Statistical Analysis for the Birnbaum-Saunders Fatigue Life Distribution under Type-Ⅱ Bilateral Censoring and Multiply Type-II Censoring

In present paper, we obtain the inverse moment estimations of parameters of the Birnbaum-Saunders fatigue life distribution based on Type-Ⅱ bilateral censored samples and multiply Type-Ⅱ censored sample. In this paper, we also get the interval estimations of the scale parameters.

Temperature Effect on the Life History of Three Types of Brachionus calyciflorus Females

The effect of temperature on the life history characteristics of amictic females (AF), unfertilized mictic females (UMF) and fertilized mictic females (FMF) in Brachionus calyciflorus was studied with replicated individual cultures at 20℃,25℃ and 30℃, and with algae Scenedesmus obliquus for their food. There were highly significant effects of both temperature and female type, independently and interactively, on the duration of juvenile and post-reproduction periods, and the number of eggs produced by the rotifer per life cycle. Among all the temperature-female type combinations, all the juvenile periods of FMF, and the post-reproduction periods of UMF and FMF at 20℃, were the longest, and the number of eggs produced by an UMF at 30℃ was the highest. There were highly significant effects of both temperature and female type on the duration of the reproduction period, but no clear correlation was observed between temperature and female type. The reproduction period of AF was longer than that of UMF and FMF. Only temperature influenced significantly the mean life-span of the three types of females. The duration of juvenile, reproduction and post-reproduction periods as well as the life-span of the three types of females were all reduced very significantly with rise of temperature, but the rates of reduction varied with female type. Among the three types of females, the number of eggs produced per life cycle by an UMF was the highest, and that of a FMF was the lowest. A significant relationship between the number of eggs produced per life cycle and temperature was observed only in the UMF.

Type 2 diabetes and quality of life

It is true that a primary goal of diabetes early diagnosis and treatment is quality of life(QoL). The term QoL is still confusing but it is agreed that it composes of four components:The physical component, mental, cogitative component, psychological and social component. Many articles have been written addressing those four components. During the last five years 15500 articles and reviews have been written addressing diabetes and coronary arterial disease, 16100 addressing diabetes and renal function, 28900 addressing diabetes and retinopathy, 16800 addressing diabetic foot ulcers and other 26300 addressing diabetic neuropathy. Moreover 17200 articles are dealing with diabetic sexual dysfunction, 24500 with the correlation of diabetes and depression 17500 about diabetes and dementia, only 1 about diabetes and family functioning and 1950000 about diabetes and QoL, indicating the worldwide interest. In order to confront this metabolic anomaly and its consequences, researchers developed numerous generic and disease specific psychometric tools. With the aid of those psychometric tools the scientific community has started to realize the gruesome effect of diabetes on patients' lives. Diabetic's QoL becomes worse when complications start to develop or comorbidities coexist. Dominant amongst complications, in health-related quality of life(HRQoL) lowering, but not related to risk factors(genetic, the weight of birth, or others) is coronary arterial disease followed by renal failure, blindness, and the combination of micro-and macrovascular complications and in some studies by sexual dysfunction. Moreover many are the comorbidities which deteriorate further the effect of diabetes in a patient life. Among them obesity, hypertension, dyslipidemia, depression, arthritis are the most common. Most intriguing field for research is the interaction of diabetes and depression and in some cases the progression to dementia. Many aspects and combinations of actions are under researchers' microscope regarding the improvement of HRQoL scores. Until now, the studies performed, have demonstrated little to moderate benefit. More of them are needed to draw safe conclusions on the topic of the best combination of actions to optimize the HRQoL scores.

Statistical Analysis for the Birnbaum-Saunders Fatigue Life Distribution under Multiply Type-ⅡCensoring

In present paper, we derive the quasi-least squares estimation(QLSE) and approximate maximum likelihood estimation(AMLE) for the Birnbaum-Saunders fatigue life distribution under multiply Type-Ⅱcensoring. Furthermore, we get the variance and covariance of the approximate maximum likelihood estimation.

Glycaemic control, treatment satisfaction and quality of life in type 2 diabetes patients in Greece: The PANORAMA study Greek results

AIM: To provide an update on glycaemic control inEuropean patients with type 2 diabetes mellitus(T2DM). We present the Greek population data of the study. METHODS: An observational multicenter, cross-sectional study evaluating glycaemic control and a range of other clinical and biological measures as well as quality of life(Qo L) and treatment satisfaction in 375 patients with T2 DM enrolled by 25 primary care sites from Greece. RESULTS: The mean age of the patients was 63.5 years and the male/female ratio 48.9%/51.1%. 79.7% of the patients exerted none or light physical activity, 82.4% were overweight or obese and 32.9% did not meet Hb A1 c target of less than 7.0%(53 mmol/mol). Patients reported high satisfaction to continue with treatment, high satisfaction with administered treatment and increased willingness to recommend treatment to others(mean Diabetes Treatment Satisfaction Questionnaire score 29.1 ± 5.6). However, 80% of the patients reported that their Qo L would be better without diabetes. Finally, the most challenging parameter reported was the lack of freedom to eat and drink. CONCLUSION: This analysis of the Greek Panorama study results showed that a considerable percentage of T2 DM patients in Greece do not achieve glycaemic target levels, despite the favourably reported patient satisfaction from administered therapy. Additionally, the majority of primary care T2 DM patients in Greece depict the negative effect of the disease in their Qo L.

Clinico-epidemiological factors of health related quality of life among people with type 2 diabetes

AIM To investigate the quality of life(QOL) and its clinical and epidemiological correlates among people with type 2 diabetes.METHODS This cross-sectional study was conducted in Tabriz, Northwest of Iran, including a total of 394 people with type 2 diabetes using convenient sampling method from November 2014 to March 2015. General information including demographic, socioeconomic status and lifestyle factors were collected by trained interviewers. Clinical information was retrieved from clinic's record and QOL was assessed using the 26-item WHOQOL-BRIFE questionnaire. Univariate and multivariate linear regression were performed to assess the related factors and QOL dimensions. RESULTS The mean of overall health related QOL was 52.11 ± 11.53 and the maximum and minimum dimensions wererespectively seen in psychological(60.38 ± 14.54) and social(38.32 ± 16.94) dimensions. The results of multiple linear regression showed a significant overall relationship between HRQOL and age(b =-1.48%, 95%CI:-0.03 and-2.93) level of education(b = 4.12%, 95%CI: 2.73 and 5.5), number of comorbidities(b =-2.41%, 95%CI:-3.89 and-9.41), and level of income(b = 1.98, 95%CI: 0.05 and 3.9), functional limitation(b =-3.59, 95%CI:-2.26 and-4.92) and psychological distress(b =-2.02%, 95%CI:-2.83 and-1.21). Level of education, functional limitation, psychological distress were associated with the score of physical, mental and environmental dimensions, and number of comorbidities was associated with the score of physical and mental dimensions. CONCLUSION Based on our findings, lifestyle modification and increasing facilities of clinics providing service can be effective steps to improve the QOL among people with type 2 diabetes.

Inference for constant-stress accelerated life test with Type-I progressively hybrid censored data from Burr-XII distribution

This paper proposes a simple constant-stress accelerated life test(ALT) model from Burr type XII distribution when the data are Type-I progressively hybrid censored. The maximum likelihood estimation(MLE) of the parameters is obtained through the numerical method for solving the likelihood equations. Approximate confidence interval(CI), based on normal approximation to the asymptotic distribution of MLE and percentile bootstrap CI is derived. Finally, a numerical example is introduced and then a Monte Carlo simulation study is carried out to illustrate the proposed method.

山东省黄河三角洲水生耐盐药用植物资源调查与分析

对山东省黄河三角洲地区水生耐盐药用植物的种类、生活型及对应药材入药部位、药性、功效进行统计调查分析。共调查到野生水生耐盐药用植物299种。根据恩格勒分类系统,这些植物隶属于76科204属;生活型以草本型为主,共222种。以299种药用植物为基源的药材共338种,其中全草入药药材144种,占药材种类数的42.60%;平性药材最多,共85种;苦味药、甘味药和辛味药数量较其他药味具有明显优势;以功效分类,清热药、利水渗湿类、活血化瘀类、化痰止咳类、止血药和补虚药占优势。针对水生耐盐药用植物特点,结合该区域自然状况,提出了合理开发和综合利用的建议。

Health Related Quality of Life in Adult with Type 2 Diabetes Mellitus

Introduction: The health related quality of life (HRQoL) has an important role in adults suffering from diabetes. Objective: To assess the health related quality of life in adult with type 2 diabetes mellitus. Materials and methods: A cross-sectional study was conducted to assess diabetic patient’s HRQoL on 119 purposively selected type-2 DM patients (aged ≥ 18 years and duration of diabetes ≥ 1 year). Data were collected by face-to-face interview and by medical record review through a Bangle version of SF-36 semi-structured questionnaire and a checklist. Place and period of study: The study was conducted at outpatient department in Gopalganj 50 bedded diabetic hospital from 1st January, 2018 to 31st December 2018. Results: The mean age of the respondents was 52.34 (SD ± 10.19) years. Age group shows a significant difference associated with all domains of quality of life except role emotion (>0.05), gender shows the significant in social and pain domain (0.05) respectively co-morbidity shows the significant difference with all domains expect pain (>0.05). Physical functioning, emotional, pain and general health of the quality of life show the significant difference associated with use of insulin (Conclusion: The overall QoL of type-2 DM patients was poor and had lower score of health related quality of life.

Prognostic Potential of B - type Natriuetic Peptide and Quality of Life in Patients with Chronic Heart Failure

Objectives To study wheth- er change of BNP levels reflect the change of cardiac function and to investigate the short - term prognostic potential of BNP and QOL in patients with CHF. Methods 96 consecutive patients admittedwith CHF between September 2002 and January 2003 were stud- ied , upon entry the study, BNP levels were measured, Patients administered the disease - specificquality of life questionnaire Minnesota living with heart failure questionnaire (LiHFe) within 1 day. BNP levels and administering LiHFe were repeated three months later. Results BNP levels were increased proportional to the severity of cardiac function. Physical domain and total score of LiHFe were significantly correlated to the severity of CHF ( p < 0. 05 ). BNP levels were de- creased in improving group(p =0. 032) . In deteriora- ting group BNP levels increased (P = 0. 043 ) . Kaplan - meier analysis according to BNP level cutoff point 150 ng/1, the life curve of higher BNP level group was significantly lower than the lower group ( p = 0. 001 ) . In univariate logistic regression, NYHA class, BNP, LVEF, LVEDD, heart size, total score of LiHFe, phys- ical domain of LiHFe and the emotional domain of LiH- Fe were all significant prognostic factors of CHF ( p < 0. 05 for all). While in multiple regression, only BNP level( p = 0. 036) and the emotional domain of LiHFe ( p = 0. 025 ) were independent prognostic factors. Conclusions Change of BNP reflects the treatment efficacy of CHF. BNP and QOL are the two major short - time prognostic factors of the chronic heart failure patients.

基于互动模式的社区自我管理活动对老年糖尿病患者生存质量干预效果分析

目的分析基于互动模式的社区自我管理活动对老年糖尿病患者生存质量的干预效果及影响因素,为提高患者生存质量提供依据。方法2016—2020年杭州市依托医联体建设及家庭医生签约服务资源,组建干预团队,以患者小组为单位开展系列自我管理活动干预。通过问卷调查方式收集基本信息、疾病状况、生存质量及自我管理行为情况。采用SPSS 19.0软件进行Friedman检验、Spearman相关检验及多重线性回归模型分析。结果共707例老年2型糖尿病患者纳入研究。干预前、干预4个月及干预10个月健康调查简表(SF-36)及2型糖尿病自我管理行为量表(2-DSCS)各维度得分差异具有统计学意义(χ^(2)>21.737,P<0.001)。干预4、10个月较干预前2-DSCS总分变化值与SF-36的各维度变化值均显著相关(r>0.125,P<0.01)。多重线性回归分析结果显示,生理健康(PCS)的影响因素有基线PCS得分、2-DSCS总分差值、伴2种及以上并发症,心理健康(MCS)的影响因素有基线MCS得分、2-DSCS总分变化值、伴有并发症及支付医疗费用比较困难(∣t∣>2.019,P<0.05)。结论基于互动模式的社区自我管理活动可有效改善患者管理行为,提升生存质量,且合并并发症、医疗费用支付能力对生存质量改善存在一定影响。

Fifteen-year follow-up of quality of life in type 1 diabetes mellitus

AIM:To evaluate metabolic control and health-related quality of life(HRQOL)in a type 1 diabetes mellitus(T1DM)population.METHODS:As part of a prospective cohort study,283T1DM patients treated with various insulin treatment modalities including multiple daily injections(MDI)and continuous subcutaneous insulin infusion(CSII)were examined annually.HRQOL was measured using the SF-36 and EuroQol questionnaires.Data regarding HRQOL,glycaemic and metabolic control from baseline and follow-up measures in 2002 and 2010 were analysed.Linear mixed models were used to calculate estimated values and differences between the three moments in time and the three treatment modalities.RESULTS:Significant changes[meanΔ(95%CI)]in body mass index[2.4 kg/m2(1.0,3.8)],systolic blood pressure[-6.4 mmHg(-11.4,-1.3)]and EuroQol-VAS[-7.3(-11.4,-3.3)]were observed over time.In 2010,168 patients were lost to follow-up.Regarding mode of therapy,52 patients remained on MDI,28 remained on CSII,and 33 patients switched from MDI to CSII during follow-up.Among patients on MDI,HRQOL decreased significantly over time:mental component summary[-9.8(-16.3,-3.2)],physical component summary[-8.6(-15.3,-1.8)]and EuroQol-VAS[-8.1(-14.0,-2.3)],P<0.05 for all.For patients using CSII,the EuroQol-VAS decreased[-9.6(-17.5,-1.7)].None of the changes over time in HRQOL differed significantly with the changes over time within the other treatment groups.CONCLUSION:No differences with respect to metabolic and HRQOL parameters between the various insulin treatment modalities were observed after 15 years of follow-up in T1DM patients.

雅鲁藏布大峡谷植物叶片碳氮磷化学计量特征

为了解雅鲁藏布大峡谷区域植物的生态适应性及N、P养分利用特征,该研究在墨脱不同森林植被区选取6个采样点,对每个采样点优势植物进行了植物叶片C、N、P化学计量特征分析。结果表明,研究区植物叶片碳含量均值为452 g kg^(-1),在不同采样点之间差异未达到显著水平,其余指标在部分采样点之间则存在一定的差异;从生活型看,研究区木本植物叶片碳含量要高于草本植物,氮含量差异不显著,磷含量则低于草本植物;在不同采样点之间木本植物叶片碳氮磷含量差异不显著,木本植物碳氮差异也不显著,但草本植物部分采样点之间磷差异达到显著水平;相关性分析显示,植物叶片C与N、C与P相关性均不显著,但N、P相关性达到极显著水平;墨脱常绿阔叶林区植物叶片C含量略低于我国南方其它常绿阔叶林区植物叶片碳含量,氮含量略高于其他区域,但P含量显著高于其他区域的植物叶片P含量,因此C/N,C/P及N/P均较低,N/P的均值为11.4。本研究结果支持植物叶片氮磷在不同生境中均存在明显正相关关系,结合生长速率假说,墨脱常绿阔叶林区的植物生长速率可能远高于我国其他常绿阔叶林区,因此研究区森林生态系统的碳汇以及面对全球N沉降背景下的响应值得进一步研究。

揿针治疗肺肾气虚型慢性阻塞性肺疾病稳定期疗效研究

目的:研究揿针治疗肺肾气虚型慢性阻塞性肺疾病(COPD)稳定期的临床疗效。方法:前瞻性选择COPD患者200例,随机分为两组,对照组给予常规西医治疗,观察组在其基础上加用予揿针治疗,疗程为8周。记录两组的临床疗效,并比较两组治疗前后中医症状积分、6 min步行距离和衰弱筛查量表评分、改良英国MRC呼吸困难指数问卷(mMRC)、肺功能及圣乔治呼吸问卷(SGRQ)评分。两组治疗后均随访6个月,记录两组急性加重的次数。结果:观察组与对照组临床总有效率分别为92.00%和71.00%,前者显著高于后者(P<0.05)。与治疗前比较,两组治疗后中医症状积分和衰弱筛查量表评分均明显降低,6 min步行距离增加(P<0.05),且观察组治疗后中医症状积分和衰弱筛查量表评分低于对照组,6 min步行距离大于对照组(P<0.05)。与治疗前比较,两组治疗后mMRC分级及平均分、SGRQ问卷总分及各维度评分均明显降低,第1秒用力呼气容积(FEV 1)、用力肺活量(FVC)、最大呼气流量(PEF)、第1秒用力呼气量/用力肺活量(FEV 1/FVC)均明显增大(P<0.05),且观察组治疗后的mMRC分级及平均分、SGRQ问卷总分及各维度评分均低于对照组(P<0.05),肺功能指标高于对照组(P<0.05)。两组治疗后均随访6个月,观察组急性加重次数显著低于对照组(P<0.05)。结论:揿针治疗肺肾气虚型COPD稳定期患者的疗效确定,不仅能改善其临床症状,改善疲劳衰弱状况与增强运动耐量,还能减轻呼吸困难程度并提高肺功能,显著改善生存质量,减少COPD急性发作次数。

基于形气神三位一体生命观探讨2型糖尿病发病机理

形、气、神构成了生命的三个要素,基于形、气、神三位一体生命观探讨2型糖尿病(T2DM)的发病机理。指出T2DM的发生、发展是形、气、神发生了病理改变。并且分别从形、气、神三个方面展开论述。其中形的改变有形态结构改变、形体动作异常和有形精微物质改变;气的改变有气不足和气化失常;神的改变有嗜欲太过和情志失调,为临床诊治T2DM提供新思路。

探讨胰岛素联用吡格列酮对2型糖尿病患者糖代谢与生活质量的影响

目的 探讨胰岛素联用吡格列酮应用于2型糖尿病患者中的治疗效果。方法 选取2020年3月—2023年3月北京丰台医院内分泌科收治的88例2型糖尿病患者为研究对象,按照抽签法分为两组,每组44例。对照组单独应用胰岛素治疗,观察组采取胰岛素联合吡格列酮治疗,比较两组患者治疗效果。结果 观察组胰岛功能指标、糖代谢指标均低于对照组,差异有统计学意义(P均<0.05);观察组生活质量评分低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论 胰岛素联用吡格列酮的应用,能够提高2型糖尿病患者的胰岛功能,改善其糖代谢紊乱状态,促进患者生活质量的提升。联合应用有助于降低患者不良反应的发生率,对提高用药的安全性、有效性意义显著。

具有稚虫迁徙机制的S型自适应混沌蜉蝣算法

针对蜉蝣优化算法(MA)全局搜索能力较弱,对子代优秀个体有效信息利用不够充分的缺点,以及在计算中后期易陷入局部收敛,进而影响优化效果的问题,提出一种具有稚虫迁徙机制的S型自适应混沌蜉蝣优化算法(S-AMA)。S-AMA算法首先采用Logistic混沌映射产生蜉蝣种群,增加算法初期种群的多样性;随后,将蜉蝣生命周期进行数学建模,并引入S型生命系数替换原有的重力惯性系数,动态调整算法探索能力和开发能力间的平衡性;最后,根据蜉蝣在缺氧环境下的种群活动,引入稚虫迁徙机制强化子代优秀个体摆脱局部最优的能力,进而更加充分地搜索最优解附近的区域,以增强算法的收敛精度。实验部分将S-AMA应用于标准函数测试集,并分别进行优化对比实验、Wilcoxon秩和检验。结果表明:与对比算法相比,S-AMA算法具有更好的寻优能力、收敛速度及鲁棒性。

全科团队服务对社区2型糖尿病家庭护理的实际效果分析

目的探讨社区2型糖尿病(T2DM)家庭护理中全科团队服务的效果。方法于2020年9月至2021年8月,在社区选取T2DM患者100例,随机分为观察组(给予全科团队服务)和对照组(给予常规护理),每组各50例。对比两组的护理效果。结果观察组血糖水平、炎症因子水平、生活质量评分、满意度评分、自我护理能力、治疗依从性、疾病知晓情况优于对照组(P<0.05)。结论全科团队服务可有效增加社区T2DM家庭护理的效果。

当归饮子加味联合咪唑斯汀治疗血虚风燥型荨麻疹的疗效及对生活质量的影响

目的探讨当归饮子加味联合咪唑斯汀治疗血虚风燥型荨麻疹的效果。方法前瞻性选取2020年4月至2023年4月北京中医药大学东直门医院收治的血虚风燥型荨麻疹患者102例作为研究对象,依据随机数字表法分为对照组与研究组,每组各51例。对照组给予咪唑斯汀,研究组给予当归饮子加味联合咪唑斯汀治疗,两组连续治疗8周。比较两组患者的疗效,治疗前、治疗8周后的荨麻疹活动度评分(UAS)、皮肤病生活质量指数(DLQI)评分、炎症因子[白细胞介素-4(IL-4)、干扰素-γ(INF-γ)、超敏C反应蛋白(hs-CRP)]、血常规相关指标[嗜酸性粒细胞(EOS)计数、白细胞计数(WBC)、中性粒细胞(NEU)计数]以及复发情况。结果研究组总有效率为92.16%,高于对照组(76.47%),差异有统计学意义(P<0.05)。治疗8周后,两组的UAS评分、DLQI评分均低于治疗前,且研究组UAS评分、DLQI评分分别为(1.72±0.54)、(6.38±2.04)分,均低于对照组[(2.43±0.63)、(8.86±2.78)分],差异均有统计学意义(P<0.05)。治疗8周后,两组的IL-4、hs-CRP水平均低于治疗前,INF-γ均高于治疗前,且研究组的IL-4、hs-CRP水平分别为(21.25±3.36)pg/mL、(12.52±4.11)mg/L,均低于对照组[(32.34±4.19)pg/mL、(18.53±6.14)mg/L],研究组INF-γ水平为(15.46±3.34)pg/mL,高于对照组[(11.14±3.68)pg/mL],差异均有统计学意义(P<0.05)。治疗8周后,两组的EOS计数、WBC、NEU计数均低于治疗前,且研究组EOS计数、WBC、NEU计数分别为(0.34±0.11)×10^(9)/L、(6.15±1.68)×10^(9)/L、(3.96±1.28)×10^(9)/L,均低于对照组[(0.43±0.13)×10^(9)/L、(7.03±1.92)×10^(9)/L、(4.74±1.56)×10^(9)/L],差异均有统计学意义(P<0.05)。随访12周,研究组复发率为11.11%,低于对照组(50.00%),差异有统计学意义(P<0.05)。结论当归饮子加味联合咪唑斯汀治疗血虚风燥型荨麻疹疗效肯定,能减轻荨麻疹活动度,改善患者生活质量,调节炎症因子、血常规相关指标,且复发率低。

超声引导下PTCD应用于BismuthⅢ型胆道梗阻患者临床对照研究

目的探讨超声引导下的经皮肝穿刺胆道引流术(PTCD)应用于BismuthⅢ、Ⅳ型胆道梗阻患者的临床疗效。方法将95例恶性胆道梗阻患者中的BismuthⅢ型患者65例设为Ⅲ型组,BismuthⅣ型患者30例设为Ⅳ型组。比较两组患者手术时间、临床疗效及术后并发症发生情况,比较治疗前后肝功能指标[丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、谷氨酰转肽酶(GGT)、碱性磷酸酶(ALP)、总胆红素(TBIL)和直接胆红素(DBIL)]水平及癌症患者生命质量测定量表(QLQ-C30)评分。结果Ⅲ型组患者手术时间短于Ⅳ型组,治疗总有效率高于Ⅳ型组(P<0.05或0.01)。治疗后两组患者血清ALT、AST、GGT、ALP、TBIL和DBIL水平均较治疗前降低,且Ⅲ型组低于Ⅳ型组(P<0.05或0.01)。治疗后两组患者QLQ-C30的总体健康状况、躯体功能、角色功能、情绪功能、认知功能、社会功能、疲乏、恶心呕吐、疼痛、呼吸困难、睡眠障碍、食欲丧失、便秘维度评分均较治疗前改善,Ⅲ型组患者QLQ-C30的总体健康状况、躯体功能、情绪功能、社会功能维度评分高于Ⅳ型组,而疲乏、恶心呕吐、疼痛、呼吸困难、睡眠障碍、食欲丧失、便秘维度评分低于Ⅳ型组(P<0.05或0.01)。Ⅲ型组患者术后并发症发生率低于Ⅳ型组,但差异无统计学意义(P>0.05)。结论相较于BismuthⅣ型胆道梗阻,超声引导下的PTCD应用于BismuthⅢ型胆道梗阻患者有较好的疗效,可以改善患者肝功能和生存质量。