[Objective] The aim was to research development plan of major agriculture-oriented county （MAOA or MAOC hereafter） based on territorial function. [Method] The relationship between Major Function Oriented Zoning （MF...[Objective] The aim was to research development plan of major agriculture-oriented county （MAOA or MAOC hereafter） based on territorial function. [Method] The relationship between Major Function Oriented Zoning （MFOZ hereafter） and agricultural development is explored with the case of Long＇an County in Guangxi. [Result] In the research, agricultural function, featured by composition and diversification, is considered one of territorial function typs, contributed by ecology, land, industries and population. With Long＇an as a study case, it can be concluded that the plan of major agriculture-oriented counties is as follows： With guidance of territorial function, the counties should formulate the strategies of major function oriented zones, strive for more social and economic resources for agricultural development, extend agricultural functions, enhance the role of agricultural additional functions, strengthen ecological conservation, improve agricultural productivity and transportation, reinforce exchange of countryside with other regions. In addition, attention should be paid to reconstruction of population and industry pattern for redistribution on the basis of evaluation on bearing capacity of resources and environment. [Conclusion] In future, major agriculture oriented county should coordinate relationship among agriculture, industries, ecology and population with rational distribution of territorial function in county to guarantee stable and sustainable agricultural development.展开更多
Long noncoding RNAs(lnc RNAs) are RNA molecules comprising more than 200 nucleotides, which are not translated into proteins. Many studies have shown that lnc RNAs are involved in regulating a variety of biological pr...Long noncoding RNAs(lnc RNAs) are RNA molecules comprising more than 200 nucleotides, which are not translated into proteins. Many studies have shown that lnc RNAs are involved in regulating a variety of biological processes, including immune, cancer, stress, development and differentiation at the transcriptional, epigenetic or post-transcriptional levels. Here, we review the role of lnc RNAs in the process of neurodevelopment, neural differentiation, synaptic function, and pathogenesis of Parkinson’s disease(PD). These pathomechanisms include protein misfolding and aggregation, disordered protein degradation, mitochondrial dysfunction, oxidative stress, autophagy, apoptosis, and neuroinflammation. This information will provide the basis of lnc RNA-based disease diagnosis and drug treatment for PD.展开更多
INTRODUCTION Launch vehicles are a precondition and main carrier for space activities for human beings.Their development have directly promoted the technology of satellite applications,manned spaceflight,deep space ex...INTRODUCTION Launch vehicles are a precondition and main carrier for space activities for human beings.Their development have directly promoted the technology of satellite applications,manned spaceflight,deep space exploration,and promoted the development of communication,navigation,environmental monitoring,resource exploitation,scientific research and so on.展开更多
Purpose: To study the property of LTP in layers Ⅱ～Ⅳof the rats visual cortex at different postnatal days induced by pairing low-frequency stimulation at layer Ⅳ with post synaptic depolarization in order to explor...Purpose: To study the property of LTP in layers Ⅱ～Ⅳof the rats visual cortex at different postnatal days induced by pairing low-frequency stimulation at layer Ⅳ with post synaptic depolarization in order to explore the synaptic and cellular mechanism of experience-dependent plasticity in the visual cortex.Methods: Postsynaptic currents (PSCs) of layers Ⅱ～Ⅳ in visual cortex slices of Wistar rats aged P0-29 d were recorded by patch-clamp whole cell recording method. Long-term potentiation (LTP) was induced by low-frequency stimulation (LFS) at 1Hz for 60～90 s.Each pulse of the LFS paired with depolarization of post-synaptic neurons to -20 mV.100μM APV, a kind of competitive N-methyl-d-aspartate (NMDA) receptor antagonist, was both applied to some slices to test the property of LTP.Results: 1. The LTP incidence was very low before P10d (5/34), and increased rapidly to the top at P15-24 d (17/28), then decreased sharply to 1/5 at P25-29 d, coinciding well with the critical period of plasticity of rat visual cortex. The LTP incidence of P15-29d (after eye opening, 18/33) was significantly higher than that of P0-14 d (before eye opening, 12/43, P ＜ 0.05). 2. Compared with non-APV applied group (30/76), LTP incidence of APV applied group (4/33) was significantly decreased (P ＜ 0.01 ). There were 4 Ⅳ-Ⅳ horizontal synapses. APV application could not block the LTP induction.Conclusions: 1. LTP was a reflection of naturally occurring, experience-dependent plasticity in rat visual cortex. The patterned visual stimuli received after eye opening might be an activation factor of the synaptic plasticity. 2. LTP of visual cortex induced by LFS in layer Ⅳ paired with postsynaptic depolarization was NMDA receptor dependent during the critical period of visual plasticity. However, there were LTP existed in Ⅳ-Ⅳ horizontal synapses which could not be blocked by 100μM APV.展开更多
The aim of this research was to value, using a multiple regression model, the role of knowledge to guarantee the development in rural areas of European Union countries over 10 years. The main question was to find out ...The aim of this research was to value, using a multiple regression model, the role of knowledge to guarantee the development in rural areas of European Union countries over 10 years. The main question was to find out relationships among some variable, as the percentage of national Gross Domestic Product （GDP） used to improve the high training, and rural development in terms of agricultural labour units. The results underlined in 2001 as an high value of rural development, in terms of working force in agriculture, was identified in some countries of European Union characterised by a low value both in high training investments and also by a low value of Human Development Index, according to the definition of The Economist. The results in 2010 pointed out an inverse correlation among the dependent variable development in rural areas and the independent variables per capita GDP and national expenditure in advanced training, in percentage of national GDP. The learning by doing and by using, the introduction of advanced training in agriculture, using Long Life Learning measures of European Union, are important to improve the development of European rural areas but, sometimes, these actions are not perceived as something of useful.展开更多
基金Supported by Key Program of National Natural Science Foundation of China(40830741)~~
文摘[Objective] The aim was to research development plan of major agriculture-oriented county （MAOA or MAOC hereafter） based on territorial function. [Method] The relationship between Major Function Oriented Zoning （MFOZ hereafter） and agricultural development is explored with the case of Long＇an County in Guangxi. [Result] In the research, agricultural function, featured by composition and diversification, is considered one of territorial function typs, contributed by ecology, land, industries and population. With Long＇an as a study case, it can be concluded that the plan of major agriculture-oriented counties is as follows： With guidance of territorial function, the counties should formulate the strategies of major function oriented zones, strive for more social and economic resources for agricultural development, extend agricultural functions, enhance the role of agricultural additional functions, strengthen ecological conservation, improve agricultural productivity and transportation, reinforce exchange of countryside with other regions. In addition, attention should be paid to reconstruction of population and industry pattern for redistribution on the basis of evaluation on bearing capacity of resources and environment. [Conclusion] In future, major agriculture oriented county should coordinate relationship among agriculture, industries, ecology and population with rational distribution of territorial function in county to guarantee stable and sustainable agricultural development.
基金CAMS Innovation Fund for Medical Sciences,Grant/Award Number:2017-I2M-2-005 and 2016-I2M-2-006Beijing Natural Science Foundation,Grant/Award Number:5171001
文摘Long noncoding RNAs(lnc RNAs) are RNA molecules comprising more than 200 nucleotides, which are not translated into proteins. Many studies have shown that lnc RNAs are involved in regulating a variety of biological processes, including immune, cancer, stress, development and differentiation at the transcriptional, epigenetic or post-transcriptional levels. Here, we review the role of lnc RNAs in the process of neurodevelopment, neural differentiation, synaptic function, and pathogenesis of Parkinson’s disease(PD). These pathomechanisms include protein misfolding and aggregation, disordered protein degradation, mitochondrial dysfunction, oxidative stress, autophagy, apoptosis, and neuroinflammation. This information will provide the basis of lnc RNA-based disease diagnosis and drug treatment for PD.
文摘INTRODUCTION Launch vehicles are a precondition and main carrier for space activities for human beings.Their development have directly promoted the technology of satellite applications,manned spaceflight,deep space exploration,and promoted the development of communication,navigation,environmental monitoring,resource exploitation,scientific research and so on.
基金Supported by Chinese National Natural Science Found (grants Nos,39970252, 39770258, 30070254).
文摘Purpose: To study the property of LTP in layers Ⅱ～Ⅳof the rats visual cortex at different postnatal days induced by pairing low-frequency stimulation at layer Ⅳ with post synaptic depolarization in order to explore the synaptic and cellular mechanism of experience-dependent plasticity in the visual cortex.Methods: Postsynaptic currents (PSCs) of layers Ⅱ～Ⅳ in visual cortex slices of Wistar rats aged P0-29 d were recorded by patch-clamp whole cell recording method. Long-term potentiation (LTP) was induced by low-frequency stimulation (LFS) at 1Hz for 60～90 s.Each pulse of the LFS paired with depolarization of post-synaptic neurons to -20 mV.100μM APV, a kind of competitive N-methyl-d-aspartate (NMDA) receptor antagonist, was both applied to some slices to test the property of LTP.Results: 1. The LTP incidence was very low before P10d (5/34), and increased rapidly to the top at P15-24 d (17/28), then decreased sharply to 1/5 at P25-29 d, coinciding well with the critical period of plasticity of rat visual cortex. The LTP incidence of P15-29d (after eye opening, 18/33) was significantly higher than that of P0-14 d (before eye opening, 12/43, P ＜ 0.05). 2. Compared with non-APV applied group (30/76), LTP incidence of APV applied group (4/33) was significantly decreased (P ＜ 0.01 ). There were 4 Ⅳ-Ⅳ horizontal synapses. APV application could not block the LTP induction.Conclusions: 1. LTP was a reflection of naturally occurring, experience-dependent plasticity in rat visual cortex. The patterned visual stimuli received after eye opening might be an activation factor of the synaptic plasticity. 2. LTP of visual cortex induced by LFS in layer Ⅳ paired with postsynaptic depolarization was NMDA receptor dependent during the critical period of visual plasticity. However, there were LTP existed in Ⅳ-Ⅳ horizontal synapses which could not be blocked by 100μM APV.
文摘The aim of this research was to value, using a multiple regression model, the role of knowledge to guarantee the development in rural areas of European Union countries over 10 years. The main question was to find out relationships among some variable, as the percentage of national Gross Domestic Product （GDP） used to improve the high training, and rural development in terms of agricultural labour units. The results underlined in 2001 as an high value of rural development, in terms of working force in agriculture, was identified in some countries of European Union characterised by a low value both in high training investments and also by a low value of Human Development Index, according to the definition of The Economist. The results in 2010 pointed out an inverse correlation among the dependent variable development in rural areas and the independent variables per capita GDP and national expenditure in advanced training, in percentage of national GDP. The learning by doing and by using, the introduction of advanced training in agriculture, using Long Life Learning measures of European Union, are important to improve the development of European rural areas but, sometimes, these actions are not perceived as something of useful.
