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Engineered 3D liver-tissue model with minispheroids formed by a bioprinting process supported with in situ electrical stimulation
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作者 WonJin Kim GeunHyung Kim 《Bioactive Materials》 SCIE CSCD 2024年第5期382-400,共19页
Three-dimensional(3D)bioprinting,an effective technique for building cell-laden structures providing native extracellular matrix environments,presents challenges,including inadequate cellular interactions.To address t... Three-dimensional(3D)bioprinting,an effective technique for building cell-laden structures providing native extracellular matrix environments,presents challenges,including inadequate cellular interactions.To address these issues,cell spheroids offer a promising solution for improving their biological functions.Particularly,minispheroids with 50-100μm diameters exhibit enhanced cellular maturation.We propose a one-step minispheroid-forming bioprinting process incorporating electrical stimulation(E-MS-printing).By stimulating the cells,minispheroids with controlled diameters were generated by manipulating the bioink viscosity and stimulation intensity.To validate its feasibility,E-MS-printing process was applied to fabricate an engineered liver model designed to mimic the hepatic lobule unit.E-MS-printing was employed to print the hepatocyte region,followed by bioprinting the central vein using a core-shell nozzle.The resulting constructs displayed native liver-mimetic structures containing minispheroids,which facilitated improved hepatic cell maturation,functional attributes,and vessel formation.Our results demonstrate a new potential 3D liver model that can replicate native liver tissues. 展开更多
关键词 BIOPRINTING In situ electric field Minispheroids In vitro liver-tissue model Hepatic lobule
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