刺病肺胃热蕴证患者150例,根据随机数字表法将其分为针-药-模治疗组(桑枇消痤颗粒+毫火针+石膏倒模)、针-药对照组(桑枇消痤颗粒+毫火针)、药-模对照组(桑枇消痤颗粒+石膏倒模),每组50例,均每周治疗1次,持续治疗4周。观察3组患者的临床疗效,比较3组治疗前后皮疹情况及生活质量[皮肤病生活质量指数量表(dermatology quality of life index,DLQI)],统计不良反应发生情况与复发率。结果:治疗4周后,针-药-模治疗组临床有效率高于针-药对照组、药-模对照组,差异有统计学意义;针-药对照组与药-模对照组比较,差异无统计学意义。3组患者皮疹情况评分、DLQI评分与治疗前比较均降低,且针-药-模治疗组低于针-药对照组及药-模对照组,差异有统计学意义;针-药对照组与药-模对照组比较,差异无统计学意义。治疗期间,3组患者不良反应发生情况比较,差异无统计学意义;结束治疗后2个月,针-药-模治疗组复发率低于针-药对照组、药-模对照组,差异有统计学意义;针-药对照组与药-模对照组比较,差异无统计学意义。结论:与“药-模”及“针-药”治疗相比,“针-药-模”相结合的综合治疗方法在粉刺病肺胃热蕴证的治疗中临床疗效更为显著,有效改善患者皮疹情况,提高生活质量,减少复发,安全性可靠。

化瘀止痛贴膏调节IL-6/STAT3信号通路对急性软组织损伤大鼠炎症反应的影响

目的探讨化瘀止痛贴膏调节白细胞介素-6(IL-6)/信号转导与转录激活子3(STAT3)信号通路对急性软组织损伤(ASTI)大鼠炎症反应的影响。方法将SPF级SD大鼠随机分为对照组、模型组、化瘀止痛贴膏低、中、高剂量组、精制狗皮膏组。利用机械冲击挫伤法建立ASTI动物模型,建模成功后,各组贴敷相应药物,1次/d,每次给药8 h,连续7 d。对大鼠进行ASTI损伤评分;采用血液流变检测仪检测血液流变学指标;苏木精和伊红(HE)染色法观察大鼠损伤部位肌肉组织病理变化;酶联免疫吸附法(ELISA)检测各组大鼠损伤部位肌肉组织中IL-6、IL-β、肿瘤坏死因子-α(TNF-α)水平;实时荧光定量PCR(qRT-PCR)法检测损伤部位肌肉组织中IL-6与STAT3 mRNA表达;蛋白免疫印迹(Western blot)法检测大鼠损伤部位肌肉组织中IL-6/STAT3信号通路蛋白表达。结果与对照组比较,模型组大鼠软组织损伤评分、全血黏度、血浆黏度、红细胞压积、肌肉组织病理学评分、IL-6、IL-β、TNF-α水平、IL-6与STAT3 mRNA表达水平及IL-6、p-STAT3/STAT3蛋白表达水平升高(均P<0.05);与模型组比较,化瘀止痛贴膏低、中、高剂量组和狗皮膏药组大鼠软组织损伤评分、全血黏度、血浆黏度、红细胞压积、肌肉组织病理学评分、IL-6、IL-β、TNF-α水平、IL-6与STAT3 mRNA表达水平及IL-6、p-STAT3/STAT3蛋白表达水平降低(均P<0.05);化瘀止痛贴膏高剂量组与精制狗皮膏组大鼠以上指标差异均无统计学意义(P>0.05)。结论化瘀止痛贴膏可能通过下调IL-6/STAT3信号通路缓解ASTI大鼠的炎症反应。