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Diagnostic value of liquid-based cytology and smear cytology in pancreatic endoscopic ultrasound-guided fine needle aspiration: A meta-analysis 被引量:2
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作者 Hang-Hai Pan Xin-Xin Zhou +2 位作者 Fei Zhao Hui-Yan Chen Yu Zhang 《World Journal of Clinical Cases》 SCIE 2020年第14期3006-3020,共15页
BACKGROUND Smear cytology(SC)using endoscopic ultrasound-guided fine needle aspiration(EUS-FNA)is the established and traditional choice for diagnosing pancreatic lesions.Liquid-based cytology(LBC)is a novel alternati... BACKGROUND Smear cytology(SC)using endoscopic ultrasound-guided fine needle aspiration(EUS-FNA)is the established and traditional choice for diagnosing pancreatic lesions.Liquid-based cytology(LBC)is a novel alternative cytological method,however,the comparative diagnostic efficacy of LBC remains inconclusive.AIM To examine the diagnostic efficacy of LBC and SC for pancreatic specimens obtained through EUS-FNA via a systematic review and meta-analysis.METHODS A systematic literature search was performed using PubMed,EMBASE,the Cochrane Library,and Web of Science.The numbers of true positives,false positives,true negatives,and false negatives for each cytological test(LBC and CS)were extracted from the included studies.The pooled sensitivity and specificity and the area under the summary receiver operating characteristic curve(AUC)were calculated,and the AUC was compared by Tukey's multiple comparisons test.The quality of the included studies was assessed using the Quality Assessment of Diagnostic Accuracy Studies II tool.RESULTS A total of 1656 patients in eight studies were included.The pooled sensitivity and specificity and the AUC for LBC were 0.76(95%CI:0.72-0.79),1.00(95%CI:0.98-1.00),and 0.9174,respectively,for diagnosing pancreatic lesions.The pooled estimates for SC were as follows:Sensitivity,0.68(95%CI:0.64-0.71);specificity,0.99(95%CI:0.96-100.00);and AUC,0.9714.Similarly,the corresponding values for LBC combined with SC were 0.87(95%CI:0.84-0.90),0.99(95%CI:0.96-1.00),and 0.9894.Tukey’s multiple comparisons test was used to compare the sensitivities and AUCs of the three diagnostic methods;statistically significant differences were found between the three methods,and LBC combined with SC was superior to both LBC(P<0.05)and SC(P<0.05).The pooled sensitivity and AUC did not change significantly in the sensitivity analysis.CONCLUSION LBC may be sensitive than SC in the cytological diagnosis of pancreatic lesions,however,the superior diagnostic performance of their combination emphasizes their integrated usage in the clinical evaluation of pancreatic lesions. 展开更多
关键词 liquid-based cytology Smear cytology Pancreatic lesions Endoscopic ultrasound-guided fine needle aspiration cytological diagnosis ROC curve
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Comparison of smear cytology with liquid-based cytology in pancreatic lesions: A systematic review and meta-analysis 被引量:2
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作者 Xiao-Hui Zhang Shi-Yang Ma +6 位作者 Na Liu Zhong-Cao Wei Xu Gao Yu-Jie Hao Yi-Xin Liu Ya-Qin Cai Jin-Hai Wang 《World Journal of Clinical Cases》 SCIE 2021年第14期3308-3319,共12页
BACKGROUND Endoscopic ultrasonography-guided fine-needle aspiration(EUS-FNA)is a safe and accurate technique to confirm the diagnosis of pancreatic cancers.Recently,numerous studies comparing the diagnostic efficacy o... BACKGROUND Endoscopic ultrasonography-guided fine-needle aspiration(EUS-FNA)is a safe and accurate technique to confirm the diagnosis of pancreatic cancers.Recently,numerous studies comparing the diagnostic efficacy of smear cytology(SC)and liquid-based cytology(LBC)for pancreatic lesions yielded mixed results.AIM To compare and identify the better cytology method for EUS-FNA in pancreatic lesions.METHODS A comprehensive search of PubMed,Embase,and Cochrane was undertaken through July 18,2020.The primary endpoint was diagnostic accuracy(sensitivity and specificity).Secondary outcomes included sample adequacy and post procedure complications.In addition,factors affecting diagnostic efficacy were discussed.RESULTS Data on a total of 1121 comparisons from 10 studies met the inclusion criteria.Pooled rates of sensitivity for SC and LBC were 78%(67%-87%)vs 75%(67%-81%),respectively.In any case,both SC and LBC exhibited a high specificity close to 100%.Inadequate samples more often appeared in LBC compared with SC.However,the LBC samples exhibited a better visual field than SC.Very few post procedure complications were observed.CONCLUSION Our data suggested that for EUS-FNA in pancreatic lesions(particularly solid lesions),SC with Rapid On-Site Evaluation represents a superior diagnostic technique.If Rapid On-Site Evaluation is unavailable,LBC may replace smears.The diagnostic accuracy of LBC depends on different LBC techniques. 展开更多
关键词 Smear cytology liquid-based cytology PANCREAS Endoscopic ultrasonography-guided fine-needle aspiration Sensitivity and specificity Diagnostic efficacy
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Comparative Study of Cell Findings by Conventional Smear and Liquid-Based Cytology for Oral Exfoliative Cytology 被引量:1
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作者 Hiroyuki Seto Masayuki Ukigaya +7 位作者 Masaaki Suemitsu Chieko Taguchi Hiroshi Yamamoto Chiori Nakamura Yoshikazu Nakayama Mitsuko Nakayama Hidekuni Tanaka Kayo Kuyama 《Open Journal of Stomatology》 2020年第7期174-188,共15页
<b><span>Background:</span></b><span> Liquid-based cytology (LBC) is a method of manufacturing cyto-diagnostic specimens. Improved accuracy is expected from standardizing specim... <b><span>Background:</span></b><span> Liquid-based cytology (LBC) is a method of manufacturing cyto-diagnostic specimens. Improved accuracy is expected from standardizing specimen production and use of this method is rapidly spreading in oral cytology. On the other hand, LBC reportedly requires training to show peculiar cell findings compared to those of conventional smear cytology (CVC). Few studies have compared detailed cell findings for oral CVC and LBC.</span><span> </span><b><span>Objec</span></b><b><span>tives:</span></b><span> The aim of this study was to compare cytological findings between CVC </span><span>and LBC using cytomorphological image analysis.</span><span> </span><b><span>Materials and Methods:</span></b><span> Cytological specimens were collected from 20 patients (negative for squamous neoplasia in 10, dysplasia in 5, squamous cell carcinoma in 5) and 5 controls of the tongue between January 2017 and December 2018. Two different preparation techniques were investigated cytomorphologically for CVC and LBC (BD Cytorich</span><sup><span style="vertical-align:super;">TM</span></sup><span>).</span><span> </span><b><span>Results:</span></b><span> LBC showed significantly higher cell numbers tha</span><span>n CVC for all lesions. LBC-to-CVC ratio ranged from 9.52 (hyp</span><span>erkeratosis) to 1.87 (deep cells in oral squamous cell carcinoma (OSCC)). Nuclear area of </span><span>normal, hyperkeratosis, and inflammation were significantly higher in LBC tha</span><span>n those of CVC. Hyperchromasia was significantly more frequent with </span><span>CVC than with LBC for hyperkeratosis, inflammation, dysplasia and OSCC. There was no significant difference in circularity between CVC and LBC </span><span>among all lesions. </span><b><span>Conclusion:</span></b><span> Only one cytomorphological disadvantage was </span><span>se</span><span>en with LBC, in the form of decreased hyperchromasia. Further </span><span>clarification of the advantages and disadvantages of LBC is needed, including management of precision and screening practices. 展开更多
关键词 liquid-based cytology (LBC) Oral Exfoliative cytology (EC) Conventional Smear cytology (CVC) Oral Squamous Cell Carcinoma (OSCC)
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Vaginal Intraepithelial Neoplasia Detected with Cervical Liquid-Based Cytology: Old Concerns or New Facilities?
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作者 Mariana Camezim Beldi Maricy Tacla +6 位作者 Marcia Farina Kamilos Fabiane Sarmanho Alexandre Ab’Saber Sheila Siqueira Venancio Avancini Ferreira Alves Edmundo C. Baracat Adhemar Longatto-Filho 《Open Journal of Obstetrics and Gynecology》 2015年第11期580-587,共8页
Background: The detection of vaginal intraepithelial neoplasia (VAIN) in cervical samples is not a common finding. Therefore, we aimed to report VAINs detected in liquid-based cytology (LBC) from women examined at Hos... Background: The detection of vaginal intraepithelial neoplasia (VAIN) in cervical samples is not a common finding. Therefore, we aimed to report VAINs detected in liquid-based cytology (LBC) from women examined at Hospital das Clínicas of Faculty of Medicine, Sao Paulo State University. Materials and Methods: We evaluated LBC samples from women referred to gynecology examination for different reasons (previous abnormal PapTest, follow up of treated cervical lesion, ecc) and women examined for regular screening proposals, and compared with biopsy diagnoses, including the controversial diagnoses of vaginal intraepithelial neoplasia (VAIN). Results: From 1866 patients, 1423 (76.3%) cases were negative and 443 (23.7%) were positive for any cellular alteration. Age of patients ranged from 12 to 86 years. We detected 25 histologically confirmed VAIN (1.3% p = 0.0002 by Fisher’s exact test IC 95% 0.0090 - 0.0198) and 1.1% VAIN (p = 0.0031 by Fisher’s exact test IC 95% 0.0077 - 0.0179). Conclusion: The identification of VAIN in routine is feasible;the professionals involved with cytological examination should be aware of these lesions in Pap test samples. 展开更多
关键词 liquid-based cytology CERVICAL Screening VAIN HPV Induced Lesions VAGINAL
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Study on the Correlation between Human Papillomavirus and Mycoplasma genitalium Combined with TCT Detection
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作者 Hairong Fang Xiaoyu Jiang +1 位作者 Lianxing Xu Huan Zhao 《Natural Science》 2024年第8期121-129,共9页
Objective: This study aims to explore the correlation between human papillomavirus (HPV) and Mycoplasma genitalium (CT) combined with TCT detection in cervical cancer screening. Method: A cross-sectional study design ... Objective: This study aims to explore the correlation between human papillomavirus (HPV) and Mycoplasma genitalium (CT) combined with TCT detection in cervical cancer screening. Method: A cross-sectional study design was adopted, and a total of 609 women who came to seek medical treatment were recruited as the study subjects. Combination testing was evaluated on cervical cancer screening by testing the women for HPV, CT with TCT detection and analyzing the relationship of cervical lesions with HPV and CT infection. Results: The study results showed that 21.57% of the subjects were infected with both HPV and CT, and 48.42% of the cases had abnormal TCT results at the same time. Further data analysis showed that HPV infection was significantly associated with abnormal TCT outcomes (p < 0.05), suggesting a possible synergistic effect of the two infections in cervical lesions. The combined sensitivity and specificity of HPV, CT and TCT detection were 21.57% and 48.42%, respectively, which were significantly higher than that of single detection. Conclusion: In summary, the results of this study support the importance of combined HPV, CT, and TCT testing in cervical cancer screening, and propose the hypothesis that combined testing may improve screening effectiveness. However, further large sample studies are needed to confirm this conclusion and explore the prospects of combined testing in clinical practice. 展开更多
关键词 Human Papillomavirus (HPV) Mycoplasma Infection of Reproductive Tract liquid-based Thin Layer cytology (tct) INFECTION Infection Rate
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宫颈HPVE6/E7检测联合计算机辅助诊断TCT及阴道炎检测在宫颈细胞学筛查中的应用价值
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作者 王巧欢 刘维维 李海英 《临床和实验医学杂志》 2024年第4期425-429,共5页
目的 分析宫颈人乳头瘤病毒(HPV)E6/E7检测联合计算机辅助诊断宫颈液基细胞学(TCT)及阴道炎检测在宫颈细胞学筛查中的应用价值。方法 采用宫颈HPVE6/E7检测、计算机辅助诊断TCT、阴道炎检测法和阴道炎+TCT+HPVE6/E7检测对2023年2~8月在... 目的 分析宫颈人乳头瘤病毒(HPV)E6/E7检测联合计算机辅助诊断宫颈液基细胞学(TCT)及阴道炎检测在宫颈细胞学筛查中的应用价值。方法 采用宫颈HPVE6/E7检测、计算机辅助诊断TCT、阴道炎检测法和阴道炎+TCT+HPVE6/E7检测对2023年2~8月在北京市昌平区中西医结合医院检查的1 586例女性进行宫颈癌筛查,发现181例疑似高级别鳞状上皮内病变(HSIL)病例,对疑似“HSIL”追加病理检查,并以病理检查作为金标准,分析上述筛查4种方法对HSIL的检出率及病理检查结果的一致性,并计算4种筛查方法对HSIL诊断的灵敏度和特异度。结果 181例疑似HSIL患者经病理检查发现共86例HSIL患者。阴道炎检测对HSIL的检出率为16.57%,Kappa值为0.488。计算机辅助诊断TCT检测对HSIL的检出率为24.86%,Kappa值为0.554。宫颈HPVE6/E7检测对HSIL的检出率为19.34%,Kappa值为0.512。阴道炎+TCT+HPVE6/E7检测对HSIL的检出率为38.67%,Kappa值为0.742。阴道炎+TCT+HPVE6/E7检测的AUC值>0.85,预测价值较高,灵敏度、特异度分别为81.40%、84.21%;阴道炎检测、TCT检测、HPVE6/E7检测的AUC值均>0.70,预测价值一般,各检测方法灵敏度、特异度分别为34.88%、52.63%,52.33%、61.05%,40.70%、64.21%。结论 宫颈HPVE6/E7、计算机辅助诊断TCT及阴道炎检测联合筛查可在一定程度上提升宫颈病变的检出率,对宫颈病变诊断具有明显指导意义。 展开更多
关键词 宫颈细胞学筛查 宫颈HPVE6/E7检测 计算机辅助诊断tct 阴道炎检测
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Research of cervical cytology screening in diagnosis of 370,000 cases with cervical lesion in Guangdong 被引量:1
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作者 Baowen Zheng Congde Chen Anxiang Wei Han Ran Dong Liu Wenling Yue Huirong Zhou Qingyi Zhu Juming Su 《The Chinese-German Journal of Clinical Oncology》 CAS 2009年第2期90-94,共5页
Objective: Analysis of the results of 37 million cases by using cervical liquid-based cytology screening, discussion the situation of cervical cancer and precancerous lesions in Guangdong province. Methods: From 200... Objective: Analysis of the results of 37 million cases by using cervical liquid-based cytology screening, discussion the situation of cervical cancer and precancerous lesions in Guangdong province. Methods: From 2002 to 2006, using liquid-based thin-layer cytology (TCT) method screening cervical lesions within 371,929 women in Guangdong. Cytological diagnosis adopt TBS (the Bethesda system) Standard (TBS improved 2001 version of the diagnostic criteria), statistic positive rate by age and region respectively. Results: 371,929 cases of gynecology cervical samples in Guangdong, 331,251 cases were negative, accounted for 91.23%; cytology positive cases: 32,548 cases were squamous intraepithelial lesions (8.96%), 486 cases were glandular epithelial lesions (0.13%); grouped according to age: 30 to 40-year-old positive rate was 9.13%, 40 to 50-year-old positive rate was 9.60%, the latter had higher cytology positive rate; grouped according to region: the total samples in PRD areas were 304.951 cases, accounted for 81.99%, in which 24301 cases were positive (8.14%), in 66978 cases (18.01%) of NON-PRD regions, 7645 cases were positive (11.87%), there were 1858 cases had biopsy/follow-up results from 2004 to 2005, and the rate was 2.88%. Conclusion: The cytological positive rate of cervical cancer and its precancerous lesions was 9.09% in Guangdong (of which the rate of cytological diagnosis as precancerous lesions was 3.40%), 30 to 50 age group had the high incidence of cervical cancer and its precursor lesions, and also the main stage of prevention for cervical cancer. Cytology positive rate was 11.87% in economic underdevelopment Non-Pearl River Delta regions, much higher than the Pearl River Delta region. 展开更多
关键词 thin liquid-based cytology cervical lesion SCREENING
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Correlative analysis between abnormal cervical cytology and pathology of vaginoscopic biopsy or conization 被引量:1
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作者 李彩娟 郎景和 +1 位作者 程雪梅 王友芳 《生殖医学杂志》 CAS 2006年第B10期69-73,共5页
Objectives: To evaluate the predictive value of cervical intraepithelial neoplasia (CIN)III/ carcinoma in situ (CIS) by correlating analysis between abnormal cervical cytologic findings and pathological diagnosis of v... Objectives: To evaluate the predictive value of cervical intraepithelial neoplasia (CIN)III/ carcinoma in situ (CIS) by correlating analysis between abnormal cervical cytologic findings and pathological diagnosis of vaginoscopic biopsies or conization.Methods: Routine cervical cytology screening was performed in 31,634 cases by fluid-based thin-layer method (ThinPrep cytology test, TCT), 948 patients had both abnormal squamous cell appearance by TCT and pathological diagnosis of vaginoscopic biopsies and /or cervical conization. The predictive value of CINIII/CIS were studied retrospectively by correlating analysis of different cytology abnormalities and pathology diagnosis.Results: Cytologically, 1,260 out of 31,634 TCT tests showed abnormal squamous cells appearance, including atypical squamous cell of undetermined significance (ASCUS) 675 cases(2.13%), low squamous intraepithelial lesion (L-SIL) 379 cases(1.20%), high squamous intraepithelial lesion (H-SIL)176 cases(0.56%),cancer 30 cases (0.09%). Among 948 patients with pathological diagnosis, there were CINII-III in 70 cases(7.38%) and CINIII/CIS in 56 cases.(5.91%). The relative risks (RR) of different precancerous TCT results in predicting CIN III/CIS validated by pathology are as follow: AUSCUS 14.7% (95% confidence interval (CI) 8.0-27.0), Lsil 13.9% (95% CI 6.3-30.9), Hsil 126.1 (95% CI 60.6-218.6). The RR of AUSCUS group is not significantly different from that of L-SIL group(P =0.951). However, the RR of CINⅢ/CIS morbidity between the H-SIL or cancer group and the ASCUS or L-SIL group are significantly different (all P value <0.01).Conclusion: Vaginoscopic biopsy could verify pathological CINⅡ-Ⅲ and CINⅢ/CIS from cases with abnormal TCT results. There is significantly greater risk of being CINⅢ/CIS validated by vaginoscopic biopsy in the H-SILpatients,while ASCUS and L-SIL group have the coequal risk. 展开更多
关键词 子宫颈肿瘤 细胞学 病理学 活组织检查
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HPV检测、TCT及宫颈刮片在宫颈癌和癌前病变筛查中的应用 被引量:45
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作者 王步军 郑飞云 《中国妇幼保健》 CAS 北大核心 2008年第5期707-709,共3页
目的:评价HPV检测、TCT(膜式液基薄层细胞学检查)及宫颈刮片在宫颈癌和癌前病变筛查中的应用价值。方法:对我院妇科门诊1008例发现宫颈异常(宫颈糜烂、肥大、接触性出血、溃疡及乳头样增生等)的患者进行HPV检测、TCT及宫颈刮片,对1项或... 目的:评价HPV检测、TCT(膜式液基薄层细胞学检查)及宫颈刮片在宫颈癌和癌前病变筛查中的应用价值。方法:对我院妇科门诊1008例发现宫颈异常(宫颈糜烂、肥大、接触性出血、溃疡及乳头样增生等)的患者进行HPV检测、TCT及宫颈刮片,对1项或多项异常者行病理组织学检查,并以病理结果为标准。对病理结果阳性的182例患者,比较3种方法的检出敏感度、高度病变和浸润癌的阳性符合率。结果:HPV检测、TCT和宫颈刮片结果阳性分别为158例、149例和98例,敏感度分别为86.8%、81.8%和53.8%,高度病变和浸润癌的阳性符合率分别为91.4%、85.0%和60.0%。宫颈刮片与TCT、HPV检测的敏感度及高度病变和浸润癌的阳性符合率都有明显差异(P<0.01),而TCT和HPV检测没有明显差异(P>0.05)。结论:TCT和HPV检测能够提高检出敏感度和高度病变的阳性符合率,在宫颈癌和癌前病变筛查中,我们可以用TCT或HPV检测提高检出率。 展开更多
关键词 HPV检测 tct(膜式液基薄层细胞学检查) 宫颈刮片 宫颈癌 癌前病变
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318例高级别宫颈上皮内瘤变及宫颈癌患者的TCT和hrHPV检测分析 被引量:40
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作者 石杏先 余立群 高国兰 《中国肿瘤临床》 CAS CSCD 北大核心 2019年第2期73-76,共4页
目的:探讨如何使用现有的筛查方法,减少高级别宫颈上皮内瘤变(cervical intraepithelial neoplasia grade 2 or 3,CIN2/3)及宫颈癌的漏诊。方法:回顾性分析2014年6月至2018年8月318例中国医科大学附属航空总医院治疗的CIN2/3及宫颈癌患... 目的:探讨如何使用现有的筛查方法,减少高级别宫颈上皮内瘤变(cervical intraepithelial neoplasia grade 2 or 3,CIN2/3)及宫颈癌的漏诊。方法:回顾性分析2014年6月至2018年8月318例中国医科大学附属航空总医院治疗的CIN2/3及宫颈癌患者的临床资料,其中CIN2/3为296例、宫颈癌为22例,采用宫颈液基薄层细胞学检查(thinprep cytology test,TCT)及高危型人乳头瘤病毒(high risk human papilloma virus,hrHPV)检测方法,分析患者的年龄、TCT和hrHPV。结果:296例CIN2/3患者中30~39岁患者为130例(43.92%)、占第1位,20~29岁年轻患者为69例(23.31%)、占第3位。318例患者中TCT阳性为199例(62.58%),hrHPV阳性为308例(96.86%),两者联合筛查阳性为313例,阳性率为98.43%(313/318)。hrHPV分型检测主要亚型依次为16、52、58、33、18、31型。结论:CIN2/3及宫颈癌的发病年龄年轻化,年轻患者筛查不容忽视。TCT单独筛查较hrHPV单独筛查易漏诊高级别病变,TCT联合hrHPV筛查可提高检出率。TCT阴性,hrHPV非16、18亚型的其他hrHPV阳性,尤其是hrHPV52、58、33、31亚型阳性患者也建议行阴道镜检查。 展开更多
关键词 高级别宫颈上皮内瘤变 宫颈癌 tct hrHPV 阴道镜
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HPV-DNA联合TCT对宫颈病变的诊断价值及效能分析 被引量:11
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作者 李日红 陈光元 谢家滨 《中国性科学》 2019年第4期43-46,共4页
目的探讨人乳头状瘤病毒(HPV-DNA)、液基薄层细胞学检测(TCT)在宫颈病变患者中的诊断价值。方法选择2016年1月至2018年1月入院治疗的200例宫颈病变患者作为研究对象,所有患者均经过病理学活检最终得到确诊,病理学活检前对所有患者进行HP... 目的探讨人乳头状瘤病毒(HPV-DNA)、液基薄层细胞学检测(TCT)在宫颈病变患者中的诊断价值。方法选择2016年1月至2018年1月入院治疗的200例宫颈病变患者作为研究对象,所有患者均经过病理学活检最终得到确诊,病理学活检前对所有患者进行HPV-DNA、TCT检测,将HPV-DNA、TCT检测结果与病理学活检结果进行比较,分析HPV-DNA联合TCT检测敏感性、特异性及准确度;记录并统计宫颈病变患者HPV-DNA、TCT检测所需费用,分析HPV-DNA联合TCT检测对宫颈病变患者中的诊断价值。结果 200例患者均顺利完成TCT检查与HPV-DNA检查,TCT检查下SCC组织及正常组织占据比例最大,分别为75.50%和10.0%;而HPV-DNA检测阳性患者为40例,占26.49%;与TCT检查结果比较HPV检查具有较高的符合率,差异无统计学意义(P>0.05);HPV-DNA检查与TCT检查结果与病理学检查CINII、SCC比较差异无统计学意义(P>0.05);HPV-DNA联合TCT检查CINI、CINII与CINIII检查与病理组织学诊断符合率,均高于单一HPV-DNA检查和TCT检查,差异具有统计学意义(P<0.05);HPV-DNA和TCT检查在宫颈疾病中的诊断敏感性、特异性比较差异无统计学意义(P>0.05);HPV-DNA联合TCT检查在宫颈疾病中诊断敏感性、特异性,均高于单一HPV-DNA检查和TCT检查,差异具有统计学意义(P<0.05)。结论将HPV-DNA联合TCT检测用于宫颈病变中具有较高的诊断价值,能获得良好的诊断效能,值得推广应用。 展开更多
关键词 人乳头状瘤病毒 液基薄层细胞学 宫颈病变 诊断价值 病理学活检
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高危型HPV联合TCT在宫颈癌筛查中的价值研究 被引量:23
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作者 王艳君 张静 《中国性科学》 2017年第12期24-27,共4页
目的:探讨高危型人乳头瘤病毒(HPV)联合液基薄层细胞检测技术(TCT)在宫颈癌筛查中的价值。方法:选择2014年6月至2016年12月在我院就诊接受HR-HPV及TCT检测的1426例患者,并行阴道镜活检做病理组织学诊断,对TCT、HR-HPV以及TCT联合HR-HPV... 目的:探讨高危型人乳头瘤病毒(HPV)联合液基薄层细胞检测技术(TCT)在宫颈癌筛查中的价值。方法:选择2014年6月至2016年12月在我院就诊接受HR-HPV及TCT检测的1426例患者,并行阴道镜活检做病理组织学诊断,对TCT、HR-HPV以及TCT联合HR-HPV检测结果分析。结果:从CINⅠ级、CINⅡ级、CINⅢ级至SCC患者TCT检测阳性率呈显著升高趋势,与宫颈炎组比较差异均具有统计学意义(P<0.05)。在多重感染患者中,其CINⅠ级、CINⅡ级、CINⅢ级至SCC患者HPV感染率显著高于宫颈炎组,比较差异均具有统计学意义(P<0.05),患者随着CIN分级的增加HR-HPV检测阳性率而显著升高,与宫颈炎组比较差异均具有统计学意义(P<0.05)。在TCT联合HPV检测中,CINⅠ~CINⅢ级及SCC组HPV感染均非常显著高于宫颈炎组,比较差异均具有统计学意义(P<0.05)。TCT联合HR-HPV检测在灵敏度、特异度、阳性预测值、阴性预测值均显著优于TCT、HR-HPV单独检测,比较差异均具有统计学意义(P<0.05)。结论:高危型HPV联合TCT在宫颈癌筛查中较单一检测可明显减少漏诊率、误诊率,使宫颈癌前病变患者早期介入治疗,降低宫颈癌患者发病率及病死率。 展开更多
关键词 高危HPV tct 宫颈癌筛查 阴道镜活检
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HPV-DNA与TCT联合检测在宫颈早期病变筛查中的相关性研究 被引量:6
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作者 兰旭青 王默琪 王琳 《标记免疫分析与临床》 CAS 2012年第5期271-272,共2页
目的探讨新柏氏液基薄层细胞学(TCT)技术联合HPV-DNA检测在宫颈早期病变筛查中的相关性。方法对2008年9月至2011年7月来我院妇科门诊就诊的375例HPV-DNA阳性患者行TCT检测,采取TBS报告方式,将TCT与HPV-DNA结果对进行照分析。结果 375例H... 目的探讨新柏氏液基薄层细胞学(TCT)技术联合HPV-DNA检测在宫颈早期病变筛查中的相关性。方法对2008年9月至2011年7月来我院妇科门诊就诊的375例HPV-DNA阳性患者行TCT检测,采取TBS报告方式,将TCT与HPV-DNA结果对进行照分析。结果 375例HPV-DNA阳性患者TCT检查者,结果良性反应性改变273例(72.8%),ASC阳性者84例(22.4%),LSIL阳性6例(1.6%),HSIL阳性12例(3.2%),HPV高危亚型感染率分别为69.23%、92.86%、100%、100%。结论 TCT联合HPV-DNA检测可提高宫颈早期病变的诊断率。 展开更多
关键词 液基薄层细胞检测技术(tct检) 人乳头瘤病毒(HPV) 宫颈早期病变
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阴道镜在TCT阳性患者中的诊断价值 被引量:2
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作者 郝凤英 魏力 刘东涌 《现代肿瘤医学》 CAS 2009年第2期305-306,共2页
目的:探讨阴道镜检查在超薄液基细胞学(TCT)阳性患者中的诊断价值。方法:对114例细胞学阳性患者行阴道镜检查,并行宫颈活检确诊,结果与TCT阴性组对照。结果:TCT阳性组阴道镜检查的敏感性、特异性、阳性预测值、阴性预测值分别为98.04%、... 目的:探讨阴道镜检查在超薄液基细胞学(TCT)阳性患者中的诊断价值。方法:对114例细胞学阳性患者行阴道镜检查,并行宫颈活检确诊,结果与TCT阴性组对照。结果:TCT阳性组阴道镜检查的敏感性、特异性、阳性预测值、阴性预测值分别为98.04%、33.33%、92.59%、66.67%,TCT阴性组为83.33%、87.88%、83.33%、87.88%,无统计学差异。结论:阴道镜在TCT阳性组有较高的灵敏度和阳性预测值,但特异性差,在TCT阴性组中有较高的特异性和阴性预测值。阴道镜检查适宜在临床广泛应用。 展开更多
关键词 阴道镜检查 宫颈病变 液基细胞学
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阴道镜下活检、TCT及HPV检测对宫颈病变的诊断价值 被引量:31
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作者 程静 张琼 《中国妇幼健康研究》 2017年第3期349-351,共3页
目的探讨利用阴道镜下活检来进行液基细胞学检查(TCT)和人乳头瘤病毒(HPV)检测对宫颈病变的诊断价值。方法 2015年1月至2016年6月期间在凉山州德昌县人民医院妇科门诊进行宫颈癌初次筛查的1 300例患者作为研究对象,进行阴道镜下活组织... 目的探讨利用阴道镜下活检来进行液基细胞学检查(TCT)和人乳头瘤病毒(HPV)检测对宫颈病变的诊断价值。方法 2015年1月至2016年6月期间在凉山州德昌县人民医院妇科门诊进行宫颈癌初次筛查的1 300例患者作为研究对象,进行阴道镜下活组织检查、TCT、以及高危型HPV-DNA检测。确诊标准是阴道镜下活检法,并以此评价TCT、HPV及二者联合检测对于宫颈癌早期病变的诊断价值。结果 1TCT检测,阳性患者有234例(18.00%),正常者及良性宫颈炎症有1 066例(82.00%);234例阳性患者中,非典型鳞状上皮细胞病变患者112例(8.62%),低度鳞状上皮内病变患者65例(5.00%),高度鳞状上皮内病变患者43例(3.31%),鳞状细胞癌患者14例(1.08%);2通过HPV-DNA检测,阳性患者有679例(52.23%);3TCT和HPV-DNA联合检测的灵敏度为100.00%,即所有患者的指标均至少有一种呈现为阳性,而TCT单独检测的灵敏度为77.12%,假阴性(漏诊率)为22.88%,HPV单独检测的灵敏度为84.50%,假阴性(漏诊率)为15.50%。HPV联合TCT检测的检出率均显著高于TCT、HPV单一检测的检出率(χ~2值分别为27.469、17.477,均P<0.01),HPV单一检测的检出率显著高于TCT单一检测的检出率(χ~2=4.759,P<0.05)。结论采用阴道镜下活检、TCT及HPV对宫颈癌早期病变进行检测,具有高效性、可行性,HPV联合TCT检测能提高宫颈癌检测灵敏度,降低假阴性率,对宫颈癌的早期筛查具有重要价值。 展开更多
关键词 宫颈病变 阴道镜下活检 液基细胞学检查 人乳头瘤病毒 诊断价值
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HR-HPV DNA检测与TCT检查的相关性研究及其在宫颈早期病变筛查中的应用 被引量:25
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作者 张旋 谭旭东 +1 位作者 陈红 韦升市 《中国优生与遗传杂志》 2008年第6期38-39,共2页
目的探讨TCT与HPV DNA检测结果的相关性,并评价该两种方法在宫颈早期病变筛查中的应用价值。方法对439名妇科门诊就诊者同时进行TCT检查和HPV DNA荧光定量PCR检测,并将两者的检测结果进行对比分析。结果439例样本中HPV DNA检测阳性者154... 目的探讨TCT与HPV DNA检测结果的相关性,并评价该两种方法在宫颈早期病变筛查中的应用价值。方法对439名妇科门诊就诊者同时进行TCT检查和HPV DNA荧光定量PCR检测,并将两者的检测结果进行对比分析。结果439例样本中HPV DNA检测阳性者154例(35.1%),TCT结果阳性者163例(37.1%);两者均为阳性者65例(14.8%);经统计学分析,两种方法的检测结果不相关(P>0.05),TCT结果的异常程度与HR-HPV的感染数量亦无相关性(P>0.05)。结论该两种方法在宫颈早期病变的筛查中不能相互替代或相互验证;两种方法联合应用可使阳性检出率明显提高。 展开更多
关键词 液基薄层细胞检测技术(tct) 人乳头瘤病毒(HPV) 相关性分析
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TCT联合高危型HPV检测在社区宫颈癌筛查中的应用价值 被引量:49
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作者 左玲 李顺英 邓亭月 《海南医学》 CAS 2016年第10期1628-1630,共3页
目的探讨宫颈液基薄层细胞学检查(TCT)联合高危型人乳头状瘤病毒(HPV)检测在社区宫颈癌筛查中的应用价值。方法随机抽取育德社区2011年1月至2014年10月行TCT和高危HPV检测的已婚妇女1 100例作为研究对象,TCT或高危型HPV任一检查结果阳... 目的探讨宫颈液基薄层细胞学检查(TCT)联合高危型人乳头状瘤病毒(HPV)检测在社区宫颈癌筛查中的应用价值。方法随机抽取育德社区2011年1月至2014年10月行TCT和高危HPV检测的已婚妇女1 100例作为研究对象,TCT或高危型HPV任一检查结果阳性者行病理组织检查,以病理组织检查为金标准,比较TCT和高危HPV筛查宫颈癌的灵敏度和特异度。结果 1 100例受检者的TCT阳性78例,阳性率为7.09%,高危型HPV阳性106例,阳性率为9.64%。TCT、HPV双阳性2例,TCT(阳)、HPV(阴)1例,TCT(阴)、HPV(阳)0例,TCT、HPV双阴性0例。TCT灵敏度为100.00%,特异度为62.93%;高危型HPV灵敏度为66.67%,特异度49.27%;TCT联合HPV(串联)灵敏度为66.67%,特异度为25.85%;TCT联合HPV(并联)灵敏度为100.00%,特异度为86.34%。不同检测方法检测宫颈癌的灵敏度和特异度比较差异具有统计学意义(P<0.05)。结论 TCT联合高危型HPV(并联)检测可以提高宫颈癌筛查的灵敏度和特异性,对于社区筛查宫颈癌具有重要的应用价值。 展开更多
关键词 液基薄层细胞学检查 高危型人乳头状瘤病毒 社区 宫颈癌
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宫颈液基薄层细胞学技术(TCT)联合阴道镜检查在宫颈病变筛查中的临床应用 被引量:16
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作者 孟亚丽 郑燕 +1 位作者 张霞 张红真 《中国疗养医学》 2011年第2期157-160,共4页
目的探讨宫颈液基薄层细胞学技术(TCT)联合阴道镜检查在宫颈病变筛查中的临床应用价值。方法选择2008-01—2010-08河北医科大学第一医院妇科门诊宫颈病变患者570例进行宫颈病变筛查,其中300例行TCT联合阴道镜活检者为实验组,270例直接... 目的探讨宫颈液基薄层细胞学技术(TCT)联合阴道镜检查在宫颈病变筛查中的临床应用价值。方法选择2008-01—2010-08河北医科大学第一医院妇科门诊宫颈病变患者570例进行宫颈病变筛查,其中300例行TCT联合阴道镜活检者为实验组,270例直接行阴道镜下取材活检者为对照组。最终以病理组织诊断为标准,比较两组间差异。结果 TCT联合阴道镜下取材行病理组织检查与未经细胞学检查,单一阴道镜下取材活检,两者结果比较,差异有统计学意义(P<0.05)。TCT联合阴道镜检查与病理组织诊断阳性符合率为72.7%(218/300),诊断CIN的特异性87.8%,敏感度48.2%;直接阴道镜下取材活检阳性率为33.0%(89/270),诊断CIN的特异性89.0%,敏感度79.8%。结论采用TCT联合阴道镜检查能较早筛查出宫颈病变,有利于宫颈癌前病变及早期宫颈癌早诊断、早治疗,提高生存率。 展开更多
关键词 液基薄层细胞学技术(tct) 阴道镜检查 宫颈病变
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宫颈TCT与活检诊断的符合率及其影响因素分析 被引量:1
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作者 石新兰 张宁 +4 位作者 杨爱萍 李振强 崔铁莉 贾静 李玉广 《中国妇幼健康研究》 2011年第6期783-785,共3页
目的 探讨宫颈薄层液基细胞学(TCT)判读与活检病理诊断的符合率,并分析其影响因素.方法 对2010年期间在我院进行薄层液基细胞学检查的病例进行回顾性研究,并与活检病理诊断进行对比分析.结果 宫颈上皮异常检出率为3.54%,55岁以上妇女... 目的 探讨宫颈薄层液基细胞学(TCT)判读与活检病理诊断的符合率,并分析其影响因素.方法 对2010年期间在我院进行薄层液基细胞学检查的病例进行回顾性研究,并与活检病理诊断进行对比分析.结果 宫颈上皮异常检出率为3.54%,55岁以上妇女上皮异常检出率明显低于46~55岁组.薄层液基细胞学判读与病理诊断的符合率为77.55%,存在判读偏低或偏高的现象.导致判读偏差的因素有细胞学取材局限,难以获取深层细胞;取材不当以致阳性细胞过少;活检取材不到位等.结论 薄层液基细胞学检查是宫颈癌筛查的有效方法,对于宫颈上皮异常,包括非典型鳞状上皮,意义不明确的病例必须进行细胞学复查、检测人乳头瘤病毒或活检,对于薄层液基细胞学判读阳性而病理诊断阴性的病人也需进一步追踪以防漏诊. 展开更多
关键词 薄层液基细胞学检查 宫颈上皮内瘤变 病理组织学 影响因素
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FNAC结合TCT检测技术在甲状腺疾病诊断中的临床应用 被引量:3
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作者 刘芳 李晓琴 《西部中医药》 2014年第1期129-131,共3页
目的:对甲状腺肿物的细针吸取细胞(fine needle aspiration cytotogy,FNAC)结合膜式薄层液基细胞学(TCT)检查作出评估。方法:细针吸取组织,涂片,并将针筒内剩余穿刺物全部冲洗至TCT样本液中,微电脑控制完全自动纸片,HE染色,同时与有病... 目的:对甲状腺肿物的细针吸取细胞(fine needle aspiration cytotogy,FNAC)结合膜式薄层液基细胞学(TCT)检查作出评估。方法:细针吸取组织,涂片,并将针筒内剩余穿刺物全部冲洗至TCT样本液中,微电脑控制完全自动纸片,HE染色,同时与有病理组织对照的病例进行对比分析。结果:行FNAC结合TCT检查,且有组织学对照的103例甲状腺疾病患者的诊断符合率高达88.3%。结论:甲状腺肿物FNAC结合TCT诊断符合率高,值得推广应用。 展开更多
关键词 甲状腺肿物 细针吸取细胞学 tct检测技术 病理诊断
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