We report a copper-catalyzed ligand-controlled selective carbonylative borofunctionalization ofα-substituted styrenes.This reaction provides a general and versatile procedure to synthesize a variety of synthetically ...We report a copper-catalyzed ligand-controlled selective carbonylative borofunctionalization ofα-substituted styrenes.This reaction provides a general and versatile procedure to synthesize a variety of synthetically usefulβ-boryl quaternary aldehydes and cyclopropyl boronate esters bearing a quaternary carbon center.With NHC(IMes=1,3-bis(2,4,6-trimethylphenyl)imidazol-2-ylidene)as the ligand,the carbene intermediate reacts with O-H bond of alcohol while the carbene intermediate would undergo C-H bond insertion when using phosphine ligand[1,2-bis(diphenylphospino)ethane]as the ligand.Formation of a carbene intermediate has been proposed as the key step for this transformation.展开更多
基金appreciate the financial support from DICP(Dalian Institute of Chemical Physics,CAS)and the K.C.Wong Education Foundation(grant no.GJTD-2020-08).
文摘We report a copper-catalyzed ligand-controlled selective carbonylative borofunctionalization ofα-substituted styrenes.This reaction provides a general and versatile procedure to synthesize a variety of synthetically usefulβ-boryl quaternary aldehydes and cyclopropyl boronate esters bearing a quaternary carbon center.With NHC(IMes=1,3-bis(2,4,6-trimethylphenyl)imidazol-2-ylidene)as the ligand,the carbene intermediate reacts with O-H bond of alcohol while the carbene intermediate would undergo C-H bond insertion when using phosphine ligand[1,2-bis(diphenylphospino)ethane]as the ligand.Formation of a carbene intermediate has been proposed as the key step for this transformation.
