PTW Detector7293种剂量验证方法在调强放射治疗中的对比研究

目的 :对比PTW Detector729 3种验证方法在调强放射治疗(intensity modulated radiation therapy,IMRT)剂量验证中的差异。方法:回顾性选取2022年1—12月于某院完成放射治疗的鼻咽癌、肺癌、乳腺癌、宫颈癌和全脑放射治疗患者共50例,使用PTW Detector729二维电离室矩阵配合PTW RW3固体水与PTW Ocavius 4D旋转模体对50例患者的IMRT计划分别进行归零机架角2D剂量验证、实际机架角2D剂量验证和实际机架角3D剂量验证。将剂量评估阈值设为10%,统计3种验证方法在3%/1 mm、2%/2 mm、3%/2 mm和3%/3 mm 4种评估标准下的γ通过率。采用SPSS 22.0统计学软件进行数据分析。结果:在10%剂量评估阈值标准下,归零机架角2D剂量验证的γ通过率最高,差异有统计学意义(P<0.05);实际机架角2D剂量验证的γ通过率高于实际机架角3D剂量验证,差异有统计学意义(P<0.05)。3种验证方法的γ通过率在3%/1 mm、2%/2 mm、3%/2 mm和3%/3 mm 4种标准下逐渐升高,且在3%/2 mm标准下均超过90%,结果满足临床放射治疗要求。结论:3种验证方法的验证结果均能达到IMRT剂量验证实践指南要求,根据IMRT开展情况选择合适的验证方法,对确保治疗方案安全、有效实施具有重要意义。

Low-noise and low-power pixel sensor chip for gas pixel detectors

Topmetal-M2 is a large-area pixel sensor chip fabricated using the GSMC 130 nm CMOS process in 2021.The pixel array of Topmetal-M2 consists of pixels of 400 rows×512 columns with a pixel pitch of 45μm×45μm.The array is divided into 16 subarrays,with pixels of 400 rows×32 columns per subarray.Each pixel incorporates two charge sensors:a diode sensor and a Topmetal sensor.The in-pixel circuit primarily consists of a charge-sensitive amplifier for energy measurements,a discriminator with a peak-holding circuit,and a time-to-amplitude converter for time-of-arrival measurements.The pixel of Topmetal-M2 has a charge input range of~0-3 k e-,a voltage output range of~0-180 mV,and a charge-voltage conversion gain of~59.56μV∕e-.The average equivalent noise charge of Topmetal-M2,which includes the readout electronic system noise,is~43.45 e-.In the scanning mode,the time resolution of Topmetal-M2 is 1 LSB=1.25μs,and the precision is^()7.41μs.At an operating voltage of 1.5 V,Topmetal-M2 has a power consumption of~49 mW∕cm~2.In this article,we provide a comprehensive overview of the chip architecture,pixel working principles,and functional behavior of Topmetal-M2.Furthermore,we present the results of preliminary tests conducted on Topmetal-M2,namely,alpha-particle and soft X-ray tests.

CVTD: A Robust Car-Mounted Video Text Detector

Text perception is crucial for understanding the semantics of outdoor scenes,making it a key requirement for building intelligent systems for driver assistance or autonomous driving.Text information in car-mounted videos can assist drivers in making decisions.However,Car-mounted video text images pose challenges such as complex backgrounds,small fonts,and the need for real-time detection.We proposed a robust Car-mounted Video Text Detector(CVTD).It is a lightweight text detection model based on ResNet18 for feature extraction,capable of detecting text in arbitrary shapes.Our model efficiently extracted global text positions through the Coordinate Attention Threshold Activation(CATA)and enhanced the representation capability through stacking two Feature Pyramid Enhancement Fusion Modules(FPEFM),strengthening feature representation,and integrating text local features and global position information,reinforcing the representation capability of the CVTD model.The enhanced feature maps,when acted upon by Text Activation Maps(TAM),effectively distinguished text foreground from non-text regions.Additionally,we collected and annotated a dataset containing 2200 images of Car-mounted Video Text(CVT)under various road conditions for training and evaluating our model’s performance.We further tested our model on four other challenging public natural scene text detection benchmark datasets,demonstrating its strong generalization ability and real-time detection speed.This model holds potential for practical applications in real-world scenarios.

Design and performance evaluation of a large field-of-view dual-particle time-encoded imager based on a depth-of-interaction detector

Time-encoded imaging is useful for identifying potential special nuclear materials and other radioactive sources at a distance.In this study,a large field-of-view time-encoded imager was developed for gamma-ray and neutron source hotspot imaging based on a depth-of-interaction(DOI)detector.The imager primarily consists of a DOI detector system and a rotary dual-layer cylindrical coded mask.An EJ276 plastic scintillator coupled with two SiPMs was designed as the DOI detector to increase the field of view and improve the imager performance.The difference in signal time at both ends and the log of the signal amplitude ratio were used to calculate the interaction position resolution.The position resolution of the DOI detector was calibrated using a collimated Cs-137 source,and the full width at half maximum of the reconstruction position of the Gaussian fitting curve was approximately 4.4 cm.The DOI detector can be arbitrarily divided into several units to independently reconstruct the source distribution images.The unit length was optimized via Am-Be source-location experiments.A multidetector filtering method is proposed for image denoising.This method can effectively reduce image noise caused by poor DOI detector position resolution.The vertical field of view of the imager was(-55°,55°)when the detector was placed in the center of the coded mask.A DT neutron source at 20 m standoff could be located within 2400 s with an angular resolution of 3.5°.

Self-powered UVC detectors based on α-Ga_(2)O_(3) with enchanted speed performance

Detectors were developed for detecting irradiation in the short-wavelength ultraviolet(UVC)interval using high-quality single-crystallineα-Ga_(2)O_(3) films with Pt interdigital contacts.The films ofα-Ga_(2)O_(3) were grown on planar sapphire substrates with c-plane orientation using halide vapor phase epitaxy.The spectral dependencies of the photo to dark current ratio,responsivity,external quantum efficiency and detectivity of the structures were investigated in the wavelength interval of 200−370 nm.The maximum of photo to dark current ratio,responsivity,external quantum efficiency,and detectivity of the structures were 1.16×10^(4) arb.un.,30.6 A/W,1.65×10^(4)%,and 6.95×10^(15) Hz^(0.5)·cm/W at a wavelength of 230 nm and an applied voltage of 1 V.The high values of photoelectric properties were due to the internal enhancement of the photoresponse associated with strong hole trapping.Theα-Ga_(2)O_(3) film-based UVC detectors can function in self-powered operation mode due to the built-in electric field at the Pt/α-Ga_(2)O_(3) interfaces.At a wavelength of 254 nm and zero applied voltage,the structures exhibit a responsivity of 0.13 mA/W and an external quantum efficiency of 6.2×10−2%.The UVC detectors based on theα-Ga_(2)O_(3) films demonstrate high-speed performance with a rise time of 18 ms in self-powered mode.

Probability-Enhanced Anchor-Free Detector for Remote-Sensing Object Detection

Anchor-free object-detection methods achieve a significant advancement in field of computer vision,particularly in the realm of real-time inferences.However,in remote sensing object detection,anchor-free methods often lack of capability in separating the foreground and background.This paper proposes an anchor-free method named probability-enhanced anchor-free detector(ProEnDet)for remote sensing object detection.First,a weighted bidirectional feature pyramid is used for feature extraction.Second,we introduce probability enhancement to strengthen the classification of the object’s foreground and background.The detector uses the logarithm likelihood as the final score to improve the classification of the foreground and background of the object.ProEnDet is verified using the DIOR and NWPU-VHR-10 datasets.The experiment achieved mean average precisions of 61.4 and 69.0 on the DIOR dataset and NWPU-VHR-10 dataset,respectively.ProEnDet achieves a speed of 32.4 FPS on the DIOR dataset,which satisfies the real-time requirements for remote-sensing object detection.

Effect of multiple coulomb scattering on the beam tests of silicon pixel detectors

In the research and development of new silicon pixel detectors,a collimated monoenergetic charged-particle test beam equipped with a high-resolution pixel-beam telescope is crucial for prototype verification and performance evaluation.When the beam energy is low,the effect of multiple Coulomb scattering on the measured resolution of the Device Under Test(DUT)must be considered to accurately evaluate the performance of the pixel chips and detectors.This study aimed to investigate the effect of multiple Coulomb scattering on the measured resolution,particularly at low beam energies.Simulations were conducted using Allpix^(2) to study the effects of multiple Coulomb scattering under different beam energies,material budgets,and telescope layouts.The simulations also provided the minimum energy at which the effect of multiple Coulomb scattering could be ignored.Compared with the results of a five-layer detector system tested with an electron beam at DESY,the simulation results were consistent with the beam test results,confirming the reliability of the simulations.

Study on the Performance of the GRANDProto300 Particle Detector Array by Simulation

The Giant Radio Array for Neutrino Detection(GRAND)is a proposed large-scale observatory designed to detect cosmic rays,gamma-rays,and neutrinos with energies exceeding 100 Pe V.The GRANDProto300 experiment is proposed as the early stage of the GRAND project,consisting of a hybrid array of radio antennas and scintillator detectors.The latter,as a mature and traditional detector,is used to cross-check the nature of the candidate events selected from radio observations.In this study,we developed a simulation software called G4GRANDProto300,based on the Geant4 software package,to optimize the spacing of the scintillator detector array and to investigate its effective area.The analysis was conducted at various zenith angles under different detector spacings,including 300,500,600,700,and 900 m.Our results indicate that,for large zenith angles used to search for cosmic-ray in the GRAND project,the optimized effective area is with a detector spacing of 500 m.The G4GRANDProto300 software that we developed could be used to further optimize the layout of the particle detector array in future work.

Metal-Halide Perovskite Submicrometer-Thick Films for Ultra-Stable Self-Powered Direct X-Ray Detectors

Metal-halide perovskites are revolutionizing the world of X-ray detectors,due to the development of sensitive,fast,and cost-effective devices.Self-powered operation,ensuring portability and low power consumption,has also been recently demonstrated in both bulk materials and thin films.However,the signal stability and repeatability under continuous X-ray exposure has only been tested up to a few hours,often reporting degradation of the detection performance.Here it is shown that self-powered direct X-ray detectors,fabricated starting from a FAPbBr_(3)submicrometer-thick film deposition onto a mesoporous TiO_(2)scaffold,can withstand a 26-day uninterrupted X-ray exposure with negligible signal loss,demonstrating ultra-high operational stability and excellent repeatability.No structural modification is observed after irradiation with a total ionizing dose of almost 200 Gy,revealing an unexpectedly high radiation hardness for a metal-halide perovskite thin film.In addition,trap-assisted photoconductive gain enabled the device to achieve a record bulk sensitivity of 7.28 C Gy^(−1)cm^(−3)at 0 V,an unprecedented value in the field of thin-film-based photoconductors and photodiodes for“hard”X-rays.Finally,prototypal validation under the X-ray beam produced by a medical linear accelerator for cancer treatment is also introduced.

Countermeasure against blinding attack for single-photon detectors in quantum key distribution

Quantum key distribution(QKD),rooted in quantum mechanics,offers information-theoretic security.However,practi-cal systems open security threats due to imperfections,notably bright-light blinding attacks targeting single-photon detectors.Here,we propose a concise,robust defense strategy for protecting single-photon detectors in QKD systems against blinding attacks.Our strategy uses a dual approach:detecting the bias current of the avalanche photodiode(APD)to defend against con-tinuous-wave blinding attacks,and monitoring the avalanche amplitude to protect against pulsed blinding attacks.By integrat-ing these two branches,the proposed solution effectively identifies and mitigates a wide range of bright light injection attempts,significantly enhancing the resilience of QKD systems against various bright-light blinding attacks.This method forti-fies the safeguards of quantum communications and offers a crucial contribution to the field of quantum information security.

High-speed performance self-powered short wave ultraviolet radiation detectors based onκ(ε)-Ga_(2)O_(3)

High-speed solar-blind short wavelength ultraviolet radiation detectors based onκ(ε)-Ga_(2)O_(3)layers with Pt contacts were demonstrated and their properties were studied in detail.Theκ(ε)-Ga_(2)O_(3)layers were deposited by the halide vapor phase epitaxy on patterned GaN templates with sapphire substrates.The spectral dependencies of the photoelectric properties of struc-tures were analyzed in the wavelength interval 200-370 nm.The maximum photo to dark current ratio,responsivity,detectiv-ity and external quantum efficiency of structures were determined as:180.86 arb.un.,3.57 A/W,1.78×10^(12) Hz^(0.5)∙cm·W^(-1) and 2193.6%,respectively,at a wavelength of 200 nm and an applied voltage of 1 V.The enhancement of the photoresponse was caused by the decrease in the Schottky barrier at the Pt/κ(ε)-Ga_(2)O_(3)interface under ultraviolet exposure.The detectors demon-strated could functionalize in self-powered mode due to built-in electric field at the Pt/κ(ε)-Ga_(2)O_(3)interface.The responsivity and external quantum efficiency of the structures at a wavelength of 254 nm and zero applied voltage were 0.9 mA/W and 0.46%,respectively.The rise and decay times in self-powered mode did not exceed 100 ms.

基于InVEST和Geodetector模型的合肥生境质量时空演变及影响因素分析

依据2000年、2010年和2020年3期土地利用数据,运用耦合模型探究合肥2000—2020年间生境质量时空变化特征并对影响因子进行分析。结果表明:2000—2020年合肥生境质量指数平均值分别为0.185、0.181、0.178,呈逐年下降趋势,较低质量区域向低质量区域的转移面积最大。合肥生境质量退化度在2000—2020年逐年下降,呈现出“环状增长”的空间分布特征。高退化度区域主要分布在低值区域外围,呈现非连续性扩张。区域生产总值、坡度以及高程是主要影响因子,双因子增强效应显著,年末总人口和人口密度为主导单因子。

Determination of Benzo[a]pyrene in Edible Oil by High Performance Liquid Chromatography-Fluorescence Detector (HPLC-FL)

In this study, an optimized high performance liquid chromatography-fluorescence detector (HPLC-FL) method for the determination of benzo[a]pyrene in edible oil was established. HPLC was performed with Thermo Fisher Scientific C18 column (250 mm×4.6 mm, 5 μm) as the chromatographic column and acetonitrile and water as the mobile phase, and the excitation wavelength and emission wavelength of fluorescence detector were 286 and 430 nm, respectively. The response was high, and the linear range was 0.5-10.0 ng/ml. The lowest limit of detection was 0.11 ng/ml, and the average recovery was 92.5%. This method is suitable for quantitative analysis of benzo[a]pyrene content in edible oil.

基于InVEST&GEO-detectors模型的会仙湿地生境质量变化及影响因素研究

喀斯特湿地是广泛分布在喀斯特地区的一种特殊的湿地类型,其生态地位举足轻重,探索喀斯特湿地生境质量变化的影响因素对喀斯特地区生态建设具有重要的意义。本文基于会仙湿地保护区2000和2020年的土地利用数据,通过InVEST模型评估会仙湿地保护区的生境质量,利用地理探测器探测影响会仙湿地保护区生境质量变化的自然和人为因素。研究结果表明:1)研究区2000至2020年建设用地明显扩张,草地和水体显著减少;2)会仙湿地保护区生境质量总体呈现下降的趋势,生境退化度有所上升,生境质量较差的区域主要集中在研究区的北部、中部和东北部;3)地理探测器识别出会仙湿地保护区生境质量空间变化受自然和人为因子的综合作用,主导影响因子是GDP(q为0.135),其次为夜间灯光指数(DMSP)(q为0.053);交互作用探测结果表明,各因子对生境质量影响呈现出双因子增强效果。研究结果有助于揭示会仙湿地保护区生境质量的时空演变过程,可针对会仙湿地生态建设的问题提出可行的应对策略。

CsI-bowl:an ancillary detector for exit channel selection inγ-ray spectroscopy experiments

A particle detector array designed for light-charged particles, known as the CsI-bowl, was built for exit channel selection for in-beam γ-ray spectroscopy experiments. This device is composed of 64 CsI(Tl) detectors, organized in a structure reminiscent of a tea-bowl. High quantum efficiency photodiodes, characterized by their minimal mass, were employed to collect scintillation light. Its design, construction, particle identification resolution, and its effectiveness in relation to exit channel selection are described in this paper. In source tests, the optimal figure of merit for the identification of α-particles and γ-rays using the charge comparison method was found to be 3.3 and 12.1 for CsI detectors coupled to photodiodes and avalanche photodiodes, respectively. The CsI-bowl demonstrated effectiveness in identifying particles, specifically the emission of protons and α-particles in the58Ni(19F, xpyn) fusion–evaporation reaction, thereby enabling the selection of the desired exit channels.

Study on the gamma rays and neutrons energy response optimization of a scintillating fiber detector for EAST with Geant4

A new scintillating fiber detector inside magnetic shielding tube was designed and assembled for use in the next round of fusion experiments in the experimental advanced superconducting tokamak to provide D–T neutron yield with time resolution.In this study,Geant4 simulations were used to obtain the pulse height spectra for ideal signals produced when detecting neutrons and gamma rays of multiple energies.One of the main sources of interference was found to be low-energy neutrons below 10–5 MeV,which can generate numerous secondary particles in the detector components,such as the magnetic shielding tube,leading to high-amplitude output signals.To address this issue,a compact thermal neutron shield containing a 1-mm Cd layer outside the magnetic shielding tube and a 5-mm inner Pb layer was specifically designed.Adverse effects on the measurement of fast neutrons and the shielding effect on gamma rays were considered.This can suppress the height of the signals caused by thermal neutrons to a level below the height corresponding to neutrons above 4 MeV because the yield of the latter is used for detector calibration.In addition,the detector has relatively flat sensitivity curves in the fast neutron region,with the intrinsic detection efficiencies(IDEs)of approximately 40%.For gamma rays with energies that are not too high(<8 MeV),the IDEs of the detector are only approximately 20%,whereas for gamma rays below 1 MeV,the response curve cuts off earlier in the low-energy region,which is beneficial for avoiding counting saturation and signal accumulation.

Design of the solar X-ray detector for the Macao Science Satellite-1B

The solar X-ray detector(SXD)onboard the Macao Science Satellite-1B was designed to monitor solar flare bursts and to study the solar activity in the 25th solar cycle.The SXD includes two parts:a soft X-ray detection unit and a hard X-ray detection unit.Both the soft X-ray detection unit and the hard X-ray detection unit include two collimators,two X-ray detectors(a silicon drift detector and a cadmium-zinc-telluride detector),and a processing circuit.Compared with similar instruments,the energy range of the SXD is wider(1–600 ke V)and the energy resolution is better(150 e V at 5.9 ke V,12%at 59.5 ke V,and 3%at 662 keV).

Review: Practical Use of a Neurophysiological Detector and the Protocol for High-Performance Liquid Chromatography

The main aim for discovery and development of the neurophysiological detector was detection of the production’ seats and criminal use of poisons in warfare. Phosphor-organic (PO) substances with acetylcholinesterase-blocking effects are prohibited in warfare by international law (Geneva Protocol. https://www.un.org/disarmament/wmd/bio/1925-geneva-protocol/). Monitoring PO analogs with acetylcholinesterase-blocking effects and their degradation products in water and soil can provide clues to unlawful production sites and the possible use of POs in warfare. Attempts to analyze POs by derivatization have had a low ability to detect them. A neurophysiological detector (NPD)-high-performance liquid chromatography (HPLC) system was developed for specific detection with high detection ability. The first official presentation of our NPD was at the 3rd International Symposium on Separation in BioSciences SBS 2003: A 100 Years of Chromatography, May 13-18, 2003, in Moscow, Russia. The NPD in connection to HPLC was developed 14 years before the presentation at the SBS in 2003. Initially, NPD combined with an HPLC system was developed for intelligence services and only for use in monitoring and espionage against the unlawful production of neuroparalytic agents, as explained in this article. NPD combined with an HPLC system was developed in Umeå, Sweden, in 1987-89;the protocol was further developed in Statens Plantevern Institutt, Ås, Norway, in 1990-92. NPD may have great utility during the current period of active warfare in Europe. The initial challenge was detecting unlawful production and use of PO compounds and their metabolites that can potentially block acetylcholinesterase. The sensor in NPD can detect and monitor substances such as tabun, soman, and modern PO poisons used in military applications. This article describes the history of the development of NPD and its aim as a sensitive sensor in detecting PO substances with acetylcholinesterase-blocking effects.

Large area^(3)He tube array detector with modular design for multi‑physics instrument at CSNS

The multi-physics instrument(MPI)is the first user cooperative instrument at the China Spallation Neutron Source(CSNS).It was designed to explore the structures of complex materials at multiple scales based on the neutron total scattering technique.This imposes the requirements for the detector,including a high detection efficiency to reduce the measurement time and a large solid angle coverage to cover a wide range of momentum transfers.To satisfy these demands,a large-area array of 3He-filled linear position-sensitive detectors(LPSDs)was constructed,each with a diameter of 1 inch and pressure of 20 atm.It uses an orbicular layout of the detector and an eight-pack module design for the arrangement of 3He LPSDs,covering a range of scattering angles from 3°to 170°with a total detector area of approximately 7 m2.The detector works in air,which is separated from the vacuum environment to facilitate installation and maintenance.The characteristics of the MPI detector were investigated through Monte Carlo(MC)simulations using Geant4 and experimental measurements.The results suggest that the detectors are highly efficient in the wavelength range of the MPI,and an efficiency over 25%is achievable for above 0.1 A neutrons.A minimal position resolution of 6.4 mm full width at half maximum(FWHM)along the tube length was achieved at a working voltage of 2200 V,and a deviation below 2 mm between the real and measured positions was attained in the beam experiment.The detector module exhibited good consistency and an excellent counting rate capacity of up to 80 kHz,which satisfied the requirements of experiments with a high event rate.Observations of its operation over the past year have shown that the detector works steadily in sample experiments,which allows the MPI to serve the user program successfully.

Electronics system for the cosmic X-ray polarization detector

This study presents an electronics system for cosmic X-ray polarization detection(CXPD).The CXPD was designed as a high-sensitivity soft X-ray polarimeter with a measurement energy range of 2-10 keV carried by a CubeSat.A stable and functionally complete electronics system under power and space constraints is a key challenge.The complete CXPD electronics system(CXPDES)comprises hardware and firmware.CXPDES adopts a three-layer electronic board structure based on functionality and available space.Two gas pixel detectors(GPDs)were placed on the top layer board,and CXPDES provided the GPDs with voltages up to-4000 V.Each GPD signal was digitized,compressed,encoded,and stored before being transmitted to the ground.The CXPDES provided stable and high-speed communication based on a scheme that separated command and data transmission,and it supports the CXPDES in-orbit upgrade.In addition,environmental monitors,silicon photomultiplier(SiPM)triggers,power management,GPDs configuration,and mode switches were included in the overall operating logic of the CXPDES.The results obtained by testing the CXPDES showed that it satisfied all the requirements of CXPD.The CXPDES provides design experience and technological readiness for future large-area X-ray polarimetry missions.