Efficacy evaluation and survival analysis of the combination of oxaliplatin plus Teysuno (SOX) with immune checkpoint inhibitors in the conversion therapy of locally advanced gastric cancer

Background:The efficacy of combining immune checkpoint inhibitors(ICIs)with chemotherapy in neoadjuvant therapy for locally advanced gastric cancer has been explored.However,limited research exists on its effectiveness in conversion therapy,and its superiority over standalone chemotherapy remains to be elucidated.This study aims to investigate the efficacy and survival outcomes of patients treated with ICIs in combination with conversion therapy for locally advanced gastric cancer.Methods:Retrospective data from patients with locally advanced gastric cancer treated with either oxaliplatin+S-1(SOX)alone or in combination with ICIs in conversion therapywere collected.Clinical andpathological characteristics,disease-free survival,andefficacy assessments in nonoperable patients were compared between the 2 treatment groups.Efficacy was further evaluated through dynamic changes in serum markers,and patients’quality of life was assessed using the QLQ-STO22(Gastric Cancer–Specific Quality of Life Questionnaire)quality-of-life measurement scale.Results:A total of 140 patients underwent conversion therapy:80 in the SOX alone group and 60 in the SOX combined with the ICIs group.There were no significant differences in baseline characteristics between the 2 groups.Compared with the SOX alone group,the SOX combined with ICIs group exhibited a higher conversion rate(83.3%vs 75%,P=0.23),R0 resection rate(90.0%vs 83.3%,P=0.31),pathological complete response(pCR)rate(18%vs 5%,P=0.02),median disease-free survival(21.4 vs 16.9 months,P=0.007),the objective response rate in nonoperable patients(60%vs 40%,P=0.301),and median progression-free survival time(7.9 vs 5.7 months,P=0.009).The QLQ-STO22 quality-of-life assessment revealed statistically significant improvements in pain,swallowing difficulties,and dietary restrictions in the combination therapy group compared with those in the monotherapy group.The enhanced efficacy of immune combination with SOX is evident,as demonstrated by the significantly prolonged surgical duration in operated patients(206.6±26.6 min vs 197.8±19.8 min,P=0.35)and intraoperative blood loss(158.9±21.2 mL vs 148.9±25.1 mL,P=0.59).No significant differences were observed in postoperative complications.Conclusions:Compared with the SOX conversion therapy regimen,SOX combined with ICIs demonstrated higher conversion rates,R0 resection rates,pathological response rates,and disease-free survival without increasing surgical difficulty or complications.Nonoperable patients also experienced longer progression-free survival and objective response rates.

Residential environmental evaluation of local cities considering regional characteristic and personal residential preference—a case study of Saga City,Japan

Questionnaire surveys and subjective evaluations on residential environment were performed in order to grasp the main factors of residential environment of small local cities. The suitable evaluation index system was established, and the regional residential environment characteristics and personal residential preference types were analyzed, so that their influence on residential environment evaluation could be grasped. The results can be applied to the residential environment planning, construction and monitoring of local cities.

Collection and Evaluation of Local Thai Rice Varieties （ Oryza sativa L. ）

This study explored the biodiversity in Local Thai rice Varieties （Oryza sativa L.） during May 2011 to March 2013 by conducting surveys and collecting rice varieties from 4 regions of Thailand. There are altogether 89 varieties of local rice which include 16 in Central region, 12 in Northern region, 23 in Northeastern region, and 38 in Southern region. Among them are of 2 types： 21 varieties of glutinous rice and 68 varieties of non-glutinous rice. Ecological classification suggested 72 varieties of lowland rice, 10 varieties of upland rice, and 7 varieties of floating rice. These varieties of rice were cultivated in the farmer fields of Nongbondaeng sub-district in Banbueng district of Chonburi province during the rainy season and off season between 2011 and 2013 and to capture their agricultural descriptors. Results revealed germination and seedling growth in 33 varieties. The Unknow 2 variety yields maximum weight of 6.47 grams per panicle, while Sor.6 Chumpae variety gives minimum weight of 0.85 grams per panicle. Aye Khong produces highest number of 317 filled grains per panicle, while the lowest is Sewkliang with 5 filled grains per panicle. Gumrai gives biggest size of seed of 0.47 × 1.01 mm, while Sangyod gives smallest size of 0.19 × 0.97 mm.

Exploration and Evaluation of Internationalization at Home in Chinese Local Higher Education

IaH incorporates resource introduction,platform construction,and environment creation,effectively addressing the limitations of traditional IA.It has emerged as a prevailing trend in the internationalizing evolution of Chinese higher education.This article takes local colleges in Zhejiang Province as an example to illustrate the importance of IaH in upgrading the quality of local higher education,analyzes the models,paths,and strategies of the agenda,and discusses its effect evaluation across teaching,research,platforms,and social service.

Research on Evaluation System of Green Residential Buildings in Cold Areas of Sichuan

With regard to the rapid growth of China’s building area and the increasing energy consumption of buildings, green buildings have become an important issue for balancing economic development and environmental impact. However, the current evaluation systems for various types of green buildings are often unable to achieve a set of standards in practice due to the distinct regional characteristics of each region. Therefore, in view of the regional characteristics of the climate, terrain, ecology, and economic development in the cold regions of Sichuan, it is important to study the evaluation system of green residential buildings suitable for the cold regions of Sichuan. This article focuses on the regional characteristics of climate, topography, ecology, and economic development in the cold regions of Sichuan, and discusses the limitations of the current standards on the practice of green building in cold regions of Sichuan through a sociological questionnaire survey on the comfort of living in the local population. Then from the two dimensions of the advantages of traditional houses and the particularity of national culture, the strategies for the optimization and improvement of the evaluation index system for green residential buildings in the cold regions of Sichuan were proposed. After comprehensively considering the factors that affect the green residential buildings, including the regional characteristics of the cold regions of Sichuan, and the green performance of buildings, local characteristics and ethnic features were included in the evaluation system. The evaluation index system of green residential buildings in the cold regions of Sichuan, consists of 92 three-level indicators. A professional hierarchical analysis software yaahp was used to establish a multi-level hierarchical model between the indicators, and the indicators were compared with each other layer by layer to clarify the importance of the indicators. Based on this, a judgment matrix for each layer was constructed and obtained. The weight of each indicator is accurate, and the scoring mechanism and grading standards are constructed according to it. Through the calculation, the consistency test of the entire model was passed, thereby confirming the scientificity and rationality of the entire evaluation system.

Reflection and reconstruction： The evaluation system of the construction of the national characteristic specialty in China

In this paper, the author reflects the evaluation and appraisal systems for the construction of the characteristic specialty. Guided by the selection of the contents and the path of the construction of the characteristic specialty, from the dimension of reviewing the problems existing in the construction, with the defects of the deliberative evaluation index as the power of the correction, on the foundation of distinguishing the necessity of the construction of the evaluation, the author u＇eats the construction and the innovation as the connotation of the evaluating indexes, refers to the data for the professional evaluation as the reference model, and reconstructs the evaluation systems of the construction of the characteristic specialty.

Reflection and reconstruction： The evaluation system of the construction of the national characteristic specialty in China

In this paper, the author reflects the evaluation and appraisal systems for the construction of the characteristic specialty. Guided by the selection of the contents and the path of the construction of the characteristic specialty, from the dimension of reviewing the problems existing in the construction, with the defects of the deliberative evaluation index as the power of the correction, on the foundation of distinguishing the necessity of the construction of the evaluation, the author treats the construction and the innovation as the connotation of the evaluating indexes, refers to the data for the professional evaluation as the reference model, and reconstructs the evaluation systems of the construction of the characteristic specialty.

Local Responses to Macro Development Policies and Their Effects on Rural System in China's Mountainous Regions:The Case of Shuanghe Village in Sichuan Province

China has promulgated a series of policies including the Western Development Program, the Grain for Green Project, agricultural support policies and building a new countryside strategy to eliminate east-west differences and urban-rural disparities since the late 1990s. This paper gives a holistic examination on local responses to the four typical macro socio-economic development policies and their effects on rural system based on a case study of a mountainous village in southern Sichuan Province. The results showed that the policies have not moved the case study village from its historically marginal status. To some extent, its socio-economic situation might have been worsened by accelerated out- migration of the youth, loss of agricultural land due to afforestation and industrial plants, increased fire hazard due to afforestation and reforestation, increased environmental pollution due to industrial enterprises attracted to the village and a steep decline in agricultural production due to loss of and inefficient use of cultivated land. Factors causing local villages' dilemmas include the nonuniformity of actors' objectives, finiteness of villagers' abilities, and the imperfect incentive and restraint mechanism for local government's activities under existing policy framework composed of uncoordinated one-size-fits- all policies. We suggest that China's rural policy in the new period should gradually shift from a sectoral to a place-based one, from top-down incentives to the development of bottom-up projects, and fully recognize the diversity of rural space, so as to lift localcapacities and make good use of the knowledge shared by different actors. Moreover, it is also necessary to integrate the various sectoral policies, and improve the interministerial and interdepartmental coordination of rural policies at regional and local levels.

Education on Sustainable Development based on Local Agenda 21

The study is contextualized through evaluating the implementation of Local Agenda Action Plan (LAAP). The goal was to address environmental challenges facing a city under the framework of sustainable development and planning. The evaluation of this conceptual framework was tested at a selected municipality of Athens (Greece), that has used a LAAP. The research was based on a structured questionnaire survey of a sample of 300 respondents selected from municipal employees (100 persons) and citizens of the selected municipality (200 persons). Analysis and interpretation of data through descriptive and factor analysis statistics establish that both municipality employees and citizens are primarily concerned with issues of environmental management. They firmly believe that sustainability initiatives at municipality might best be implemented through a collaborative approach at the local community level, involving local citizens working in partnership with local government. Furthermore, the study established the importance of education, aware-ness and training as a response to environmental issues currently facing the municipality. The awareness and training activities should be developed and should involve the members of the community in the needed environmental manage-ment processes. In view of the Decade Education for Sustainable Development (UNESCO 2005-2015), this should en-able the Council to create opportunities for income generation, while simultaneously promoting citizens’ environmental responsible behaviors and improving service delivery by municipality employees.

基于Gloabl-Local评估方法的U-Net图像分割

精确的图像分割是完成图像中物体姿态、大小估计的重要步骤,但由于物体的多样性、复杂性等原因,使得图像分割在计算机视觉领域仍然是具有挑战性的任务。针对标准U-Net模型实现端到端的图像分割时精确度不高、训练难以收敛等问题设计了一种基于Gloabl-Local评估方法的U-Net图像分割方法。首先根据同时兼顾全局信息和局部信息能够得到精确的图像分割图,论文提出了Gloabl-Local训练过程易拟合等问题,提出了改进U-Net法和4个公共显著性检测数据集训练改进U-Net网络模型,大大提高了图像分割的准确率。论文的方法平均准确率达到90.74%,与标准U-Net相比具有更好的分割效果。此方法实现了准确高效的图像分割,为估计图像中物体的姿态、大小提供了可靠依据。

Local dimming效果与分区数的关系研究

Local dimming(区域背光调控)是改善被动发光的液晶显示器性能的重要技术。采用一套自主开发的仿真算法,在充分验证其准确性后,对液晶显示器的对比度和光晕指数随分区数的变化关系进行了计算仿真与分析,最终形成背光分区数设计指引。分析结果表明:对比度随分区数的增加而增加,RTINGS棋盘格图片最大价值点(导数为1的点)为300分区,要达到足够接近最大对比度,则需要1600分区左右;背光行列分区数为8的倍数时有更好的对比度体现;光晕指数与对比度随分区数变化的趋势相似,RTINGS十字架图片最大价值点(导数为1)为500分区。

地方高校教师数字素养标准化评估与提升策略研究

随着信息技术的迅猛发展和数字化时代的到来,教师数字素养已成为教育领域中不可忽视的核心能力。地方高校教师数字素养的评估与提升不仅能够适应新时代下的全新教学要求,提升教学质量,同时能够促进教师专业能力的提升,适应数字化社会发展需求。本文首先介绍了地方高校教师数字素养标准化评估方法,其中包括制定评估标准、开发评估工具、设计评估流程,进而介绍了提升地方高校教师数字素养的有效策略,以期能够让教师更好地运用数字技术提升高校教学质量。

断点回归方法及应用实现

目的完整、系统介绍断点回归设计(RDD)原理及统计方法,为其在公共卫生领域应用提供参考。方法在介绍断点回归设计原理基础上,用室内甲醛干预的实例演示了利用Stata软件实现断点回归统计方法的过程,介绍和比较属于参数法的多项式回归和属于非参数法的局部线性回归的分析方法和结果。结果RDD是一种准实验设计,对研究对象没有随机分组,而是选择一个与干预措施有关的变量,根据该变量的取值选择切点划分干预组和对照组。RDD在内部有效性方面优于其他准实验设计,但外部有效性受到一定限制。基于观察性资料的RDD不仅可控制可观测的混杂因素,还可控制无法观测的混杂因素,也更符合伦理道德。在本文实例中,多项式回归和局部线性回归两种分析方法的结果基本一致。结论RDD在公共卫生领域的真实世界研究中有广阔的应用前景,为科学评估干预政策和提供高质量决策依据提供新的思路和方法。

定向·定位·定型·定力:分类评价与地方应用型本科高校的实践与超越

分类评价作为重要的政策工具,在地方应用型本科高校定向、定位、定型以及形成定力过程中发挥了重要引导作用。但总体而言,政府定类基础上的“选位评价”、规范性基础上的“竞争性评价”、多元数据基础上的“单一性评价”等分类评价举措具有明显的管理导向,在高等教育高质量发展的背景下,政府应从“管理者”转向“促进者”,评价依据应从“断面数据”转向“成长数据”,评价过程应从“群体画像”转向“个案剖析”。当前,要重点关注在分类管理政策基础上,完善间接制度环境;在横向类型维度基础上,纵向划分发展阶段;在多主体参与基础上,强化协同创新。

地方高校课堂教学质量评价体系重构探析

在深入剖析和反思当前地方高校课堂教学质量评价在评价目的、评价形式及评价标准中存在的主要问题基础上,从理念、定位和方法等不同角度探讨了基于质量提升的课堂教学质量评价改革策略,重构了以学生发展和质量提升为中心的地方高校课堂教学质量评价新体系。

地方高校教师学术评价的困局、变局和破局

《深化新时代教育评价改革总体方案》明确提出,要扭转不科学的教育评价导向,推进教育评价关键领域改革取得实质性突破。地方高校教师学术评价作为教育评价的关键领域之一,理应有显著的进展和实质性的突破。然而,当前地方高校教师学术评价仍然存在评价主体错位、评价标准单一和评价方式简化等问题。究其本源,地方高校教师学术评价的问题源于工具理性和价值理性的失衡与绩效文化的泛化。因此,改进地方高校教师学术评价应呼唤价值理性的崛起和过滤绩效文化的影响,遵循学术逻辑,厘清学术评价主体;强化价值认同,坚持分类评价标准;改进量化评价,健全同行评议机制。

新文科背景下高等院校毕业论文存在问题及优化路径探讨——以师范类地方本科院校汉语言文学专业为例

新文科建设理念的提出为汉语言文学专业毕业论文在交叉学科选题、人工智能AI辅助、个性化指导等方面的质量提升提供技术实现路径。提升高校师范类汉语言文学专业毕业论文质量需要建设综合性的制度保障路径,实现学校、二级学院、基层教学组织和指导教师等各个层面协同发力,推动教学大纲、专业课程与毕业论文课程需求的有机衔接。高校教师要发挥指导教师的学术专长,引导学生结合学情、个体特点打造出最有价值的选题。

基于OBE理念的教学质量评价体系研究与实践

OBE理念是一种以学习成果为导向,注重学生能力培养和学习目标达成的教育理念。在人才培养中,教学质量评价作为保障体系的关键环节至关重要。选取广西医科大学第一临床医学院,旨在探讨基于OBE理念的教学质量评价体系在地方医学院校的应用情况。通过对OBE理念在学院的应用情况、评价指标体系及实际运行情况的深入研究,强调了OBE理念在地方医学院校教学质量评价中的重要性。研究着重于完善评价体系并积极应对挑战,旨在提升教学质量并保证人才培养的有效性与质量。

新一轮审核评估背景下地方本科高校质量保障体系建设探究

实施新一轮本科教育教学审核评估是执行《深化新时代教育评价改革总体方案》和《关于深化新时代教育督导体制机制改革的意见》的关键措施。这一举措旨在积极适应高等教育发展的新阶段,通过评估促进建设、改革、管理和强化,加速构建具有中国特色的高等教育评估体系。本文详细论述了新一轮审核评估对地方本科高校质量保障的具体要求,并识别了当前地方本科高校质量保障体系建设面临的挑战,包括总体审核评估标准的缺失、学生综合发展成果审核评估的不足、高校间互评的缺乏以及动态审核评估机制的不健全等问题。针对这些问题,文章提出了构建地方高校质量保障体系的策略:制定科学规范的审核评估标准,加强学生发展成果的审核评估,促进高校间的交流与互评,以及建立动态的审核评估机制。