Objective:To determine the change in the quality of life(QoL)of patients who applied to a tertiary outpatient clinic according to their COVID-19 status.Methods:This cross-sectional study comprised 1370 participants.Sh...Objective:To determine the change in the quality of life(QoL)of patients who applied to a tertiary outpatient clinic according to their COVID-19 status.Methods:This cross-sectional study comprised 1370 participants.Short form-12(SF-12),which includes Physical Component Summary(PCS)and Mental Component Summary(MCS)domains,was used to evaluate the QoL.Different linear regression models created using PCS-12 and MCS-12 were dependent variables.Results:A total of 19.2% of participants had acute COVID-19,and 8.4%had long COVID-19.The most common sypmtoms were fatigue(72.6%),headache(42.5%),and joint pain(39.8%)in patients with long COVID-19.The model including all participants showed that long COVID-19 reduced the QoL in multivariate analysis for both MCS and PCS,while acute COVID-19 had no significant effect on the QoL comparing with those without COVID-19.Model that included participants with COVID-19 showed that long COVID-19 negatively affected the QoL in the multivariate model for PCS-12 and MCS-12.Variables that were significant in the multivariate model for those who had long COVID-19 were having a chronic disease and presence of ongoing symptoms.Females were disadvantaged for PCS-12 and MCS-12 in the multivariate models including all participants,and models including participants who have had COVID-19.Low educational group were disadvantaged for PCS-12 in the multivariate model including all participants.This group were also disadvantaged for PCS-12 and MCS-12 in the multivariate models including participants who had COVID-19.Conclusions:In studies,acute COVID-19 and long COVID-19 should be treated as separate categories.The effects of long COVID-19 should be considered when providing and planning health services.The effect of gender,and education,on QoL shows that health inequalities continue to be effective during the pandemic period.展开更多
We have been experiencing multiple waves of the coronavirus disease 2019(COVID-19)pandemic.With these unprecedented waves,we have entered into an era of‘new normal’.This pandemic has enforced us to rethink the very ...We have been experiencing multiple waves of the coronavirus disease 2019(COVID-19)pandemic.With these unprecedented waves,we have entered into an era of‘new normal’.This pandemic has enforced us to rethink the very basics of childhood learning:Habits,health etiquette,and hygiene.Rehabilitation has immense importance during this pandemic considering a few aspects.Multidisciplinary COVID-19 rehabilitation clinics are essential to address the demand.The equitable distribution of COVID-19 rehabilitation services for differently-abled individuals during the pandemic is an important aspect.Rehabilitation needs identification and further studies on various rehabilitation interventions are among the key unmet future research needs.展开更多
BACKGROUND Coronavirus disease 2019(COVID-19)has crippled humanity since early 2020.Various sequelae of COVID-19 have been reported in different body systems.Musculoskeletal symptoms are widely reported during COVID-1...BACKGROUND Coronavirus disease 2019(COVID-19)has crippled humanity since early 2020.Various sequelae of COVID-19 have been reported in different body systems.Musculoskeletal symptoms are widely reported during COVID-19 infection,but musculoskeletal complications in long COVID-19 are underreported.However,post-COVID-19 survivors have reported complaints of persisting or new-onset fatigue,myalgia,arthralgia,arthritis,muscle weakness,etc in clinical practice.The well-known detrimental effects of steroids on the musculoskeletal system coupled with their over-the-counter availability can also be anticipated since they were the cornerstone of life-saving management in this pandemic.AIM To determine the musculoskeletal complications in long COVID.METHODS We performed a systematic review of‘systematic reviews and meta-analyses’.RESULTS Of the 63 articles screened,24 articles were included.Two articles specifically discussed children and adolescents.One article discussed rehabilitation intervention.No article addressed rehabilitation of musculoskeletal issues in long COVID-19 in particular.Fatigue was the most common musculoskeletal complication.CONCLUSION Fatigue is found to be very common along with myalgia and arthralgia.There were no studies on rehabilitation intervention in musculoskeletal complications specifically.Considering the lacuna in literature and the needs of the current situation,further studies are warranted to standardize effective rehabilitation interventions in musculoskeletal complications.More homogenous studies are needed.Studies on functional impairment due to musculoskeletal involvement are essential.展开更多
Under the effects of COVID-19 and a number of ongoing lockdown tactics,anxiety symptoms and poor sleep quality have become common mental health issues among college freshmen and are intimately related to their emotion...Under the effects of COVID-19 and a number of ongoing lockdown tactics,anxiety symptoms and poor sleep quality have become common mental health issues among college freshmen and are intimately related to their emotional adaptation.To explore this connection,this study gathered data from a sample of 256 freshmen enrolled in an elite university in China in September 2022.The association between sleep quality,anxiety symptoms,and emotional adaptation was clarified using correlation analysis.Additionally,the mediating function of anxiety symptoms between sleep quality and emotional adaptation was investigated using a structural equation model.The results reveal that:(1)Chinese elite university freshmen who were subjected to prolonged lockdown had poor sleep quality and mild anxiety symptoms;(2)a significant positive correlation between poor sleep quality and anxiety symptoms was identified;(3)anxiety symptoms were found to have a significant negative impact on emotional adaptation;(4)poor sleep quality had a negative impact on emotional adaptation through anxiety symptoms.This research makes a valuable contribution by offering insights into the intricate relationship between sleep quality and emotional adaptation among freshmen in elite Chinese universities during prolonged lockdown conditions,and it is beneficial for schools and educators to further improve school schedules and psychological health initiatives.展开更多
BACKGROUND QTc interval prolongation with an increased risk of torsade de pointes(Tsd)has been described in coronavirus disease 2019(COVID-19)patients treated with hydroxychloroquine(HCQ)and azithromycin(AZI)in Wester...BACKGROUND QTc interval prolongation with an increased risk of torsade de pointes(Tsd)has been described in coronavirus disease 2019(COVID-19)patients treated with hydroxychloroquine(HCQ)and azithromycin(AZI)in Western countries.In the DR Congo,few studies have evaluated the safety of this association or proposed new molecules.AIM To determine the incidence of QTc prolongation and Tsd in COVID-19 patients treated with HCQ-AZIs vs doubase C(new molecule).METHODS In present randomized clinical trial,we have included patients with mild or moderate COVID-19 treated with either HCQ-AZI or doubase C.Electrocardiogram(ECG)changes on day 14 of randomization were determined based on pretreatment tracing.Prolonged QTc was defined as≥500 ms on day 14 or an increase of≥80 ms compared to pretreatment tracing.Patients with cardiac disease,those undergoing other treatments likely to prolong QTc,and those with disturbed ECG tracings were excluded from the study.RESULTS The study included 258 patients(mean age 41±15 years;52%men;3.4%diabetics,11.1%hypertensive).Mild and moderate COVID-19 were found in 93.5%and 6.5%of patients,respectively.At baseline,all patients had normal sinus rhythm,a mean heart rate 78±13/min,mean PR space 170±28 ms,mean QRS 76±13 ms,and mean QTc 405±30 ms.No complaints suggesting cardiac involvement were reported during or after treatment.Only four patients(1.5%)experienced QTc interval prolongation beyond 500 ms.Similarly,only five patients(1.9%)had an increase in the QTc interval of more than 80 ms.QTc prolongation was more significant in younger patients,those with high viral load at baseline,and those receiving HCQ-AZI(P<0.05).None of the patients developed Tsd.CONCLUSION QTc prolongation without Tsd was observed at a lower frequency in patients treated with HCQ-AZI vs doubase C.The absence of comorbidities and concurrent use of other products that are likely to cause arrhythmia may explain our results.展开更多
Background Coronavirus disease 2019(COVID-19)can involve persistence,sequelae,and other clinical complications that last weeks to months to evolve into long COVID-19.Exploratory studies have suggested that interleukin...Background Coronavirus disease 2019(COVID-19)can involve persistence,sequelae,and other clinical complications that last weeks to months to evolve into long COVID-19.Exploratory studies have suggested that interleukin-6(IL-6)is related to COVID-19;however,the correlation between IL-6 and long COVID-19 is unknown.We designed a systematic review and meta-analysis to assess the relationship between IL-6 levels and long COVID-19.Methods Databases were systematically searched for articles with data on long COVID-19 and IL-6 levels published before September 2022.A total of 22 published studies were eligible for inclusion following the PRISMA guidelines.Analysis of data was undertaken by using Cochran's Q test and the Higgins I-squared(I2)statistic for heterogeneity.Random-effect meta-analyses were conducted to pool the IL-6 levels of long COVID-19 patients and to compare the differences in IL-6 levels among the long COVID-19,healthy,non-postacute sequelae of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection(non-PASC),and acute COVID-19 populations.The funnel plot and Egger's test were used to assess potential publication bias.Sensitivity analysis was used to test the stability of the results.Results An increase in IL-6 levels was observed after SARS-CoV-2 infection.The pooled estimate of IL-6 revealed a mean value of 20.92 pg/ml(95%CI=9.30–32.54 pg/ml,I2=100%,P<0.01)for long COVID-19 patients.The forest plot showed high levels of IL-6 for long COVID-19 compared with healthy controls(mean difference=9.75 pg/ml,95%CI=5.75–13.75 pg/ml,I2=100%,P<0.00001)and PASC category(mean difference=3.32 pg/ml,95%CI=0.22–6.42 pg/ml,I2=88%,P=0.04).The symmetry of the funnel plots was not obvious,and Egger’s test showed that there was no significant small study effect in all groups.Conclusions This study showed that increased IL-6 correlates with long COVID-19.Such an informative revelation suggests IL-6 as a basic determinant to predict long COVID-19 or at least inform on the“early stage”of long COVID-19.展开更多
目的:分析新型冠状病毒感染(COVID-19)相关心律失常的文献,探索该领域的研究现状、热点并预测未来的趋势,为后来的研究者提供借鉴。方法:选择Web of Science的核心合集数据库,每项研究都进行了文献计量和视觉分析,使用CiteSpace和VOSvie...目的:分析新型冠状病毒感染(COVID-19)相关心律失常的文献,探索该领域的研究现状、热点并预测未来的趋势,为后来的研究者提供借鉴。方法:选择Web of Science的核心合集数据库,每项研究都进行了文献计量和视觉分析,使用CiteSpace和VOSviewer软件生成知识图谱。结果:共鉴定出768篇文章,发文涉及美国、意大利和中国为首的319个国家/地区和4 366个机构,领先的研究机构是梅奥诊所和哈佛医学院。New England Journal of Medicine是该领域最常被引用的期刊。在6 687位作者中,Arbelo Elena撰写的研究最多,Guo T被共同引用的次数最多,心房纤颤是最常见的关键词。结论:随着COVID-19的暴发,对COVID-19所致新发/进行性心律失常事件的研究蓬勃发展,未来的研究者可能会对COVID-19感染后新发或遗留的快速性心律失常/缓慢性心律失常的发生机制进行进一步的探索。展开更多
文摘Objective:To determine the change in the quality of life(QoL)of patients who applied to a tertiary outpatient clinic according to their COVID-19 status.Methods:This cross-sectional study comprised 1370 participants.Short form-12(SF-12),which includes Physical Component Summary(PCS)and Mental Component Summary(MCS)domains,was used to evaluate the QoL.Different linear regression models created using PCS-12 and MCS-12 were dependent variables.Results:A total of 19.2% of participants had acute COVID-19,and 8.4%had long COVID-19.The most common sypmtoms were fatigue(72.6%),headache(42.5%),and joint pain(39.8%)in patients with long COVID-19.The model including all participants showed that long COVID-19 reduced the QoL in multivariate analysis for both MCS and PCS,while acute COVID-19 had no significant effect on the QoL comparing with those without COVID-19.Model that included participants with COVID-19 showed that long COVID-19 negatively affected the QoL in the multivariate model for PCS-12 and MCS-12.Variables that were significant in the multivariate model for those who had long COVID-19 were having a chronic disease and presence of ongoing symptoms.Females were disadvantaged for PCS-12 and MCS-12 in the multivariate models including all participants,and models including participants who have had COVID-19.Low educational group were disadvantaged for PCS-12 in the multivariate model including all participants.This group were also disadvantaged for PCS-12 and MCS-12 in the multivariate models including participants who had COVID-19.Conclusions:In studies,acute COVID-19 and long COVID-19 should be treated as separate categories.The effects of long COVID-19 should be considered when providing and planning health services.The effect of gender,and education,on QoL shows that health inequalities continue to be effective during the pandemic period.
文摘We have been experiencing multiple waves of the coronavirus disease 2019(COVID-19)pandemic.With these unprecedented waves,we have entered into an era of‘new normal’.This pandemic has enforced us to rethink the very basics of childhood learning:Habits,health etiquette,and hygiene.Rehabilitation has immense importance during this pandemic considering a few aspects.Multidisciplinary COVID-19 rehabilitation clinics are essential to address the demand.The equitable distribution of COVID-19 rehabilitation services for differently-abled individuals during the pandemic is an important aspect.Rehabilitation needs identification and further studies on various rehabilitation interventions are among the key unmet future research needs.
文摘BACKGROUND Coronavirus disease 2019(COVID-19)has crippled humanity since early 2020.Various sequelae of COVID-19 have been reported in different body systems.Musculoskeletal symptoms are widely reported during COVID-19 infection,but musculoskeletal complications in long COVID-19 are underreported.However,post-COVID-19 survivors have reported complaints of persisting or new-onset fatigue,myalgia,arthralgia,arthritis,muscle weakness,etc in clinical practice.The well-known detrimental effects of steroids on the musculoskeletal system coupled with their over-the-counter availability can also be anticipated since they were the cornerstone of life-saving management in this pandemic.AIM To determine the musculoskeletal complications in long COVID.METHODS We performed a systematic review of‘systematic reviews and meta-analyses’.RESULTS Of the 63 articles screened,24 articles were included.Two articles specifically discussed children and adolescents.One article discussed rehabilitation intervention.No article addressed rehabilitation of musculoskeletal issues in long COVID-19 in particular.Fatigue was the most common musculoskeletal complication.CONCLUSION Fatigue is found to be very common along with myalgia and arthralgia.There were no studies on rehabilitation intervention in musculoskeletal complications specifically.Considering the lacuna in literature and the needs of the current situation,further studies are warranted to standardize effective rehabilitation interventions in musculoskeletal complications.More homogenous studies are needed.Studies on functional impairment due to musculoskeletal involvement are essential.
基金the Tianjin Philosophy and Social Science Planning Project“Research on Value-Added Evaluation of Career Adaptability for Engineering Students Oriented towards Outstanding Engineers”,Grant Number TJJXQN22-001.
文摘Under the effects of COVID-19 and a number of ongoing lockdown tactics,anxiety symptoms and poor sleep quality have become common mental health issues among college freshmen and are intimately related to their emotional adaptation.To explore this connection,this study gathered data from a sample of 256 freshmen enrolled in an elite university in China in September 2022.The association between sleep quality,anxiety symptoms,and emotional adaptation was clarified using correlation analysis.Additionally,the mediating function of anxiety symptoms between sleep quality and emotional adaptation was investigated using a structural equation model.The results reveal that:(1)Chinese elite university freshmen who were subjected to prolonged lockdown had poor sleep quality and mild anxiety symptoms;(2)a significant positive correlation between poor sleep quality and anxiety symptoms was identified;(3)anxiety symptoms were found to have a significant negative impact on emotional adaptation;(4)poor sleep quality had a negative impact on emotional adaptation through anxiety symptoms.This research makes a valuable contribution by offering insights into the intricate relationship between sleep quality and emotional adaptation among freshmen in elite Chinese universities during prolonged lockdown conditions,and it is beneficial for schools and educators to further improve school schedules and psychological health initiatives.
文摘BACKGROUND QTc interval prolongation with an increased risk of torsade de pointes(Tsd)has been described in coronavirus disease 2019(COVID-19)patients treated with hydroxychloroquine(HCQ)and azithromycin(AZI)in Western countries.In the DR Congo,few studies have evaluated the safety of this association or proposed new molecules.AIM To determine the incidence of QTc prolongation and Tsd in COVID-19 patients treated with HCQ-AZIs vs doubase C(new molecule).METHODS In present randomized clinical trial,we have included patients with mild or moderate COVID-19 treated with either HCQ-AZI or doubase C.Electrocardiogram(ECG)changes on day 14 of randomization were determined based on pretreatment tracing.Prolonged QTc was defined as≥500 ms on day 14 or an increase of≥80 ms compared to pretreatment tracing.Patients with cardiac disease,those undergoing other treatments likely to prolong QTc,and those with disturbed ECG tracings were excluded from the study.RESULTS The study included 258 patients(mean age 41±15 years;52%men;3.4%diabetics,11.1%hypertensive).Mild and moderate COVID-19 were found in 93.5%and 6.5%of patients,respectively.At baseline,all patients had normal sinus rhythm,a mean heart rate 78±13/min,mean PR space 170±28 ms,mean QRS 76±13 ms,and mean QTc 405±30 ms.No complaints suggesting cardiac involvement were reported during or after treatment.Only four patients(1.5%)experienced QTc interval prolongation beyond 500 ms.Similarly,only five patients(1.9%)had an increase in the QTc interval of more than 80 ms.QTc prolongation was more significant in younger patients,those with high viral load at baseline,and those receiving HCQ-AZI(P<0.05).None of the patients developed Tsd.CONCLUSION QTc prolongation without Tsd was observed at a lower frequency in patients treated with HCQ-AZI vs doubase C.The absence of comorbidities and concurrent use of other products that are likely to cause arrhythmia may explain our results.
文摘Background Coronavirus disease 2019(COVID-19)can involve persistence,sequelae,and other clinical complications that last weeks to months to evolve into long COVID-19.Exploratory studies have suggested that interleukin-6(IL-6)is related to COVID-19;however,the correlation between IL-6 and long COVID-19 is unknown.We designed a systematic review and meta-analysis to assess the relationship between IL-6 levels and long COVID-19.Methods Databases were systematically searched for articles with data on long COVID-19 and IL-6 levels published before September 2022.A total of 22 published studies were eligible for inclusion following the PRISMA guidelines.Analysis of data was undertaken by using Cochran's Q test and the Higgins I-squared(I2)statistic for heterogeneity.Random-effect meta-analyses were conducted to pool the IL-6 levels of long COVID-19 patients and to compare the differences in IL-6 levels among the long COVID-19,healthy,non-postacute sequelae of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection(non-PASC),and acute COVID-19 populations.The funnel plot and Egger's test were used to assess potential publication bias.Sensitivity analysis was used to test the stability of the results.Results An increase in IL-6 levels was observed after SARS-CoV-2 infection.The pooled estimate of IL-6 revealed a mean value of 20.92 pg/ml(95%CI=9.30–32.54 pg/ml,I2=100%,P<0.01)for long COVID-19 patients.The forest plot showed high levels of IL-6 for long COVID-19 compared with healthy controls(mean difference=9.75 pg/ml,95%CI=5.75–13.75 pg/ml,I2=100%,P<0.00001)and PASC category(mean difference=3.32 pg/ml,95%CI=0.22–6.42 pg/ml,I2=88%,P=0.04).The symmetry of the funnel plots was not obvious,and Egger’s test showed that there was no significant small study effect in all groups.Conclusions This study showed that increased IL-6 correlates with long COVID-19.Such an informative revelation suggests IL-6 as a basic determinant to predict long COVID-19 or at least inform on the“early stage”of long COVID-19.
文摘目的:分析新型冠状病毒感染(COVID-19)相关心律失常的文献,探索该领域的研究现状、热点并预测未来的趋势,为后来的研究者提供借鉴。方法:选择Web of Science的核心合集数据库,每项研究都进行了文献计量和视觉分析,使用CiteSpace和VOSviewer软件生成知识图谱。结果:共鉴定出768篇文章,发文涉及美国、意大利和中国为首的319个国家/地区和4 366个机构,领先的研究机构是梅奥诊所和哈佛医学院。New England Journal of Medicine是该领域最常被引用的期刊。在6 687位作者中,Arbelo Elena撰写的研究最多,Guo T被共同引用的次数最多,心房纤颤是最常见的关键词。结论:随着COVID-19的暴发,对COVID-19所致新发/进行性心律失常事件的研究蓬勃发展,未来的研究者可能会对COVID-19感染后新发或遗留的快速性心律失常/缓慢性心律失常的发生机制进行进一步的探索。
