We sought to evaluate the efficacy and effects of low-dose tacrolimus （FK506） to recipients with living donor liver transplantation （LDLT）. A total of 66 patients who underwent LDLT between 2001 and 2007 were enro...We sought to evaluate the efficacy and effects of low-dose tacrolimus （FK506） to recipients with living donor liver transplantation （LDLT）. A total of 66 patients who underwent LDLT between 2001 and 2007 were enrolled in this study. According to different doses of tacrolimus, the recipients were randomly divided into two groups： the low-dose tacrolimus group （group A） and the normal-dose tacrolimus group （group B）. The blood concentration of tacrolimus and its side effects including infection, hyperglycemia, hypertension, high blood creatinine and jaundice were monitored once a week at the perioperative period, and once a month thereafter. Besides, the survival rates of the recipients were analyzed at the 1and 3-year time point after operation. Among these patients, no significant acute rejection was detected after LDLT. The incidences of infection, hyperglycemia, liver dysfunction and renal impairment in group A were markedly lower than those in group B. However, no significant differences were detected in the incidence of hypertension between the two groups. Moreover, the recipients in each group had a similar survival rate according to the results of 1and 3-year follow-up. The incidence of side effects that associated with tacrolimus positively correlated with tacrolimus blood concentration. In conclusion, long-term and low-dose administration of tacrolimus is a safe and effective treatment for LDLT recipients.展开更多
To the Editor:We read with great interest the article by Yang et al.[1]evaluating the effects of postoperative serum total cholesterol(s TC)changes on early allograft dysfunction and survival after living donor liver ...To the Editor:We read with great interest the article by Yang et al.[1]evaluating the effects of postoperative serum total cholesterol(s TC)changes on early allograft dysfunction and survival after living donor liver transplantation(LDLT).By the multivariate regression analysis,they showed that patients with s TC<1.42 mmol/L on postoperative day 3 had 4.08-fold and 2.72-fold greater risks of展开更多
It is represented the review about the effect of low doses of ionized radiation on different types of biological objects (Japanese quail embryos, Aspergillus niger, Spirostomum ambiguum Ehrbg., mezenchim stem cells of...It is represented the review about the effect of low doses of ionized radiation on different types of biological objects (Japanese quail embryos, Aspergillus niger, Spirostomum ambiguum Ehrbg., mezenchim stem cells of mice bone brain, dry seeds of the highest plants, blood lymphocytes of pilots and cosmonauts) and water medium. In model experiments under the chronic ionized radiation in doses comparable with the doses of ionized radiation inside the orbital space stations and during the flight in interplanetary space was shown alike with morphological deviations (Japanese quail embryos, Aspergillus niger), the phenomenon of radiation hormezis (Aspergillus niger, mezenchim stem cells), the increasing of the germination of seeds, the decreasing of spontaneous motion activity of spirostoms and DNA damage, chromosome aberrations and the increased radio-sensitivity to adding radiation load in blood lymphocytes. These data testified the fact that the definite factor of ionized radiation effect is the changing of water medium state. Thus under the interplanetary cosmic flight and long stay on the orbit in the region of magnetosphere the studying kinds of radiation first effected on the water medium of organism as a result morpho-functional structures were changed.展开更多
Objective: To explore the different effects of living high - training low and living low - training low on insulin sensitivity and cytokine secretion in obese children. Methods: A total of 218 obese children who were ...Objective: To explore the different effects of living high - training low and living low - training low on insulin sensitivity and cytokine secretion in obese children. Methods: A total of 218 obese children who were treated in this hospital between September 2015 and February 2018 were selected and randomly divided into the living high - training low group (n=109) and living low - training low group (n=109). Living high - training low group received living high- training low intervention, living low - training low group received living low - training low intervention, and the intervention of both groups lasted for 4 weeks. The differences in serum levels of insulin sensitivity-related indexes as well as the contents of appetite-related hormones and adipocytokines were compared between the two groups of children before intervention and after 4 weeks of intervention. Results: Before intervention, the levels of insulin sensitivity-related indexes as well as the contents of appetite-related hormones and adipocytokines in serum were not significantly different between the two groups of obese children. After 4 weeks of intervention, serum insulin sensitivity-related indexes ISI, FPIR and GDR levels of living high-training low group were higher than those of living low - training low group;appetite-related hormones CCK and PYY3-36 contents were higher than those of living low - training low group whereas Ghrelin content was lower than that of living low - training low group;adipocytokines omentin-1 and APN contents were higher than those of living low - training low group whereas chemerin and LEP contents were lower than those of living low - training low group. Conclusion: Compared with traditional living low - training low intervention, living high - training low intervention is more effective in improving the insulin sensitivity and balance the secretion of appetite-related hormones and adipocytokines in obese children.展开更多
文摘We sought to evaluate the efficacy and effects of low-dose tacrolimus （FK506） to recipients with living donor liver transplantation （LDLT）. A total of 66 patients who underwent LDLT between 2001 and 2007 were enrolled in this study. According to different doses of tacrolimus, the recipients were randomly divided into two groups： the low-dose tacrolimus group （group A） and the normal-dose tacrolimus group （group B）. The blood concentration of tacrolimus and its side effects including infection, hyperglycemia, hypertension, high blood creatinine and jaundice were monitored once a week at the perioperative period, and once a month thereafter. Besides, the survival rates of the recipients were analyzed at the 1and 3-year time point after operation. Among these patients, no significant acute rejection was detected after LDLT. The incidences of infection, hyperglycemia, liver dysfunction and renal impairment in group A were markedly lower than those in group B. However, no significant differences were detected in the incidence of hypertension between the two groups. Moreover, the recipients in each group had a similar survival rate according to the results of 1and 3-year follow-up. The incidence of side effects that associated with tacrolimus positively correlated with tacrolimus blood concentration. In conclusion, long-term and low-dose administration of tacrolimus is a safe and effective treatment for LDLT recipients.
文摘To the Editor:We read with great interest the article by Yang et al.[1]evaluating the effects of postoperative serum total cholesterol(s TC)changes on early allograft dysfunction and survival after living donor liver transplantation(LDLT).By the multivariate regression analysis,they showed that patients with s TC<1.42 mmol/L on postoperative day 3 had 4.08-fold and 2.72-fold greater risks of
文摘It is represented the review about the effect of low doses of ionized radiation on different types of biological objects (Japanese quail embryos, Aspergillus niger, Spirostomum ambiguum Ehrbg., mezenchim stem cells of mice bone brain, dry seeds of the highest plants, blood lymphocytes of pilots and cosmonauts) and water medium. In model experiments under the chronic ionized radiation in doses comparable with the doses of ionized radiation inside the orbital space stations and during the flight in interplanetary space was shown alike with morphological deviations (Japanese quail embryos, Aspergillus niger), the phenomenon of radiation hormezis (Aspergillus niger, mezenchim stem cells), the increasing of the germination of seeds, the decreasing of spontaneous motion activity of spirostoms and DNA damage, chromosome aberrations and the increased radio-sensitivity to adding radiation load in blood lymphocytes. These data testified the fact that the definite factor of ionized radiation effect is the changing of water medium state. Thus under the interplanetary cosmic flight and long stay on the orbit in the region of magnetosphere the studying kinds of radiation first effected on the water medium of organism as a result morpho-functional structures were changed.
文摘Objective: To explore the different effects of living high - training low and living low - training low on insulin sensitivity and cytokine secretion in obese children. Methods: A total of 218 obese children who were treated in this hospital between September 2015 and February 2018 were selected and randomly divided into the living high - training low group (n=109) and living low - training low group (n=109). Living high - training low group received living high- training low intervention, living low - training low group received living low - training low intervention, and the intervention of both groups lasted for 4 weeks. The differences in serum levels of insulin sensitivity-related indexes as well as the contents of appetite-related hormones and adipocytokines were compared between the two groups of children before intervention and after 4 weeks of intervention. Results: Before intervention, the levels of insulin sensitivity-related indexes as well as the contents of appetite-related hormones and adipocytokines in serum were not significantly different between the two groups of obese children. After 4 weeks of intervention, serum insulin sensitivity-related indexes ISI, FPIR and GDR levels of living high-training low group were higher than those of living low - training low group;appetite-related hormones CCK and PYY3-36 contents were higher than those of living low - training low group whereas Ghrelin content was lower than that of living low - training low group;adipocytokines omentin-1 and APN contents were higher than those of living low - training low group whereas chemerin and LEP contents were lower than those of living low - training low group. Conclusion: Compared with traditional living low - training low intervention, living high - training low intervention is more effective in improving the insulin sensitivity and balance the secretion of appetite-related hormones and adipocytokines in obese children.
