Lidocaine hydrochloride loaded isomaltulose microneedles for efficient local anesthesia of the skin

Lidocaine hydrochloride(LIDH) as an anesthetic is widely used in local anesthesia. Dissolving microneedles(MNs) have great application value in the field of skin anesthesia. However, the limited drug-loading of dissolving MNs is an existing challenge that affects clinical use. In this study, we have screened isomaltulose(ISO) as the proper matrix material for the MNs by using molecular dynamics(MD) simulation. Our findings indicate that ISO has good compatibility with LIDH, and the LIDH-loaded ISO MNs(LI-MNs) have high drug-loading capacity. The drug-loading capacity of LI-MNs could reach 80%, and it could effectively puncture the skin. In addition, the preparation method of customized LI-MNs was established based on three-dimensional(3D) printing technology. It was shown that the administration time of LI-MNs could be controlled within 3 min. Also, the LI-MNs were able to provide the local anesthetic efficacy within2 min and sustained for more than 2 h. Significantly, LI-MNs had more efficient drug efficacy compared to the topical creams and the majority of existing LIDH-loaded dissolving MNs. They even provided a longer duration of action than the injections. Overall, the LI-MNs with high drug-loading have a promising application prospect.

Anesthetic Effect of Compound Artevacaine Hydrochloride in Patients Undergoing Oral Implantation

Objective:To investigate and analyze the anesthetic effect of compound artevacaine hydrochloride in patients undergoing oral implantation.Methods:In this study,60 patients receiving oral implant surgery in our hospital were selected as the research subjects,and the operation time was from July 2019 to March 2021.Patients were randomly selected and divided into groups for the study.30 patients receiving lidocaine hydrochloride anesthesia were used as the control group,and 30 patients receiving compound artevacaine hydrochloride anesthesia were used as the research group.The anesthetic effect and safety of the two groups were compared and analyzed.Results:The anesthetic effect of the study group was significantly better than that of the control group(P<0.05).The blood pressure and heart rate in the study group were significantly lower than those in the control group(P<0.05).There was no significant difference in blood pressure and heart rate between the two groups before anesthesia(P>0.05).There was no significant difference in the incidence of ADR between the two groups(P>0.05).Conclusions:For patients undergoing oral implant surgery,choosing compound artevacaine hydrochloride as anesthetic drug has obvious anesthetic effect and can stabilize patients'life indexes.The anesthetic effect is obvious,and there is no obvious adverse reaction,and the clinical value is obvious.