By means of Lagrange duality of Hill's maximum plastic work principle theory of the convex program, a dual problem under Mises' yield condition has been derived and whereby a non-differentiable convex optimization m...By means of Lagrange duality of Hill's maximum plastic work principle theory of the convex program, a dual problem under Mises' yield condition has been derived and whereby a non-differentiable convex optimization model for the limit analysis is developed. With this model, it is not necessary to linearize the yield condition and its discrete form becomes a minimization problem of the sum of Euclidean norms subject to linear constraints. Aimed at resolving the non-differentiability of Euclidean norms, a smoothing algorithm for the limit analysis of perfect-plastic continuum media is proposed. Its efficiency is demonstrated by computing the limit load factor and the collapse state for some plane stress and plain strain problems.展开更多
This paper describes an incompatible finite element model satisfying the consistency condition of energy to solve the numerical precision problem of finite element solution in perfectly plastic analysis. In this paper...This paper describes an incompatible finite element model satisfying the consistency condition of energy to solve the numerical precision problem of finite element solution in perfectly plastic analysis. In this paper the reason and criterion of the application of the model to plastic limit analysis are discussed, and an algorithm of computing plastic limit load is given.展开更多
Mesenchymal stem cell differentiation towards osteogenic, chondrogenic and adipogenic lineages have been extensively described and reproduced in the literature. In contrast, cardiomyogenic differentiation still remain...Mesenchymal stem cell differentiation towards osteogenic, chondrogenic and adipogenic lineages have been extensively described and reproduced in the literature. In contrast, cardiomyogenic differentiation still remains largely controversial. In this study the authors aim to shed new light into this unclear phenomenon and test whether BMMSC (bone marrow mesenchymal stem cells) and ATMSC (adipose tissue derived mesenchymal stem cells) are able to differentiate into functional cardiomyocytes, investigating two differentiation protocols. AT and BMMSC behaved differently when cultured in differentiation media and presented lower levels of proliferation and alkaline phosphatase production, expression of cardiomyocyte-specific transcription factors such as GATA-4, Nkx2-5 and proteins such as ct and 13 Myosin Heavy Chains. Furthermore, MSC started to express higher levels of Connexin-43 and c~ sarcomeric actinin protein. Unfortunately, though, MSC did not present cardiomyocyte-like electrophysiological properties. In order to analyze a possible explanation for such limited plasticity, the authors decided to address the issue using a quantitative approach. Gene expression was quantified by Real time PCR, and, for the first time, the authors show that a possible explanation for limited plasticity of MSC is that even though differentiated cells presented differential gene expression, the levels of key cardiomyogenic genes did not reach expression levels presented by adult cardiomyocytes, nor were maintained along differentiation, reaching peaks at 4 days of stimulation, and decaying thereafter.展开更多
Discontinuous lining is a special form of support in underground excavation. Based on the method of plastic limit analysis, it is found the upper and the lower bound solution of the pressure of circular discontinuous ...Discontinuous lining is a special form of support in underground excavation. Based on the method of plastic limit analysis, it is found the upper and the lower bound solution of the pressure of circular discontinuous lining and discussed support parameter of discontinuous lining and its applicable conditions , which provides theoretical basis for the design and calculation of discontinuous lining.展开更多
According to the lower-bound theorem of limit analysis the Rigid Finite Element Meth-od(RFEM)is applied to structural limit analysis and the linear programmings for limit analysis are deducedin this paper.Moreover,the...According to the lower-bound theorem of limit analysis the Rigid Finite Element Meth-od(RFEM)is applied to structural limit analysis and the linear programmings for limit analysis are deducedin this paper.Moreover,the Thermo-Parameter Method(TPM)and Parametric Variational principles(PVP)are used to reduce the computational effort while maintaining the accuracy of solutions.A better solution isalso obtained in this paper.展开更多
Through laboratory test, the relationships among change of compactibility, liquid/plastic limit, free swell, swell ratio without load, california bearing ratio (CBR) and soakage (after being soaked in water), and mix-...Through laboratory test, the relationships among change of compactibility, liquid/plastic limit, free swell, swell ratio without load, california bearing ratio (CBR) and soakage (after being soaked in water), and mix-ratio of quick lime and time were studied. The results show that optimum water content, plastic limit and CBR of high liquid limit clay improved by quick lime increase with the increase of mix-ratio of quick lime, while the maximum dry density, liquid limit, plasticity index, soakage (after being immersed in water), free swell, and swell ratio without load decrease with the increase of mix-ratio of quick lime. Plastic limit of high liquid clay improved by quick lime gradually increases with time, while the liquid limit, plasticity index, free swell and swell ratio without load gradually decrease with time. When the mix-ratio of quick lime exceeds 2%, after 14 d, swell ratio without load of the improved clay is zero, its free swell is about 30% of that of untreated soil, and its plasticity index is less than 26 for sub-grade material, satisfying the requirement by 'Specifications for Design of Highway Subgrade'.展开更多
According to the Mohr-Coulomb yield criterion, the stress field of the infinite slope is derived under a vertical uniform load q on the top of the slope. It is indicated that elastic and elasto-plastic states would oc...According to the Mohr-Coulomb yield criterion, the stress field of the infinite slope is derived under a vertical uniform load q on the top of the slope. It is indicated that elastic and elasto-plastic states would occur in the slope. When q is smaller than the critical load, q(p), the slope is in the elastic state. If q equals q(p), the slope is in the critical state, and the plastic deformation would occur along the critical angle. With the increase of q, the plastic zone would extend, and the slope is in the elasto-plastic State. If q equals limit load, the slope is in the limit equilibrium state. The slope may be divided into three zones. Some charts of the critical angle, the critical and limit load coefficients are presented in this paper.展开更多
基金Project supported by the National Natural Science Foundation of China (Nos.10572031, 10332010)
文摘By means of Lagrange duality of Hill's maximum plastic work principle theory of the convex program, a dual problem under Mises' yield condition has been derived and whereby a non-differentiable convex optimization model for the limit analysis is developed. With this model, it is not necessary to linearize the yield condition and its discrete form becomes a minimization problem of the sum of Euclidean norms subject to linear constraints. Aimed at resolving the non-differentiability of Euclidean norms, a smoothing algorithm for the limit analysis of perfect-plastic continuum media is proposed. Its efficiency is demonstrated by computing the limit load factor and the collapse state for some plane stress and plain strain problems.
文摘This paper describes an incompatible finite element model satisfying the consistency condition of energy to solve the numerical precision problem of finite element solution in perfectly plastic analysis. In this paper the reason and criterion of the application of the model to plastic limit analysis are discussed, and an algorithm of computing plastic limit load is given.
文摘Mesenchymal stem cell differentiation towards osteogenic, chondrogenic and adipogenic lineages have been extensively described and reproduced in the literature. In contrast, cardiomyogenic differentiation still remains largely controversial. In this study the authors aim to shed new light into this unclear phenomenon and test whether BMMSC (bone marrow mesenchymal stem cells) and ATMSC (adipose tissue derived mesenchymal stem cells) are able to differentiate into functional cardiomyocytes, investigating two differentiation protocols. AT and BMMSC behaved differently when cultured in differentiation media and presented lower levels of proliferation and alkaline phosphatase production, expression of cardiomyocyte-specific transcription factors such as GATA-4, Nkx2-5 and proteins such as ct and 13 Myosin Heavy Chains. Furthermore, MSC started to express higher levels of Connexin-43 and c~ sarcomeric actinin protein. Unfortunately, though, MSC did not present cardiomyocyte-like electrophysiological properties. In order to analyze a possible explanation for such limited plasticity, the authors decided to address the issue using a quantitative approach. Gene expression was quantified by Real time PCR, and, for the first time, the authors show that a possible explanation for limited plasticity of MSC is that even though differentiated cells presented differential gene expression, the levels of key cardiomyogenic genes did not reach expression levels presented by adult cardiomyocytes, nor were maintained along differentiation, reaching peaks at 4 days of stimulation, and decaying thereafter.
文摘Discontinuous lining is a special form of support in underground excavation. Based on the method of plastic limit analysis, it is found the upper and the lower bound solution of the pressure of circular discontinuous lining and discussed support parameter of discontinuous lining and its applicable conditions , which provides theoretical basis for the design and calculation of discontinuous lining.
基金The project supported by National Natural Science Foundation of China
文摘According to the lower-bound theorem of limit analysis the Rigid Finite Element Meth-od(RFEM)is applied to structural limit analysis and the linear programmings for limit analysis are deducedin this paper.Moreover,the Thermo-Parameter Method(TPM)and Parametric Variational principles(PVP)are used to reduce the computational effort while maintaining the accuracy of solutions.A better solution isalso obtained in this paper.
文摘Through laboratory test, the relationships among change of compactibility, liquid/plastic limit, free swell, swell ratio without load, california bearing ratio (CBR) and soakage (after being soaked in water), and mix-ratio of quick lime and time were studied. The results show that optimum water content, plastic limit and CBR of high liquid limit clay improved by quick lime increase with the increase of mix-ratio of quick lime, while the maximum dry density, liquid limit, plasticity index, soakage (after being immersed in water), free swell, and swell ratio without load decrease with the increase of mix-ratio of quick lime. Plastic limit of high liquid clay improved by quick lime gradually increases with time, while the liquid limit, plasticity index, free swell and swell ratio without load gradually decrease with time. When the mix-ratio of quick lime exceeds 2%, after 14 d, swell ratio without load of the improved clay is zero, its free swell is about 30% of that of untreated soil, and its plasticity index is less than 26 for sub-grade material, satisfying the requirement by 'Specifications for Design of Highway Subgrade'.
文摘According to the Mohr-Coulomb yield criterion, the stress field of the infinite slope is derived under a vertical uniform load q on the top of the slope. It is indicated that elastic and elasto-plastic states would occur in the slope. When q is smaller than the critical load, q(p), the slope is in the elastic state. If q equals q(p), the slope is in the critical state, and the plastic deformation would occur along the critical angle. With the increase of q, the plastic zone would extend, and the slope is in the elasto-plastic State. If q equals limit load, the slope is in the limit equilibrium state. The slope may be divided into three zones. Some charts of the critical angle, the critical and limit load coefficients are presented in this paper.