Backgroud： This study aimed to determine the effects of early antibiotic intervention（EAI） on subsequent blood parameters, apparent nutrient digestibility, and fecal fermentation profile in pigs with different diet...Backgroud： This study aimed to determine the effects of early antibiotic intervention（EAI） on subsequent blood parameters, apparent nutrient digestibility, and fecal fermentation profile in pigs with different dietary crude protein（CP） levels. Eighteen litters of piglets（total 212） were randomly allocated to 2 groups and were fed a creep feed diet with or without in-feed antibiotics（olaquindox, oxytetracycline calcium and kitasamycin） from postnatal d 7 to d 42. On d 42, the piglets within the control or antibiotic group were mixed, respectively, and then further randomly assigned to a normal-（20%, 18%, and 14% CP from d 42 to d 77, d 77 to d 120, and d 120 to d 185,respectively） or a low-CP diet（16%, 14%, and 10% CP from d 42 to d 77, d 77 to d 120, and d 120 to d 185,respectively）, generating 4 groups. On d 77（short-term） and d 185（long-term）, serum and fecal samples were obtained for blood parameters, microbial composition and microbial metabolism analysis.Results： EAI increased（P 〈 0.05） albumin and glucose concentrations in low-CP diet on d 77, and increased（P 〈 0.05） urea concentration in normal-CP diet. On d 185, EAI increased（P 〈 0.05） globulin concentration in normal-CP diets, but decreased glucose concentration. For nutrient digestibility, EAI increased（P 〈 0.05）digestibility of CP on d 77. For fecal microbiota, the EAI as well as low-CP diet decreased（P 〈 0.05） E. coli count on d 77. For fecal metabolites, on d 77, EAI decreased（P 〈 0.05） total amines concentration but increased skatole concentration in low-CP diet. On d 185, the EAI increased（P 〈 0.05） putrescine and total amines concentrations in low-CP diets but reduced（P 〈 0.05） in the normal-CP diets. The low-CP diet decreased the concentrations of these compounds.Conclusions： Collectively, these results indicate that EAI has short-term effects on the blood parameters and fecal microbial fermentation profile. The effects of EAI varied between CP levels, which was characterized by the significant alteration of glucose and putrescine concentration.展开更多
Following the instant square conservative scheme, implicit, explicit and semiimplicit schemes have also been formulated. Based on the theory of perfect square conservative scheme, which has assimilated the reasonable ...Following the instant square conservative scheme, implicit, explicit and semiimplicit schemes have also been formulated. Based on the theory of perfect square conservative scheme, which has assimilated the reasonable part of the idea of formulating the explicit scheme by adjustable dissipation, and the idea of actualizing the implicit scheme via 'instant linearization', a general compensation formulation展开更多
Objective: To observe the long-term effect of homoharringtonine (HHT) on chronic granulocytic leukemia (CGL) and its pharmacological mechanism. Methods: 76 patients with newly diagnosed early chronic phase CGL receive...Objective: To observe the long-term effect of homoharringtonine (HHT) on chronic granulocytic leukemia (CGL) and its pharmacological mechanism. Methods: 76 patients with newly diagnosed early chronic phase CGL received treatment of merely 1.5 mg/m2 daily HHT for induction remission and long-term maintenance treatment. The apoptosis rate of bone marrow CD34+ cells induced by HHT was assayed with flow cytometer. Results: 86.8% patients achieved CHR, 13.2% patients PHR and 31.8% patients got cytogenetic response in HHT treatment group, which was longer than 31 (8-54) months in hydroxyurea (HU) group (P<0.05). The effect of apoptosis induction HHT was stronger on CGL-CP patients bone marrow CD34+ cells than on normal person bone marrow CD34+ cells. Conclusion: HHT is a very effective drug for remission induction and long-term maintenance treatment in early chronic phase CGL patients.展开更多
Full-scale measurements are regarded as the most reliable method to evaluate wind effects on large buildings and structures. Some selected results are presented in this paper from the full-scale measurement of wind ef...Full-scale measurements are regarded as the most reliable method to evaluate wind effects on large buildings and structures. Some selected results are presented in this paper from the full-scale measurement of wind effects on a long-span steel roof structure during the passage of Typhoon Fanapi. Some fi eld data, including wind speed and direction, acceleration responses, etc., were continuously and simultaneously recorded during the passage of the typhoon. Comprehensive analysis of the measured data is conducted to evaluate the typhoon-generated wind characteristics and its effects on a long-span steel roof. The fi rst four natural frequencies and their vibration mode shapes of the Guangzhou International Sports Arena(GISA) roof are evaluated by the stochastic subspace identifi cation(SSI) method and comparisons with those from fi nite element(FE) analysis are made. Meanwhile, damping ratios of the roof are also identifi ed by the SSI method and compared with those identifi ed by the random decrement method; the amplitude-dependent damping behaviors are also discussed. The fullscale measurement results are further compared with the corresponding wind tunnel test results to evaluate its reliability. The results obtained from this study are valuable for academic and professional engineers involved in the design of large-span roof structures.展开更多
The spontaneous radiation from a single pulse electron beam in Free Electron Lasers is dealt withby solving one-dimensional wave equations.The obtained results show that there is the long pulse effect aswell as the we...The spontaneous radiation from a single pulse electron beam in Free Electron Lasers is dealt withby solving one-dimensional wave equations.The obtained results show that there is the long pulse effect aswell as the well-known short pulse effect.展开更多
The analysis approach of semi-active control for long-span rigid-continuous bridge under seismic travelling wave input is established. Magnetorheological dampers are set on the positions of the bridge beatings. The se...The analysis approach of semi-active control for long-span rigid-continuous bridge under seismic travelling wave input is established. Magnetorheological dampers are set on the positions of the bridge beatings. The semi-active control calculation and analysis are performed for a five-span rigid-continuous bridge under seismic travelling waves with different apparent surface velocities. The results indicate that travelling wave effect remarkably influences the uncontrolled seismic responses, the semi-active control seismic responses and vibration control effects for the long-span rigid-continuous bridge. It is disadvantageous to the responses of the beams and the piers under the travelling wave input with lower apparent surface velocity, and travelling wave effect can decrease the vibration control effects evidently. Therefore, the travelling wave effect should be considered for the selection of the parameter values of semi-active control system in order to get the designing control effect.展开更多
基金supported by National Key Basic Research Program of China(2013CB127300)Natural Science Foundation of China(31430082)
文摘Backgroud： This study aimed to determine the effects of early antibiotic intervention（EAI） on subsequent blood parameters, apparent nutrient digestibility, and fecal fermentation profile in pigs with different dietary crude protein（CP） levels. Eighteen litters of piglets（total 212） were randomly allocated to 2 groups and were fed a creep feed diet with or without in-feed antibiotics（olaquindox, oxytetracycline calcium and kitasamycin） from postnatal d 7 to d 42. On d 42, the piglets within the control or antibiotic group were mixed, respectively, and then further randomly assigned to a normal-（20%, 18%, and 14% CP from d 42 to d 77, d 77 to d 120, and d 120 to d 185,respectively） or a low-CP diet（16%, 14%, and 10% CP from d 42 to d 77, d 77 to d 120, and d 120 to d 185,respectively）, generating 4 groups. On d 77（short-term） and d 185（long-term）, serum and fecal samples were obtained for blood parameters, microbial composition and microbial metabolism analysis.Results： EAI increased（P 〈 0.05） albumin and glucose concentrations in low-CP diet on d 77, and increased（P 〈 0.05） urea concentration in normal-CP diet. On d 185, EAI increased（P 〈 0.05） globulin concentration in normal-CP diets, but decreased glucose concentration. For nutrient digestibility, EAI increased（P 〈 0.05）digestibility of CP on d 77. For fecal microbiota, the EAI as well as low-CP diet decreased（P 〈 0.05） E. coli count on d 77. For fecal metabolites, on d 77, EAI decreased（P 〈 0.05） total amines concentration but increased skatole concentration in low-CP diet. On d 185, the EAI increased（P 〈 0.05） putrescine and total amines concentrations in low-CP diets but reduced（P 〈 0.05） in the normal-CP diets. The low-CP diet decreased the concentrations of these compounds.Conclusions： Collectively, these results indicate that EAI has short-term effects on the blood parameters and fecal microbial fermentation profile. The effects of EAI varied between CP levels, which was characterized by the significant alteration of glucose and putrescine concentration.
基金scientific projects for China's Seventh and Eighth Five-Year-Plan1991-1992 Director's Foundation of IAP, Academia Sinica.
文摘Following the instant square conservative scheme, implicit, explicit and semiimplicit schemes have also been formulated. Based on the theory of perfect square conservative scheme, which has assimilated the reasonable part of the idea of formulating the explicit scheme by adjustable dissipation, and the idea of actualizing the implicit scheme via 'instant linearization', a general compensation formulation
文摘Objective: To observe the long-term effect of homoharringtonine (HHT) on chronic granulocytic leukemia (CGL) and its pharmacological mechanism. Methods: 76 patients with newly diagnosed early chronic phase CGL received treatment of merely 1.5 mg/m2 daily HHT for induction remission and long-term maintenance treatment. The apoptosis rate of bone marrow CD34+ cells induced by HHT was assayed with flow cytometer. Results: 86.8% patients achieved CHR, 13.2% patients PHR and 31.8% patients got cytogenetic response in HHT treatment group, which was longer than 31 (8-54) months in hydroxyurea (HU) group (P<0.05). The effect of apoptosis induction HHT was stronger on CGL-CP patients bone marrow CD34+ cells than on normal person bone marrow CD34+ cells. Conclusion: HHT is a very effective drug for remission induction and long-term maintenance treatment in early chronic phase CGL patients.
基金National Natural Science Foundation of China under Grant Nos.51222801 and 51378134Yangcheng Scholarship in Guangzhou Municipal Universities under Project No.12A004Sthe Research Funding for Ph.D Programme in Higher Education Universities under Project No.20124410110005
文摘Full-scale measurements are regarded as the most reliable method to evaluate wind effects on large buildings and structures. Some selected results are presented in this paper from the full-scale measurement of wind effects on a long-span steel roof structure during the passage of Typhoon Fanapi. Some fi eld data, including wind speed and direction, acceleration responses, etc., were continuously and simultaneously recorded during the passage of the typhoon. Comprehensive analysis of the measured data is conducted to evaluate the typhoon-generated wind characteristics and its effects on a long-span steel roof. The fi rst four natural frequencies and their vibration mode shapes of the Guangzhou International Sports Arena(GISA) roof are evaluated by the stochastic subspace identifi cation(SSI) method and comparisons with those from fi nite element(FE) analysis are made. Meanwhile, damping ratios of the roof are also identifi ed by the SSI method and compared with those identifi ed by the random decrement method; the amplitude-dependent damping behaviors are also discussed. The fullscale measurement results are further compared with the corresponding wind tunnel test results to evaluate its reliability. The results obtained from this study are valuable for academic and professional engineers involved in the design of large-span roof structures.
文摘The spontaneous radiation from a single pulse electron beam in Free Electron Lasers is dealt withby solving one-dimensional wave equations.The obtained results show that there is the long pulse effect aswell as the well-known short pulse effect.
基金National Natural Science Foundation of China (50439030)
文摘The analysis approach of semi-active control for long-span rigid-continuous bridge under seismic travelling wave input is established. Magnetorheological dampers are set on the positions of the bridge beatings. The semi-active control calculation and analysis are performed for a five-span rigid-continuous bridge under seismic travelling waves with different apparent surface velocities. The results indicate that travelling wave effect remarkably influences the uncontrolled seismic responses, the semi-active control seismic responses and vibration control effects for the long-span rigid-continuous bridge. It is disadvantageous to the responses of the beams and the piers under the travelling wave input with lower apparent surface velocity, and travelling wave effect can decrease the vibration control effects evidently. Therefore, the travelling wave effect should be considered for the selection of the parameter values of semi-active control system in order to get the designing control effect.
