BACKGROUNDEctopic thyroid at the base of the tongue is a rare congenital condition, and it iseven rarer to have clinical symptoms and require surgical intervention. Thisdisease is easily misdiagnosed preoperatively. T...BACKGROUNDEctopic thyroid at the base of the tongue is a rare congenital condition, and it iseven rarer to have clinical symptoms and require surgical intervention. Thisdisease is easily misdiagnosed preoperatively. This article reports the diagnosis,surgical treatment, and follow-up of a case of lingual thyroid.CASE SUMMARYThe patient was a 54-year-old woman who presented with laryngeal foreign bodysensation and dysphagia for 20 d. The lingual thyroid was considered for generalexamination, and surgery was performed to transpose the lingual thyroid to theright submaxillary region. Pathological analysis confirmed thyroid tissue. Thepatient experienced complete remission after surgery, but developed hypothyroidismand required thyroid hormone replacement therapy, and her thyroidfunction gradually recovered over time.CONCLUSIONWe report a rare case of lingual thyroid with marked laryngeal foreign body sensationand dysphagia. Symptoms were completely relieved by transposition surgerybut postoperative hypothyroidism developed.展开更多
As more and more Chinese students are trying to study abroad, IELTS becomes one of the most important tests all around China. After years’development, IELTS speaking teaching still meets certain difficulties. This pa...As more and more Chinese students are trying to study abroad, IELTS becomes one of the most important tests all around China. After years’development, IELTS speaking teaching still meets certain difficulties. This paper gives specific advice based on certain applied linguistics theory, i. e. Grammar-translation Method, Audiolingualism, and Natural Order Hypothesis, trying to provide enlightenment for future IELTS speaking teaching.展开更多
Objective:To evaluate the functional results and complications of the lingual mucosal graft(LMG)urethroplasty and to sum up the current state of the art of this surgical technique.Methods:A systematic search of PubMed...Objective:To evaluate the functional results and complications of the lingual mucosal graft(LMG)urethroplasty and to sum up the current state of the art of this surgical technique.Methods:A systematic search of PubMed and Scopus electronic databases was performed,according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)statement.Studies involving male patients treated with LMG urethroplasty for urethral stricture were included.Complete protocol is available at http://www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42017080121.A meta-analysis comparing functional and long-term oral complication outcomes of LMG and buccal mucosal graft(BMG)was performed,calculating the odds ratio(OR)and 95%confidence interval(CI).Results:Twenty original articles were included in the qualitative analysis.Strictures of 1.5e16.5 cm have been treated with LMG urethroplasty,due to the improvement of harvesting technique and very low rate of long-term oral complications.Very good functional results have been reported by different authors for LMG urethroplasty,with lower rate of oral complications than BMG.The meta-analysis included six comparative studies involving 187 and 178 patients treated with LMG and BMG urethroplasty,respectively.An OR of 1.65(95%CI[0.95e2.87],I^2=0%)and 0.18(95%CI[0.03e1.26],I^2=68%)were found for LMG vs.BMG urethroplasty,in terms of success and oral complication rate,respectively.Conclusion:LMG urethroplasty can be reasonably considered a first choice technique for urethral stricture with very good results.Oral complications are temporary and minimally disabling,basically less than those for BMG,and depend mainly on the graft extent.展开更多
Objective: Microcapsule chemoembolism is a promising treatment of tumors. We describe a deep lingual arterial embolization of tongue carcinoma with microcapsuled carboplatinum. Methods: Lingual artery cast specimens f...Objective: Microcapsule chemoembolism is a promising treatment of tumors. We describe a deep lingual arterial embolization of tongue carcinoma with microcapsuled carboplatinum. Methods: Lingual artery cast specimens from cadavers were microscopically examined, and 78 patients with tongue cancer were recruited and treated with the deep lingual arterial embolization therapy. Results: Microcapsule embolism occurred approximately at the fifth or sixth level of the deep lingual artery branches. The five-year survival rate was 88.5% (69 out of 78), and the ten-year survival rate 52.6% (41 out of 78). Conclusion: The deep lingual arterial embolization of tongue carcinoma with microcapsuled carboplatinum is an effective therapy to treat carcinoma in mid-margin or mid-body of the tongue.展开更多
The dorsal lingual epithelium,which is composed of taste buds and keratinocytes differentiated from K14^(+)basal cells,discriminates taste compounds and maintains the epithelial barrier.N6-methyladenosine(m^(6)A)is th...The dorsal lingual epithelium,which is composed of taste buds and keratinocytes differentiated from K14^(+)basal cells,discriminates taste compounds and maintains the epithelial barrier.N6-methyladenosine(m^(6)A)is the most abundant mRNA modification in eukaryotic cells.How METTL3-mediated m^(6)A modification regulates K14^(+)basal cell fate during dorsal lingual epithelium formation and regeneration remains unclear.Here we show knockout of Mettl3 in K14^(+)cells reduced the taste buds and enhanced keratinocytes.Deletion of Mettl3 led to increased basal cell proliferation and decreased cell division in taste buds.Conditional Mettl3 knock-in mice showed little impact on taste buds or keratinization,but displayed increased proliferation of cells around taste buds in a protective manner during post-irradiation recovery.Mechanically,we revealed that the most frequent m^(6)A modifications were enriched in Hippo and Wnt signaling,and specific peaks were observed near the stop codons of Lats1 and FZD7.Our study elucidates that METTL3 is essential for taste bud formation and could promote the quantity recovery of taste bud after radiation.展开更多
Objective： To explore the clinical effect of electro-acupuncture （EA） in treating patients with lingual hemangioma （LHG）. Methods： EA therapy was applied on 36 patients by directly inserting the platinum needles...Objective： To explore the clinical effect of electro-acupuncture （EA） in treating patients with lingual hemangioma （LHG）. Methods： EA therapy was applied on 36 patients by directly inserting the platinum needles into LHG through a trocar with plastic insulating cannula to protect the normal tissues and connecting the needles with the electro-chemical therapeutic apparatus of model ZAY-B. Then electricity was given until the tumor body got contracted and rigid. The result was assessed 6 months after EA was started. Results： All patients were treated effectively, namely, the effective rate was 100%, with the therapeutic effect reaching grade Ⅰ in 29 patients （80.6%）, grade Ⅱ in 7 （19.4%）, and all having the function of tongue recovered to normal. Conclusion： EA shows special superiorities in treating LHG, proved to bring a- bout less injury and quick recovery and being simple in operation. Especially when applied on huge LHG, it could not only remove the tumor, but also preserve the function of the tongue, so it is a brand-new approach that is likely to be accepted by patients.展开更多
In order to evaluate the clinical value of the lines described in the Standard Nomenclature of Scalp Acupuncture Lines, 105 patients suffering from cerebral infarction have been treated by needling along the anterior ...In order to evaluate the clinical value of the lines described in the Standard Nomenclature of Scalp Acupuncture Lines, 105 patients suffering from cerebral infarction have been treated by needling along the anterior and posterior oblique lines of vertex-temple, and the line 1 and line 2 lateral to vertex. The markedly effective rate was 71.43%, and the total effective rate 88.57%. After treatment, such symptoms as hemiplegia, lingual dysfunction, facial and tongue paralysis, and the laboratory indexes of blood fat, fibrinogen and hemorrheology were obviously unproved (P【0.01 or 0.05). The therapeutic effect of scalp acupuncture was obviously better than that of Western medicine (P【0.01).展开更多
BACKGROUND Lingual nerve injury(LNI)is a rare complication following the use of laryngeal mask airway(LMA).The occurrence of this unexpected complication causes uncomfortable symptoms in patients and worsens their qua...BACKGROUND Lingual nerve injury(LNI)is a rare complication following the use of laryngeal mask airway(LMA).The occurrence of this unexpected complication causes uncomfortable symptoms in patients and worsens their quality of life.We present an unusual case of LNI caused by the use of an LMA in percutaneous nephrolithotomy(PCNL).CASE SUMMARY A 49-year-old man presented to our hospital with a 3-year history of intermittent left lower back pain.Abdominal computed tomography showed a 25 mm×20 mm stone in the left renal pelvis.PCNL surgery using LMA was performed to remove the renal stone.The patient reported numbness on the tip of his tongue after the operation,but there were no signs of swelling or trauma.The patient was diagnosed with LNI after other possible causes were ruled out.The symptom of numbness eventually improved after conservative medical therapy for 1 wk.The patient completely recovered 3 wk after surgery.CONCLUSION This is the first case report describing LNI with the use of LMA in PCNL.In our case,an inappropriate LMA size,intraoperative movement,and a specific surgical position might be potential causes of this rare complication.展开更多
The position and branching of the lingual nerve (LN) in the mandibular third molar region were documented in 30 head hemi-sections (16: right and 14: left). In all the dissections, the LN was found below the level of ...The position and branching of the lingual nerve (LN) in the mandibular third molar region were documented in 30 head hemi-sections (16: right and 14: left). In all the dissections, the LN was found below the level of the posterior alveolar crest (PAC). Branching was observed in 26 (86.7%) of the 30 specimen in which one branch was most frequently given per hemi-section. All branches were located superior to the main trunk of the LN. The mean vertical distance of the LN from the PAC was 10.3 ± 5.2 mm (range: 2.8 - 19.9 mm) whereas the mean antero-posterior distance was 7.1 ± 2.8 mm (range: 1.3 - 15.6 mm). The mean mandibular height from the PAC was 28.7 ± 4.0 mm (range: 23.3 - 40.7 mm). The vertical distance and mandibular height correlated positively giving a ratio of 1:2.7 between the two parameters. There was no significant difference between the two sides of the head. Position of the LN differed from previous studies suggesting that ethnicity may have a role in morphometry of the nerve. Use of different methodology may also contribute to this. Branches of the LN being closer to the PAC may be more prone to injury than the main trunk during surgical treatment.展开更多
Results of the treatment of centralaphasia are generally unsatisfactory,espec-ially poor in cases with a duration of the dis-ease for more than half a year.Conventionalacupuncture methods have shown someeffectiveness ...Results of the treatment of centralaphasia are generally unsatisfactory,espec-ially poor in cases with a duration of the dis-ease for more than half a year.Conventionalacupuncture methods have shown someeffectiveness for the condition,but over展开更多
文摘BACKGROUNDEctopic thyroid at the base of the tongue is a rare congenital condition, and it iseven rarer to have clinical symptoms and require surgical intervention. Thisdisease is easily misdiagnosed preoperatively. This article reports the diagnosis,surgical treatment, and follow-up of a case of lingual thyroid.CASE SUMMARYThe patient was a 54-year-old woman who presented with laryngeal foreign bodysensation and dysphagia for 20 d. The lingual thyroid was considered for generalexamination, and surgery was performed to transpose the lingual thyroid to theright submaxillary region. Pathological analysis confirmed thyroid tissue. Thepatient experienced complete remission after surgery, but developed hypothyroidismand required thyroid hormone replacement therapy, and her thyroidfunction gradually recovered over time.CONCLUSIONWe report a rare case of lingual thyroid with marked laryngeal foreign body sensationand dysphagia. Symptoms were completely relieved by transposition surgerybut postoperative hypothyroidism developed.
文摘As more and more Chinese students are trying to study abroad, IELTS becomes one of the most important tests all around China. After years’development, IELTS speaking teaching still meets certain difficulties. This paper gives specific advice based on certain applied linguistics theory, i. e. Grammar-translation Method, Audiolingualism, and Natural Order Hypothesis, trying to provide enlightenment for future IELTS speaking teaching.
文摘Objective:To evaluate the functional results and complications of the lingual mucosal graft(LMG)urethroplasty and to sum up the current state of the art of this surgical technique.Methods:A systematic search of PubMed and Scopus electronic databases was performed,according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)statement.Studies involving male patients treated with LMG urethroplasty for urethral stricture were included.Complete protocol is available at http://www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42017080121.A meta-analysis comparing functional and long-term oral complication outcomes of LMG and buccal mucosal graft(BMG)was performed,calculating the odds ratio(OR)and 95%confidence interval(CI).Results:Twenty original articles were included in the qualitative analysis.Strictures of 1.5e16.5 cm have been treated with LMG urethroplasty,due to the improvement of harvesting technique and very low rate of long-term oral complications.Very good functional results have been reported by different authors for LMG urethroplasty,with lower rate of oral complications than BMG.The meta-analysis included six comparative studies involving 187 and 178 patients treated with LMG and BMG urethroplasty,respectively.An OR of 1.65(95%CI[0.95e2.87],I^2=0%)and 0.18(95%CI[0.03e1.26],I^2=68%)were found for LMG vs.BMG urethroplasty,in terms of success and oral complication rate,respectively.Conclusion:LMG urethroplasty can be reasonably considered a first choice technique for urethral stricture with very good results.Oral complications are temporary and minimally disabling,basically less than those for BMG,and depend mainly on the graft extent.
文摘Objective: Microcapsule chemoembolism is a promising treatment of tumors. We describe a deep lingual arterial embolization of tongue carcinoma with microcapsuled carboplatinum. Methods: Lingual artery cast specimens from cadavers were microscopically examined, and 78 patients with tongue cancer were recruited and treated with the deep lingual arterial embolization therapy. Results: Microcapsule embolism occurred approximately at the fifth or sixth level of the deep lingual artery branches. The five-year survival rate was 88.5% (69 out of 78), and the ten-year survival rate 52.6% (41 out of 78). Conclusion: The deep lingual arterial embolization of tongue carcinoma with microcapsuled carboplatinum is an effective therapy to treat carcinoma in mid-margin or mid-body of the tongue.
基金supported by the National Natural Science Foundation of China(81970913 and 82125006)。
文摘The dorsal lingual epithelium,which is composed of taste buds and keratinocytes differentiated from K14^(+)basal cells,discriminates taste compounds and maintains the epithelial barrier.N6-methyladenosine(m^(6)A)is the most abundant mRNA modification in eukaryotic cells.How METTL3-mediated m^(6)A modification regulates K14^(+)basal cell fate during dorsal lingual epithelium formation and regeneration remains unclear.Here we show knockout of Mettl3 in K14^(+)cells reduced the taste buds and enhanced keratinocytes.Deletion of Mettl3 led to increased basal cell proliferation and decreased cell division in taste buds.Conditional Mettl3 knock-in mice showed little impact on taste buds or keratinization,but displayed increased proliferation of cells around taste buds in a protective manner during post-irradiation recovery.Mechanically,we revealed that the most frequent m^(6)A modifications were enriched in Hippo and Wnt signaling,and specific peaks were observed near the stop codons of Lats1 and FZD7.Our study elucidates that METTL3 is essential for taste bud formation and could promote the quantity recovery of taste bud after radiation.
文摘Objective： To explore the clinical effect of electro-acupuncture （EA） in treating patients with lingual hemangioma （LHG）. Methods： EA therapy was applied on 36 patients by directly inserting the platinum needles into LHG through a trocar with plastic insulating cannula to protect the normal tissues and connecting the needles with the electro-chemical therapeutic apparatus of model ZAY-B. Then electricity was given until the tumor body got contracted and rigid. The result was assessed 6 months after EA was started. Results： All patients were treated effectively, namely, the effective rate was 100%, with the therapeutic effect reaching grade Ⅰ in 29 patients （80.6%）, grade Ⅱ in 7 （19.4%）, and all having the function of tongue recovered to normal. Conclusion： EA shows special superiorities in treating LHG, proved to bring a- bout less injury and quick recovery and being simple in operation. Especially when applied on huge LHG, it could not only remove the tumor, but also preserve the function of the tongue, so it is a brand-new approach that is likely to be accepted by patients.
文摘In order to evaluate the clinical value of the lines described in the Standard Nomenclature of Scalp Acupuncture Lines, 105 patients suffering from cerebral infarction have been treated by needling along the anterior and posterior oblique lines of vertex-temple, and the line 1 and line 2 lateral to vertex. The markedly effective rate was 71.43%, and the total effective rate 88.57%. After treatment, such symptoms as hemiplegia, lingual dysfunction, facial and tongue paralysis, and the laboratory indexes of blood fat, fibrinogen and hemorrheology were obviously unproved (P【0.01 or 0.05). The therapeutic effect of scalp acupuncture was obviously better than that of Western medicine (P【0.01).
文摘BACKGROUND Lingual nerve injury(LNI)is a rare complication following the use of laryngeal mask airway(LMA).The occurrence of this unexpected complication causes uncomfortable symptoms in patients and worsens their quality of life.We present an unusual case of LNI caused by the use of an LMA in percutaneous nephrolithotomy(PCNL).CASE SUMMARY A 49-year-old man presented to our hospital with a 3-year history of intermittent left lower back pain.Abdominal computed tomography showed a 25 mm×20 mm stone in the left renal pelvis.PCNL surgery using LMA was performed to remove the renal stone.The patient reported numbness on the tip of his tongue after the operation,but there were no signs of swelling or trauma.The patient was diagnosed with LNI after other possible causes were ruled out.The symptom of numbness eventually improved after conservative medical therapy for 1 wk.The patient completely recovered 3 wk after surgery.CONCLUSION This is the first case report describing LNI with the use of LMA in PCNL.In our case,an inappropriate LMA size,intraoperative movement,and a specific surgical position might be potential causes of this rare complication.
文摘The position and branching of the lingual nerve (LN) in the mandibular third molar region were documented in 30 head hemi-sections (16: right and 14: left). In all the dissections, the LN was found below the level of the posterior alveolar crest (PAC). Branching was observed in 26 (86.7%) of the 30 specimen in which one branch was most frequently given per hemi-section. All branches were located superior to the main trunk of the LN. The mean vertical distance of the LN from the PAC was 10.3 ± 5.2 mm (range: 2.8 - 19.9 mm) whereas the mean antero-posterior distance was 7.1 ± 2.8 mm (range: 1.3 - 15.6 mm). The mean mandibular height from the PAC was 28.7 ± 4.0 mm (range: 23.3 - 40.7 mm). The vertical distance and mandibular height correlated positively giving a ratio of 1:2.7 between the two parameters. There was no significant difference between the two sides of the head. Position of the LN differed from previous studies suggesting that ethnicity may have a role in morphometry of the nerve. Use of different methodology may also contribute to this. Branches of the LN being closer to the PAC may be more prone to injury than the main trunk during surgical treatment.
文摘Results of the treatment of centralaphasia are generally unsatisfactory,espec-ially poor in cases with a duration of the dis-ease for more than half a year.Conventionalacupuncture methods have shown someeffectiveness for the condition,but over
