Evolution of Viral Load in Patients Infected with HIV-1 at Point G University Hospital

Introduction: HIV, the human immunodeficiency virus, is the etiological agent of acquired immunodeficiency syndrome (AIDS). The aim of this study was to assess the evolution of the viral load in patients under treatment. Methodology: This was a study carried out from July 2017 to June 2022 at the Point G University Hospital laboratory. The determination of the viral load of patients was carried out by PCR on the ABOTT M2000sp/rt platform. Results: A total of 129 patients infected with HIV-1, aged 19 to 72 years with a mean age of 40.05 years ± 10.71;all on antiretroviral chemotherapy. The female gender predominated among our patients. The most common treatment regimen was 2INTI + 1INNTI with 72.9% followed by 2INTI + 1INI with 13.2%. As for the combinations of molecules, the combination TDF + 3TC + EFV and TDF + 3TC + DTG predominated, respectively 65.1% and 13.2%. 89.9% of our patients had undetectable viremia after 12 months of treatment (p < 0.005) with an average viral load which had evolved from 681315.65 copies/ml ± 1616908.484 to M0 at 5742.36 copies /ml ± 35756.883 at M12 (p Conclusion: Generally speaking, antiretroviral treatment had contributed to controlling viral loads, however the therapeutic combination TDF + 3TC + DTG had made it possible to obtain more patients with undetectable viremia instead.

Complete solutions for elastic fields induced by point load vector in functionally graded material model with transverse isotropy

The paper develops and examines the complete solutions for the elastic field induced by the point load vector in a general functionally graded material(FGM)model with transverse isotropy.The FGMs are approximated with n-layered materials.Each of the n-layered materials is homogeneous and transversely isotropic.The complete solutions of the displacement and stress fields are explicitly expressed in the forms of fifteen classical Hankel transform integrals with ten kernel functions.The ten kernel functions are explicitly expressed in the forms of backward transfer matrices and have clear mathematical properties.The singular terms of the complete solutions are analytically isolated and expressed in exact closed forms in terms of elementary harmonic functions.Numerical results show that the computation of the complete solutions can be achieved with high accuracy and efficiency.

Strength and failure characteristics of marble spheres subjected to paired point loads

Failure of irregular rock samples may provide implications in the rapid estimation of rock strength,which is imperative in rock engineering practice.In this work,analytical,experimental and numerical investigations were carried out to study the mechanical properties and failure characteristics of rock spheres under paired point loads.Analytical solutions indicted that with the increase in sample size(contact angle)and decrease in Poisson’s ratio,the uneven tensile stress in theta direction decreased.Then laboratory experiments were carried out to investigate the load characteristics and failure mode of spherical marble samples with different sizes subjected to a pair of diametral point loads.The discrete element method(DEM)was adopted to study the failure process of rock spheres.The effect of the sphere diameter on the point load contact angle was examined in terms of peak load,crushed zone distribution and energy dissipation.Experimental and numerical results showed that the samples primarily fail in tension,with crushed zones formed at both loading points.With increase in the sample size,the contact angle,crushed area and total work increase.As the specimen diameter increases from 30 mm to 50 mm,the peak load on the specimen increases from 3.6 kN to 8.8 kN,and the percentage of crushed zone(ratio of crushing zone to sample radius,d/r)increased from 0.191 to 0.262.The results of the study have implications for understanding the failure of irregular rock specimens under point loading conditions and their size effects.

Mechanical behavior of red sandstone under cyclic point loading

The mechanical properties of red sandstone subjected to cyclic point loading were investigated. Tests were conducted using MTS servohydraulic landmark test system, under cyclic loadings with constant amplitudes and increasing multi-level amplitudes. The frequencies range from 0.1 to 5 Hz and lower limit load ratios range from 0 to 0.60. Laboratory investigations were performed to find the effect of the frequency and the lower limit load ratio on the fatigue life and hysteresis properties of sandstone. The results show that the fatigue life of sandstone decreases first and then increases with the increase of frequency and lower limit load ratio. Under the same cycle number, the spacing between hysteresis loops increases with rising frequency and decreasing lower limit load ratio. The existence of “training” and “memory” effects in red sandstone under cyclic point loading was proved.

Analysis on the Pollution Load of Non-point Source Pollution and Surface Runoff of A Typical Village in Baiyangdian Lake Basin

[Objective] The characteristic of non-point source pollution of a typical village in Baiyangdian Lake basin was studied.[Method] The discharge of domestic sewage and solid wastes of the typical village was investigated,and both pollutant and nutrient element content were monitored,as well as the water quality and quantity of rainfall runoff.[Result] The non-point source pollution of livestock manure was far more serious than the sum of domestic sewage and domestic waste in this village,and the annual emission of total organic carbon(TOC),total nitrogen(TN) and total phosphorus(TP) was 37 794.0,4 102.9 and 1 923.7 kg,respectively.The event mean concentration(EMC)of chemical oxygen demand COD,TN and TP in rainfall runoff was 44.5,78.8,1.3 mg/L,respectively,and annual pollution load was 7.6,13.4 and 0.2 kg/hm2,respectively,while the annual pollution load of COD accounted for 5.1% of standard farmland,and that of TN and TP occupied 4.5% and 0.49% of slope farmland.[Conclusion] Livestock manure was the main source of non-point source pollution in the village and the annual pollution load of non-point source pollution was obtained.

The use of point load test for Dubai weak calcareous sandstones

Intact rock is typically described according to its uniaxial compressive strength （UCS）. The UCS is needed in the design of geotechnical engineering problems including stability of rock slopes and design of shallow and deep foundations resting on and/or in rocks. Accordingly, a correct measure-ment/evaluation of the UCS is essential to a safe and economic design. Typically, the UCS is measured using the unconfined compression tests performed on cylindrical intact specimens with a minimum length to width ratio of 2. In several cases, especially for weak and very weak rocks, it is not possible to extract intact specimens with the needed minimum dimensions. Thus, alternative tests （e.g. point load test, Schmidt hammer） are used to measure rock strength. The UCS is computed based on the results of these tests through empirical correlations. The literature includes a plethora of these correlations that vary widely in estimating rock strength. Thus, it is paramount to validate these correlations to check their suitability for estimating rock strength for a specific location and geology. A review of the available correlations used to estimate the UCS from the point load test results is performed and summarized herein. Results of UCS, point load strength index and Young＇s modulus are gathered for calcareous sandstone specimens extracted from the Dubai area. A correlation for estimating the UCS from the point load strength index is proposed. Furthermore, the Young＇s modulus is correlated to the UCS.

Variable Parameter Nonlinear Control for Maximum Power Point Tracking Considering Mitigation of Drive-train Load

Since mechanical loads exert a significant influence on the life span of wind turbines, the reduction of transient load on drive-train shaft has received more attention when implementing a maximum power point tracking U+0028 MPPT U+0029 controller. Moreover, a trade-off between the efficiency of wind energy extraction and the load level of drive-train shaft becomes a key issue. However, for the existing control strategies based on nonlinear model of wind turbines, the MPPT efficiencies are improved at the cost of the intensive fluctuation of generator torque and significant increase of transient load on drive train shaft. Hence, in this paper, a nonlinear controller with variable parameter is proposed for improving MPPT efficiency and mitigating transient load on drive-train simultaneously. Then, simulations on FAST U+0028 Fatigue, Aerodynamics, Structures, and Turbulence U+0029 code and experiments on the wind turbine simulator U+0028 WTS U+0029 based test bench are presented to verify the efficiency improvement of the proposed control strategy with less cost of drive-train load. © 2017 Chinese Association of Automation.

Effect of loading point position on fracture mode of rock

Anti symmetric four point bending specimen with different loading point positions was used to study effect of loading point position on fracture mode of rock in order to explore a feasible method for achieving Mode Ⅱ fracture and determining Mode Ⅱ fracture toughness of rock, K ⅡC . Numerical and experimental results show that the distance between the inner and outer loading points, L 1+ L 2, has a great influence on stresses at notch tip and fracture mode. When L 1+ L 2>0.5 L or 0.1 L < L 1+ L 2<0.5 L , maximum principal stress σ 1 exceeds the tensile strength σ t. The ratio of τ max / σ 1 is relatively low or high and thus Mode Ⅰ or mixed mode fracture occurs. When L 1+ L 2< 0.1 L , σ 1 is smaller than σ t and the ratio of τ max / σ 1 is much higher, which facilitates the occurrence of Mode Ⅱ fracture.

Estimating Unconfined Compressive Strength of Sedimentary Rocks in United Arab Emirates from Point Load Strength Index

In this paper, three rock types including Sandstone, Mudstone, and Crystalline Gypsum were part of a laboratory study conducted to develop a dataset for predicting the unconfined compressive strength of UAE intact sedimentary rock specimens. Four hundred nineteen rock samples from various areas along the coastal region of the UAE were collected and tested for the development of this dataset and evaluation of models. From the statistical analysis of the data, regression equations were established among rock parameters and correlations were expressed and compared by the ones proposed in literature.

Nanoindentation Models of Monolayer Graphene and Graphyne under Point Load Pattern Studied by Molecular Dynamics

Molecular dynamics simulations are performed to study the nanoindentation models of monolayer suspended graphene and graphyne. Fullerenes are selected as indenters. Our results show that Young＇s modulus of monolayer-thick graphyne is almost half of that of graphene, which is estimated to be 0.50 TPa. The mechanical properties of graphene and graphyne are different in the presence of strain. A pre-tension has an important effect on the mechanical properties of a membrane. Both the pre-tension and Young＇s modulus plots demonstrate index behavior. The toughness of graphyne is stronger than that of graphene due to Young＇s modulus magnitude. Young＇s moduli of graphene and graphyne are almost independent of the size ratio of indenter to membrane.

多目标金属露天矿配矿装载点选取问题及求解算法

目的:为了减少矿产资源浪费,提高贫矿的利用率,针对大型金属露天矿多装载点配矿问题,综合考虑矿石剩余量不足、铲装设备数量有限等因素对配装载点选取的影响,以品位偏差最小、生产成本最小、车辆总排队时间最短为目标建立配矿装载点选取模型。方法:采用二维矩阵整数编码法,并设计一种基于随机片段交叉与特定变异算子相结合的间接二次遗传优化算法对模型进行求解。结果:以国内某大型金属露天矿实际生产数据为例进行仿真实验,结果表明:所得出的装载点选取方案在受铲装设备数量限制、优先开采矿石剩余量相对较少装载点的条件下,仍能满足配矿计划需求。结论:所提模型、算法能普遍适用于大型金属露天矿山开采,使装载点的矿石得到充分利用。意义:提高了企业的经济效益和矿山整体开采效率。

Simulation on the Time Progress of the Non-Point Source Pollution Load in Initial Stage Runoff for Small Watershed

Taking a reservoir in South China as an example, we use rainfall-runoff unit hydrograph method to analyze the time changing process of surface runoff inflow, which generated by typical design rainfall. On the basis of time series data of flow and water quality in control section of the main rivers in Xili Reservoir, we establish mathematical response relation between non-point source pollutants flux, such as flux of COD, flux of NH3-H, in catchment area of control section and runoff. Then we simulate the time dynamic change progress of non-point source pollution load which generate with the initial stage runoff that generated by design rainfall and flow into reservoir. It can provide technical parameters for the design of non-point source which generate from early runoff treatment project.

基于黄金分割搜索的电压暂降域快速识别方法

针对大型复杂电网中敏感负荷的电压暂降域难以准确识别的问题,提出一种基于黄金分割搜索的电压暂降域快速识别方法。首先,求得网络中发生各类短路故障时敏感负荷节点的电压暂降幅值解析式,并引入节点判定向量和线路关联向量,以及相应的判定准则,实现对所有线路临界点的快速分类计算;接着详细阐述了传统插值法存在的问题,并提出一种由黄金分割搜索改进的插值法,以期为正割迭代提供更优的初值点,提高临界点计算的准确度;因考虑到拟合的二次曲线难免存在偏差,故使用故障点法作为补充算法,用以计算有求解困难的线路;最后,以IEEE30节点标准测试系统为例,验证了该方法能在保证计算精度的前提下,简化电压暂降域的求解过程,提高算法的收敛速度,并广泛适用于大型复杂电网。

Contact Force Distribution and Static Load-carrying Capacity of Large Size Double Row Four-point Contact Ball Bearing

Clearance not only affects the startup torque,rotation precision and stiffness of bearing,but also affects the load distribution,load-carrying capacity and life of bearing.A computational model in which the clearance of bearing is first included is presented for determining the contact force distribution and static load-carrying capacity of a double row four-point contact ball bearing which is subjected to the combined radial,axial and overturning moment loadings.The relation between the negative axial clearance and the contact force distribution is analyzed.The static load-carrying capacity curves are established,and the effects of the changes in negative axial clearance,curvature radius coefficient of raceway groove and initial contact angle on the static load-carrying capacity are analyzed.The results show that,with the increase in the absolute value of negative clearance,the maximum contact load decreases first and then increases.The clearance values in the range of 0.2 mme0 mm have little effect on the static load-carrying capacity of bearing.With the increase in the curvature radius coefficient of raceway groove and the decrease in the initial contact angle,the static load capacity of bearing decreases.

多电压等级配电系统智能软开关协同配置

配电网逐步发展成为光伏、电动汽车等新型源荷的主要承载平台,面临的电压越限和线路过载等问题逐步加剧。柔性配电装置具有良好的调控能力,成为提高配电网运行灵活性的有效手段。已有的柔性化升级主要面向中压或低压配电网,多电压等级配电网柔性互联的潜力被忽视。因此,该文开展多电压等级配电系统智能软开关协同配置方法研究。首先,提出多电压等级配电系统智能软开关协同配置策略;其次,在计及源荷不确定性影响下,考虑源荷典型场景的概率化波动,建立多电压等级配电系统智能软开关协同配置模型。最后,为实现大规模优化配置模型的可靠收敛,采用凸差规划算法进行求解。选取实际配电网算例对优化配置模型和求解算法进行验证,结果表明,所提方法可以有效解决多电压等级配电系统智能软开关协同配置问题,支撑配电网承载高比例新型源荷,在提高系统运行安全性的同时具有更好的经济效益。

考虑可平移负荷和智能软开关的主动配电网故障恢复方法

在配电网发生故障后,主动配电网能够实现用户侧参与功率的实时供需平衡,满足故障后的负荷恢复。用户参与配电网的调度也是提升故障后负荷恢复比例的途径之一,可平移负荷具有较强的可控性,有效提升了主动配电网的灵活性,智能软开关等新兴可控设备的接入,也使负荷的快速供电成为可能。本文建立了考虑可平移负荷和智能软开关的主动配电网故障恢复模型,并考虑了负荷的重要性系数。通过改进的IEEE 33节点算例进行仿真分析,构建单一故障、多点故障、短时故障的场景,验证了本文所提出方法的有效性以及可控装置对故障后负荷恢复量的提升。

体外预应力节段式UHPC无腹筋梁抗剪性能试验研究

体外预应力节段式超高性能混凝土(UHPC)无腹筋桥梁由于其施工工业化水平高且构造简单,得到广泛地关注,但其抗剪性能研究尚不成熟,相关规范也相对滞后。为了研究体外预应力节段式UHPC无腹筋梁的抗剪性能,开展了静力破坏试验,共制作了5根体外预应力节段式UHPC无腹筋梁、2根体外预应力节段式UHPC有腹筋梁和1根体外预应力整体式UHPC无腹筋梁,选取了剪跨比、钢纤维掺量、箍筋间距为研究参数进行试验。结果表明:接缝张开后梁刚度明显下降;添加钢纤维的试验梁的裂缝多而密;钢纤维的掺入可以提高梁的开裂强度、极限强度和裂后性能,2%钢纤维掺量的梁开裂强度比1.5%和0%掺量的增大8.20%和1.16倍;配箍筋的梁在钢纤维失效后箍筋开始受力,并且很快达到屈服,箍筋的存在可以提高梁极限承载力,无腹筋梁的极限承载力比箍筋间距为150 mm和75 mm的梁低15.9%和19.6%。采用AASHTO GSCB INTERIM-2003标准中计算干接缝节段式梁的折减系数0.85。在不考虑安全系数的情况下,法国规范NF P 18-710中UHPC梁抗剪承载力计算公式可以准确地预测含钢纤维体外预应力节段式UHPC无腹筋梁的抗剪强度,其试验值和预测值比值的平均值为1.04,标准差为0.28。

点荷载试验在典型露天采场超高边坡工程地质勘察中的应用

夏日哈木镍钴矿山拟建大型超高边坡露天采场,需进行边坡工程地质勘察工作。岩石抗压强度是重要的工程地质参数,如何在青藏高原山区快速获得各类岩石的单轴抗压强度等参数非常关键,尤其是各类难以进行室内压缩试验的风化或蚀变岩石。本次在野外现场采用济南矿岩HDH-1型岩石点荷载仪对矿区内各类岩石进行点荷载试验,并通过前人总结的点荷载强度与单轴抗压强度转换公式计算出了各类岩石的单轴抗压强度及层状(条带状)岩石的各向异性指数。本次点荷载试验克服了昆仑山区岩石测试加工工序复杂、周期较长、成本高等因素,且适用于风化层、蚀变带内不易进行室内压缩试验的岩石,是一种间接测量估算岩石相关强度参数的快捷方法,对以后西部山区的工程地质勘察工作具有较为广泛的借鉴作用。

地震荷载下边坡大变形失稳破坏形式研究

采用物质点法分析边坡失稳破坏模式,通过改变土体参数,确定浅层、中层与深层破坏形式边坡模型,进而分析在考虑土体应变软化模型及不同地震荷载作用下,三种边坡破坏模式的破坏过程和变化规律.研究表明,在静态计算中考虑应变软化时,边坡破坏过程较为复杂,滑体沿着滑面整体滑移后,浅层破坏滑体会持续破坏成碎散块体,中层破坏滑体持续分裂成小块体,深层破坏滑体出现新的层状失效区.动态计算中不考虑应变软化时,地震荷载不改变边坡的破坏形式,但加剧边坡的滑移和变形,且随着地震荷载峰值加速度的增加而增加.在考虑应变软化时,地震荷载峰值加速度的增加会改变边坡破坏形式,摩擦角在这个过程中起着重要作用.研究结果可为边坡治理、预防滑坡提供参考.

薄壁型钢UHPC组合箱梁受弯性能试验研究

提出一种新型薄壁型钢UHPC组合箱梁,开展了6根薄壁型钢UHPC组合箱梁与1根薄壁型钢箱梁对比梁的四点弯曲静载试验,利用三维数字图像相关测量技术对箱梁的应力-应变与变形及裂缝性能进行测试分析。研究结果表明:外包UHPC能使薄壁型钢箱梁的破坏形态由局部压屈破坏转变为底部薄壁型钢下翼缘及纵筋先后达到屈服后顶部UHPC压碎的正截面受弯破坏;外包50 mm厚UHPC的未配纵筋与箍筋的组合箱梁试件XL2的正截面受弯承载力比薄壁型钢箱梁试件XL1的对应值提升77.5%;薄壁型钢表面焊接了纵筋与箍筋的组合箱梁试件XL3~XL7的整体协同工作性能得到了大幅度提升,其中,XL4试件的正截面受弯承载力比未配纵筋与箍筋的XL2试件的对应值提升了178.8%;增大薄壁型钢壁厚与外包UHPC层厚度也能在一定程度上提高薄壁型钢UHPC组合箱梁的正截面受弯承载力与抗裂能力。