目的系统梳理针药结合治疗哮喘的临床研究文献,利用数据挖掘探讨其潜在的临床优势与针灸选穴规律。方法检索收录在中国知网、维普资讯中文期刊服务平台、万方数据知识服务平台、中国生物医学文献数据库及PubMed、Web of Science、Embase...目的系统梳理针药结合治疗哮喘的临床研究文献,利用数据挖掘探讨其潜在的临床优势与针灸选穴规律。方法检索收录在中国知网、维普资讯中文期刊服务平台、万方数据知识服务平台、中国生物医学文献数据库及PubMed、Web of Science、Embase、Scoups等数据库中的近20年临床研究文献,建立“针药结合治疗哮喘数据库”,运用频数统计及SPSS Modeler 18.0、Gephi0.10.1软件进行文献挖掘分析。结果①针刺优势以靶器官功能与多项血生化指标(免疫功能指标、血清炎症因子)的调节为主;中药优势为能进一步增强肺通气功能;针刺与中药联合应用可显著提高哮喘患者临床疗效。②针刺治疗哮喘重要程度排名前5位的腧穴依次为肺俞、定喘、足三里、肾俞、膻中,关联规则分析显示定喘-肺俞支持度最高,其次为脾俞-肺俞;足太阳膀胱经与手太阴肺经为常用经脉。③体现针刺优势的腧穴处方重视局部选穴,循经选穴,上下配穴。结论针药结合治疗哮喘是提高疗效的主要原因,其临床优势在于局部与整体兼顾,“标本同治,从肺论治,局部选穴,远近配穴”的临床取穴规律是针刺优势的体现之一,这为针药结合的科学应用提供了新思路。展开更多
Radiotherapy has a not well-established role in the pre-operative and in the post-operative setting in gastric cancer(GC) patients. Randomized trials report controversial outcomes and impact on survival. In the D2 loc...Radiotherapy has a not well-established role in the pre-operative and in the post-operative setting in gastric cancer(GC) patients. Randomized trials report controversial outcomes and impact on survival. In the D2 loco-regional node resection era, after a wellperformed radical surgery, local treatment using radiotherapy combined to chemotherapy should be considered for locally advanced GC. Prognostic factors could help the better selection of subgroups that present high risk of loco-regional recurrence. Then, the addition of radiotherapy could improve the diseasefree survival and also quality of life. There are no large prospective studies that have assessed specific factors predicting for recurrence or survival, but only retrospective series, some of them including high number of patients with homogeneous characteristics. In locally advanced GC adding radiotherapy to the postoperative chemotherapy seems to improve outcomes and quality of life. Prognostic factors such as T-stage, N-status, nodal ratio, and other histological factors should be considered to submit patients to postoperative combined treatment. Larger prospective series are necessary to investigate the role of combined chemoradiation after radical D2-resection, especially in locally advanced GC. Further prospective investigations are needed to suggest prognostic factors that have significant impact on survival and recurrence, improving the management and outcomes, particularly in locally advanced GC patients.展开更多
Selecting acupoints according to channel pathway is the major point selection principle in acupuncture treatment for which there is a consensus. However, defining the disease location remains the premise of acupoint s...Selecting acupoints according to channel pathway is the major point selection principle in acupuncture treatment for which there is a consensus. However, defining the disease location remains the premise of acupoint selection based on channel pathway. What is the substance of disease location identification in clinical acupuncture？ Besides indicating acupoint selection according to channel pathway, what guidance can it provide for acupuncture treatment？ This is the main topic discussed in this article.展开更多
文摘目的系统梳理针药结合治疗哮喘的临床研究文献,利用数据挖掘探讨其潜在的临床优势与针灸选穴规律。方法检索收录在中国知网、维普资讯中文期刊服务平台、万方数据知识服务平台、中国生物医学文献数据库及PubMed、Web of Science、Embase、Scoups等数据库中的近20年临床研究文献,建立“针药结合治疗哮喘数据库”,运用频数统计及SPSS Modeler 18.0、Gephi0.10.1软件进行文献挖掘分析。结果①针刺优势以靶器官功能与多项血生化指标(免疫功能指标、血清炎症因子)的调节为主;中药优势为能进一步增强肺通气功能;针刺与中药联合应用可显著提高哮喘患者临床疗效。②针刺治疗哮喘重要程度排名前5位的腧穴依次为肺俞、定喘、足三里、肾俞、膻中,关联规则分析显示定喘-肺俞支持度最高,其次为脾俞-肺俞;足太阳膀胱经与手太阴肺经为常用经脉。③体现针刺优势的腧穴处方重视局部选穴,循经选穴,上下配穴。结论针药结合治疗哮喘是提高疗效的主要原因,其临床优势在于局部与整体兼顾,“标本同治,从肺论治,局部选穴,远近配穴”的临床取穴规律是针刺优势的体现之一,这为针药结合的科学应用提供了新思路。
文摘Radiotherapy has a not well-established role in the pre-operative and in the post-operative setting in gastric cancer(GC) patients. Randomized trials report controversial outcomes and impact on survival. In the D2 loco-regional node resection era, after a wellperformed radical surgery, local treatment using radiotherapy combined to chemotherapy should be considered for locally advanced GC. Prognostic factors could help the better selection of subgroups that present high risk of loco-regional recurrence. Then, the addition of radiotherapy could improve the diseasefree survival and also quality of life. There are no large prospective studies that have assessed specific factors predicting for recurrence or survival, but only retrospective series, some of them including high number of patients with homogeneous characteristics. In locally advanced GC adding radiotherapy to the postoperative chemotherapy seems to improve outcomes and quality of life. Prognostic factors such as T-stage, N-status, nodal ratio, and other histological factors should be considered to submit patients to postoperative combined treatment. Larger prospective series are necessary to investigate the role of combined chemoradiation after radical D2-resection, especially in locally advanced GC. Further prospective investigations are needed to suggest prognostic factors that have significant impact on survival and recurrence, improving the management and outcomes, particularly in locally advanced GC patients.
文摘Selecting acupoints according to channel pathway is the major point selection principle in acupuncture treatment for which there is a consensus. However, defining the disease location remains the premise of acupoint selection based on channel pathway. What is the substance of disease location identification in clinical acupuncture？ Besides indicating acupoint selection according to channel pathway, what guidance can it provide for acupuncture treatment？ This is the main topic discussed in this article.
