The Impact of Lifestyle Factors on Migraine Frequency and Severity in Neurology

Objective: This systematic review examines the impact of lifestyle factors on migraine frequency and severity through a comprehensive analysis of lifestyle factors such as diet, physical activity, sleep patterns, stress, mental health, and environmental influences. Methods: We thoroughly searched Google Scholar, PUBMED, Scopus, and Web of Science databases using keywords related to migraines and lifestyle factors. Keywords incorporated the Boolean operator “and” to narrow search results. Following the PRISMA guidelines, we identified, screened, and evaluated studies for inclusion, resulting in nine studies meeting the eligibility criteria. Results: A total of 4917 records were initially identified from Scopus (2786), PubMed (854), and Web of Science (1277). Following deduplication, 3657 records underwent title screening, with 382 additionally screened by abstract. Ultimately, 88 full-text articles were assessed, resulting in 9 studies meeting eligibility for qualitative synthesis: 7 prospective and 2 retrospective studies. Our findings highlight the multifaceted role of lifestyle factors in migraine pathophysiology and management. Dietary habits, such as high-calorie, high-fat, and gluten-containing diets were linked to migraine triggers. Moderate physical activity showed beneficial effects on migraine management, while intense exercise could exacerbate symptoms. Poor sleep hygiene and insomnia were strongly associated with increased migraine frequency and severity. Chronic stress and poor mental health significantly contributed to migraine exacerbation, with stress management techniques proving beneficial. Environmental factors, including light, sound, weather changes, and allergens, were also identified as significant migraine triggers. Conclusions: Personalized lifestyle modifications, tailored to individual patient profiles, are crucial in managing migraines. Evidence-based recommendations include balanced diets, moderate physical activity, improved sleep hygiene, stress management techniques, and environmental adaptations.

The moderating impact of lifestyle factors on sex steroids, sexual activities and aging in Asian men

The present study sought to evaluate the relative associations of exercise, sleep and other lifestyle habits with aging, sex hormones, percent body fat （%BF） and sexual activities in men living in the community. A better understanding of this complex interrelationship is important in helping the formulation of modalities for a holistic approach to the management of aging men. The results showed that age is a major determinant for many physiological parameters, including sleep, hormonal and metabolic parameters, some lifestyle factors and sexual activities. Testosterone （T）, bioavailable testosterone （BloT） and dehydroepiandrosterone sulphate （DHEAS） concentrations decreased with age, while estradiol （E2）, sex hormone-binding globulin （SHBG） and %BF increased with age. In addition, there exist intricate associations among hormonal and lifestyle factors, %BF and age. High-intensity exercise and longer duration of sleep were associated with higher concentrations of T and BloT. T was shown to be associated positively with men who were engaged in masturbation. DHEAS was associated with men wanting more sex and with good morning penile rigidity. Older Singaporean men tended to sleep for shorter duration, but exercised more intensely than younger men. Coital and masturbation frequencies decreased with age, and a significantly greater number of younger men were engaged in masturbation. Relationship between the partners is a key determinant of sexuality in men. It appears that T may have a limited, while dehydroepiandrosterone （DHEA） have a greater role than previously suggest, as a motivational signal for sexual function in men. Both biological and psychosocial factors interact with each other to influence sexual functions in men. Hence, a biopsychosocial approach may be more appropriate for a more lasting resolution to sexual dysfunctions in men.

Interplay between oral health and lifestyle factors for cancer risk in rural and urban China:a population-based cohort study

Background:Although poor oral health and several lifestyle factors have been found to be associated with cancer risk,their joint relationship has rarely been studied.Methods:We prospectively examined the associations of oral health and healthy lifestyle factors with cancer risk among 0.5 million rural and urban residents from the China Kadoorie Biobank(2004-2015).Oral health status was assessed from self-reported baseline questionnaires.A healthy lifestyle index comprising non-smoking,non-drinking,ideal body shape,physical activity and healthy diet was calculated for each participant,and categorized into favorable,intermediate and unfavorable lifestyle behavior.We calculated hazard ratios(HRs)and 95%confidence intervals(CIs)relating oral health and healthy lifestyle index to cancer risk using Cox proportional hazards models.We estimated the population attributable risk percent(PAR%)and 95%CIs using multivariate models.Results:During a median follow-up of 9 years,23,805 new cancer cases were documented,with 52%from rural areas and 48%from urban areas.Compared with those with good oral health and favorable lifestyle,participants with poor oral health and unfavorable lifestyle had a higher risk of developing cancer in both rural(adjusted HR,1.55[95%CI,1.39-1.74];P for trend<0.001)and urban areas(adjusted HR,1.44[95%CI,1.24-1.67];P for trend<0.001).A significant multiplicative interaction between oral health and healthy lifestyle index on cancer risk was found in rural residents(P for interaction=0.004)rather than in urban residents(P for interaction=0.973).Assuming poor oral health as an additional risk factor,the PAR%of total cancer increased by 3.0%and 1.1%for participants with intermediate lifestyle and unfavorable lifestyle,respectively.Conclusions:These findings suggest a joint effect of oral health and common lifestyle factors on cancer risk.Promotion of healthy lifestyle by integration of good oral health would be beneficial to consider in cancer prevention strategies.

Modifiable factors mediating the effects of educational attainment on gestational diabetes mellitus: A two-step Mendelian randomization study

BACKGROUND Although there is currently a wealth of evidence to indicate that maternal educational attainment is associated with gestational diabetes mellitus(GDM),the specific modifiable risk factors that mediate the causal relationship between these two variables have yet to be identified.AIM To identify the specific modifiable risk factors that mediate the causal relationship between the level of maternal education and GDM.METHODS Mendelian randomization(MR)was conducted using data from genome-wide association studies of European populations.We initially performed a two-sample MR analysis using data on genetic variants associated with the duration of education as instruments,and subsequently adopted a two-step MR approach using metabolic and lifestyle factors as mediators to examine the mechanisms underlying the relationship between the level of maternal education and risk of developing GDM.In addition,we calculated the proportions of total causal effects mediated by identified metabolic and lifestyle factors.RESULTS A genetically predicted higher educational attainment was found to be associated with a lower risk of developing GDM(OR:0.71,95%CI:0.60-0.84).Among the metabolic factors assessed,four emerged as potential mediators of the education-GDM association,which,ranked by mediated proportions,were as follows:Waist-to-hip-ratio(31.56%,95%CI:12.38%-50.70%),body mass index(19.20%,95%CI:12.03%-26.42%),high-density lipoprotein cholesterol(12.81%,95%CI:8.65%-17.05%),and apolipoprotein A-1(7.70%,95%CI:4.32%-11.05%).These findings proved to be robust to sensitivity analyses.CONCLUSION Our findings indicate a causal relationship between lower levels of maternal education and the risk of developing GDM can be partly explained by adverse metabolic profiles.

Biological factors driving colorectal cancer metastasis

Approximately 20%of colorectal cancer(CRC)patients present with metastasis at diagnosis.Among Stage I-III CRC patients who undergo surgical resection,18%typically suffer from distal metastasis within the first three years following initial treatment.The median survival duration after the diagnosis of metastatic CRC(mCRC)is only 9 mo.mCRC is traditionally considered to be an advanced stage malignancy or is thought to be caused by incomplete resection of tumor tissue,allowing cancer cells to spread from primary to distant organs;however,increa-sing evidence suggests that the mCRC process can begin early in tumor development.CRC patients present with high heterogeneity and diverse cancer phenotypes that are classified on the basis of molecular and morphological alterations.Different genomic and nongenomic events can induce subclone diversity,which leads to cancer and metastasis.Throughout the course of mCRC,metastatic cascades are associated with invasive cancer cell migration through the circulatory system,extravasation,distal seeding,dormancy,and reactivation,with each step requiring specific molecular functions.However,cancer cells presenting neoantigens can be recognized and eliminated by the immune system.In this review,we explain the biological factors that drive CRC metastasis,namely,genomic instability,epigenetic instability,the metastatic cascade,the cancer-immunity cycle,and external lifestyle factors.Despite remarkable progress in CRC research,the role of molecular classification in therapeutic intervention remains unclear.This review shows the driving factors of mCRC which may help in identifying potential candidate biomarkers that can improve the diagnosis and early detection of mCRC cases.

Lifestyle: an underrated but potentially important influencing factor on semen quality

Lifestyle factors play a crucial role in the influence of semen quality,and they are especially significant in the context of traditional Chinese medicine(TCM)clinical treatment for poor semen quality.TCM theory emphasizes the importance of healthy lifestyle habits for overall well-being.Therefore,it is essential to consider lifestyle factors in the clinical management of TCM and semen quality.Lifestyle can act as a bias factor that affects research quality,making it vital to pay special attention to its impact in clinical trial research on male semen quality.This article aims to improve the quality and design of clinical research on male sperm quality by examining the effects of various lifestyle factors on semen quality,including physical activities,dietary patterns,smoking,alcohol consumption,coffee intake,sleep,and psychological stress.Each lifestyle factor has its own distinct influence on semen quality,and there is a synergistic effect when multiple lifestyle factors are combined.These findings emphasize the need for careful consideration of lifestyle factors and their interactions in the design and implementation of TCM clinical trial research.

Metabolic syndrome, lifestyle risk factors, and distal colon adenoma: A retrospective cohort study

AIM: To investigate relationships between colorectal adenoma incidence, metabolic syndrome (MS) components and lifestyle factors. METHODS: We conducted a retrospective cohort study using data from individuals who had multiple sigmoidoscopies for colon cancer at the Health Promotion Center of Ulsan University Hospital in Korea from 1998 to 2007. RESULTS: By multivariate analysis, the incidence of distal colon adenoma was increased by more than 1.76 times in individuals with at least one component of MS compared to those without a component of MS. After adjustment for age, gender, smoking, drinking, and physical exercise, only high body mass index (BMI) was significantly associated with the incidence of distal colon adenoma (Hazard ratio 1.66, 95% confidence interval 1.05-2.62). CONCLUSION: Our results suggest that high BMI may increase the risk of colorectal adenoma in Korean adults.

Dietary and socio-economic factors in relation to Helicobacter pylori re-infection

AIM:To examine if dietary and socio-economic factors contribute to Helicobacter pylori(H pylori)re-infection. METHODS:The population of patients consisted of subjects in whom H pylori infection had been successfully treated in the past.Patients were divided into two groups:Ⅰ-examined group(111 persons with H pylori re-infection)andⅡ-control group(175 persons who had not been re-infected).The respondents were interviewed retrospectively on their dietary habits and socio-economic factors. RESULTS:A statistically significant lower frequency of fermented dairy products(P<0.0001),vegetables (P=0.02),and fruit(P=0.008)consumption was noted among patients with H pylori re-infection as compared to those who had not been re-infected. CONCLUSION:High dietary intake of probiotic bacteria,mainly Lactobacillus,and antioxidants,mainly vitamin C(contained in fruit and vegetables),might decrease the risk of H pylori re-infection.

Exposure to Hyaluronan and Radon-Containing Water during the Treatment of Periodontal Pockets

Hyaluronic acid (HA) preparations have emerged as pivotal components in contemporary dentistry, gaining widespread recognition for their multifaceted roles in various biological functions. Extensive literature underscores the significance of HA in maintaining tissue water balance, fostering cell proliferation, promoting rapid cell migration, influencing cell differentiation during organism development, and facilitating tissue regeneration. Notably, HA’s interactions with cell surface receptors contribute to the viscosity of synovial fluid, activate the immune system, and enhance cartilage elasticity. Beyond these established functions, HA has also been investigated for its potential involvement in determining and studying the hormetic effects of radon water, adding a novel dimension to its applications in dental research. A thorough exploration of existing studies reveals a nuanced understanding of how HA interventions impact the outcomes of dental procedures. The comprehensive scope of these investigations allows for a more accurate assessment of the potential effectiveness of specific interventions and provides valuable insights into post-procedural prognoses for individual patients. This synthesis of literature serves as the foundation for elucidating the intricate interplay between HA, radon exposure, and their relevance in modern dental practices.

Physical exercise in the prevention and treatment of Alzheimer’s disease

Dementia is one of the greatest global challenges for health and social care in the 21st century.Alzheimer’s disease(AD),the most common type of dementia,is by no means an inevitable consequence of growing old.Several lifestyle factors may increase,or reduce,an individual’s risk of developing AD.Much has been written over the ages about the benefits of exercise and physical activity.Among the risk factors associated with AD is a low level of physical activity.The relationship between physical and mental health was established several years ago.In this review,we discuss the role of exercise(aerobic and resistance)training as a therapeutic strategy for the treatment and prevention of AD.Older adults who exercise are more likely to maintain cognition.We address the main protective mechanism on brain function modulated by physical exercise by examining both human and animal studies.We will pay especial attention to the potential role of exercise in the modulation of amyloid b turnover,inflammation,synthesis and release of neurotrophins,and improvements in cerebral blood flow.Promoting changes in lifestyle in presymptomatic and predementia disease stages may have the potential for delaying one-third of dementias worldwide.Multimodal interventions that include the adoption of an active lifestyle should be recommended for older populations.

Nonalcoholic steatohepatitis and hepatocellular carcinoma: Beyond the boundaries of the liver

The burden of non-alcoholic steatohepatitis (NASH) related hepatocellularcarcinoma (HCC) is drawing attention due to the emerging epidemic of obesityand metabolic syndrome and is expected to increase in the near future.Antidiabetic medications, air pollutants, and newer genetic mutations are latestconcerns as risk factors for HCC development in patients with NASH. Althoughmolecular signatures are very accurate, they are not cost-effective and cannot beapplied in larger population due to logistic issues. We need multicentric longitudinalstudies including diverse geographical areas to evaluate the complexinterplay of different risk factors and genetics in these patients.

Why Tibb is:a science of medicine,the art of care

Tibb also known as Unani-Tibb,Greco-Arab,Western Holistic,Unani and Persian medicine,is an ancient holistic medical system that originated approximately 10000 years ago,based on the humoral and temperamental theories that was hypothesised by Hippocrates and Galen.The“completeness”of this medical discipline as“a science of medicine-the art of care”was greatly influenced by renowned scholars including Ibn Sina during the 9th and 13th century,who refined the philosophical principles of;physis,temperament,humours,and the six lifestyle factors,of which physis,the body’s natural ability to heal itself,is a primary principle in the maintenance and restoration of health.Tibb as“a science of medicine”is detailed within the context of Ibn Sina’s principle of cause and effect and the“art of care”is highlighted in the holistic and fully integrative approach of Tibb,based on its philosophical principles.The paper concludes with a brief comparison between Tibb and Western medicine.

Exploring the potential impact of nutritionally actionable genetic polymorphisms on idiopathic male infertility:a review of current evidence

Infertility affects about 15%of the world's population.In 40%-50%of infertile couples,a male factor underlies the problem,but in about 50%of these cases,the etiology of male infertility remains unexplained.Some clinical data show that lifestyle interventions may contribute to male reproductive health.Cessation of unhealthy habits is suggested for preserving male fertility;there is growing evidence that most preexisting comorbidities,such as obesity and metabolic syndrome,are highly likely to have an impact on male fertility.The analysis of genetic polymorphisms implicated in metabolic activity represents one of the most exciting areas in the study of genetic causes of male infertility.Although these polymorphisms are not directly connected with male infertility,they may have a role in specific conditions associated with it,that is,metabolic disorders and oxidative stress pathway genes that are potentially associated with an increased risk of male infertility due to DNA and cell membrane damage.Some studies have examined the impact of individual genetic differences and gene-diet interactions on male infertility,but their results have not been synthesized.We review the current research to identify genetic variants that could be tested to improve the chances of conceiving spontaneously through personalized diet and/or oral vitamin and mineral supplementation,by examining the science of genetic modifiers of dietary factors that affect nutritional status and male fertility.

Assessing Cardiovascular Health Using Life＇s Simple 7 in a Chinese Population Undergoing Stroke Prevention

Background： The American Heart Association/American Stroke Association proposed a metric called Life＇s Simple 7 （LS7） to define cardiovascular health （CVH）. The presence of a large number of ideal components of CVH is associated with lower cardiovascular disease and all-cause mortality. We aimed to assess CVH using LS7 in a Chinese population undergoing primary and secondary stroke prevention. Methods： Patients with either ischemic stroke or cardiovascular risk factors were enrolled in the study from October 2010 to July 2013. LS7 components were scored as poor （0 points）, intermediate （1 point）, or ideal （2 points）. The overall LS7 score was categorized as inadequate （0-4）, average （5-9）, or optimal （10-14） CVH. The Chi-square test, Mann-Whitney U-test, and Kruskal-Wallis test were used. Results： In total, 706 patients were enrolled. （1） The distribution of the overall LS7 score （n = 255） indicated that 9.4%, 82.4%, and 8.2% of the patients had inadequate, average, and optimal CVH, respectively. The proportion of patients with optimal CVH undergoing secondary stroke prevention was lower than that for patients undergoing primary stroke prevention （3.8% vs. 12.8%, P = 0,005）. The vast laaajority of participants （76.1%） presented with 〈2 ideal health components. （2） The proportions of patients with poor, intermediate, and ideal status, respectively, lbr the following LS7 components were assessed： Total cholesterol （n = 275; 5.1%, 73.8%, and 21.1%）, blood pressure （11 = 351 ; 32.5%. 59.0%, and 8.5%）, blood glucose （n = 280; 9.3%, 39.6%, and 51.1%）, physical activity （n = 540; 90.7%, 8.7%, and 0.6%）, diet （n = 524; 0.2%. 92.4%, and 7.4%）, smoking （n = 619： 20.7%, 2.9%, and 76.4%）, and body mass index （n = 259; 6.6%, 35.5%, and 57.9%）. Conclusions： Few Chinese patients undergoing stroke prevention had optimal CVH （determined using LS7）. Additionally, fewer patients undergoing secondary prevention had optimal CVH than those undergoing primary prevention. In particular, physical activity and diet status in this population require improvement.