Engineering Change Management Adaptive to PLM

Engineering Change (EC) management for a Product Lifecycle Management (PLM) system, including EC data model, EC evaluation and EC implementation is presented. A method of dynamic and parallel EC evaluation is proposed, which breaks an EC evaluation task into several subtasks. Such subtasks can be dynamically and simultaneously proceeded, disassembled and communicated by different specialists, and at the same time a set of EC objects is created. This approach provides flexible and effective evaluation of the EC. The EC implementation followed will further ensure the completeness and consistency of EC data.

Organizational evolution of project management teams over the whole lifecycle of megaprojects:Case study of the Hong Kong-Zhuhai-Macao Bridge

Project management teams are critical in the implementation of megaprojects,but their evolution throughout the project lifecycle has not been clearly explained.This paper explores the organizational evolution of megaproject management teams through a longitudinal retrospective case study of the Hong Kong–Zhuhai–Macao Bridge(HZMB)project.The organizational evolution is examined in terms of management objectives,management content,and organizational structure.The organizational evolution of the HZMB project management team exhibits stage differentiation with the coexistence of turbulence and stability.Changes in the external environment are the driving force for organizational evolution,whereas a flexible organizational strategy is critical in promoting this evolution.Basing on the HZMB case study,this paper summarizes six critical measures that facilitate the organizational evolution of megaproject management teams.Our findings add value to megaproject management theory and provide a better understanding of the dynamics and complexity of megaproject organizational management.

Transforming Molecules into Medicines: Role of CDMOS in Phase-Appropriate Technology Transfers in Advancing Pharmaceutical Innovation

CDMOs are emerging as critical drivers of innovation within the pharmaceutical and biotech industries. As the pharmaceutical industry continues to evolve, we can expect to see CDMOs play an increasingly important role in drug development and manufacturing. Many companies within these sectors are now leveraging the expertise of CDMOs through technology transfers to foster innovation and enhance the development of new drug products. In the extensive field of drug development, technology transfer plays a crucial role at multiple stages, ranging from preclinical phases to commercialization. By working closely with drug developers, CDMOs can ensure that technologies are transferred seamlessly between phases of drug development, allowing for a more efficient and cost-effective development process. CDMOs also bring a wealth of experience in various areas of drug development, including process development, analytical testing, quality control, and manufacturing. This expertise, combined with a focus on innovation, can help drug developers to overcome technical challenges and optimize their drug development programs. CDMOs can provide drug developers with various manufacturing capabilities, from small-scale clinical trials to large-scale commercial production. This flexibility allows drug developers to focus on their core competencies while relying on CDMOs to provide the necessary infrastructure and support for drug manufacturing. The critical role of CDMOs in advancing pharmaceutical innovation in phase-appropriate technology transfer where there will be a lot of effort and patience with strong technical expertise is required. This article explores the various types of Technology transfer from preclinical to commercial stages and successful strategies to foster innovation.

PLM Solutions:Emerging Unification Force Across the Enterprise

Over last few years, web services, Java 2 and XML have provided the cheaper means for trading partners to make use of EDI. It is now possible to share data with less reliance on expensive dedicated EDI networks. The second comes the realization that Product Definition can be reused by virtually all business processes downstream. This has made collaborative product development a practical reality. These technologies have enabled effective implementation of Product Lifecycle Management (PLM) Solutions. This paper presents a literature review about PLM solutions, looking at its definitions, through to its need and scope of applications. It also presents the most generally envisaged architecture, explaining as to how it may be looked at and what it is expected to deliver. At the end it examines the market trend and revenue growth over recent years including future trends for the most prominent vendors pitched in the field of PLM solutions.

Application of blockchain in the field of intelligent manufacturing:Theoretical basis,realistic plights,and development suggestions

Blockchain technology is considered one of the promising technologies of the information technology era.The core features of blockchain,such as decentralization,transparency,high security,and tamper-proof nature,bring great convenience for large-scale social cooperation and data sharing.Blockchain has a broad application prospect in the field of intelligent manufacturing.The key issues of this field,such as distributed collaborative production,industrial big data sharing and security,transparent logistics,and supply chain,are naturally consistent with the core characteristics of the blockchain technology.This study aims to analyze the application of blockchain in the field of intelligent manufacturing.First,we introduce the basic connotation and applications of blockchain.Then,we propose the theoretical basis for the application of blockchain in the field of intelligent manufacturing.Finally,we point out the realistic plights and provide some suggestions to promote the application of blockchain in the field of intelligent manufacturing.