Order of Precedence Between Local Laws of Cities with Subordinate Districts and Regulations of Provincial Governments Clarifying Premises for Discussion Based on the Characteristics of Laws

The lack of descriptions regarding the order of precedence between the local laws of cities with subordinate districts and the regulations of provincial governments in Legislation Law of the People's Republic of China(Legislation Law) has led to two divergent views. One holds that "the local laws of cities with subordinate districts should take precedence over the regulations of provincial governments," while the other supports the exact opposite. This is a value judgment issue in legislation. To reach a solution, we need to clarify the premises based on the characteristics of the laws in question so that a basic common ground can be established for discussion. The first premise for traditional legislation is that a law should be based on experience as well as logic; the second is that the experience of authority subjects, plus the three aspects of logic should outweigh the experience of social subjects, plus the three aspects of logic. With respect to postmodern legislation, the first premise is that experience should override logic, and the second is that the experience of the authority subject should take precedence over that of social subject, with no requirements for logical consistency. Since Legislation Law fal s into the category of postmodern legislation, according to the premises, the argument that the local laws of cities with subordinate districts should take precedence enjoys wider acceptance, but the view is logically challenged in terms of conceptual consistency, system consistency and principle consistency. More studies must be conducted to facilitate the discussion.

Preferential Policy and Tax Regulations Income Tax of Enterprises and Local Income Tax

*Newly-built joint ventures engaged in new and high technological enterprises shall enjoy a 15 percent reduction of income tax for two years, or a 24 percent reduction for two years and a 50 percent reduction in the following three years. A choice between the two may be decided by the said enterprises. **Service industry, those enterprises with a foreign capital of more than US$5 million shall be exempt from the tax

Regulation of bone phosphorus retention and bone development possibly by related hormones and local bone-derived regulators in broiler chicks

Background:Phosphorus is essential for bone mineralization in broilers,however,the underlying mechanisms remain unclear.We aimed to investigate whether bone phosphorus retention and bone development might be regulated by related hormones and local bone-derived regulators in broilers.Methods:Broilers were fed diets containing different levels of non-phytate phosphorus(NPP)0.15%,0.25%,0.35%,0.45% and 0.55% or 0.15%,0.22%,0.29%,0.36% and 0.43% from 1 to 21 or 22 to 42 days of age.Serum and tibia samples were collected for determinations of bone phosphorus retention and bone development parameters,related hormones and local bone-derived regulators of broiler chickens on d 14,28 and 42,respectively.Results:Tibia ash phosphorus,total phosphorus accumulation in tibia ash(TP_(TA)),bone mineral concentration(BMC),bone mineral density(BMD),bone breaking strength(BBS),and ash on d 14,28 or 42,serum 1,25-dihydroxyvitamin D_(3)(1,25(OH)_(2)D_(3))on d 28 and 42,mRNA expressions of tibia fibroblast growth factor 23(FGF23)and dentin matrix protein 1(DMP1)on d 14 and 28 increased linearly or quadratically(P<0.05),while serum parathyroid hormone(PTH)on d 28,tibia alkaline phosphatase(ALP)on d 14,28 and 42,bone gal protein(BGP)on d 14,and mRNA expression of tibia phosphate-regulating gene with homologies to endopeptidases on the X chromosome(PHEX)on d 14 and 28 decreased linearly or quadratically(P<0.04)as dietary NPP level increased.TPTA,BMC,BMD,and ash on d 28 and 42,BBS on d 28,and ash phosphorus on d 42 were positively correlated(r=0.389 to 0.486,P<0.03)with serum 1,25(OH)_(2)D_(3).All of the above parameters were positively correlated(r=0.380 to 0.689,P<0.05)with tibia DMP1 mRNA expression on d 14,28 and 42,but negatively correlated(r=−0.609 to−0.538,P<0.02)with serum PTH on d 28,tibia ALP on d 14,28 and 42,and BGP on d 14.TP_(TA),BMC and ash on d 14 and BMD on d 28 were negatively correlated(r=−0.397 to−0.362,P<0.03)with tibia PHEX mRNA expression,and BMD on d 28 was positively correlated(r=0.384,P=0.04)with tibia FGF23 mRNA expression.Conclusions:These results suggested that bone phosphorus retention and bone development parameters had moderate to strong correlations with serum PTH and 1,25(OH)2D3 and tibia DMP1,PHEX,FGF23,ALP and BGP in broilers during the whole growth period,and thus they might be partly regulated by these related hormones and local bone-derived regulators.

The Politics of Local Regulation in Tanzania:The Quest for Multilevel Regulatory Governance

Regulation is currently perceived as an art and craft of governance where the regulatory processes are an outcome of interdependences between political actors,bureaucrats,business community,and the public at large.However,it is now extensively recognized that this interdependency is beyond one level of government particularly in the era of decentralization where regulatory outcomes are a result of a complex set of interacting levels.This study concedes that regulatory processes are intrinsically political endeavor.Principally,local government regulatory processes are characterized by multiple actors at different levels of governance,i.e.,the local government itself and stakeholders within its jurisdiction and the central government.In fact power dispersion has a vertical direction consisting of actors stemming from different governmental levels as a consequence of decentralization.The complexities of the relationships of multiple actors at different levels of government and across the same level of government create a number of risks that jeopardize quality local regulation that need to be managed calling for multilevel regulatory governance anchored on effective stakeholder engagement and coordination.Particularly,engagement with local government during the design of new regulations is largely poor resulting in a missed opportunity to have informed decisions that enhance quality local regulation.To augment multilevel governance,it is imperative to improve the interface between central and local government with local authorities recognized as“co-producers”of regulatory outcomes.Effective implementation of Regulatory Impact Assessment(RIA)that safeguards proper analysis of proposed and existing regulation is of paramount importance to ensure evidenced based regulations,analysis of cost implications for the local government,the capacity of LGAs in to implement as well as legitimacy of regulations.Therefore this study examines the political tradeoffs between the central and local government and among other stakeholders.

Regulations for the Manufacture and Control of Live Poliovirus Vaccine: International Experience and China’s Path

The eradication of poliomyelitis is a landmark achievement in the history of public health, providing strong protection for children’s health. The introduction of the Chinese Regulations for the Manufacture and Control of Live Poliovirus Vaccine is a prerequisite and safeguard for the large-scale production and use of domestically produced live poliovirus vaccines, serving as an indispensable component of vaccine safety. This article, based on archival documents, letters, collections of essays, and oral interviews, examines the historical experience of the development of Chinese Regulations for the Manufacture and Control of Live Poliovirus Vaccine. It contends that the emphasis on localization and the active engagement in international cooperation are critical factors in the swift introduction of Chinese Regulations for the Manufacture and Control of Live Poliovirus Vaccine.

A model of local labor market regulation of China in the transition period

With the establishment of labor market of China, market is playing a more and mare important role in allocation of human resources. However, with the transition of economy in China and industrial upgrading in recent years, many labor problems have occurred which do harm to the sustainable development of local economy. The paper researches on the labor market issues of China from the perspective of local labor market regulation. Firstly, it reviews the theories of local labor market regulation. And then the main components of local labor market regulation of China are identified and the evaluation index system is established. The results of analysis of the calculated output show that （1） the local labor market regulation of China has an obvious character of gradient distribution geographically and decreases gradually from east to west; （2） of all the regulations, the regulation of the development of human capital has the most significant impact on local economy currently which is followed by the regulation of labor relation and the regulation of market participation. As to the regulation of social security, it has no Significant impact on the development of local economy.

Physiological roles of mitogen-activated-protein-kinase-activated p38-regulated/activated protein kinase

Mitogen-activated protein kinases(MAPKs)are a family of proteins that constitute signaling pathways involved in processes that control gene expression,cell division, cell survival,apoptosis,metabolism,differentiation and motility.The MAPK pathways can be divided into conventional and atypical MAPK pathways.The first group converts a signal into a cellular response through a relay of three consecutive phosphorylation events exerted by MAPK kinase kinases,MAPK kinase,and MAPK.Atypical MAPK pathways are not organized into this three-tiered cascade.MAPK that belongs to both conventional and atypical MAPK pathways can phosphorylate both non-protein kinase substrates and other protein kinases.The latter are referred to as MAPK-activated protein kinases.This review focuses on one such MAPK-activated protein kinase,MAPK-activated protein kinase 5(MK5)or p38-regulated/activated protein kinase(PRAK).This protein is highly conserved throughout the animal kingdom and seems to be the target of both conventional and atypical MAPK pathways.Recent findings on the regulation of the activity and subcellular localization,bona fide interaction partners and physiological roles of MK5/PRAK are discussed.

Transcriptional dysregulation in neurodegenerative diseases:who tipped the balance of Yin Yang 1 in the brain?

Yin Yang 1(YY1) is a multi-functional transcription factor that regulates gene expression in a range of cell types,including neurons.It controls neuronal differentiation,as well as neuronal specification and migration during the development of the mammalian nervous system.Besides,YY1 also mediates the transcription of genes that are required for neuronal survival.An impairment of the transcriptional function of YY1 causes neuronal death.This review summarizes recent research findings that unveil the dysfunction of YY1 in multiple neurodegenerative disorders.The expression of disease proteins perturbs the function of YY1 via distinct molecular mechanisms,including recruitment to protein aggregates,protein degradation and aberrant nuclear/cytoplasmic shuttling.Understanding the pathogenic roles of YY1 will further broaden our knowledge of the disease mechanisms in distinct neurodegenerative disorders.

Oxygen vacancies with localized electrons direct a functionalized separator toward dendrite-free and high loading LiFePO_(4)for lithium metal batteries

The pursuit of high energy density has promoted the development of high-performance lithium metal batteries(LMBs).However,the underestimated but non-negligible dendrites of Li anode have been observed to shorten battery lifespan.Herein,a composite separator(TiO_(2-x)@PP),in which TiO_(2)with electron-localized oxygen vacancies(TiO_(2-x))is coated on a commercial PP separator,is fabricated to homogenize lithium ion transport and stabilize the lithium anode interface.With the utilization of TiO_(2-x)@PP separators,the symmetric lithium metal battery displays enhanced cycle stability over 800 h under a high current density of 8 m A cm^(-2).Moreover,the LMBs assembled with high-loading LiFePO_(4)(9.24 mg cm^(-2))deliver a stable cycling performance over 900 cycles at a rate of 0.5 C.Comprehensive theoretical studies based on density functional theory(DFT)further unveil the mechanism.The favorable TiO_(2-x)is beneficial for facilitating fast Li+migration and impeding anions transfer.In addressing the Li dendrite issues,the use of TiO_(2-x)@PP separator potentially provides a facile and attractive strategy for designing well-performing LMBs,which are expected to meet the application requirements of rechargeable batteries.

Caffeine and Pressure Flow Autoregulation

The benefits or detriments of caffeine on the human cardiovascular system have not been thoroughly studied and are still poorly understood. In a world where caffeinated beverages are evidently the adult drug of choice (e.g. coffee, energy drinks, soda, tea),?investigating its effects on our bodies is of great importance. In this study,?we examined the effects of caffeine, taken as a tablet, on pressure-flow autoregulation. Young adults between 18 and 21 years of age were the experimental subjects. They were instrumented to monitor systemic arterial blood pressure, peripheral blood flow, calculated peripheral vascular resistance, and the electrocardiogram during an autoregulatory maneuver in the absence and presence of caffeine. Caffeine-mediated vasoconstriction was observed as early as 15 minutes after its consumption. Sixty minutes post-caffeine, vasoconstriction was so prominent that autoregulation was abolished. This was reflected, in part, as a significant reduction in blood flow that accompanied a 3-fold increase in calculated peripheral resistance and a significant increase in systemic arterial pressure. Heart rate was unaffected by caffeine under our experimental conditions. We conclude that caffeine has the ability to inhibit significant cardiovascular properties including pressure-flow autoregulation. Even though more work is needed, the significant caffeine-mediated changes in flow, pressure and resistance during autoregulation could have serious consequences for the cardiovascular system specifically, and for one’s overall health in general.

Analysis of the Cellular Localization of Herpes Simplex Virus 1 Immediate-early Protein ICP22

Nuclear proteins often form punctiform structures, but the precise mechanism for this process is unknown. As a preliminary study, we investigated the aggregation of an HSV-1 immediate-early protein, infected-cell protein 22 （ICP22）, in the nucleus by observing the localization of ICP22-EGFP fusion protein Results showed that, in high-level expression conditions, ICP22-EGFP gradually concentrates in the nucleus, persists throughout the cell cycle without disaggregation even in the cell division phase, and is finally distributed to daughter cells. We subsequently constructed a mammalian cell expression system, which had tetracycline- dependent transcriptional regulators. Consequently, the location of ICP22-EGFP in the nucleus changed with distinct induction conditions. This suggests that the cellular location of ICP22 is also influenced by promoter regulation, in addition to its own structure. Our findings provide new clues for the investigation of transcriptional regulation of viral genes. In addition, the non-protease reporter system we constructed could be utilized to evaluate the role of intemal ribosome entry sites （IRES） on transcriptional regulation.

Redox regulation of classⅡHDACs and cardiac hypertrophy

Oxidative stress plays an essential role in regulating growth and death of cardiac myocytes. ClassⅡhistone deacetylases（cⅡ-HDACs） are localized primarily in the nucleus in unstimulated cardiac myocytes and negatively regulate cardiac hypertrophy by interacting with pro-hypertrophic transcription factors,including myocyte enhancer factor 2（MEF2）,calmodulin-binding transcription activator （CAMTA）,and nuclear factor activated T cells （NFATs）.Nuclear localization of cII-HDACs is regulated not only by phosphorylation but also through oxidation of conserved cysteine residues（Ago et al 2007）,suggesting that posttranslational modulation plays an important role in mediating pathological cardiac hypertrophy and heart failure. In this presentation,I will discuss how reactive oxygen species（ROS） are produced in the heart under stress and how ROS regulate the subcellular localization of cII-HDACs,thereby causing pathological hypertrophy.The NADPH oxidase family is a group of transmembrane proteins producing superoxide and hydrogen peroxide.Nox4 is localized primarily in mitochondria,endoplasmic reticulum,and nucleus, whose expression is upregulated by pressure overload and heart failure.Nox4 plays an essential role in mediating increases in ROS in the failing heart.Increased oxidative stress induces oxidation of cysteine resides in cⅡ-HDACs,such as C667 and C669 in HDAC4,which in turn causes nuclear exit of cⅡ-HDACs.The cⅡ-HDACs are further phospho-rylated by the HDAC kinases,including Ca2+ calmodulin kinase and PKD,leading to prolonged cytoplasmic localization of cⅡ-HDACs and consequent cardiac hypertrophy.Thioredoxin 1（Trx1）,an anti-oxidant, reduces the critical cysteine residues in cⅡ-HDACs, thereby restoring the nuclear localization of cⅡ-HDACs and inhibiting pathological hypertrophy. Downregulation of Nox4 enhances nuclear localization of HDAC4,thereby inhibiting cardiac hypertrophy, suggesting that endogenous Nox4 mediates oxidation of HDAC4. In summary,oxidative stress plays an important role in regulating the subcellular localization of cⅡ-HDACs, critical regulators of pathological cardiac hypertrophy.Nox4 is upregulated in response to cardiac hypertrophy and heart failure,thereby playing a major role in mediating oxidative stress in the failing heart.Both Trxl and Nox4 play an essential role in regulating the oxidation status of cⅡ-HDACs, thereby critically regulating pathological hypertrophy and heart failure.I will also discuss pharmacological interventions targeting phosphorylation and/or oxidation of cⅡ-HDACs,which may be effective in treating pathological hypertrophy and heart failure in patients.

Influence of local environmental target constraints on enterprise OFDI

By collecting the environmental target constraints in the annual government work report of prefecture-level cities,this paper studies its impact on local enterprises’OFDI.The main conclusions are as follows:(1)Both direct and indirect constraints have a significant positive impact on enterprises’OFDI,and the degree of direct constraints is stronger than that of indirect constraints.(2)Environmental target constraints of local governments will affect corporate OFDI behavior by affecting production costs,local economic development level and local openness,and(3)There are regional heterogeneity and investment type heterogeneity in the impact of environmental goal constraints on corporate OFDI.The suggestions are as follows:government departments can appropriately strengthen the constraint intensity of environmental targets and formulate specific restraint rules for industries with different levels of pollution,so as to effectively make use of the technology spillover effects brought about by OFDI to promote the upgrading of domestic industrial structure.When making OFDI,enterprises should clarify the investment motivation,strengthen corporate social responsibility,and make use of technology spillover effect to promote the upgrading and development of home country industry while being beneficial to their own development.

论地方性法规的空间效力

地方性法规的空间效力是指地方性法规在什么空间范围内具有法律效力。地方性法规的空间效力可以分为“整体效力”“局部效力”“特定效力”和“区外效力”四种形式,其中“区外效力”是地方性法规的空间效力最鲜明的效力特征。我国现行宪法、立法法和有关法律并没有确立地方性法规的一般性空间效力,只是对“局部效力”和“特定效力”在制度上加以明确,对于地方性法规在“本行政区域”之外是否具有法律效力没有作出禁止性规定。从经济特区法规、自治条例和单行条例的立法程序来看,都不能作出否定地方性法规所具有的“区外效力”的结论。地方性法规的“区外效力”在横向和纵向两个方面进行效力延伸,横向空间效力是指地方性法规在其他行政区域的法律效力,纵向空间效力是指地方性法规能否约束中央层面的执法和司法审判机构。根据中国法的“域外适用”理论和政策要求,在确保地方性法规的合宪性、合法性前提下,地方性法规的“区外效力”应当得到制度的肯定和支持。

利率市场化改革的信贷配置质量效应研究

不当行政干预造成区域壁垒,诱发寻租问题,是导致要素市场分割与资源错配的重要成因,信贷市场尤为如此。基于商业银行信贷行为选择视角,运用2003—2019年我国31个省份的面板数据,对地方政府干预情形下我国利率市场化改革的信贷配置质量效应加以研究。结果表明,在干预市场条件下,商业银行具有较强的信贷寻租动机,信贷投放更倾向于迎合地方政府需求而非商业化导向;利率市场化改革带来的市场约束收紧尽管可促使商业银行增强信贷投放的商业性,显著增强区域贷款增长对盈利能力的敏感性,但无法对其信贷寻租动机形成有效抑制,以致其对信贷配置的质量效应难以发挥。而良好的地方政府治理可有效提升利率市场化改革的信贷配置质量效应。研究结论有助于厘清高质量发展要求下深化利率市场化改革的关键点,也为新形势下破除地方行政壁垒、增强地方金融监管效能以助推全国统一大市场建设提供经验参考。

我国地方性全民阅读法规框架体系、共性特点与地方特色研究

文章在研究国家及地方全民阅读法规的立法情况基础上,分析22部地方性全民阅读法规的立法结构与框架体系,发现其在全民阅读统筹协调与组织管理体系、全民阅读基础设施建设与服务、社会力量广泛参与全民阅读服务、阅读保障与法律责任方面存在共性特点,同时也在本地优质阅读资源、阅读节日设定与地方特色阅读品牌建设、考评与激励机制方面具有地方特色,并提出了地方性全民阅读法规未来的研究方向,以期为国家或地方开展全民阅读立法、修订等提供参考与借鉴。

论地方性法规补充设定行政处罚制度的具体适用——以北京市45部地方性法规为分析样本

2021年修订的《行政处罚法》首次突破了地方性法规设定行政处罚的原有模式,赋予了地方性法规补充设定行政处罚的权力,彰显了中央与地方分权理论的实践价值,切实弥补了上位法的立法空白,是发挥地方积极性的与时俱进的一项全新举措。立足具体立法实践,以北京市颁布生效的45部地方性法规为研究样本,从行政处罚补充设定的数量、行政处罚补充设定的集中领域、行政处罚补充设定的种类等多个角度对当前补充设定处罚制度进行实践考察,尝试性提出制度完善建议:一方面,厘定地方性法规补充设定行政处罚的适用空间;另一方面,完善地方性法规行政处罚补充设定的制度框架。

高校异地校区的空间布局与分类调控——基于“距离—效益—政策”分析框架

高校异地校区与主校区间的空间差异,导致办学成本和效益的差异。在特定空间节点中,主校区资源保障能力、属地支持能力和距离阻力三种力量叠加所形成的办学净效益的高低,是决定异地校区设置科学性、合理性高低的根本因素。理性决策者将会选择办学净效益最大化的区位作为异地校区空间布局的最优点。空间距离对办学活动的阻碍作用未能被有效根除或缓解,导致办学成本过高、办学净效益较低,是某些异地校区陷入发展困境的现实原因。高校异地校区分类调控的政策措施包括:要结合距离、效益等因素分类施策,严格清理和控制跨省异地校区,以“国家统领、省级统筹、地市支持、高校落实”的思路,促进省内异地校区规范化、高质量发展。

地方政府债务、异质性环境规制与绿色技术创新——基于247个城市的面板数据分析

本文基于2011~2021年我国247个地级及以上城市的面板数据,实证检验了地方政府债务对绿色技术创新的影响,并探索了异质性环境规制在其中起到的中介效应。研究发现:(1)地方政府债务对绿色技术创新存在总体的促进作用;(2)从机制来看,地方政府债务通过削弱指导性环境规制、增强处罚性环境规制倒逼企业等主体促进绿色技术创新;(3)产业结构升级以及数字经济水平均对地方政府债务影响绿色技术创新存在正向的调节效应。

党内法规制定工作规划实施中的地方主体及其责任问题研究

推动落实《中央党内法规制定工作规划纲要(2023—2027年)》是学习贯彻习近平新时代中国特色社会主义思想、深化依规治党、高质量推进党内法规制度建设的政治任务和行动自觉。地方党委是全面从严治党、依规治党的法定责任主体,是规划纲要制定实施的基础问题库、重要资料库。随着新时代新征程持续推动依规治党精神落实于地方党的建设,地方应在中国式现代化的目标指引下,为规划纲要实施厚植政治、理论和实践基础。其主要努力方向包括提升学习宣传规划纲要的自觉性主动性、厘清规划纲要实施的地方责任、实事求是编制地方党内法规制定工作规划计划以及扎实推进规划纲要的实施。