Traditional Chinese Medicine Treatment, Gua Sha, can Induce Subtle Molecular Changes in Gene Expression

Objective Here, we explored molecular changes that could potentially mediate healing effects of Gua Sha — a method employed by the Chinese traditional medicine with proven track records of safe and efficient applications dating back to ancient times as well as support from randomized controlled trials performed by modern medical studies — yet remaining almost entirely unexplored by the modern-day high-throughput methods of the-omics sciences.Methods We investigated transcriptome changes occurring shortly after Gua Sha treatment in the whole blood of healthy volunteers using bulk RNA-seq analysis. We applied various analytical tools to identify genes with consistent expression changes in multiple individuals in response to Gua Sha and their networks.Results We found that while the changes were very subtle and individual-specific, we could identify consistent upregulation of three histone genes. Further analysis of the potential regulatory networks of these histone genes revealed the enrichment of functions involved in the immune response and inflammation.Conclusion The significance of these results in the context of potential effects of Gua Sha and the next steps in exploring the molecular mechanisms of action of this technique are discussed.

The Totem Culture of Chinese Dragon

This paper addresses the totem culture of Chinese dragon by introducing the origin of the Chinese dragon,exploring the totem culture by its social and folk customs and the relations with each country's cultural features.

Efficacy and Safety of Lianhua Qingke Tablets in the Treatment of Long Coronavirus Disease (COVID) Cough: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Clinical Study

Lianhua Qingke tablets,a patented traditional Chinese medicine that has validated clinical efficacy for treating cough caused by severe acute respiratory syndrome coronavirus 2 infection,lack rigorous evidence-based research evaluating their effect on long coronavirus disease(COVID)cough.A randomized,double-blind,placebo-controlled,multicenter clinical study was conducted among patients with long COVID cough from 19 hospitals and 23 community health centers in China.Patients were randomized 1:1 to receive either Lianhua Qingke tablets or placebo orally for 14 days(four tablets,1.84 g,three times a day).The primary endpoint indicator was the disappearance of cough,with the remission of cough also considered.Among 482 randomized patients,480(full analysis set 480;per-protocol set 470;safety set 480)were included in the primary analysis.According to the full analysis,the time until cough disappearance was significantly shorter in the trial group than in the control group,with a significant increase in the 14-day cough disappearance rate.Accordingly,the time to cough remission was significantly shorter in the trial group than in the control group.The change in the total symptom score was significantly greater in the trial group than in the control group on days 7 and 14,consistent with the results indicated by the visual analog scale(VAS)and cough evaluation test(CET)scores.No serious adverse events were recorded during the study.Lianhua Qingke tablets significantly improved the clinical symptoms of patients with long COVID cough.

How Long Can Chinese Enterprises Become Famous Transnational Ones

Entry into WTO means that Chinese enterprises, which were deeply influenced by planned economy, will scramble for profits with those world famous transnational companies of strong strength. Facing such competitive situation, how can China cultivate more famous and strong Chinese transnational companies on the international market? This is a question for many economists and enterprisers to make serious research.

To Compare English Long Sentences And Chinese Long Sentences & Discuss How To Translate The Two Kinds of Long Sentences

In my paper, I compare the characteristics of English long sentences and Chinese long sentences, and I also talk about how to translate long sentences. There are at least two or three modifiers involving no less than one subordinate clause in an English long complex sentence. There are at least twenty words and three or four comparatively independent phrases that are connected together by meaning in a Chinese sentence. The differences between them are the rules of making sentences and the structure. In my paper I also talk about how to translate long sentences, and here are the rules: a) break the formal structure; b) reorganize every part according to the habits of the receptor language. If we can master the rules, we can translate the English and Chinese long sentences better.

Chinese Named Entity Recognition with Character-Level BLSTM and Soft Attention Model

Unlike named entity recognition(NER)for English,the absence of word boundaries reduces the final accuracy for Chinese NER.To avoid accumulated error introduced by word segmentation,a deep model extracting character-level features is carefully built and becomes a basis for a new Chinese NER method,which is proposed in this paper.This method converts the raw text to a character vector sequence,extracts global text features with a bidirectional long short-term memory and extracts local text features with a soft attention model.A linear chain conditional random field is also used to label all the characters with the help of the global and local text features.Experiments based on the Microsoft Research Asia(MSRA)dataset are designed and implemented.Results show that the proposed method has good performance compared to other methods,which proves that the global and local text features extracted have a positive influence on Chinese NER.For more variety in the test domains,a resume dataset from Sina Finance is also used to prove the effectiveness of the proposed method.

The effect of traditional Chinese medicine“Tian Gui Recipe (TGR)”on obesity and anovulation in androgen-sterilized rats(ASR)

Objectives: A traditional Chinese medicine “Tian Gui Recipe (TGR)” has been used to effectively treat clomiphene resistant anovulatory disease and obesity, especially in polycystic ovary syndrome (PCOS) cases with hyperinsulinemia. The effect of TGR on obesity and anovulation was investigated in androgen-sterilized rats (ASR).Methods: Female SD rats at the age of 9 days were divided into 3 groups. Group ASR (n=15): anovulation was demonstrated at the age of 70 days by vaginal smear in rats while 1.25 mg of testosterone propionate was injected subcutaneously on its 9th neonatal day. Group A+H (n=25): TGR were administered to ASR at the age of 80 days for 3 weeks. Rats with regular estrous cycle and ovulation after herbal treatment were included in this group. Group C (n=15): normal ovulated rats were recruited. Around the age of 112 days or on proestrous day, all rats were sacrificed under anesthesia. Serum leptin, testosterone (T), estrogen (E2), follicular stimulating hormone (FSH), luteinizing hormone (LH) levels were measured with radioimmunoassay (RIA). Double immunofluorescent staining combined with confocal laser scanning microscope and dual in situ hybridization were carried out on sections through areas of arcuate nucleus (ARC) to determine whether estrogen receptor (ER) immunoreactivity (IR) or long form of leptin receptor (OB-Rb) mRNA were expressed in neuropeptide Y (NPY) immuno- and mRNA-containing neurons, and their relationship to proopiomelanocortin (POMC) mRNA-containing neurons. Immunohistochemistry and in situ hybridization were used to observe the levels of ER-, NPY-,gonadotrophin releasing hormone (GnRH)-IR and gene expression levels of NPY, OB-Rb, and POMC in ARC. Meanwhile, the criteria of energy state,including daily food intake, retroperitoneal fat depot pad and body weight,were measured and evaluated. Values of immunohistochemistry and in situ hybridization were expressed in mean optic density (MOD).Results:Seventeen out of the 25 rats (68%) in Group A+H were ovulated after herbal treatment. ASR characterized with significantly high metabolic rate, energy imbalance and obesity (P<0.01,P<0.01,P<0.01).The mean serum leptin, T, E2 levels of ASR were significantly higher than that of Group C and Group A+H (P<0.01,P<0.01), while being contraryto that of FSH, LH levels (P<0.01,P<0.01). ERs were proved distributing in NPY-containing neurons, OB-Rb coexpressed in NPY-synthesizing neurons, and both NPY- and POMC- mRNA expressing neurons overlapped in ARC. Compared to Group C, levels of NPY mRNA and NPY, POMC mRNA expressions increased (P<0.01,P<0.01,P<0.01),OB-Rb mRNA, ER and GnRH immunoreactive expression decreased significantly in the hypothalamus of ASR (P<0.01,P<0.01,P<0.01).These dramatic neuroendocrine changes became normal in ovulated ASR after the herbal treatment (all P>0.05).Conclusion: The elevated peripheral estrogen caused by high testosterone and leptin levels in ASR may down-regulate their corresponding receptors oriented on hypothalamic NPY-containing neurons respectively, therefore challenge the NPY mRNA and NPY,POMC mRNA overexpression. The overexpression of NPY, POMC gene transcription and translation stimulate food intake, promote the deposit of adipocyte tissue, and inhibit GnRH expression and GnRH/FSH, LH release, which contribute to the occurrence of obesity and anovulation in ASR. “TGR” may reverse these abnormal neuroendocrine cascades by lowering levels of testosterone, estrogen and leptin.

An introductory discussion about National Library of China's development of a Chinese Newspaper Digital Repository mechanism

Newspapers can preserve vast amount of first-hand historical information for research.They are reliable and valuable primary sources for studies on politics,economy,society,humanities,science and technology,culture,folkways and customs of a country for a specific period of history.Accordingly,these authors in this paper support that a Chinese Newspaper Digital Repository(CNDR)initiative led by National Library of China(NLC)be firmly established and put into operation in quick order.These authors' conviction and assertion are made only after they have given a careful study and analysis of the problems of current newspaper preservation methods,including print newspapers preservation,preserving newspapers by microfilming technology,and digital publication of newspapers.These authors also have taken into consideration of the legal issues involved about such an undertaking.Based on the review of the efforts and achievements on long-term preservation of newspapers home and abroad,these authors have critiqued the technical scheme of the NLC' Chinese Newspaper Digital Repository,including such important factors as system design,metadata schema,system structure,and the achievements of this project in Phase I.Finally,these authors have recommended that a collaborative operation mechanism and also a new comprehensive service paradigm in the realm of information delivery be established in CNDR's overall strategic planning.

中国式现代化与绿色发展

中国式现代化是人与自然和谐共生的现代化,绿色发展是其显著特征和突出品质。中国积极推进生态环境建设,人与自然的关系相应地从生态赤字缓慢扩大期、生态赤字快速扩大期、再进入生态赤字缩小期、局部生态盈余期,未来将转向生态盈余期。党的十八大以来,中国生态文明建设在生态环境质量改善、生态保护修复、绿色低碳转型、全球生态治理贡献、中国特色制度体系创新等方面发生了历史性、转折性、全局性变化,但生态环境保护仍面临基础性问题,结构性压力、根源性压力、趋势性压力尚未根本缓解。为此,中国必须坚持长期主义,避免短期机会主义,坚持绿色增长,追求绿色发展的长期价值,并以绿色发展推进人与自然和谐共生现代化,即高质量发展与高水平保护统筹推进,整体推进与重点攻坚协同并进,科技创新与制度创新双轮驱动,正向激励与反向倒逼双向发力,多元参与与协同治理并行不悖,实践探索和经验总结紧密结合。

长蛇灸联合熏洗包熏蒸治疗气滞血瘀型腰椎间盘突出症对患者疼痛介质及炎症因子的影响

目的:探讨长蛇灸联合熏洗包熏蒸在腰椎间盘突出症(气滞血瘀型)患者治疗中的应用价值,观察其对炎症因子、疼痛介质水平的影响。方法:将2019年6月—2020年12月因腰椎间盘突出症于南昌市洪都中医院就诊且中医证型属于气滞血瘀型的90例患者纳入研究,用随机数字表法将患者分为对照组、观察A组、观察B组,各30例。对照组予硬膜外封闭治疗,观察A组予硬膜外封闭治疗+熏洗包熏蒸治疗治疗,观察B组予硬膜外封闭治疗+熏洗包熏蒸+长蛇灸治疗。治疗2周后比较临床效果。结果:治疗后,三组血清肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、超敏C反应蛋白(hypersensitive C reactive protein,hs-CRP)、白介素-1β(interleukin-1,IL-1β)、血清前列腺素E2(prostaglandin E2,PGE2)、5-羟色胺(5-hydroxytryptamine,5-HT)水平均较治疗前降低,观察B组均低于观察A组、对照组,观察A组上述指标水平均低于对照组,差异均有统计学意义(P<0.05)。治疗后三组视觉模拟评分法(visual analogue scale,VAS)评分均降低,日本骨科协会(Japanese orthopaedic association,JOA)评分及血清β-内啡肽(β-endorphin,β-EP)均较治疗前升高,观察B组VAS评分数值水平低于观察A组、对照组,JOA评分及β-EP数值水平则均高于观察A组及对照组,观察A组VAS评分水平低于对照组,JOA评分及β-EP数值则均更高,差异均有统计学意义(P<0.05)。结论:对于腰椎间盘突出症(气滞血瘀型)患者而言采用长蛇灸联合熏洗包熏蒸可减轻炎症反应,降低疼痛介质,改善临床症状及腰椎功能,安全性高,有助于临床效果提高。

新时代中华传统体育文化传承与发展的实践困境与优势突破研究

本文运用文献资料法、逻辑分析法、案例分析法等研究方法,在阐明新时代中华传统体育文化的时代价值基础上,分析了新时代中华传统体育文化传承与发展的实践困境:发展传承方式单一,传承主体缺失;城镇化变革对中华传统体育文化的挑战;社会价值认知不足与教育体系缺位;资金资源不足与商业化运作。据此,提出了新时代中华传统体育文化传承与发展的优势突破:新时代中华传统体育文化传承体系的多元化、新时代国际环境下文化软实力提升的政策导向、新时代科技与传媒应用下体育文化的重振再生、新时代学校育人理念下中华传统体育文化的课程融入。

“以技为喻”释“雕龙”——《文心雕龙》书名再探

“以技为喻”是以百工技艺比譬文学创作的独特言说方式,是《文心雕龙》“象喻”批评最重要的分支与譬喻类型。《文心雕龙》书名中的“雕龙”一词,除与“雕龙奭”的典故相关外,亦是以雕龙技艺比类文学创作的“象喻”言说。在“以技为喻”视阈下考察,刘勰以《文心雕龙》命名其论文钜制,寄寓了三重意涵:一是借古代雕龙技艺渐趋繁复的历史演进以及“雕龙奭”典故的修辞指向,说明“雕缛成体”的文学规律;二是借雕龙技艺“金相玉式”“符采相胜”的审美经验,阐述“文质彬彬”“尽善尽美”的文学理想;三是借“龙纹”沟通天人的媒介作用,确立文学“赞天地化育”之神圣功能。

长征精神助推中国式现代化建设的逻辑理路

伟大长征孕育伟大长征精神,长征精神具有永恒的时代价值。新时代新征程,牢记党的初心和使命、革命理想和革命宗旨,重温红军长征的丰功伟绩,弘扬伟大长征精神,是推进“人口规模巨大的现代化”“全体人民共同富裕的现代化”“物质文明和精神文明相协调的现代化”“人与自然和谐共生的现代化”“走和平发展道路的现代化”的内在要求和精神动力。

中国文章学巨著的阐释与应用

《〈文心雕龙〉精义今释》内容丰赡、精义迭出,呈现出“开宗明义、提出己见”“以‘文’为线,勾连各章”“道以文明,泽被后世”等特点。全书论断明晰、指导现实,具有学术价值和现实价值。本书也是内蒙古师范大学龙学团队为龙学界奉上的又一部新的力作。

时毓民教授治疗小儿慢性咳嗽临证经验

时毓民教授认为,慢性咳嗽的病位在肺脾肾,其本质在于肺脾肾虚。文章从降中有宣以调气机、分别清解肺之余邪、活血化瘀贯穿始终、润肺止咳相佐为用、重视温阳滋肾纳气、益气滋阴固本善后六个方面总结时教授论治小儿慢性咳嗽的临证经验,并附验案一则。

新时代高校龙舟运动的挑战、机遇与纾解策略探究

作为中华传统文化的瑰宝,龙舟运动不仅承载着深厚的文化底蕴,还体现着民族精神。近几年,随着国家对传统文化的不断重视,龙舟运动在高校中得到了快速发展,但是在发展过程中龙舟运动也面临着诸多挑战和机遇。为此,该文采用文献资料法等研究方法,对新时期高校龙舟运动面临的挑战以及蕴含的机遇进行了分析,并提出了新时代高校龙舟运动的纾解策略,以期能促进高校龙舟运动的健康可持续发展。