Imperative for long-term management and surveillance in Kawasaki disease

Kawasaki disease(KD)is a significant pediatric vasculitis known for its potential to cause severe coronary artery complications.Despite the effectiveness of initial treatments,such as intravenous immunoglobulin,KD patients can experience long-term cardiovascular issues,as evidenced by a recent case report of an adult who suffered a ST-segment elevation myocardial infarction due to previous KD in the World Journal of Clinical Cases.This editorial emphasizes the critical need for long-term management and regular surveillance to prevent such complications.By drawing on recent research and case studies,we advocate for a structured approach to follow-up care that includes routine cardiac evaluations and preventive measures.

Action Based Approach to Archaeological Reconstruction Projects: Case of the Karnak Temple in Egypt

The proposed paper deals with a numerical approach that could better assist the archaeologist in the archaeological reconstruction projects.The goal of our research is to explore and study the use of computerized tools in archaeological reconstruction projects of monumental architecture in order to propose new ways in which such technology can be used.

Effects of 42-year long-term fertilizer management on soil phosphorus availability, fractionation,adsorption–desorption isotherm and plant uptake in flooded tropical rice

Soil phosphorus(P) fractionation, adsorption, and desorption isotherm, and rice yield and P uptake were investigated in flooded tropical rice(Oryza sativa L.) following 42-year fertilizer and manure application. The treatments included low-input [unfertilized control without N, P, or K(C0N0)], farmyard manure(FYM)(C1N0), NP(C0NP), NPK(C0NPK), FYM + NP(C1NP), and high-input treatment, FYM + NPK(C1NPK). Grain yield was increased significantly by 74%over the control under the combined application of FYM + NPK. However, under low- and high-input treatments, yield as well as P uptake was maintained at constant levels for 35 years.During the same period, high yield levels and P uptake were maintained under the C0 NP, C0 NPK,and C1 NPK treatments. These are unique characteristics of a tropical flooded ecosystem, which is a self-sustaining system for rice production. The Fe–P fraction was highest compared to the Ca–P and Al–P fractions after 42 years of fertilizer application and was significantly higher under FYM + NPK treatment. The P adsorption capacity of soil was highest under the low-input treatment and lowest under long-term balanced fertilization(FYM + NPK). In contrast, P desorption capacity was highest under NPK and lowest in the control treatment. Long-term balanced fertilization in the form of FYM + NPK for 42 years lowered the bonding energy and adsorption capacity for P in soil but increased its desorption potential, increasing P availability to the plant and leading to higher P uptake and yield maintenance.

Modelling long-term deformation of granular soils incorporating the concept of fractional calculus

Many constitutive models exist to characterise the cyclic behaviour of granular soils but can only simulate deformations for very limited cycles. Fractional derivatives have been regarded as one potential instrument for modelling memory-dependent phenomena. In this paper, the physical connection between the fractional derivative order and the fractal dimension of granular soils is investigated in detail. Then a modified elasto-plastic constitutive model is proposed for evaluating the long-term deformation of granular soils under cyclic loading by incorporating the concept of fac- tional calculus. To describe the flow direction of granular soils under cyclic loading, a cyclic flow potential consider- ing particle breakage is used. Test results of several types of granular soils are used to validate the model performance.

Do tau-synaptic long-term depression interactions in the hippocampus play a pivotal role in the progression of Alzheimer’s disease?

Cognitive decline in Alzheimer’s disease correlates with the extent of tau pathology,in particular tau hyperphosphorylation that initially appears in the transentorhinal and related regions of the brain including the hippocampus.Recent evidence indicates that tau hyperphosphorylation caused by either amyloid-βor long-term depression,a form of synaptic weakening involved in learning and memory,share similar mechanisms.Studies from our group and others demonstrate that long-term depression-inducing low-frequency stimulation triggers tau phosphorylation at different residues in the hippocampus under different experimental conditions including aging.Conversely,certain forms of long-term depression at hippocampal glutamatergic synapses require endogenous tau,in particular,phosphorylation at residue Ser396.Elucidating the exact mechanisms of interaction between tau and long-term depression may help our understanding of the physiological and pathological functions of tau/tau(hyper)phosphorylation.We first summarize experimental evidence regarding tau-long-term depression interactions,followed by a discussion of possible mechanisms by which this interplay may influence the pathogenesis of Alzheimer’s disease.Finally,we conclude with some thoughts and perspectives on future research about these interactions.

Effect of long-term fertilization on phosphorus fractions in different soil layers and their quantitative relationships with soil properties

Investigating the dynamics and distribution of soil phosphorus(P) fractions can provide a basis for enhancing P utilization by crops. Four treatments from a 29-year long-term experiment in black soil with maize cropping were involved in this study: no fertilizer(CK), inorganic nitrogen and potassium(NK), inorganic nitrogen, phosphorus, and potassium(NPK), and NPK plus manure(NPKM). We analyzed soil P fractions in different soil layers using a modified Hedley sequential method. The long-term NPKM treatment significantly increased total P by 0.6–1.6 times in the different soil layers. The Olsen-P concentration far exceeded the environmental threshold for soil Olsen-P(50.6 mg kg) in the NPKM treatment in the 0–60 cm soil profile. Moreover, the concentrations and proportion of labile and partially labile inorganic P(Pi) fractions(i.e., Na HCO-extracted Pi, Na OH-extracted Pi, and dilute HClextracted Pi) to the sum of all P fractions(Pt) in the 0–60 cm soil profile were higher in the NPKM treatment than in the NPK treatment, indicating that manure could promote the transformation of non-labile into more labile forms of P in soil, possibly by manure reducing P fixation by soil particles. Soil organic matter, Mehlich-3 extractable iron(Fe), and organic-bound aluminum were increased by fertilization, and were the main factors influencing the differences in the P fractions in the 0–20 cm soil layer. Soil mineral components, i.e., free Fe oxide and Ca CO, were the main factors influencing the P fractions in the subsoil. The soil P transformation process varied with soil layer and fertilization. Application of manure fertilizer can increase the labile(Olsen) P concentrations of the various soil layers, and thus should reduce the mineral P fertilizer requirement for crop growth and reduce potential environmental damage.

Effects of long-term fertilization on oxidizable organic carbon fractions on the Loess Plateau,China

The effects of long-term fertilization on pools of soil organic carbon （SOC） have been well studied, but limited information is available on the oxidizable organic carbon （OOC） fractions, especially for the Loess Plateau in China. We evaluated the effects of a 15-year fertilization on the OOC fractions （F1, F2, F3 and F4） in the 0-20 and 20-40 cm soil layers in flat farmland under nine treatments （N （nitrogen, urea）, P （phosphorus, monocalcium phosphate）, M （organic fertilizer, composted sheep manure）, N＋P （NP）, M＋N （MN）, M＋P （MP）, M＋N＋P （MNP）, CK （control, no fertilizer） and bare land （BL, no crops or fertilizer））. SOC content increased more markedly in the treatment containing manure than in those with inorganic fertilizers alone. F1, F2, F4 and F3 accounted for 47%, 27%, 18% and 8% of total organic carbon, respectively. F1 was a more sensitive index than the other C fractions in the sensitivity index （SI） analysis. F1 and F2 were highly correlated with total nitrogen （TN） and available nitrogen （AN）, F3 was negatively correlated with pH and F4 was correlated with TN. A cluster analysis showed that the treatments containing manure formed one group, and the other treatments formed another group, which indicated the different effects of fertilization on soil properties. Long-term fertilization with inorganic fertilizer increased the F4 fraction while manure fertilizer not only increased labile fractions （F1） in a short time, but also increased passive fraction （F4） over a longer term. The mixed fertilizer mainly affected F3 fraction. The study demonstrated that manure fertilizer was recommended to use in the farmland on the Loess Plateau for the long-term sustainability of agriculture.

Active fraction combination from Liuwei Dihuang decoction(LW-AFC) ameliorates corticosterone-induced long-term potentiation impairment in mice in vivo

Liuwei Dihuang decoction(LW), a classic formula in traditional Chinese medicine(TCM), has been used for nearly one thousand years for various diseases with characteristic features of kidney yin deficiency. LW consists of 6herbs including Dihuang[prepared root of Rehmannia glutinosa(Gaertn) DC], Shanyao(rhizome of Dioscorea polystachya Turcz), Shanzhuyu(fruit of Cornus officinalis Siebold Zucc), Mudanpi(root bark of Paeonia × suffruticosa Andrews),Zexie(rhizome of Alisma plantago-aquatica L) and Fuling(scleorotia of Wolfiporia extensa(Peck) Ginns)LW-active fraction combination(LW-AFC) is extracted from LW, it is effective for the treatment of kidney yin deficiency in many animal models. There are 3 fractions in LW-AFC, a polysaccharide fraction(LWB-B), a glycoside fraction(LWD-b) and an oligosaccharide fraction(CA-30). Our previous results indicate that LW-AFC has similar pharmacological effects to LW, modulating the balance of the NIM network. LW-AFC has positive effects in many animal models of kidney deficiency or disturbance of the NIM network. LW-AFC could improve the cognitive ability in Alzheimer′s disease(AD) animal models(APP/PS1, SAMP8), where modulating immune function and balancing the NIM network may play an important role in its cognition improving effects. Our study also showed that LW-AFC had protective effects on stress-induced disturbances of the NIM network. However, the underlying mechanisms remain elusive and need further investigation. OBJECTIVE This study evaluated the effects of LW-AFC and the active fractions(polysaccharide, LWB-B;glycoside, LWD-b;oligosaccharide,CA-30) on corticosterone(Cort)-induced long-term potentiation(LTP) impairment in vivo. METHODS LTP was used to evaluate the synaptic plasticity. LW-AFC was orally administered for seven days. The active fractions were given by either chronic administration(ig, ip, 7 d) or single administration(icv, ig, ip). Cort was injected subcutaneously 1 h before the high-frequency stimulation(HFS) to induce LTP impairment. Moreover, in order to research on the possible effective pathways, an antibiotic cocktail and an immunosuppressant were also used. RESULTS Chronic administration(ig) of LW-AFC and its three active fractions could ameliorate Cort-induced LTP impairment. Single administration(icv, ig, ip) of any of the active fractions had no effect on Cort-induced LTP impairment, while chronic administration(ig, ip) of LWB-B or LWD-b showed positive effects against Cort. Interestingly, CA-30 only showed protective effects via ig administration,and there was little effect when CA-30 was administered ip In addition, when the intestinal microbiota was disrupted by application of the antibiotic cocktail, CA-30 showed little protective effects against Cort. The effects of LW-AFC were also abolished when the immune function was inhibited. In the hippocampal tissue, Cort treatment increased corticosterone and glutamate, and LW-AFC could inhibit the Cort-induced elevation of corticosterone and glutamate;there was little change in D-serine in Cort-treated animals, but LW-AFC could increase the D-serine levels. CONCLUSION LW-AFC and its three active fractions could ameliorate Cort-induced LTP impairment. Their protective effects are unlikely by a direct way, and immune modulation might be the common pathway. CA-30 could protect LTP from impairment via modulating the intestinal microbiota. Decreasing corticosterone and glutamate and increasing D-serine in the Cort-treated animals’ hippocampal tissue might be one of the mechanisms for the neural protective effects of LW-AFC. Further study is needed to understand the underlying mechanisms.

Interaction of soil microbial communities and phosphorus fractions under long-term fertilization in paddy soil

Understanding the impact of biological activities on the soil phosphorus(P)distribution under long-term fertilizer application can facilitate better soil P fertility management.Therefore,the primary objectives of this study were to investigate the effect of long-term(since 1981)fertilizer application on the soil P fractions and microbial community and to evaluate correlations between the microbial community structure and P distribution.The following treatments were implemented in a long-term field trial:no fertilization(CK),inorganic N and K(NK),inorganic P and K(PK),inorganic N,P and K(NPK)and manure+NPK(MNPK)fertilization.The study showed that the soil pH,soil organic carbon and total and available N and P concentrations were considerably higher in the MNPK treatment than in the CK treatment.The soil microbial biomass C,N and P concentrations were also significantly higher in the MNPK treatment than in the CK treatment.Among fertilization treatments,theβ-1,4-glucosidase,α-1,4-glucosidase,urease,acid phosphatase and phosphodiesterase activities were the highest in the MNPK treatment.Compared to inorganic fertilization,the MNPK treatment increased the labile soil P fractions and decreased the residual soil P concentration.Continuous fertilization significantly affected the soil microbial composition.The total phospholipid fatty acid(PLFA)concentrations in the NK,PK,NPK and MNPK treatments were 23.3,43.1,48.7 and 87.7%higher,respectively,than in the CK treatment.A significant correlation was observed between the microbial community and soil P fractions.Moreover,the aggregated boosted tree(ABT)model showed that among the various soil biochemical properties,the total PLFA concentration was the factor that most influenced the active P pool,accounting for 35.4%of the relative influence of all soil biochemical properties examined.These findings reveal that combined manure and inorganic fertilizer application is a better approach than applying inorganic fertilizer alone for sustaining long-term P fertility by mediating soil biological activity.

Treatment outcomes and adverse drug reactions among patients with drug-resistant tuberculosis receiving all-oral,long-term regimens:First record viewing report from Pakistan

Objective:To assess the effectiveness and adverse drug reactions of all-oral regimens for patients with multidrug-resistant tuberculosis.Methods:This retrospective study was conducted at 10 Programmatic Management of Drug Resistant Tuberculosis sites in Punjab province of Pakistan.Patients receiving treatment for drug resistant tuberculosis from July 2019 to December 2020 with at least interim result i.e.6th month culture conversion or final outcomes(cured,complete,lost to follow-up,failure,death)available,were included in the study.Data was extracted from electronic data management system.For the reporting and management of adverse drug events,active tuberculosis drug safety monitoring and management was implemented across all sites.All the data was analyzed using SPSS version 22.Results:Out of 947 drug resistant tuberculosis patients included in this study,579(68%)of the patients had final outcomes available.Of these,384(67.9%)successfully completed their treatment.Out of 368(32%)patients who had their interim results available,all had their 6th month culture negative.Combining new medications was thought to result in serious adverse outcomes such as QT prolongation.However,this study did not record any severe adverse events among patients.Conclusions:All-oral regimens formulation guided by overall treatment effectiveness resulted in treatment outcomes comparable to those obtained with traditional injectable treatment.

Organic matter fractions within macroaggregates in response to long-term fertilization in calcareous soil after reclamation

Soil organic carbon(SOC)plays a key role in improving soil quality and optimizing crop yield.Yet little is known about the fate of macroaggregates(>0.25 mm)under long-term fertilization and their relative importance in SOC sequestration in reclaimed calcareous soil.Therefore,the effects of mineral fertilizers and organic manure on the mechanisms of organic carbon(OC)stabilization in macroaggregates were investigated in this study.Four treatments were used:unfertilized control(CK),mineral fertilizer(NPK),compost chicken manure alone(M),and mineral fertilizers plus manure(MNPK).Samples from the 0–20 cm layer of soil receiving 11-year-long fertilization were separated into four fractions based on the macroaggregates present(unprotected coarse and fine particulate organic matter,cPOM and fPOM;physically protected intra-microaggregate POM,i POM;and biochemically protected mineral associated OM,MOM)by the physical fractionation method.Compared with the control,the long-term application of NPK had little effect on SOC content,total nitrogen(TN)content,and OC and TN contents of macroaggregate fractions.In contrast,incorporation of organic manure(MNPK)significantly increased SOC(45.7%)and TN(24.3%)contents.Application of MNPK increased OC contents within macroaggregate-extracted fractions of cPOM(292.2%),fPOM(136.0%)and iPOM(124.0%),and TN contents within cPOM(607.1%),fPOM(242.5%)and iPOM(127.6%),but not the mineral associated organic carbon(MOM-C)and nitrogen(MOM-N)contents.Unprotected C fractions were more strongly and positively correlated with SOC increase than protected C fractions,especially for cPOM-C,indicating that SOC sequestration mainly occurred via cPOM-C in the studied calcareous soil.In conclusion,MNPK increased the quantity and stability of SOC by increasing the contents of cPOM-C and cPOM-N,suggesting that this management practice(MNPK)is an effective strategy to develop sustainable agriculture.

BCCLR:A Skeleton-Based Action Recognition with Graph Convolutional Network Combining Behavior Dependence and Context Clues

In recent years,skeleton-based action recognition has made great achievements in Computer Vision.A graph convolutional network(GCN)is effective for action recognition,modelling the human skeleton as a spatio-temporal graph.Most GCNs define the graph topology by physical relations of the human joints.However,this predefined graph ignores the spatial relationship between non-adjacent joint pairs in special actions and the behavior dependence between joint pairs,resulting in a low recognition rate for specific actions with implicit correlation between joint pairs.In addition,existing methods ignore the trend correlation between adjacent frames within an action and context clues,leading to erroneous action recognition with similar poses.Therefore,this study proposes a learnable GCN based on behavior dependence,which considers implicit joint correlation by constructing a dynamic learnable graph with extraction of specific behavior dependence of joint pairs.By using the weight relationship between the joint pairs,an adaptive model is constructed.It also designs a self-attention module to obtain their inter-frame topological relationship for exploring the context of actions.Combining the shared topology and the multi-head self-attention map,the module obtains the context-based clue topology to update the dynamic graph convolution,achieving accurate recognition of different actions with similar poses.Detailed experiments on public datasets demonstrate that the proposed method achieves better results and realizes higher quality representation of actions under various evaluation protocols compared to state-of-the-art methods.

Clinical manifestations,diagnosis and long-term prognosis of adult autoimmune enteropathy:Experience from Peking Union Medical College Hospital

BACKGROUND Autoimmune enteropathy(AIE)is a rare disease whose diagnosis and long-term prognosis remain challenging,especially for adult AIE patients.AIM To improve overall understanding of this disease’s diagnosis and prognosis.METHODS We retrospectively analyzed the clinical,endoscopic and histopathological characteristics and prognoses of 16 adult AIE patients in our tertiary medical center between 2011 and 2023,whose diagnosis was based on the 2007 diagnostic criteria.RESULTS Diarrhea in AIE patients was characterized by secretory diarrhea.The common endoscopic manifestations were edema,villous blunting and mucosal hyperemia in the duodenum and ileum.Villous blunting(100%),deep crypt lymphocytic infiltration(67%),apoptotic bodies(50%),and mild intraepithelial lymphocytosis(69%)were observed in the duodenal biopsies.Moreover,there were other remarkable abnormalities,including reduced or absent goblet cells(duodenum 94%,ileum 62%),reduced or absent Paneth cells(duodenum 94%,ileum 69%)and neutrophil infiltration(duodenum 100%,ileum 69%).Our patients also fulfilled the 2018 diagnostic criteria but did not match the 2022 diagnostic criteria due to undetectable anti-enterocyte antibodies.All patients received glucocorticoid therapy as the initial medication,of which 14/16 patients achieved a clinical response in 5(IQR:3-20)days.Immunosuppressants were administered to 9 patients with indications of steroid dependence(6/9),steroid refractory status(2/9),or intensified maintenance medication(1/9).During the median of 20.5 months of followup,2 patients died from multiple organ failure,and 1 was diagnosed with non-Hodgkin’s lymphoma.The cumulative relapse-free survival rates were 62.5%,55.6%and 37.0%at 6 months,12 months and 48 months,respectively.CONCLUSION Certain histopathological findings,including a decrease or disappearance of goblet and Paneth cells in intestinal biopsies,might be potential diagnostic criteria for adult AIE.The long-term prognosis is still unsatisfactory despite corticosteroid and immunosuppressant medications,which highlights the need for early diagnosis and novel medications.

Workout Action Recognition in Video Streams Using an Attention Driven Residual DC-GRU Network

Regular exercise is a crucial aspect of daily life, as it enables individuals to stay physically active, lowers thelikelihood of developing illnesses, and enhances life expectancy. The recognition of workout actions in videostreams holds significant importance in computer vision research, as it aims to enhance exercise adherence, enableinstant recognition, advance fitness tracking technologies, and optimize fitness routines. However, existing actiondatasets often lack diversity and specificity for workout actions, hindering the development of accurate recognitionmodels. To address this gap, the Workout Action Video dataset (WAVd) has been introduced as a significantcontribution. WAVd comprises a diverse collection of labeled workout action videos, meticulously curated toencompass various exercises performed by numerous individuals in different settings. This research proposes aninnovative framework based on the Attention driven Residual Deep Convolutional-Gated Recurrent Unit (ResDCGRU)network for workout action recognition in video streams. Unlike image-based action recognition, videoscontain spatio-temporal information, making the task more complex and challenging. While substantial progresshas been made in this area, challenges persist in detecting subtle and complex actions, handling occlusions,and managing the computational demands of deep learning approaches. The proposed ResDC-GRU Attentionmodel demonstrated exceptional classification performance with 95.81% accuracy in classifying workout actionvideos and also outperformed various state-of-the-art models. The method also yielded 81.6%, 97.2%, 95.6%, and93.2% accuracy on established benchmark datasets, namely HMDB51, Youtube Actions, UCF50, and UCF101,respectively, showcasing its superiority and robustness in action recognition. The findings suggest practicalimplications in real-world scenarios where precise video action recognition is paramount, addressing the persistingchallenges in the field. TheWAVd dataset serves as a catalyst for the development ofmore robust and effective fitnesstracking systems and ultimately promotes healthier lifestyles through improved exercise monitoring and analysis.

Prevalence and long-term prognosis in Takayasu arteritis patients with left ventricular dilatation and a decreased ejection fraction:data from 1,105 Chinese cases

Background Left ventricular dilatation and a decreased ejection fraction is one of the most serious complications in patients with Takayasu arteritis(TA).We aim to describe the prevalence,clinical features,treatment,and long-term prognosis of TA patients with this complication.

Mechanisms of active fraction combination from Liuwei Dihuang Decoction(LW-AFC) on long-term potentiation impairment in vivo

OBJECTIVE Liuwei Dihuang Decoction(LW)-active fraction combination(LW-AFC,consist of 3 fractions polysaccharide,LWB-B;glycoside,LWD-b;oligosaccharide,CA-30)is extracted from LW,it is effective for the treatment of kidney yin deficiency in many animal models.This study evaluated the effects and mechanisms of LW-AFC and the active fractions on corticosterone(Cort)-induced long-term potentiation(LTP)impairment in vivo.METHODS LTP was used to evaluate the synaptic plasticity.LW-AFC was orally administered for seven days.The active fractions were given by either chronic administration(ig,ip,7 d)or single administration(icv,ig,ip).Cort was injected subcutaneously 1h before the high-frequency stimulation(HFS)to induce LTP impairment.Moreover,in order to research on the possible effective pathways,an antibiotic cocktail and an immunosuppressant were also used.RESULTS Chronic administration(ig)of LW-AFC and its three active fractions could ameliorate Cort-induced LTP impairment.Single administration(icv,ig,ip)of any of the active fractions had no effect on Cort-induced LTP impairment,while chronic administration(ig,ip)of LWB-B or LWD-b showed positive effects against Cort.Interestingly,CA-30 only showed protective effects via ig administration,and there was little effect when CA-30 was administered ip In addition,when the intestinal microbiota was disrupted by application of the antibiotic cocktail,CA-30 showed little protective effects against Cort.The effects of LW-AFC were also abolished when the immune function was inhibited.In the hippocampal tissue,Cort treatment increased Cort and glutamate,and LW-AFC could inhibit the Cort-induced elevation of Cort and glutamate;there was little change in D-serine in Cort-treated animals,but LW-AFC could increase the D-serine levels.CONCLUSION LW-AFC and its three active fractions could ameliorate Cort-induced LTP impairment.Their protective effects are unlikely by a direct way,and immune modulation might be the common pathway.CA-30 could protect LTP from impairment via modulating the intestinal microbiota.Decreasing Cort and glutamate and increasing D-serine in the Cort-treated animals'hippocampal tissue might be one of the mechanisms for the neural protective effects of LW-AFC.Further study is needed to understand the underlying mechanisms.

Development of a new Cox model for predicting long-term survival in hepatitis cirrhosis patients underwent transjugular intrahepatic portosystemic shunts

BACKGROUND Transjugular intrahepatic portosystemic shunt(TIPS)placement is a procedure that can effectively treat complications of portal hypertension,such as variceal bleeding and refractory ascites.However,there have been no specific studies on predicting long-term survival after TIPS placement.AIM To establish a model to predict long-term survival in patients with hepatitis cirrhosis after TIPS.METHODS A retrospective analysis was conducted on a cohort of 224 patients who un-derwent TIPS implantation.Through univariate and multivariate Cox regression analyses,various factors were examined for their ability to predict survival at 6 years after TIPS.Consequently,a composite score was formulated,encompassing the indication,shunt reasonability,portal venous pressure gradient(PPG)after TIPS,percentage decrease in portal venous pressure(PVP),indocyanine green retention rate at 15 min(ICGR15)and total bilirubin(Tbil)level.Furthermore,the performance of the newly developed Cox(NDC)model was evaluated in an in-ternal validation cohort and compared with that of a series of existing models.RESULTS The indication(variceal bleeding or ascites),shunt reasonability(reasonable or unreasonable),ICGR15,post-operative PPG,percentage of PVP decrease and Tbil were found to be independent factors affecting long-term survival after TIPS placement.The NDC model incorporated these parameters and successfully identified patients at high risk,exhibiting a notably elevated mortality rate following the TIPS procedure,as observed in both the training and validation cohorts.Additionally,in terms of predicting the long-term survival rate,the performance of the NDC model was significantly better than that of the other four models[Child-Pugh,model for end-stage liver disease(MELD),MELD-sodium and the Freiburg index of post-TIPS survival].CONCLUSION The NDC model can accurately predict long-term survival after the TIPS procedure in patients with hepatitis cirrhosis,help identify high-risk patients and guide follow-up management after TIPS implantation.

Long-term outcomes after endoscopic removal of malignant colorectal polyps:Results from a 10-year cohort

BACKGROUND Choosing an optimal post-polypectomy management strategy of malignant colorectal polyps is challenging,and evidence regarding a surveillance-only strategy is limited.AIM To evaluate long-term outcomes after endoscopic removal of malignant colorectal polyps.METHODS A single-center retrospective cohort study was conducted to evaluate outcomes after endoscopic removal of malignant colorectal polyps between 2010 and 2020.Residual disease rate and nodal metastases after secondary surgery and local and distant recurrence rate for those with at least 1 year of follow-up were invest-igated.Event rates for categorical variables and means for continuous variables with 95%confidence intervals were calculated,and Fisher’s exact test and Mann-Whitney test were performed.Potential risk factors of adverse outcomes were RESULTS In total,135 lesions(mean size:22.1 mm;location:42%rectal)from 129 patients(mean age:67.7 years;56%male)were enrolled.The proportion of pedunculated and non-pedunculated lesions was similar,with en bloc resection in 82%and 47%of lesions,respectively.Tumor differentiation,distance from resection margins,depth of submucosal invasion,lymphovascular invasion,and budding were reported at 89.6%,45.2%,58.5%,31.9%,and 25.2%,respectively.Residual tumor was found in 10 patients,and nodal metastasis was found in 4 of 41 patients who underwent secondary surgical resection.Univariate analysis identified piecemeal resection as a risk factor for residual malignancy(odds ratio:1.74;P=0.042).At least 1 year of follow-up was available for 117 lesions from 111 patients(mean follow-up period:5.59 years).Overall,54%,30%,30%,11%,and 16%of patients presented at the 1-year,3-year,5-year,7-year,and 9-10-year surveillance examinations.Adverse outcomes occurred in 9.0%(local recurrence and dissemination in 4 patients and 9 patients,respectively),with no difference between patients undergoing secondary surgery and surveillance only.CONCLUSION Reporting of histological features and adherence to surveillance colonoscopy needs improvement.Long-term adverse outcome rates might be higher than previously reported,irrespective of whether secondary surgery was performed.

Bone Marrow Transplant Long-Term Survivors’ Satisfaction with Quality of Life: Comparison with a Control Group

Purpose: To evaluate the global quality of life (QoL) of survivors with 10-year or more post-transplant, and to identify risk factors that interfere with well-being. Methods: This is a prospective analytic transversal study with 214 survivors of Bone Marrow Transplant (BMT) and 264 healthy people identified among blood donors, treated as the control group, of both sexes, 18 years or older. The protocol includes a demographic-socioeconomic questionnaire, World Health Organization Quality of Life (WHOQOL) and the Karnofsky Performance Status Scale. Results: 53.7% of the survivor group members are satisfied with their QoL. A similar result can be found in the control group (54.2%). Chronological maturity, anxiety, sexual difficulty, and being a provider are factors that interfere negatively in the QoL of male survivors. In female survivors, the risk factors are anxiety, low educational level, not having a stable partner, being a provider, and not being Caucasian. Conclusions: Survivors are as satisfied with their QoL as the control group. QoL is understood as a perceptive process composed of objective (functional and relational capacity) and subjective phenomenon (perceptive composition).

基于LDA主题模型的GitHub Actions工作流项目推荐算法

在CI/CD实践中,自动化已成为软件开发实践中的一种规范。GitHub引入GitHub Actions为软件维护者提供自动化的持续集成工作流方案,尽管其为开发者提供了诸多便利,GitHub社区也提供了许多第三方的GitHub Actions服务,但仍然只有极少的项目在使用。为了满足开发人员对工作流自动化的需求,减少非开发任务工作量,提出一种基于隐含狄利克雷分布(LDA)主题模型和Jensen-Shannon距离的GitHub Actions工作流项目推荐算法。通过对GitHub Actions存储库的README文件进行主题建模,将GitHub的事件描述文本和用户输入作为模型输入,为正在开发的代码仓库推荐GitHub Actions服务。将该推荐模型与标准的基于余弦相似度的方法进行比较的实验结果表明,该方法能有效改善开源软件仓库的推荐精度。