The basic core traditional C hinese medicine for the prevention and treatment of COVID-19 and its active mechanisms

Background:COVID-19 has had a dramatic impact on human health,economies,societies,and livelihoods around the world.Traditional Chinese medicine(TCM)formulae have played an important role in the prevention and treatment of COVID-19.WHO evaluated the role of TCM in treating of COVID-19 and encouraged other countries to promote the use of TCM formulae.However,the key is to find the basic core traditional Chinese medicine(BC-TCM)among those formulae.Methods:For the first time,we mined the data of TCM formulae in CNIPA and analyzed herb characteristics and association rules.We then determined the BC-TCM and screened main compounds and therapeutic targets.Finally,the potential molecular mechanisms were explored by using enrichment analyses and molecular docking.Results:This study screened 123 patented TCM formulae,including 312 herbs.According to frequency statistics and association rules,nine herbs(Gan Cao,Jin Yinhua,Guang Huoxiang,Fu Ling,Huang Qi,Jie Geng,Lian Qiao,Cang Zhu,Ku Xingren)were selected as the BC-TCM.The BC-TCM involved 166 main compounds and 48 therapeutic targets.The active compounds Hederagenin,Spinasterol,Beta-sitosterol,and Liquiritin had high binding activity to the COVID-19 targets 3CL,ACE2,and core targets RELA,HSP90AA1,STAT3,MAPK3,and TP53 according to molecular docking results.Interestingly,Hederagenin might be a potential compound for the prevention and treatment of COVID-19.Conclusion:Our research predicted and confirmed the preventive therapeutic effect of BC-TCM on COVID-19.This has the potential to broaden the scope of TCM,guide people in using clinical formulae,and provide valuable insights for future TCM discovery research.

Application of integrated traditional Chinese and Western medicine in the treatment of juvenile localized scleroderma with skin ulcer: a case report

Background:Juvenile Localized Scleroderma(JLS)is a rare pediatric rheumatic disease characterized by inflammation and skin sclerosis.The side effect of consensus-recommended medications and the risk of disability posed challenges to the JLS treatment.We intend to demonstrate the potential of traditional Chinese medicine in treating JLS with skin ulcers and reducing the dose of glucocorticoid.Method:Here we report a case of a 13-year-old male with JLS who took oral methotrexate tablets of 10 mg/week and methylprednisolone of 6 mg/day for over six months without significant effect and suffered from skin ulcers on the dorsal feet one month after drug cessation.Subsequently,the patient was treated with integrated traditional Chinese and Western medicine of low-dose glucocorticosteroid,adjusted Shenqi Huoxue formula and Jinshe Xiaoyan formula,etc.Results:After integrated treatment,the patient’s dorsal feet ulcers healed and the skin sclerosis and hyperpigmentation improved significantly.Conclusions:This case report suggests that integrated traditional Chinese and Western medicine can be used as an effective treatment for JLS.

Current situation and influencing factors of classroom situationdeviant behavior of undergraduate nursing students in colleges oftraditional Chinese medicine

Objective: To investigate the current situation and influencing factors of classroom situation deviant behavior ofundergraduate nursing students in colleges of traditional Chinese medicine. Methods: Three hundred andeighty-two undergraduate nursing students in Tianjin University of Traditional Chinese Medicine were investigatedby general situation questionnaire, Classroom Situation Deviation Behavior questionnaire, Utrecht WorkEngagement Scale-Student and Mobile phone addiction index scale. Results: The scores of the ClassroomSituation Deviation Behavior questionnaire of nursing students were (46.04 ± 14.94). The results of multiple linearregression analysis showed that gender, academic ranking, family income (RMB/month), learning involvement andmobile phone dependence were the influencing factors, accounting for 32.9% of the total variation. Conclusion:The classroom situation deviant behavior of undergraduate nursing students in colleges of traditional Chinesemedicine is moderately upper-level. It is suggested that the management departments of colleges should strictlyenforce the classroom management system, improve the teaching level of teachers, guide students to develop goodlearning habits, and constantly stimulate students' learning enthusiasm in order to reduce the occurrence ofclassroom situation deviation behavior.

Clinical research progress of oral administration of traditional Chinese medicine in the treatment of dry eyes

Dry eye is a common and frequently occurring ophthalmology disease with complex etiology and easy recurrence.Oral administration of traditional Chinese medicine has the characteristicsof high curative effect and little toxic and side effect in the treatment of dry eye.This paper collates the domestic reported clinical studies on the oral administration of traditional Chinese medicine in the treatment of dry eye,which are discussed from four aspects:special prescription for specific disease,addition and subtraction of main prescription,treatment based on syndrome differentiation and proprietary Chinese medicine.The curative effect and advantages of traditional Chinese medicine in the treatment of dry eye are demonstrated,providing a reference for the treatment of dry eye in the future.

Therapeutic Effect of Oral Administration and External Therapy of Traditional Chinese Medicine on Cervical Tuberculous Lymphadenopathy

Objective:To analyze the clinical effect and value of oral administration and external therapy of traditional Chinese medicine for treatment of cervical tuberculous lymphadenopathy.Methods:A total of 56 patients with cervical tuberculous lymphadenopathy admitted to our hospital from January 1 to January 2018 were recruited.By using double-blind method,the patients were divided into control group(n=28)and experimental group(n=28).Control group comprised of patients with conventional anti-tuberculosis treatment,while the experimental group comprised of patients treated with oral administration and external therapy of traditional Chinese medicine.Total effective rate,incidence of complication and level of T lymphocyte subsets were compared between the two groups of cervical tuberculous lymphadenopathy patients.Results:Post-treatment data of total effective rate,complication rate,CD3+,CD4+,CD8+,CD4+/CD8+of the experimental group were compared with the control group.P<0.05;statistical analysis showed statistical significance.Post-treatment data of CD3+,CD4+,CD8+,CD4+/CD8+of both control and experimental groups were compared with pre-treatment data.P<0.05;statistical analysis showed statistical significance.Conclusion:Oral administration and external therapy of traditional Chinese medicine possesses significant effect in treatment of cervical tuberculous lymphadenopathy.

A meta-analysis of the efficacy of traditional Chinese medicine alone in the treatment of refractory gastroesophageal reflux disease

Background:To systematically evaluate the efficacy and safety of traditional Chinese medicine in the treatment of refractory gastroesophageal reflux.Methods:PubMed,The Cochrane Library,Embase,Web of Science,China National Knowledge Infrastructure,Wanfang Database,China Science and Technology Journal Database and Chinese BioMedical Literature Database were searched for randomized controlled trials of traditional Chinese medicine in the treatment of refractory gastroesophageal reflux from database establishment time to December 2020.After two researchers independently screened the literature,extracted data and evaluated the bias risk included in the study,RevMan5.3 software was used for meta-analysis.Results:A total of 12 randomized controlled trials,were included,including 893 patients.The results of meta-analysis showed that the total effective rate of the treatment group(relative risk=1.28,95%confidence interval(CI)(1.19,1.38),P<0.00001),RGERDQ(refractory gastroesophageal reflux disease)score(mean difference(MD)=−3.35,95%CI(−4.13,−2.57),P<0.00001],acid reflux(acid in the stomach comes out of the mouth)[MD=−0.30,95%CI(−0.45,−0.15),P<0.00001],heartburn(the feeling that the heart is burned)(MD=−0.44,95%CI(−0.60,−0.29),P<0.00001,and retrosternal pain(MD=−0.27,95%CI(−0.44,−0.10),P<0.00001,belching(MD=−0.40,95%CI(−0.57,−0.24),P<0.00001],endoscopic mucosal score(MD=−0.62,95%CI(−0.78,−0.46),P<0.00001],the differences were statistically significant,and the effective rate of mucosal improvement under endoscopy was P=0.93>0.05,with no statistically significant difference.Conclusion:The current evidence shows that traditional Chinese medicine in the treatment of refractory gastroesophageal reflux disease is better than that of western medicine in the total effective rate,relieving acid reflux,heartburn,retrosternal pain and belching symptoms,but it is impossible to judge the improvement of mucosa under endoscope.Due to the limitations of the quality and quantity of included studies,more high-quality studies are needed to confirm the above conclusions.

The Great Significance of Establishing Strategic Status of Traditional Chinese Medicine (TCM)

Traditional Chinese Medicine(TCM), based on the philosophic idea of “correlation between man and nature” and “balance of Yin and Yang” and characterized by “integrated concept” and “syndrome identification & treatment determination”, adjusts and activates the self-recuperating ability to rectify its differentiation from normality of human body to meet the goal of preventing and treating diseases mainly by means of traditional Chinese medicinal herbs, acupuncture and moxibustion, etc. The idea of “Human should be in harmony with Nature including bacterium, virus, etc., but not to exterminate microbe in a large scale”, held and promoted by TCM gives, rise to a delicate physiological equilibrium kept between man and microbe and this is just the development trend of medical science in future. For thousands years, TCM has made indelible contribution to the reproduction and prosperity of the Chinese nation, and under the countless attacks of pestilence has never made its people’s death in millions, not such as once occurred in Europe. TCM is also characterized by its “simple, convenient, cheap and effective”method of treatment” and is especially good at preventing and treating chronic diseases, complicate multi-system diseases and new-type virus diseases. Therefore, only when the sanitation and healthcare system is established can the health of 13 billion people in China and the problem of shortage of doctor and medicine for 900 million rural population and large number of poverty-stricken urban population be solved. It is strongly suggested that five promotion projects, namely: TCM policy and statute guarantee, TCM qualified personnel cultivation, TCM scientific research, development of TCM in rural areas and TCM administrative system reform should be carried out in real earnest to make TCM develop in a sustainable way.

A Protocol for Digitalized Collection of Traditional Chinese Medicine(TCM)Pulse Information Using Bionic Pulse Diagnosis Equipment

Pulse diagnosis equipment used in Traditional Chinese Medicine(TCM)has long been developed for collecting pulse information and in TCM research.However,it is still difficult to implement pulse taking automatically or efficiently in clinical practice.Here,we present a digital protocol for TCM pulse information collection based on bionic pulse diagnosis equipment,which ensures high efficiency,reliability and data integrity of pulse diagnosis information.A four-degree-of-freedom pulse taking platform together with a wrist bracket can satisfy the spatial positioning and angle requirements for individually adaptive pulse acquisition.Three-dimensional reconstruction of a wrist surface and an image localization model are combined to provide coordinates of the acquisition position and detection direction automatically.Three series elastic joints can not only simulate the TCM pulse taking method that“Three fingers in a straight line,the middle finger determining the‘Guan’location and finger pulp pressing on the radial artery,”but also simultaneously carry out the force-controlled multi-gradient pressing process.In terms of pulse information integrity,this proposed protocol can generate rich pulse information,including basic individual information,pulse localization distribution,multi-gradient dynamic pulse force time series,and objective pulse parameters,which can help establish the fundamental data sets that are required as the pulse phenotype for subsequent comprehensive analysis of pulse diagnosis.The implementation of this scheme is beneficial to promote the standardization of the digitalized collection of pulse information,the effectiveness of detecting abnormal health status,and the promotion of the fundamental and clinical research of TCM,such as TCM pulse phenomics.

高校招生视域下中医院校护理本科人才培养策略研究

目的了解全国中医院校护理学类本科专业招生现状,为中医院校培养具有中医特色的护理人才提供参考。方法采用目的抽样法,选取全国24所中医院校2021-2022年公布的护理学类本科专业招生情况作为研究对象,通过文本分析法进行资料分析。结果专业设置和专业布点在校际区域间差异较大,专业目标和课程设置对中医特色逐渐彰显,针对拔尖人才培养聚力不够,招生模式传统单一,生源质量整体偏弱。结论高校可通过优化专业结构、调整招生策略、深化教学改革、强化培养特色等,提升中医院校护理本科人才培养质量。

创新创业人才培养视域下中医药院校无机化学双语教学的理念、价值和路径

随着经济全球化和国际交流的加深,培养具备跨文化交流和创新创业能力的中医药人才已成为中医药院校教育改革的核心任务之一。该文以创新创业人才培养视域为切入点,探讨了中医药院校在无机化学课程中引入双语教学的理念、价值和路径,并提出了相关策略和建议,以期为“高品质、国际化、创新型”中药专业人才的培养提供理论和实践参考。

北京协和医学院临床医学改革试点班中医课程的教学评价

目的对首三届北京协和医学院临床医学专业“4+4”改革试点班的《中医学》课程进行教学评价。方法采用问卷星无记名问卷调查方式,统计及分析总结2019级、2020级和2021级学生填写的《中医学教学问卷调查表》。结果大部分学生对中医感兴趣、认为有必要学习《中医学》课程,认为《中医学》授课教师充分备课,教学内容与教材、教学大纲、授课PPT相匹配,教学内容与临床紧密结合,对教学手段和方法满意。结论教学评价有助于教师总结教学经验和提升《中医学》课程的教学质量。

扶阳健脾汤-滋阴养胃汤顺势给药和逆势给药对健康大鼠生理指标的影响

目的通过顺势和逆势给药大鼠扶阳健脾汤和滋阴养胃汤的研究来进一步验证中医阴阳分药分时服用方剂学理论,以及评价扶阳健脾汤和滋阴养胃汤的亚急性毒性。方法选取无特定病原体级SD大鼠48只,雌雄各半,按性别、体质量(空腹)排序,采用计算机随机法分为顺势饲喂组、逆势饲喂组、阴阳合药饲喂组和对照组,每组12只。对顺势饲喂组大鼠早上给予滋阴养胃汤颗粒制剂溶液,下午给予扶阳健脾汤颗粒制剂溶液灌胃,逆势饲喂组大鼠给药顺序与顺势饲喂组相反;阴阳合药饲喂组大鼠给予扶阳健脾汤和滋阴养胃汤合药颗粒制剂混合溶液灌胃,分早晚两次给药;给予对照组早晚灌胃等量超纯水,四组大鼠均每周给药5 d,共给药7周。分别于饲喂第1天、第10天、第20天、第30天、第45天时观察各级大鼠的皮肤毛发、行为状态、兴奋程度、激怒反应、睡眠状态、大便状态。分别于饲喂后第1周、第3周、第5周、第7周的周一、三、五测定大鼠采食量和体质量,饲喂7周后检测大鼠血液常规和血生化指标,计算脏器系数。结果饲喂第3周、第5周、第7周,顺势饲喂组日均采食量明显低于对照组;饲喂第5周、第7周,逆势饲喂组体质量明显高于对照组;饲喂7周后,顺势饲喂组和逆势饲喂组的心脏脏器系数明显低于对照组,而顺势饲喂组的脾脏脏器系数明显高于对照组;顺势饲喂组单核细胞计数明显低于对照组,顺势饲喂组和阴阳合药饲喂组的甘油三酯明显低于对照组,顺势饲喂组的血清总胆固醇明显低于对照组,顺势饲喂组、逆势饲喂组、阴阳合药饲喂组的空腹血糖明显低于对照组,顺势饲喂组、逆势饲喂组、阴阳合药饲喂组的肌酐明显高于对照组;顺势饲喂组和阴阳合药饲喂组的白蛋白明显高于对照组。结论顺势给药、逆势给药、混合给药可引起大鼠空腹血糖降低,肌酐增高;此外,顺势给药还可引起大鼠心脏脏器系数、单核细胞计数、甘油三酯、总胆固醇降低,脾脏脏器系数、白蛋白增高,表明顺势给药会促进大鼠的气血运行,有利于减少食物的摄入以及促进大鼠代谢体内的碳水化合物和蛋白质的代谢,从而进一步验证了中医阴阳分药分时服用方剂学理论。

高等中医药院校核医学课程思政的探索与实践

核医学是利用放射性核素标记的分子探针进行疾病诊断、治疗及科研工作的学科,是现代医学的重要组成部分,其在解码中医、服务中医药科研和中医药临床疗效评价等方面具有独特优势。本文探索高等中医药院校核医学课程思政的教学改革,挖掘核医学课程思政元素,把课程思政与核医学教学有机融合,将知识传授和价值引领有机统一,培养学生的中医文化自信、家国情怀、科技创新意识和职业道德素养,同时提高教师自身的政治觉悟,培养教师的育德能力。

高等中医药院校西医内科学教学的创新探索

在高等中医药院校中医专业的学习中,西医内科学亦为重要的临床专业课程之一,但西医内科学教学面临与中医课程交叉、课时压缩、学生基础薄弱等相应问题,增加了该课程的学习难度。随着现代社会对医学人才的要求不断提高,中医药院校的临床专业学生也必须掌握西医的理论基础和临床疾病。为了贯彻国家“新医科”建设,提高中医专业西医内科学教学水平,提升本科生分析及解决临床问题的能力,笔者所在教研室总结出内科专业主讲教师+教学秘书责任制、现代化教学手段+问题/病例切入式教学、充分利用现代网络和床旁教学等不同教学模式,在实际运用中取得了很好的教学效果,得到授课教师和学生的广泛认可。文章就相关教学经验进行总结,以期为中医药院校本科生的西医内科学教学提供一定的有益建议,提高本科生的西医内科学教学水平。

基于中医药文化自信的中医药院校课程思政建设探究——以福建中医药大学为例

新形势下,课程思政是高校思想政治教育的重要组成部分,也是探索“培养什么人”“怎样培养人”“为谁培养人”[1]等根本问题的重要举措,课程思政建设已经成为中医药院校的主要任务之一。本文以福建中医药大学为例,深入分析中医药院校课程思政建设中弘扬中医药文化现状,并进一步探讨如何充分发挥中医药院校课程思政建设在弘扬中医药文化中的积极作用,将立德树人作为课程思政建设的最高宗旨,顺利推动中医药院校课程思政建设。

争创“双一流”中医药高校背景下构建良好导学关系模式探索

[目的]探索在争创“双一流”中医药高校的背景下,导学关系新模式的构建举措,以不断提升中医药高校研究生培养质量。[方法]在争创“双一流”中医药高校背景下,介绍构建良好导学关系的现实意义,基于导师和研究生两大主体的视角,对当前中医药高校研究生培养中导学关系存在的突出问题进行分析。[结果]以浙江中医药大学为例,从强化“尊师重道”正向影响、纠正导学关系失衡和完善相关制度三个方面入手,提出了相应的可行性建议。通过良好导学关系的构建,导学关系普遍得到了正向影响,师生间的沟通更加密切而高效。通过一系列正向激励机制,导师在学术引领、学业指导和生活关怀等方面更加积极主动地为研究生提供支持和帮助,研究生也更加积极地配合导师开展各项科研工作,研究生发表学术论文的数量和质量得到了显著的提升,导师团队的科研、教学工作开展更加高效,进展显著。[结论]通过一系列有效举措,浙江中医药大学着力探索导学关系新模式的构建,显著改善了导学关系,不仅对提升研究生专业思想水平、沟通交流能力、科研创新能力有积极的作用,同时也为导师顺利完成教学科研工作提供了保障,值得进一步完善并推广。

面向“双创”教育的“一主体三维度”中医药院校本科生创新能力培养新模式探索

高等中医药院校在加强学生专业培养的同时,需响应国家“大众创业、万众创新”战略,着力培养高质量的创新创业人才。以重点实验室为依托,探索面向“双创”教育的“一主体三维度”中医药院校本科生创新能力培养新模式,为中医药院校培养高质量的创新创业人才提供参考。

“新文科”理念下中医药院校汉语国际教育专业课程建设的思考与探索

当前“新文科”建设的重点工作在于对高校文科专业的专业优化与课程改革。中医药院校汉语国际教育专业应抓住“新文科”建设的良好契机,加大课程建设力度,使课程体系与课程结构更能准确体现院校和专业特色,重视课程内容的知识创新,促进课程教学方法和教学手段的改革,加强专业化的教师队伍建设。通过课程建设和教学创新,切实解决学生学习中的“痛点”问题,提升人才培养质量,促进学科与专业的发展。

中医药院校工匠精神培育评价体系建构

基于对中医药院校学生工匠精神培育的实践经验和理论研究,构建一套科学可行的工匠精神培育成效评价体系,并通过实证研究验证其有效性和可靠性。该评价体系由思想理念、技能水平、品德素养、责任意识和创新能力等方面构成,每个方面包括若干个具体的评价指标,通过权重分配和综合评价方法,得出中医药院校学生工匠精神培育的总体成效评价结果。该评价体系具有科学性、公正性、实用性和可行性,可以为中医药院校学生工匠精神培育提供有效的评价工具和参考依据。

江苏地方医派传承发展张仲景学说刍议

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