An OTA-C filter for ECG acquisition systems with highly linear range and less passband attenuation

A fifth order operational transconductance amplifier-C （OTA-C） Butterworth type low-pass filter with highly linear range and less passband attenuation is presented for wearable bio-telemetry monitoring applications in a UWB wireless body area network. The source degeneration structure applied in typical small transconduc- tance circuit is improved to provide a highly linear range for the OTA-C filter. Moreover, to reduce the passband attenuation of the filter, a cascode structure is employed as the output stage of the OTA. The OTA-based circuit is operated in weak inversion due to strict power limitation in the biomedical chip. The filter is fabricated in a SMIC 0.18-μm CMOS process. The measured results for the filter have shown a passband gain of -6.2 dB, while the -3-dB frequency is around 276 Hz. For the 0.8 Vpp sinusoidal input at 100 Hz, a total harmonic distortion （THD） of-56.8 dB is obtained. An electrocardiogram signal with noise interference is fed into this chip to validate the function of the designed filter.

A NEW SOLVENT POLYMERIC MEMBRANE pH SENSOR WITH WIDE LINEAR pH RANGE

A new solvent polymeric membrane (SPM)pH2sensor based on 4,4'-bis (N, N-didecylamino)methyl)azobenzene as neutral carricr has been reported. It has excellent pH response characteristics with the linear response range (1.7—13.2)much wider than that of similar SPM pH sensors reported so far. The sensor has a theoretical Nernstian response of 57.4+0.2V/pH(at 20℃)without super—Nernstian response phenomenon.

An Enzyme Electrode Based on the Covalently Binding of Horseradish Peroxidase to a Self-assembling Monolayer Modified Gold Electrode

A new procedure for developing high performance enzyme electrode is described. The procedure is based on the covalently binding of horseradish peroxidase to a self-assembling monolayer on a gold electrode. An enhanced catalytic current is observed with addition of hydrogen peroxide into phosphate buffer solution (PBS) in the presence of mediators. The electrode exhibits high sensitivity and a wide linear range to hydrogen peroxide.

Recent research process on perovskite photodetectors:A review for photodetector——materials,physics,and applications

The perovskite photodetectors can be used for image sensing, environmental monitoring, optical communication, and chemical/biological detection. In the recent five years, the perovskite photoelectric detectors with various devices are welldesigned and have made unprecedented progress of light detection. It is necessary to emphasize the most interesting works and summarize them to provide researchers with systematic information. In this review, we report the recent progress in perovskite photodetectors, including highly sensitive, ultrafast response speed, high gain, low noise, flexibility, and narrowband, concentrating on the photodetection performance of versatile halide perovskites(organic–inorganic hybrid and all inorganic compositions). Currently, organic–inorganic hybrid and all-inorganic halide microcrystals with polycrystalline film, nanoparticle/wire/chip, and block monocrystalline morphology control show important performance in response rate,decomposition rate, noise equivalent power, linear dynamic range, and response speed. It is expected that a comprehensive compendium of the research status of perovskite photodetectors will contribute to the development of this area.

A high sensitive 66 dB linear dynamic range receiver for 3-D laser radar

This study presents a CMOS receiver chip realized in 0.18μm standard CMOS technology and in- tended for high precision 3-D laser radar. The chip includes an adjustable gain transimpedance pre-amplifier, a post-amplifier and two timing comparators. An additional feedback is employed in the regulated cascode tran- simpedance amplifier to decrease the input impedance, and a variable gain transimpedance amplifier controlled by digital switches and analog multiplexer is utilized to realize four gain modes, extending the input dynamic range. The measurement shows that the highest transimpedance of the channel is 50 kΩ, the uncompensated walk error is 1.44 ns in a wide linear dynamic range of 66 dB （1 ： 2000）, and the input referred noise current is 2.3 pA/√ （rms）, resulting in a very low detectable input current of 1μA with SNR = 5.

A ratiometric fluorescent probe based on carbon dots assembly for intracellular lysosomal polarity imaging with wide range response

Lysosomal polarity is considered a key indicator of lysosomal function due to its significant impact on membrane fluidity and enzymatic reactions in lysosomes. Monitoring lysosomal polarity can gain insight into the related physiological and pathological processes and develop new diagnostic methods. However, current fluorescent probes with lysosomal polarity response suffer from narrow linear range, photobleaching and complicated preparation. Herein, a ratiometric fluorescent probe(r-b CDs) for intracellular lysosomal polarity imaging is designed and constructed by amide bond assembly of polarity-sensitive red fluorescent carbon dots(r CDs) and referenced blue fluorescent carbon dots(b CDs). r-b CDs show a much wider linear range of polarity response(orientation polarizability Δf from 0.020 to 0.315) than other probes, and the interference of uneven distribution and instrument factors can be effectively eliminated by ratiometric fluorescent sensing. Imaging of intracellular lysosomal polarity with r-b CDs is implemented to observe the polarity variation caused by the change of cell state and the difference between cancer cells and normal cells. This work provides a promising tool for studying the related physiological and pathological processes and developing new diagnostic methods.