Dear Editor,Primary vitreoretinal lymphoma（PVRL）is a rare form of ocular malignancy and it is usually considered as a subset of primary central nervous system lymphoma（PCNSL）.An insidious onset associated with del...Dear Editor,Primary vitreoretinal lymphoma（PVRL）is a rare form of ocular malignancy and it is usually considered as a subset of primary central nervous system lymphoma（PCNSL）.An insidious onset associated with delays in diagnosis iscommon.展开更多
目的全面评估春季卡他性角结膜炎患儿的干眼状况,了解其伴随干眼的临床特点及与病情严重程度的相关性。方法取2015年01至06月儿童医院眼科门诊诊断为春季卡他性角结膜炎的患儿65例(65只眼,右眼数据)为观察组。取年龄、性别与之匹配的正...目的全面评估春季卡他性角结膜炎患儿的干眼状况,了解其伴随干眼的临床特点及与病情严重程度的相关性。方法取2015年01至06月儿童医院眼科门诊诊断为春季卡他性角结膜炎的患儿65例(65只眼,右眼数据)为观察组。取年龄、性别与之匹配的正常儿童65例(65只眼,右眼数据)为对照组,分别进行症状评估、裂隙灯检查、泪膜破裂时间(break—up time,BUT)检查、角膜荧光素染色试验(fluorescein,FL)及眼睑刷上皮病变(Lid-wiper epitheliopathy,LWE)检查。对数据进行统计分析和评价。结果 (1)春季卡他性角结膜炎患儿的干眼症状评分较正常儿童明显升高,两者差异有统计学意义(Z=-8.589 P <0.01),其中畏光(23.59%)、异物感(18.08%)、瞬目异常(14.49%)、迎风不适(20.90%)是患儿最常见的症状;(2)春卡患儿的裂隙灯检查体征评分明显高于正常儿童组(Z=-9.902 P <0.01);(3)干眼相关检查:春卡患儿的泪膜破裂时间(7.06±3.51)较正常儿童(13.34±4.82)明显缩短(Z=-6.729 P <0.01);角膜荧光素染色评分(1.82±1.69)较正常儿童(0.23±0.46)明显升高(Z=-6.355 P <0.01);眼睑刷上皮病变的评分(1.03±1.00)较正常儿童(0.31±0.50)明显升高(Z=-4.463P <0.01);(4)春卡患儿干眼症状的严重程度与患儿的体征评分相关(r=0.259 P <0.05);角膜荧光素染色评分与体征评分相关(r=0.269 P <0.05);泪膜破裂时间与角膜荧光素染色(r=-0.283 P <0.05)及眼睑刷上皮病变(r=-0.252 P <0.05)的严重程度相关;角膜荧光素染色与眼睑刷上皮病变(r=0.307 P <0.05)的严重程度相关。结论春季卡他性角结膜炎的患儿伴随明显的干眼,其干眼的严重程度与患儿结膜炎的严重程度呈正相关。为进一步探讨春卡患儿病情转归过程中的干眼变化情况提供了基础,也为春卡患儿急性期使用人工泪液辅助治疗提供了用药依据。展开更多
BACKGROUND Diffuse retinal pigment epitheliopathy(DRPE)associated with bullous retinal detachment is a severe variant of DRPE that is frequently misdiagnosed and often improperly treated.CASE SUMMARY A 36-year-old fem...BACKGROUND Diffuse retinal pigment epitheliopathy(DRPE)associated with bullous retinal detachment is a severe variant of DRPE that is frequently misdiagnosed and often improperly treated.CASE SUMMARY A 36-year-old female patient complained of"painless vision decline in the left eye with obscuration for 10 d".Slit-lamp microscopic fundus examination revealed white-yellow subretinal exudates in the posterior pole in both eyes,retinal detachment with shifting subretinal fluid in the left eye,and no retinal hiatus.Fundus fluorescein angiography revealed multiple subretinal leakage foci and localized hypofluorescent lesions with patched hyperfluorescence.There was fluorescence leakage in the retinal vessels in the retinal detachment area and occluded blood vessels in the lower and peripheral areas.Indocyanine green angiography revealed multifocal lamellar hyperfluorescence in the middle stage and low fluorescence in the retinal detachment area in the late stage.Retinal anatomical reduction significantly improved with intravitreal conbercept injections.CONCLUSION Intravitreal injection of conbercept can anatomically reattach the retina in patients with bullous retinal detachment.展开更多
文摘Dear Editor,Primary vitreoretinal lymphoma（PVRL）is a rare form of ocular malignancy and it is usually considered as a subset of primary central nervous system lymphoma（PCNSL）.An insidious onset associated with delays in diagnosis iscommon.
文摘目的全面评估春季卡他性角结膜炎患儿的干眼状况,了解其伴随干眼的临床特点及与病情严重程度的相关性。方法取2015年01至06月儿童医院眼科门诊诊断为春季卡他性角结膜炎的患儿65例(65只眼,右眼数据)为观察组。取年龄、性别与之匹配的正常儿童65例(65只眼,右眼数据)为对照组,分别进行症状评估、裂隙灯检查、泪膜破裂时间(break—up time,BUT)检查、角膜荧光素染色试验(fluorescein,FL)及眼睑刷上皮病变(Lid-wiper epitheliopathy,LWE)检查。对数据进行统计分析和评价。结果 (1)春季卡他性角结膜炎患儿的干眼症状评分较正常儿童明显升高,两者差异有统计学意义(Z=-8.589 P <0.01),其中畏光(23.59%)、异物感(18.08%)、瞬目异常(14.49%)、迎风不适(20.90%)是患儿最常见的症状;(2)春卡患儿的裂隙灯检查体征评分明显高于正常儿童组(Z=-9.902 P <0.01);(3)干眼相关检查:春卡患儿的泪膜破裂时间(7.06±3.51)较正常儿童(13.34±4.82)明显缩短(Z=-6.729 P <0.01);角膜荧光素染色评分(1.82±1.69)较正常儿童(0.23±0.46)明显升高(Z=-6.355 P <0.01);眼睑刷上皮病变的评分(1.03±1.00)较正常儿童(0.31±0.50)明显升高(Z=-4.463P <0.01);(4)春卡患儿干眼症状的严重程度与患儿的体征评分相关(r=0.259 P <0.05);角膜荧光素染色评分与体征评分相关(r=0.269 P <0.05);泪膜破裂时间与角膜荧光素染色(r=-0.283 P <0.05)及眼睑刷上皮病变(r=-0.252 P <0.05)的严重程度相关;角膜荧光素染色与眼睑刷上皮病变(r=0.307 P <0.05)的严重程度相关。结论春季卡他性角结膜炎的患儿伴随明显的干眼,其干眼的严重程度与患儿结膜炎的严重程度呈正相关。为进一步探讨春卡患儿病情转归过程中的干眼变化情况提供了基础,也为春卡患儿急性期使用人工泪液辅助治疗提供了用药依据。
基金Supported by Guiding Project of Changshu Health Committee,No.CSWZD202021Project of the Affiliated Changshu Hospital of Xuzhou Medical University,No.CSEY202125。
文摘BACKGROUND Diffuse retinal pigment epitheliopathy(DRPE)associated with bullous retinal detachment is a severe variant of DRPE that is frequently misdiagnosed and often improperly treated.CASE SUMMARY A 36-year-old female patient complained of"painless vision decline in the left eye with obscuration for 10 d".Slit-lamp microscopic fundus examination revealed white-yellow subretinal exudates in the posterior pole in both eyes,retinal detachment with shifting subretinal fluid in the left eye,and no retinal hiatus.Fundus fluorescein angiography revealed multiple subretinal leakage foci and localized hypofluorescent lesions with patched hyperfluorescence.There was fluorescence leakage in the retinal vessels in the retinal detachment area and occluded blood vessels in the lower and peripheral areas.Indocyanine green angiography revealed multifocal lamellar hyperfluorescence in the middle stage and low fluorescence in the retinal detachment area in the late stage.Retinal anatomical reduction significantly improved with intravitreal conbercept injections.CONCLUSION Intravitreal injection of conbercept can anatomically reattach the retina in patients with bullous retinal detachment.
