Lichens,as dual organisms comprising a major mycobiont and a major photobiont,exhibit remarkable survival capabilities in extreme conditions,such as those found in Antarctica.Despite their adaptability,the diversity a...Lichens,as dual organisms comprising a major mycobiont and a major photobiont,exhibit remarkable survival capabilities in extreme conditions,such as those found in Antarctica.Despite their adaptability,the diversity and distribution of lichen photobionts in the ice-free areas of maritime Antarctica remain less understood compared to their mycobiont counterparts.In our study,we investigated the diversity of both lichen mycobionts and photobionts in 56 samples collected from the Fildes Region on King George Island,maritime Antarctica.Through sequencing of the nuclear ribosomal internal transcribed spacer regions and subsequent phylogenetic analysis,we examined the relationships and association patterns between mycobionts and photobionts.Our findings revealed 19 taxa of lichen mycobionts across 13 families and seven orders,along with nine photobiont species within the class Trebouxiophyceae.These photobionts encompassed six Trebouxia species,one Asterochloris species,one Chloroidium species,and one Stichococcus species.In particular,a new Trebouxia lineage(Trebouxia sp.OTU D08)and a new Chloroidium lineage were found.The analysis indicated that many mycobionts could be associated with multiple photobiont species,a pattern also observed among the photobionts.These results contribute significantly to our understanding of the complex diversity of lichen mycobionts and photobionts in the ice-free areas of maritime Antarctica.展开更多
BACKGROUND Lichen amyloidosis(LA)is a chronic,severely pruritic skin disease,which is the most common form of primary cutaneous amyloidosis.The treatment of LA has been considered to be difficult.LA may be associated ...BACKGROUND Lichen amyloidosis(LA)is a chronic,severely pruritic skin disease,which is the most common form of primary cutaneous amyloidosis.The treatment of LA has been considered to be difficult.LA may be associated with atopic dermatitis(AD),and in this setting,the treatment options may be more limited.Herein,we report four cases of LA associated with AD successfully treated by dupilumab.CASE SUMMARY In this article,we describe four cases of patients who presented with recurrent skin rash accompanied by severe generalized intractable pruritus,diagnosed with refractory LA coexisting with chronic AD.Previous treatments had not produced any apparent improvement.Thus,we administered dupilumab injection subcutaneously at a dose of 600 mg for the first time and 300 mg every 2 wk thereafter.Their lesions all markedly improved.CONCLUSION Dupilumab may be a new useful treatment for LA coexisting with AD.展开更多
识别学科交叉研究的前沿主题,并对演化趋势进行分析,有助于揭示学科交叉融合的方向,为未来创新性、突破性研究提供参考。首先,基于引文视角构建测度论文学科交叉性的指标,识别具有学科交叉性的研究论文;其次,通过BERT-LDA模型识别研究主...识别学科交叉研究的前沿主题,并对演化趋势进行分析,有助于揭示学科交叉融合的方向,为未来创新性、突破性研究提供参考。首先,基于引文视角构建测度论文学科交叉性的指标,识别具有学科交叉性的研究论文;其次,通过BERT-LDA模型识别研究主题,利用余弦相似度计算主题之间的相似度,构建主题演化路径;最后,基于新颖度、增长性、关注度、影响力构建前沿主题识别指标体系,识别具有前沿性的学科交叉研究主题。以图书情报学(Library and Information Science,LIS)为例展开研究,研究结果显示,2004—2023年该学科领域的交叉研究主题呈现出逐渐细化和深入的特点,主要集中在信息挖掘与知识发现、互联网信息行为、医疗信息学3个方面;现阶段学科交叉研究前沿主题为医疗数据模型、舆情治理与情感分析、机器学习与深度学习;基于信息技术的研究方法和其在不同领域的应用研究具有良好的应用前景,有可能成为未来LIS领域的核心研究主题。展开更多
The concentration difference in the near-surface region of lithium metal is the main cause of lithium dendrite growth.Resolving this issue will be key to achieving high-performance lithium metal batteries(LMBs).Herein...The concentration difference in the near-surface region of lithium metal is the main cause of lithium dendrite growth.Resolving this issue will be key to achieving high-performance lithium metal batteries(LMBs).Herein,we construct a lithium nitrate(LiNO_(3))-implanted electroactiveβphase polyvinylidene fluoride-co-hexafluoropropylene(PVDF-HFP)crystalline polymorph layer(PHL).The electronegatively charged polymer chains attain lithium ions on the surface to form lithium-ion charged channels.These channels act as reservoirs to sustainably release Li ions to recompense the ionic flux of electrolytes,decreasing the growth of lithium dendrites.The stretched molecular channels can also accelerate the transport of Li ions.The combined effects enable a high Coulombic efficiency of 97.0%for 250 cycles in lithium(Li)||copper(Cu)cell and a stable symmetric plating/stripping behavior over 2000 h at 3 mA cm^(-2)with ultrahigh Li utilization of 50%.Furthermore,the full cell coupled with PHL-Cu@Li anode and Li Fe PO_(4) cathode exhibits long-term cycle stability with high-capacity retention of 95.9%after 900 cycles.Impressively,the full cell paired with LiNi_(0.87)Co_(0.1)Mn_(0.03)O_(2)maintains a discharge capacity of 170.0 mAh g^(-1)with a capacity retention of 84.3%after 100 cycles even under harsh condition of ultralow N/P ratio of 0.83.This facile strategy will widen the potential application of LiNO_(3)in ester-based electrolyte for practical high-voltage LMBs.展开更多
It is well accepted that a lithiophilic interface can effectively regulate Li deposition behaviors,but the influence of the lithiophilic interface is gradually diminished upon continuous Li deposition that completely ...It is well accepted that a lithiophilic interface can effectively regulate Li deposition behaviors,but the influence of the lithiophilic interface is gradually diminished upon continuous Li deposition that completely isolates Li from the lithiophilic metals.Herein,we perform in-depth studies on the creation of dynamic alloy interfaces upon Li deposition,arising from the exceptionally high diffusion coefficient of Hg in the amalgam solid solution.As a comparison,other metals such as Au,Ag,and Zn have typical diffusion coefficients of 10-20 orders of magnitude lower than that of Hg in the similar solid solution phases.This difference induces compact Li deposition pattern with an amalgam substrate even with a high areal capacity of 55 mAh cm^(-2).This finding provides new insight into the rational design of Li anode substrate for the stable cycling of Li metal batteries.展开更多
基金supported by CAMS Innovation Fund for Medical Sciences(Grant no.2021-I2M-1-055)National Microbial Resource Center(Grant no.NMRC-2023-3).
文摘Lichens,as dual organisms comprising a major mycobiont and a major photobiont,exhibit remarkable survival capabilities in extreme conditions,such as those found in Antarctica.Despite their adaptability,the diversity and distribution of lichen photobionts in the ice-free areas of maritime Antarctica remain less understood compared to their mycobiont counterparts.In our study,we investigated the diversity of both lichen mycobionts and photobionts in 56 samples collected from the Fildes Region on King George Island,maritime Antarctica.Through sequencing of the nuclear ribosomal internal transcribed spacer regions and subsequent phylogenetic analysis,we examined the relationships and association patterns between mycobionts and photobionts.Our findings revealed 19 taxa of lichen mycobionts across 13 families and seven orders,along with nine photobiont species within the class Trebouxiophyceae.These photobionts encompassed six Trebouxia species,one Asterochloris species,one Chloroidium species,and one Stichococcus species.In particular,a new Trebouxia lineage(Trebouxia sp.OTU D08)and a new Chloroidium lineage were found.The analysis indicated that many mycobionts could be associated with multiple photobiont species,a pattern also observed among the photobionts.These results contribute significantly to our understanding of the complex diversity of lichen mycobionts and photobionts in the ice-free areas of maritime Antarctica.
文摘BACKGROUND Lichen amyloidosis(LA)is a chronic,severely pruritic skin disease,which is the most common form of primary cutaneous amyloidosis.The treatment of LA has been considered to be difficult.LA may be associated with atopic dermatitis(AD),and in this setting,the treatment options may be more limited.Herein,we report four cases of LA associated with AD successfully treated by dupilumab.CASE SUMMARY In this article,we describe four cases of patients who presented with recurrent skin rash accompanied by severe generalized intractable pruritus,diagnosed with refractory LA coexisting with chronic AD.Previous treatments had not produced any apparent improvement.Thus,we administered dupilumab injection subcutaneously at a dose of 600 mg for the first time and 300 mg every 2 wk thereafter.Their lesions all markedly improved.CONCLUSION Dupilumab may be a new useful treatment for LA coexisting with AD.
文摘识别学科交叉研究的前沿主题,并对演化趋势进行分析,有助于揭示学科交叉融合的方向,为未来创新性、突破性研究提供参考。首先,基于引文视角构建测度论文学科交叉性的指标,识别具有学科交叉性的研究论文;其次,通过BERT-LDA模型识别研究主题,利用余弦相似度计算主题之间的相似度,构建主题演化路径;最后,基于新颖度、增长性、关注度、影响力构建前沿主题识别指标体系,识别具有前沿性的学科交叉研究主题。以图书情报学(Library and Information Science,LIS)为例展开研究,研究结果显示,2004—2023年该学科领域的交叉研究主题呈现出逐渐细化和深入的特点,主要集中在信息挖掘与知识发现、互联网信息行为、医疗信息学3个方面;现阶段学科交叉研究前沿主题为医疗数据模型、舆情治理与情感分析、机器学习与深度学习;基于信息技术的研究方法和其在不同领域的应用研究具有良好的应用前景,有可能成为未来LIS领域的核心研究主题。
基金support from the National Science Foundation of China (No.51971249)the Natural Science Foundation of Shandong Province,China (No.ZR2020KE012)the Science and Technology Planning Project of Longkou City,China (No.2021KJJH025).
基金the financial support from the National Natural Science Foundation of China(Nos.22205191 and 52002346)the Science and Technology Innovation Program of Hunan Province(No.2021RC3109)+1 种基金the Natural Science Foundation of Hunan Province,China(No.2022JJ40446)Guangxi Key Laboratory of Low Carbon Energy Material(No.2020GXKLLCEM01)。
文摘The concentration difference in the near-surface region of lithium metal is the main cause of lithium dendrite growth.Resolving this issue will be key to achieving high-performance lithium metal batteries(LMBs).Herein,we construct a lithium nitrate(LiNO_(3))-implanted electroactiveβphase polyvinylidene fluoride-co-hexafluoropropylene(PVDF-HFP)crystalline polymorph layer(PHL).The electronegatively charged polymer chains attain lithium ions on the surface to form lithium-ion charged channels.These channels act as reservoirs to sustainably release Li ions to recompense the ionic flux of electrolytes,decreasing the growth of lithium dendrites.The stretched molecular channels can also accelerate the transport of Li ions.The combined effects enable a high Coulombic efficiency of 97.0%for 250 cycles in lithium(Li)||copper(Cu)cell and a stable symmetric plating/stripping behavior over 2000 h at 3 mA cm^(-2)with ultrahigh Li utilization of 50%.Furthermore,the full cell coupled with PHL-Cu@Li anode and Li Fe PO_(4) cathode exhibits long-term cycle stability with high-capacity retention of 95.9%after 900 cycles.Impressively,the full cell paired with LiNi_(0.87)Co_(0.1)Mn_(0.03)O_(2)maintains a discharge capacity of 170.0 mAh g^(-1)with a capacity retention of 84.3%after 100 cycles even under harsh condition of ultralow N/P ratio of 0.83.This facile strategy will widen the potential application of LiNO_(3)in ester-based electrolyte for practical high-voltage LMBs.
基金supported by the National Key Research and Development Program of China(2019YFA0205700)Scientific Research Projects of Colleges and Universities in Hebei Province(JZX2023004)+2 种基金Research Program of Local Science and Technology Development under the Guidance of Central(216Z4402G)support from Ministry of Science and Higher Education of Russian Federation(project FFSG-2022-0001(122111700046-3),"Laboratory of perspective electrode materials for chemical power sources")support from"Yuanguang"Scholar Program of Hebei University of Technology
文摘It is well accepted that a lithiophilic interface can effectively regulate Li deposition behaviors,but the influence of the lithiophilic interface is gradually diminished upon continuous Li deposition that completely isolates Li from the lithiophilic metals.Herein,we perform in-depth studies on the creation of dynamic alloy interfaces upon Li deposition,arising from the exceptionally high diffusion coefficient of Hg in the amalgam solid solution.As a comparison,other metals such as Au,Ag,and Zn have typical diffusion coefficients of 10-20 orders of magnitude lower than that of Hg in the similar solid solution phases.This difference induces compact Li deposition pattern with an amalgam substrate even with a high areal capacity of 55 mAh cm^(-2).This finding provides new insight into the rational design of Li anode substrate for the stable cycling of Li metal batteries.
基金the National Natural Science Foundation of China (Nos. 52071179, 5227010325)the Natural Science Foundation of Jiangsu Province, China (No. BK20221493)the Fundamental Research Funds for the Central Universities, China (Nos. 30920021160, 30919011405)。
