TRIZ TECHNOLOGY FORECASTING AS QFD INPUT WITHIN THE NPD ACTIVITIES

As a result of the fierceness of business competition, companies, to remaincompetitive, have to charm their customers by anticipating their needs and being able to rapidlydevelop exciting new products for them. To overcome this challenge, technology forecasting isconsidered as a powerful tool in today's business environment, while there are as many successstories as there are failures, a good application of this method will give a good result. Amethodology of integration of patterns or lines of technology evolution in TRIZ parlance ispresented, which is also known as TRIZ technology forecasting, as input to the QFD process to designa new product. For this purpose, TRIZ technology forecasting, one of the TRIZ major tools, isdiscussed and some benefits compared to the traditional forecasting techniques are highlighted. Thena methodology to integrate TRIZ technology forecasting and QFD process is highlighted.

Differential Expression of Genes in HepG2 Cells Caused by UC001kfo RNAi as Shown by RNA-seq

The differential expression of genes in HepG2 cells caused by UC001 kfo RNAi was investigated using RNA-seq. HepG2 cells were infected by Lenti-sh UC001 kfo lentivirus particles. The expression of UC001 kfo m RNA in the HepG2-sh UC001 kfo cell line was detected by real-time PCR. RNA-seq technology was used to identify the difference in the expression of genes regulated by lnc RNA UC001 kfo in the HepG2 cell line. Gene ontology and signaling pathway analysis were performed to reveal the biological functions of the genes encoding of significantly different m RNAs. The results showed that m RNAs were differentially expressed between the HepG2-sh UC001 kfo cell line and the HepG2 cell line. The UC001 kfo m RNA was significantly down-regulated in the stable cell line HepG2-sh UC001kfo（P〈0.001）. Additionally, we found 19 signaling pathways or functional classifications encompassing 30 genes that played a role in cancer characteristics, cell adhesion, invasion and migration. The results also showed that the expression of many genes associated with cancer cell invasion and metastasis was decreased with the down-regulation of the lnc RNA UC001 kfo. Lnc RNA UC001 kfo may play a role in regulating cancer cell invasion and metastasis. It was suggested that m RNAs were differentially expressed in the HepG2 cell line after the down-regulation of lnc RNA-UC001 kfo. Some took part in the extracellular matrix, cell adhesion, motility, growth, and localization. The genes encoding of differentially expressed m RNAs may participate in cell invasion and metastasis.

Towed line array sonar platform noise suppression based on spatial matrix filtering technology

The spatial matrix filter was designed and used for solving the problem to detect a weak target who was influenced by the strong nearby platform noise interference of the towed line array sonar. The MFP technology and the DOA estimation technology were combined together by using the sound propagation characteristics of both target and interference. The spatial matrix filter with platform noise zero response constraint was designed by the near-field platform noise normal modes copy vectors and the far-field plane wave bearing vectors together. The optimal solution of the optimization problem for designing the spatial matrix filter was deduced directly, and it was simplified by the generalized singular value decomposition. The total response error to the plane wave bearing vectors and the total response to the platform noise copy vectors were given. The phenomena that strong interferences existed in the bearing course and blind areas existed after filtering were analyzed by the correlation between the plat- form noise copy vectors and the plane wave bearing vectors. It could be found from simulations that it has less blind area and higher detection ability by using the spatial matrix filtering technology.