Ground motions are significantly influenced by dynamic characteristics of overburden soil layers near ground surface,as thick and soft soil layers would obviously amplify the ground motion strength. The conventional r...Ground motions are significantly influenced by dynamic characteristics of overburden soil layers near ground surface,as thick and soft soil layers would obviously amplify the ground motion strength. The conventional research method on soil nonlinear dynamic characteristics under strong motions is based on experiments in laboratories for the deficiency of observation data,but it is difficult to reliably simulate the complex factors of soils in actual earthquake durations,including loading paths,boundary conditions,and drainage conditions. The incremental data of the vertical downhole observation array,which is comprised of at least one observation point on ground surface and one observation point in a downhole rock base, makes it possible to study soil nonlinear dynamics according to in situ observation data,and provides new basic data and development opportunities to soil nonlinear dynamics studies.展开更多
The discharge patterns of neurons in auditory centers encode information about sounds.However,few studies have focused on the synaptic mechanisms underlying the shaping of discharge patterns using intracellular record...The discharge patterns of neurons in auditory centers encode information about sounds.However,few studies have focused on the synaptic mechanisms underlying the shaping of discharge patterns using intracellular recording techniques.Here,we investigated the discharge patterns of inferior collicular（IC）neurons using intracellular recordings to further elucidate the mechanisms underlying the shaping of discharge patterns.Under in vivo intracellular recording conditions,recordings were obtained from 66 IC neurons in 18 healthy adult mice（Mus musculus,Km）under free field-stimulation.Fiftyeight of these neurons fired bursts of action potentials（APs）to auditory stimuli and the remaining eight just generated local responses such as excitatory（n=4）or inhibitory（n=4）postsynaptic potentials.Based on the APs and subthreshold responses,the discharge patterns were classified into seven types：phasic（24/58,41.4%）,phasic burst（8/58,13.8%）,pauser（4/58,6.9%）,phasic-pauser（1/58,1.7%）,chopper（2/58,3.4%）,primary-like tonic（14/58,24.1%）and sound-induced inhibitory（5/58,8.6%）.We concluded that（1）IC neurons exhibit at least seven distinct discharge patterns;（2）inhibition participates in shaping the discharge pattern of most IC neurons and plays a role in sculpting the pattern,except for the primary-like tonic pattern which was not shapedby inhibition;and（3）local neural circuits are the likely structural basis that shapes the discharge patterns of IC neurons and can be formed either in the IC or in lower-level auditory structures.展开更多
基金funded by the Special Research Fund for Seismology(201408020)the Natural Science Foundation of China (51578514,U1434210)
文摘Ground motions are significantly influenced by dynamic characteristics of overburden soil layers near ground surface,as thick and soft soil layers would obviously amplify the ground motion strength. The conventional research method on soil nonlinear dynamic characteristics under strong motions is based on experiments in laboratories for the deficiency of observation data,but it is difficult to reliably simulate the complex factors of soils in actual earthquake durations,including loading paths,boundary conditions,and drainage conditions. The incremental data of the vertical downhole observation array,which is comprised of at least one observation point on ground surface and one observation point in a downhole rock base, makes it possible to study soil nonlinear dynamics according to in situ observation data,and provides new basic data and development opportunities to soil nonlinear dynamics studies.
基金supported by grants from the National Natural Science Foundation of China (31070971,31000959)
文摘The discharge patterns of neurons in auditory centers encode information about sounds.However,few studies have focused on the synaptic mechanisms underlying the shaping of discharge patterns using intracellular recording techniques.Here,we investigated the discharge patterns of inferior collicular（IC）neurons using intracellular recordings to further elucidate the mechanisms underlying the shaping of discharge patterns.Under in vivo intracellular recording conditions,recordings were obtained from 66 IC neurons in 18 healthy adult mice（Mus musculus,Km）under free field-stimulation.Fiftyeight of these neurons fired bursts of action potentials（APs）to auditory stimuli and the remaining eight just generated local responses such as excitatory（n=4）or inhibitory（n=4）postsynaptic potentials.Based on the APs and subthreshold responses,the discharge patterns were classified into seven types：phasic（24/58,41.4%）,phasic burst（8/58,13.8%）,pauser（4/58,6.9%）,phasic-pauser（1/58,1.7%）,chopper（2/58,3.4%）,primary-like tonic（14/58,24.1%）and sound-induced inhibitory（5/58,8.6%）.We concluded that（1）IC neurons exhibit at least seven distinct discharge patterns;（2）inhibition participates in shaping the discharge pattern of most IC neurons and plays a role in sculpting the pattern,except for the primary-like tonic pattern which was not shapedby inhibition;and（3）local neural circuits are the likely structural basis that shapes the discharge patterns of IC neurons and can be formed either in the IC or in lower-level auditory structures.
