The study on the mechanism of Sodium aescinate combined with Xuesaitong for cerebral thrombosis treatment

Objective:To observe the mechanism of Sodium aescinate combined with Xuesaitong for cerebral thrombosis treatment and offer clinical help to cerebral thrombosis treatment. Methods:A total of 92 patients with cerebral thrombosis were selected and randomly divided into groups: the observation group (46 people) and the control group (46 people).The patient in the control group were treated with conventional therapy and the patients in the observation group were treated with Sodium aescinate combined with Xuesaitong on the basis of conventional therapy. Inflammatory factors (IL-6, IL-10, TNF-α and CRP), Nerve cell factor (NSE, NGF and NTF) and blood rheology indexes (Fg, BVH, BVL and PV) were detected and analyzed before and after treatment.Results:The comparison of inflammatory factors, Nerve cell factor and blood rheology indexes in the two groups before treatment were not statistically significant. Inflammatory factors (IL-6, TNF-α and CRP), Nerve cell factor (NSE) and blood rheology indexes (Fg, BVH, BVL and PV) in both groups after treatment significantly decreased compared with that before treatment. Inflammatory factors (IL-10), Nerve cell factor (GF and NTF) in both groups after treatment significantly increased compared with that before treatment. The changes were statistically significant. Inflammatory factors (IL-6, TNF-α and CRP), Nerve cell factor (NSE) and blood rheology indexes (Fg, BVH, BVL and PV) in observation group after treatment decreased more significantly than that in control group, and inflammatory factors (IL-10), Nerve cell factor (GF and NTF) increased more significantly than that in control group. The difference between two groups was considered statistically significant.Conclusion:Sodium aescinate combined with Xuesaitong could inhibit the inflammatory reaction, improve the blood flow condition and promote rehabilitation in patients with cerebral thrombosis. So it has a very important clinical significance of the treatment to cerebral hemorrhage.

Study on mechanism of Simiao Yong'an Decoction in treatment of deep venous thrombosis based on network pharmacology

Objective:To explore the mechanism of Simiao Yong'an Decoction in treating deep venous thrombosis based on the method of network pharmacology.Methods:Through TCMSP database,the effective components of each traditional Chinese medicine in Simiao Yong'an Decoction were obtained and their targets were predicted.The targets of deep venous thrombosis were collected by CTD database,and the key targets were obtained by intersection of the component targets and the disease targets;Protein-Protein Interaction(PPI)network was constructed by String database.The drugs-components-targets-disease network map was constructed by using the software of Cytoscape 3.7.2.GO function and KEGG pathway enrichment of Simiao Yong'an Decoction in the treatment of deep venous thrombosis were analyzed by using the plug-in of ClueGo.Results:121 effective components and 137 potential targets of Simiao Yong'an Decoction were obtained.There were 1172 targets of deep venous thrombosis.There were 214 biological processes analyzed by GO Biological Process and 72 pathways analyzed by KEGG analysis.Conclusion:Simiao Yong'an Decoction may act on ESR1,AR,PTGS2 and other key targets,as well as AGE-RAGE signaling pathway,PI3K-Akt signaling pathway,MAPK signaling pathway,IL-17 signaling pathway,TNF signaling pathway,RLX signaling pathway and other pathways to treat deep venous thrombosis.

Cerebral venous sinus thrombosis in pregnancy: A case report

BACKGROUND Cerebral venous thrombosis(CVT)is a rare but life-threatening disease in pregnant women.Anticoagulation is the first-line therapy for CVT management.However,some patients have poor outcomes despite anticoagulation.Currently,the endovascular treatment of CVT in pregnant women remains controversial.We report a rare case of CVT in a pregnant woman who was successfully treated with two stent retriever devices.CASE SUMMARY The patient was a 29-year-old pregnant woman.She was first diagnosed with hyperemesis gravidarum due to severe nausea and vomiting for one week.As the disease progressed,she developed acute left hemiplegia.Imaging confirmed the diagnosis of superior sagittal sinus,right transverse sinus and sinus sigmoideus thrombosis.As anticoagulant therapy was ineffective,she underwent thrombectomy.After the mechanical thrombectomy,her headache diminished.Three weeks later,the patient was completely independent.At a 3-mo follow-up,no relapse of symptoms was observed.CONCLUSION Mechanical thrombectomy may be an effective alternative therapy for CVT in pregnant women if anticoagulation therapy fails.

Acute extensive portal and mesenteric venous thrombosis after splenectomy:Treated by interventional thrombolysis with transjugular approach

AIM:To present a series of cases with symptomatic acute extensive portal vein(PV)and superior mesenteric vein(SMV)thrombosis after splenectomy treated by transjugular intrahepatic approach catheter-directed thrombolysis. METHODS:A total of 6 patients with acute extensive PV-SMV thrombosis after splenectomy were treated by transjugular approach catheter-directed thrombolysis. The mean age of the patients was 41.2 years.After access to the portal system via the transjugular approach,pigtail catheter fragmentation of clots, local urokinase injection,and manual aspiration thrombectomy were used for the initial treatment of PV-SMV thrombosis,followed by continuous thrombolytic therapy via an indwelling infusion catheter in the SMV,which was performed for three to six days. Adequate anticoagulation was given during treatment, throughout hospitalization,and after discharge. RESULTS:Technical success was achieved in all 6 patients.Clinical improvement was seen in these patients within 12-24 h of the procedure.No complications were observed.The 6 patients were discharged 6-14 d(8±2.5 d)after admission.The mean duration of follow-up after hospital discharge was 40±16.5 mo.Ultrasound and contrast-enhanced computed tomography confirmed patency of the PV and SMV,and no recurrent episodes of PV-SMV thrombosis developed during the follow-up period. CONCLUSION:Catheter-directed thrombolysis via transjugular intrahepatic access is a safe and effective therapy for the management of patients with symptomatic acute extensive PV-SMV thrombosis.

Efficacy of percutaneous mechanical thrombus removal in acute lower extremity deep venous thrombosis

BACKGROUND Acute lower extremity deep venous thrombosis(LEDVT)is a common vascular emergency with significant morbidity risks,including post-thrombotic syndrome(PTS)and pulmonary embolism.Traditional treatments like catheter-directed thrombolysis(CDT)often result in variable success rates and complications.AIM To investigate the therapeutic efficacy of percutaneous mechanical thrombus removal in acute LEDVT.METHODS A retrospective analysis was performed to examine 58 hospitalised patients with acute LEDVT between August 2019 and August 2022.The patients were categorised into the percutaneous mechanical thrombectomy(PMT)group(n=24)and CDT group(n=32).The follow-up,safety and treatment outcomes were compared between the two groups.The main observational indexes were venous patency score,thrombus removal effect,complications,hospitalisation duration and PTS.RESULTS The venous patency score was 9.04±1.40 in the PMT group and 8.81±1.60 in the CDT group,and the thrombus clearance rate was 100%in both groups.The complication rate was 8.33%in the PMT group and 34.84%in the CDT group,and the difference was statistically significant(P<0.05).The average hospitalisation duration was 6.54±2.48 days in the PMT group and 8.14±3.56 days in the CDT group.The incidence of PTS was lower in the PMT group than in the CDT group;however,the difference was not statistically significant(P<0.05).CONCLUSION Compared with CDT,treatment of LEDVT via PMT was associated with a better thrombus clearance rate,clinical therapeutic effect and PTS prevention function,but the difference was not statistically significant.Moreover,PMT was associated with a reduced urokinase dosage,shortened hospitalisation duration and reduced incidence of complications,such as infections and small haemorrhages.These results indicate that PMT has substantial beneficial effects in the treatment of LEDVT.

Angiojet机械血栓清除治疗急性下肢深静脉血栓疗效分析

目的:探讨Angiojet机械血栓清除对急性下肢深静脉血栓(LEDVT)伴髂静脉受压综合征(IVCS)患者肢体肿胀及静脉通畅度的影响。方法:选取2020年7月—2022年8月LEDVT伴IVCS患者101例,按照随机数字表法分为对照组(50例)和观察组(51例)。对照组给予导管接触性溶栓(CDT)治疗,观察组在对照组基础上联合Angiojet机械血栓清除治疗。对比两组患者下肢肿胀程度、静脉通畅度、凝血功能及并发症情况。结果:两组术后大腿、小腿患健侧周径差水平较术前降低,且观察组低于对照组(P<0.05);观察组血栓清除率高于对照组(P<0.05);两组术后静脉通畅度评分水平较术前降低,且观察组低于对照组(P<0.05);两组术后D-二聚体(D-D)水平较术前升高,但观察组低于对照组(P<0.05);纤维蛋白原(FIB)水平较术前降低,且观察组高于对照组(P<0.05);两组并发症发生率比较,差异无统计学意义(P>0.05)。结论:Angiojet机械血栓清除可调节LEDVT伴IVCS患者下肢肿胀程度,改善凝血功能,调节静脉通畅度,安全性好,术后无复发。

Mechanism of ligustrazini against thrombosis

Objective To investigate the mechanism of Chinese medicine ligustrazini against thrombosis, and the effects of ligustrazini on plasminogen activator inhibitor (PAI 1) expression in normal endothelial cells and lipopolysaccharide (LPS) stimulated endothelial cells Methods Human umbilical vein endothelial cells (HUVECs) were cultured by trypsin digestion method PAI 1 protein in HUVEC conditioned medium was measured by Sandwich enzyme linked immunosorbent assay (ELISA), and PAI 1 mRNA expression was determined by Northern blot analysis Using electrophoretic mobility shift assay (EMSA), we observed HUVEC nuclear factor kappa B (NF κB) nuclear translocation Results LPS treatment of cultured HUVECs resulted in a significant increase in PAI 1 protein and mRNA expression by these cells However, when HUVECs were incubated with LPS plus ligustrazini, the upregulation of PAI 1 by LPS was abated Moreover, ligustrazini could decrease the basal level of PAI 1 protein and mRNA in HUVECs as compared with control Nuclear extracts prepared from HUVECs stimulated by LPS demonstrated that binding to the NF kB oligo nucleotide increased as compared with the unstimulated cells, but ligustrazini did not change those binding in the absence or presence of LPS Conclusions Ligustrazini inhibited both basal and LPS induced PAI 1 protein and mRNA expression in endothelial cells, and the modulation of PAI 1 in HUVECs by ligustrazini might have other mechanisms rather than NF kB pathway

三七总皂苷预防血栓的机制

三七总皂苷(PNSs)作为三七的有效提取成分,用于预防血栓历史悠久。PNSs下调炎性因子表达,促进血管内皮细胞生长,上调抗凝物质和舒张血管分子表达,调节内皮细胞功能;PNSs多靶点抑制血小板黏附、释放和聚集;PNSs通过调节组织型纤溶酶原激活物和抑制物动态平衡,维持纤维蛋白溶解系统活性;PNSs降低血液黏度,改善红细胞指标,多途径抑制血栓形成。

两种经皮机械血栓清除方式对急性下肢缺血的疗效与安全性研究

目的比较两种经皮机械血栓清除方式(Rotarex机械血栓切除和Angiojet机械血栓抽吸)对急性下肢缺血的临床疗效及安全性差异。方法回顾性选取2020年2月至2023年2月浙江省台州医院血管外科收治并行机械血栓清除治疗的急性下肢缺血患者98例,其中采用机械血栓切除术38例(Rotarex组),机械血栓抽吸术60例(Angiojet组)。收集两组患者基线资料,比较两组手术技术成功率等临床疗效指标、并发症情况等安全性评估指标。结果两组患者缺血原因、缺血程度、发病时间等基线资料比较差异均无统计学意义(均P>0.05)。Rotarex组患者手术技术成功率为100.00%,Angiojet组为98.33%。Rotarex组血栓清除后残存狭窄[(46.18±12.97)%比(54.25±14.67)%]、支架置入率(47.37%比73.33%)、踝肱指数改善值[(0.67±0.10)比(0.63±0.11)]、术后住院天数[5(3,6)d比7(5.5,8.5)d]均优于Angiojet组(均P<0.05)。两组患者缺血症状改善情况、30 d内截肢率、30 d内再次手术率比较差异均无统计学意义(均P>0.05)。与术前比较,Angiojet组患者术后WBC、中性粒细胞/淋巴细胞计数比值、CRP升高(均P<0.05),而Hb下降(P<0.05)。两组患者围术期肝肾功能、Fib、D-二聚体指标和并发症发生情况比较差异均无统计学意义(均P>0.05)。结论Rotarex机械血栓切除和Angiojet机械血栓抽吸这两种方式对急性下肢缺血均有良好的疗效及安全性,但Rotarex系统相对更具疗效优势,血栓清除效率更佳,且对内环境影响更小,安全性更高。

肺部手术后动静脉栓塞危险因素和临床转归研究进展

据2019年数据统计,全国手术量达到了6 930万人次,其中肺部手术作为外科手术中的重要组成部分,且手术量逐年递增。但伴随手术量增加,围手术期的并发症也逐渐增多,而血栓作为围术期并发症之一,给患者的预后带来了不良影响。因此,了解肺部围手术期血栓形成的病因、危险因素、机制等,同时在肺部围手术期采取有效预防措施,可以减少因肺部手术而导致的血栓所带来的不良影响。本文将对肺部术后血栓的发病率、危险因素、临床表现、治疗和预后等展开论述,期望为相关临床研究提供新的认识。

间歇充气加压泵预防脑卒中病人深静脉血栓的研究进展

从间歇充气加压泵用于脑卒中深静脉血栓预防的作用机制、临床应用与应用评价3个方面展开综述,总结现有研究存在的不足,为今后的研究指出方向,以期为脑卒中病人深静脉血栓的预防提供临床实践指导。

机械性血栓清除术与置管溶栓治疗急性下肢深静脉血栓的短中期疗效对比

目的 探讨机械性血栓清除术(PMT)与置管溶栓术(CDT)治疗急性下肢深静脉血栓(LEDVT)的短中期疗效。方法 收集2019年4月至2021年4月于合肥市第二人民医院就诊的85例急性LEDVT患者的临床资料,按照治疗方法的不同将其分为PMT组(n=37)和CDT组(n=48)。比较两组患者大腿周径差、小腿周径差、尿激酶使用量、溶栓时间,术后出血、血红蛋白尿及血栓形成后综合征(PTS)发生情况。结果 两组患者大腿周径差、小腿周径差比较,差异均无统计学意义(P>0.05)。PMT组患者溶栓时间明显短于CDT组患者,尿激酶使量明显小于CDT组患者,差异均有统计学意义(P<0.01)。两组患者血红蛋白尿、出血/皮下血肿发生率比较,差异均有统计意义(P<0.05)。PMT组患者血栓完全清除率、血栓大部分清除率均高于CDT组患者,差异均有统计学意义(P<0.05)。术后6个月,两组患者PTS程度比较,差异均无统计学意义(P>0.05)。术后12个月,PMT组患者无PTS、轻度PTS比例均小于CDT组患者,差异均有统计学意义(P<0.05)。结论 PMT与CDT血栓清除率相似,PMT在避免短中期发生PTS方面更有优势,PMT溶栓时间短,溶栓药物使用剂量小,缩短了患者的住院时间。

机械血栓清除系统联合导管接触性溶栓治疗急性髂股深静脉血栓形成的临床疗效

目的比较经皮机械血栓切除术(PMT)联合导管接触性溶栓(CDT)与单纯CDT治疗急性髂股深静脉血栓形成(DVT)的临床疗效。方法收集2017年10月至2021年9月郑州大学第五附属医院收治的123例急性髂股DVT患者的临床资料,按照手术方式的不同将患者分为联合组(n=59)和单纯CDT组(n=64)。观察两组患者的技术成功率。比较两组患者的临床疗效,尿激酶用量,治疗前后患侧与健侧膝下10 cm和膝上15 cm处周径差,溶栓时间,住院时间,术后一期靶血管通畅率,术后6、12个月血栓形成后综合征(PTS)发生率及围手术期并发症发生率。结果所有患者手术均取得成功,技术成功率为100%。治疗后,联合组患者的显效率高于单纯CDT组患者,差异有统计学意义(P﹤0.05);联合组患者的尿激酶用量明显少于单纯CDT组患者,差异有统计学意义(P﹤0.01);联合组患者膝下10 cm、膝上15 cm处患侧与健侧的周径差均低于单纯CDT组患者,差异均有统计学意义(P﹤0.05)。治疗后,联合组患者的溶栓时间、住院时间均明显短于单纯CDT组患者,差异均有统计学意义(P﹤0.01)。联合组患者的术后一期靶血管通畅率高于单纯CDT组患者,差异有统计学意义(P﹤0.05)。联合组患者术后6、12个月PTS发生率均低于单纯CDT组,差异均有统计学意义(P﹤0.05)。两组患者的围手术期并发症发生率比较,差异无统计学意义(P﹥0.05)。结论与单纯CDT治疗相比,经皮机械血栓切除术联合CDT治疗急性髂股DVT的临床疗效更好,术后一期靶血管通畅率更高,尿激酶使用量更少,患肢肿胀减退更好,溶栓时间、住院时间更短,术后PTS、围手术期并发症发生率更低。

急性脑梗死患者外周血炎性小体NLRP3表达及与颅内动脉血栓病理成分、预后的相关性分析

目的 探讨急性脑梗死(ACI)患者外周血炎性小体NOD样受体热蛋白结构域相关蛋白3(NLRP3)表达,并分析其与颅内动脉血栓病理成分、预后的相关性。方法 选取2022年1—12月收治的92例ACI作为观察组,另选取健康志愿者92例作为对照组,检测外周血NLRP3 mRNA、蛋白及血清水平。观察组行机械取栓治疗,采用HE染色法半定量分析血栓取出物,并分为红细胞富集血栓者、纤维蛋白富集血栓者。比较不同组别、不同血栓病理成分、不同预后患者外周血炎性小体NLRP3水平,分析其与血栓病理成分相关性及对预后不良风险的关系。结果 观察组NLRP3 mRNA、蛋白表达及血清水平高于对照组,红细胞富集血栓者高于纤维蛋白富集血栓者,且与红细胞富集血栓呈正相关(P<0.05,P<0.01);预后不良者NLRP3 mRNA、蛋白表达及血清水平高于预后良好者(P<0.01);NLRP3 mRNA、蛋白高表达及血清高水平患者预后不良风险分别是低表达、低水平患者的2.182、2.500、2.182倍(P<0.05)。结论 ACI患者外周血炎性小体NLRP3水平升高,且与颅内动脉红细胞富集血栓相关,可增加预后不良发生风险。

真实分岔静脉下多种血液流变模型的溶栓治疗差异数值研究

静脉血栓栓塞(VTE)是一种常见的心血管疾病,建立基于计算流体力学(CFD)的数值模型是开展血栓治疗研究的重要手段.然而,血液的流变模型众多,多种血液流变模型之间存在显著的差异.目前,针对不同血液流变模型间的差异表现尚未得到充分研究.本研究提出一种生物流体力学模型以用于静脉血栓治疗数值研究,研究考虑静脉血流、血管结构以及药物传质间的作用耦合,并将血液视为不同流变特性的7种流体、静脉瓣膜视为超弹性固体、血栓块视为多孔材料.针对患者理想化和特异性的血管模型进行数值模拟,综合分析静脉血栓的溶栓治疗数值结果.结果表明,患者特异性血管模型更接近实际血管情况,其受分岔、弯曲等局部特征的影响,流速变化明显、涡流强度和Pe较高、瓣膜位移值较大.同时,不同血液流变学模型的研究结果不同.在患者特异性模型下,牛顿模型的血液黏度较小,流速和Pe较大,物质传质更快,溶栓表现较优;非牛顿模型中Bingham流体表现差异最显著,其血液黏度值较高,Pe较小,溶栓表现较差.本研究提倡采用患者实际血管模型、考虑血液实际流变特性进行静脉血栓数值研究,以推动血栓治疗领域的数字医疗、智慧医疗技术进步.

彩色多普勒超声在急性下肢深静脉血栓机械性清除治疗中的临床价值

目的 探讨彩色多普勒超声在急性下肢深静脉血栓(DVT)经皮机械性血栓清除(PMT)治疗中的临床价值。方法 选取我院收治的急性DVT患者132例,分为超声引导PMT治疗者82例(超声组)和静脉造影监测PMT治疗者50例(造影组),均行下腔静脉滤器置入、PMT联合导管直接溶栓治疗,比较两组术后静脉通畅情况、患肢周径差、血生化指标、手术时间、并发症发生情况及疗效。结果 超声组、造影组术后静脉通畅率分别为(82.03±12.51)%、(77.67±14.36)%,两组比较差异无统计学意义。超声组平均手术时间少于造影组[(1.08±0.32)h vs.(2.36±0.25)h],术后血红蛋白含量高于造影组[(125.66±15.48)g/L vs.(91.53±11.73)g/L],并发症发生率低于造影组(12.2%vs. 26.0%),差异均有统计学意义(均P<0.05);两组患肢周径差、手术前后D-二聚体浓度、术前血红蛋白含量、Villalta评分及流行病学和经济研究-生活质量评分比较差异均无统计学意义。结论 彩色多普勒超声在引导急性DVT患者PMT治疗中具有安全、有效、手术时间短、并发症少等优势,在术后可准确评估其疗效,具有重要的临床价值。

早期减容对左髂静脉压迫综合征伴急性髂静脉血栓的治疗效果

目的 探讨早期机械性血栓抽吸减容对左髂静脉压迫综合征伴急性髂静脉血栓的治疗效果。方法 收集2018年10月至2022年10月青岛市市立医院收治的58例左髂静脉压迫综合征伴急性髂静脉血栓患者的临床资料,根据治疗方法的不同将患者分为观察组[n=28,直接行经皮机械性血栓清除术(PMT)进行减容,开通髂静脉后再放置髂静脉支架]和对照组(n=30,Ⅰ期仅放置溶栓导管进行溶栓,Ⅱ期行PMT后放置髂静脉支架)。比较两组患者的治疗情况,包括溶栓时间、尿激酶总量、血栓清除率、溶栓并发症发生情况,以及术后6个月的患肢周径变化率、血栓后综合征(PTS)评分、髂静脉通畅率。结果 58例患者均成功开通狭窄髂静脉。观察组患者的溶栓时间明显短于对照组患者,尿激酶总量、溶栓并发症发生率均明显少于对照组患者,患肢周径变化率明显高于对照组患者,差异均有统计学意义(P<0.01);两组患者的血栓清除等级、术后6个月PTS评分、术后6个月髂静脉通畅率比较,差异均无统计学意义(P>0.05)。两组患者治疗后均未出现严重并发症。结论 在左髂静脉压迫综合征伴急性髂静脉血栓的治疗过程中,早期机械性血栓抽吸减容能够减少溶栓时间与溶栓剂量,减少溶栓并发症的发生,提高肢体周径变化率,快速缓解临床症状,但在远期通畅率方面,二者并无差别。

AngioJet机械血栓清除术对急性下肢深静脉血栓形成患者的应用效果

目的探究AngioJet机械血栓清除术在急性下肢深静脉血栓形成(DVT)患者治疗中的应用效果。方法选取2019年12月至2022年12月南阳市第一人民医院收治的76例急性下肢DVT患者,采用随机数字表法分为观察组和对照组,各38例。观察组接受AngioJet机械血栓清除术治疗,对照组接受经皮人工血栓抽吸(MAT)术治疗。比较两组血栓清除率、手术相关指标、患健肢周径差、凝血纤溶指标[纤维蛋白原(FIB)、D-二聚体(D-D)]及术后并发症情况。结果观察组血栓清除率高于对照组,置管取栓时间短于对照组(P<0.05);术后3、7 d观察组患健侧大腿与小腿周径差小于对照组(P<0.05);术后3、7 d两组纤维蛋白原、D-二聚体水平比较,差异无统计学意义(P>0.05);两组术后并发症总发生率比较,差异无统计学意义(P>0.05)。结论AngioJet机械血栓清除术与MAT术治疗急性下肢DVT均能改善患者凝血功能,且具有良好的安全性,但前者在血栓清除率与置管取栓时间上更具优势,也更有利于减轻患侧下肢水肿症状。

经皮机械性血栓清除术治疗急性下肢深静脉血栓合并髂静脉压迫综合征的临床疗效观察

目的探讨经皮机械性血栓清除术治疗急性下肢深静脉血栓(DVT)合并髂静脉压迫综合征的疗效及预后。方法收集2019年1月至2020年8月昆山市第一人民医院收治的62例急性下肢DVT合并髂静脉压迫综合征患者的临床资料,按照治疗方案的不同分为治疗组(在下腔静脉滤器保护下行经皮机械性血栓清除术+CDT治疗,同期行髂静脉狭窄腔内球囊扩张成形及支架置入术)和对照组(在下腔静脉滤器保护下行CDT治疗,同期行髂静脉狭窄腔内球囊扩张成形及支架置入术),每组31例。比较两组患者的尿激酶用量、溶栓时间、住院时间、溶栓管造影次数、血栓清除率、消肿程度、静脉临床严重程度评分法(VCSS)评分及血栓后综合征(PTS)发生率。结果治疗组患者的尿激酶用量明显低于对照组患者,血栓清除率明显高于对照组患者,溶栓时间、住院时间均明显短于对照组患者,溶栓管造影次数明显少于对照组患者,差异均有统计学意义(P﹤0.01)。治疗后,治疗组患者的大腿周径差、小腿周径差均小于对照组患者,差异均有统计学意义(P﹤0.05)。治疗后6个月,治疗组患者的VCSS评分和Villata评分﹥4分的患者比例均低于对照组患者,差异均有统计学意义(P﹤0.05)。结论经皮机械性血栓清除术+CDT治疗+腔内球囊扩张成形及支架置入术治疗急性下肢DVT合并髂静脉压迫综合征的疗效显著,患者预后较好。