This study investigates the long-term performance of laboratory dam concrete in different curing environments over ten years and the microstructure of 17-year-old laboratory concrete and actual concrete cores drilled ...This study investigates the long-term performance of laboratory dam concrete in different curing environments over ten years and the microstructure of 17-year-old laboratory concrete and actual concrete cores drilled from the Three Gorges Dam.The mechanical properties of the laboratory dam concrete,whether cured in natural or standard environments,continued to improve over time.Furthermore,the laboratory dam concrete exhibited good resistance to diffusion and a refined microstructure after 17 years.However,curing and long-term exposure to the local natural environment reduced the frost resistance.Microstructural analyses of the laboratory concrete samples demonstrated that moderate-heat cement and fine fly ash(FA)particles were almost fully hydrated to form compact micro structures consisting of large quantities of homogeneous calcium(alumino)silicate hydrate(C-(A)-S-H)gels and a few crystals.No obvious interfacial transition zones were observed in the microstructure owing to the longterm pozzolanic reaction.This dense and homogenous microstructure was the crucial reason for the excellent long-term performance of the dam concrete.A high FA volume also played a significant role in the microstructural densification and performance growth of dam concrete at a later age.The concrete drilled from the dam surface exhibited a loose microstructure with higher microporosity,indicating that concrete directly exposed to the actual service environment suffered degradation caused by water and wind attacks.In this study,both macro-performance and microstructural analyses revealed that the application of moderate-heat cement and FA resulted in a dense and homogenous microstructure,which ensured the excellent long-term performance of concrete from the Three Gorges Dam after 17 years.Long-term exposure to an actual service environment may lead to microstructural degradation of the concrete surface.Therefore,the retained long-term dam concrete samples need to be further researched to better understand its microstructural evolution and development of its properties.展开更多
The application of reclaimed asphalt pavement(RAP)and reclaimed asphalt shingles(RAS)on asphalt pavement can reduce the asphalt paving cost,conserve energy and protect the environment.However,the use of high contents ...The application of reclaimed asphalt pavement(RAP)and reclaimed asphalt shingles(RAS)on asphalt pavement can reduce the asphalt paving cost,conserve energy and protect the environment.However,the use of high contents of RAP and RAS in asphalt pavement may lead to durability issues,especially the fatigue cracking and thermal cracking.It is necessary to conduct a series of analyses on asphalt mixtures containing high RAP and RAS,and seek methods to enhance their long-term performance.This paper provides a comprehensive over-view of the long-term performance of recycled asphalt mixtures containing high contents of RAP and RAS.The findings in this research show that rutting resistance of high recycled asphalt mixtures is not a concern,whereas their resistance to fatigue and thermal cracking is not conclusive.Recycling agents can be used to improve the thermal cracking resistance of high recycled asphalt mixtures.An optimum decision on recycling agents will improve the durability properties of high recycled asphalt mixtures.It is recommended that to use a balanced mixture design approach with testing of the blended asphalt binders will provide better understanding of long-term performance of recycled asphalt mixtures containing high RAP and RAS.展开更多
In order to comprehensively utilize the remaining bamboo residue of bamboo products,this paper presents a research on recycling the bamboo fibers from bamboo residue for improving the performance of the asphalt mixtur...In order to comprehensively utilize the remaining bamboo residue of bamboo products,this paper presents a research on recycling the bamboo fibers from bamboo residue for improving the performance of the asphalt mixtures.First of all,the basic performance parameters of sinocalamus affinis fiber,phyllostachys pubescens fiber,green bamboo fiber were tested and analyzed,and the optimal content and length were put forward.Then,the mix ratio design of the bamboo fiber modified asphalt mixture was further designed through the response surface method,and was verified the rationality of the mix ratio.Finally,the mixture specimens were made according to the experimental design mix ratio,and the high temperature,low temperature performance and moisture susceptibility of the bamboo fiber modified mixtures asphalt were tested.The results showed that the high temperature performance,low temperature performance and moisture susceptibility of bamboo fiber modified asphalt mixtures were improved compared with the performance of SBS modified asphalt mixture.When the length of bamboo fiber is 7.25 mm and the content of 0.22%,the road performance of the asphalt mixture was optimal.Consequentially,the decomposition of bamboo residue into bamboo fiber and its application in asphalt pavement can improve the reuse of bamboo waste,with remarkable environmental benefits and great promotion value.展开更多
Tin halide perovskites(THPs)have received extensive attention due to their low toxicity and excellent optoelectronic properties,and are considered to be the most promising alternatives to develop efficient lead-free p...Tin halide perovskites(THPs)have received extensive attention due to their low toxicity and excellent optoelectronic properties,and are considered to be the most promising alternatives to develop efficient lead-free perovskite solar cells.However,due to the unique and inherent characteristics of Sn^(2+)being easily oxidized to Sn^(4+)and fast crystallization,tin perovskite solar cells(TPSCs)show relatively poor performance and stability,compared to the lead counterparts.Recently,the introduction of bulky organic spacers into three-dimensional(3D)THPs for dimensional regulation can not only prevent the intrusion of water and oxygen,but also inhibit the self-doping effect and ion migration.In this review,we will detail how dimensional regulation enables TPSCs with high performance and superior stability.First,we summarize the intrinsic properties of THPs and analyze the root causes of their poor performance and instability.Next,we discuss the specific structure and types of the dimensional regulation strategy.Then,the mechanism of dimensional regulation is discussed in detail,mainly from inhibiting the Sn^(2+)oxidation,optimizing crystallization,passivating defects,and improving energy level alignment.Finally,future challenges and prospects for dimensional regulation are elaborated to help researchers develop more efficient and stable TPSCs.展开更多
To research the dynamic mechanical properties and road performances of flame retardant asphalt mortars and mixtures, four different asphalt mortars/mixtures were prepared: a reference group and three asphalt mortars/m...To research the dynamic mechanical properties and road performances of flame retardant asphalt mortars and mixtures, four different asphalt mortars/mixtures were prepared: a reference group and three asphalt mortars/mixtures containing composite flame retardant materials(M-FRs) of different proportions. Temperature sweep, frequency sweep, repeated creep test, force ductility test and bending beam rheological test were carried out to research the dynamic mechanical properties of asphalt mortars containing M-FRs; wheeltracking test, low-temperature bending test and freeze-thaw split test were used to study the road performances of asphalt mixtures containing M-FRs. The results show that high-temperature performances of the three flame retardant asphalt mortars improve greatly, while low-temperature cracking resistances decline. Both hightemperature performances and water stabilities of asphalt mixtures containing M-FRs are quite good and exceed the specification requirements. However, their low-temperature performances decline in different degrees. In summary, besides their good flame retardancy, the flame retardant asphalt mortars and mixtures also exhibit acceptable road performance.展开更多
An understanding of the influence of contractor monitoring on performance of road infrastructural projects in Uganda provided an impetus for this study. The objectives of the study were to: assess the relationship bet...An understanding of the influence of contractor monitoring on performance of road infrastructural projects in Uganda provided an impetus for this study. The objectives of the study were to: assess the relationship between contractors monitoring and performance of national road infrastructure projects and the relationship between contractor monitoring components and performance of national road infrastructure projects in Uganda. Purposive sampling was employed in selecting the procurement professionals, engineers and simple random sampling was adopted in selecting private consultants, members of parliament and respondents from the civil society organizations. Data for this study were collected using a closed ended questionnaire and interviews. Some of the major finding from this study include: weak procurement rules which lead to awarding road projects to incompetent contractors;contractor monitoring being handled by unqualified, incompetent and inexperienced professionals;lack of contractors and contract supervisors appraisal system;delay of contractors payments which affects timelines in services delivery;lack of a strong internal project monitoring and evaluation mechanism at the Uganda National Roads Agency (UNRA). The research therefore recommends the establishment of an Independent Public Infrastructure Development and Monitoring Unit by government and adoption of systems that appraise both contractors and contract supervisors with clear disciplinary actions for unsatisfactory performance by the UNRA.展开更多
Road safety performance function(SPF) analysis using data-driven and nonparametric methods, especially recent developed deep learning approaches, has gained increasing achievements. However, due to the learning mechan...Road safety performance function(SPF) analysis using data-driven and nonparametric methods, especially recent developed deep learning approaches, has gained increasing achievements. However, due to the learning mechanisms are hidden in a"black box" in deep learning, traffic features extraction and intelligent importance analysis are still unsolved and hard to generate.This paper focuses on this problem using a deciphered version of deep neural networks(DNN), one of the most popular deep learning models. This approach builds on visualization, feature importance and sensitivity analysis, can evaluate the contributions of input variables on model's "black box" feature learning process and output decision. Firstly, a visual feature importance(Vi FI) method that describes the importance of input features is proposed by adopting diagram and numerical-analysis. Secondly,by observing the change of weights using Vi FI on unsupervised training and fine-tuning of DNN, the final contributions of input features are calculated according to importance equations for both steps that we proposed. Sequentially, a case study based on a road SPF analysis is demonstrated, using data collected from a major Canadian highway, Highway 401. The proposed method allows effective deciphering of the model's inner workings and allows the significant features to be identified and the bad features to be eliminated. Finally, the revised dataset is used in crash modeling and vehicle collision prediction, and the testing result verifies that the deciphered and revised model achieves state-of-theart performance.展开更多
Dynamic environmental testing is an effective means to study the energy and long-term hygrothermal performance of building enclosures. Southeast University is designing and building a large-scale dynamic environment s...Dynamic environmental testing is an effective means to study the energy and long-term hygrothermal performance of building enclosures. Southeast University is designing and building a large-scale dynamic environment simulation testing facility. It can simuhaneously and dynamically simulate temperature, relative humidity, infrared solar radiation, UV radiation, and precipitation. A transformation is needed to predict the energy and long-term hygrothermal performance of building enclosures under real service conditions using data obtained from accelerated tests.展开更多
Based on the investigation of long-life asphalt pavement at home and abroad,the development of long-life asphalt pavement technology in Shandong Province,China is reviewed in this paper.The structural combination char...Based on the investigation of long-life asphalt pavement at home and abroad,the development of long-life asphalt pavement technology in Shandong Province,China is reviewed in this paper.The structural combination char-acteristics of typical long-life asphalt pavement in Shandong Province and their popularization and application are introduced.The application effect of combined base long-life asphalt pavement,which has been widely promoted,is evaluated.At the same time,taking the Binda perpetual pavement test road in Shandong Province as an example,the dynamic response and long-term performance evolution of long-life asphalt pavement are analyzed over a period of more than 17 years.Sections S1,S2,and S3 present information about full-depth asphalt pavement.Section S4 describes combined base asphalt pavement.The results show that the maximum strain of S1–S4 is within the endurance strain limit.S1,S2,S3 and S4 are all expected to be long-life asphalt pavements.In the current study,Sections S1–S4 were maintained in good condition during a service period of more than 17 years with no structural cracks and good deflection,rutting,and IRI indexes.The deflection index was stable without growth,and the IRI was also relatively stable following the opening to traffic.The rutting depth un-derwent a slight cumulative increase within 8 years of opening,and then stabilized.The average rutting depth over the 17-year period was less than 15 mm.Therefore,S1–S4 meet the design standards required for use as long-life pavements.From the perspectives of resource saving,energy saving,and emission reduction and service performance,full-depth asphalt pavement can be considered to represent a new generation of green and durable pavement structures with great future promotion potential.展开更多
Ordinary concrete presents short service life when used for building and repairing high-grade road with heavy traffic due to its large brittleness, poor bending flexibility and serious shrinkage on drying. In this pap...Ordinary concrete presents short service life when used for building and repairing high-grade road with heavy traffic due to its large brittleness, poor bending flexibility and serious shrinkage on drying. In this paper, a new kind of high performance concrete has been designed by means of combination of organic, inorganic material as well as metal material. The research and application have shown that this new concrete can significantly counteract the deficiency of ordinary concrete and give excellent mechanical properties and pavement performances. The application of this new kind of concrete is of great social and economic significance.展开更多
The long-term performance of moderate heat Portland cement with double-expansive sources (DE cement) in the system of high MgO clinker and gypsum was studied by XRD, SEM/EDAX and test methods for strength and expans...The long-term performance of moderate heat Portland cement with double-expansive sources (DE cement) in the system of high MgO clinker and gypsum was studied by XRD, SEM/EDAX and test methods for strength and expansion of cement. Results indicate that the periclase particle, whose size was 5-7.5μm in DE cement clinker containing 4.8 % MgO, existed individually. The periclase hydration in hardened DE cement paste started at about 60 days and completed up to 2 000 days, and ettringite in the paste was stable from 3 days to 2 000 days. Under the conditions of 4.5%-5.0 % MgO in clinker and 2.8%-3.4 %SO3 in cement, ettringite expansion and brucite expansion in DE cement paste had a continuity, entirety and stability. At the ages of 90, 365,730 and 2 000 days the expansion of the paste reached 0.07%-0.11%, 0.16%-0.21%, 0.21%-0.27 %, and 0.29%-0.38%, respectively. The results suggest that by using this cement in mass concrete it may compensate its temperature shrinkage and autogenous shrinkage to some extent.展开更多
A number of studies conducted in Kenya </span><span style="font-family:Verdana;">and </span><span style="font-family:Verdana;">internationally indicate</span>...A number of studies conducted in Kenya </span><span style="font-family:Verdana;">and </span><span style="font-family:Verdana;">internationally indicate</span><span style="font-family:Verdana;">d</span><span style="font-family:""><span style="font-family:Verdana;"> that most of the construction firms and contractors do not seem to strictly observe safety administration in construction industry, hence compromised performance at implementation stage of projects and even later in the post implementation or post-delivery stage. The study aimed to examine the influence of contractors’ safety record on road performance. This is to create better understanding of how the safety record of contractors could either positively or negatively influence performance of roads during post-delivery stage. The study used both descriptive survey research design and correlation design based on a pragmatic mixed method approach. Through stratified sampling and proportionate sampling, a sample of 210 was drawn from a population of 460 comprising of registered contractors and Public Service Vehicles (PSV) drivers within Nairobi County in Kenya. Questionnaires were distributed using simple random sampling. The questionnaires returned were 153 in total representing 72.8% of all questionnaires distributed to the respondents. Data was descriptively analyzed using percentages, frequencies, means and standard deviations for measuring central tendency and variability. Inferential analysis was done by use of correlation and regression. The descriptive analysis revealed that safety policy management system, insurance policy, and adequacy of standards in addressing safety outcome are to some extent practiced and adhered to. However, compliance behavior to safety procedures is still weak and requires improvement. The null hypothesis was tested and the results obtained from a simple linear regression indicated that, R = 0.657, R</span><sup><span style="font-size:12px;font-family:Verdana;">2</span></sup><span style="font-family:Verdana;"> = 0.431, B = 0.359, t = 10.703, F (1,151) = 114.558, p = 0.000 < 0.05. This means that contractors’ safety record has a strong positive and significant relationship with road performance and that 43.1% of variation in performance is explained by safety record. This study recommends that contractors’ safety record should be part</span></span><span style="font-family:Verdana;">,</span><span style="font-family:Verdana;"> and parcel of the evaluation criteria used in selection of a suitable road contractor to ensure road performance is achieved even after construction is completed. The study is significant in that it contributes to the body of knowledge by providing empirical data on the need for safety procedures in urban road construction and beyond.展开更多
Curling results from the temperature differential across the concrete slab thickness and may induce undue stresses in newly placed slab. This study deals with the finite element (FE) analysis of curling, curling str...Curling results from the temperature differential across the concrete slab thickness and may induce undue stresses in newly placed slab. This study deals with the finite element (FE) analysis of curling, curling stresses, field measurement of curling on a newly built jointed plain concrete pavement, and comparison of its long-term performance using both Mechanistic-Empirical Pavement Design Guide (MEPDG) and HIPERPAVII software. The FE analysis was performed with a software program, ANSYS. The test section was modeled as a three-layer system with 300 mm concrete slab, 100 mm treated drainable base, and 150 mm lime-treated subgrade. All layers were assumed to be linear elastic. Temperature data was collected at five different depth locations across the concrete slab with digital data loggers. Curling was measured on five different days with a simple setup. The effect of temperature nonlinearities across the slab thickness was also examined. The results show that both upward and downward curling increase as the temperature differential increases. The maximum stress resulting from the combined effect of curling and traffic loading due to positive temperature differential is higher than that due to the negative temperature differential of the same magnitude. Since temperature differential has a significant influence on curling, both curling and curling stresses can be mitigated at an early age with temperature control, namely via enhanced curing. Both MEPDG and HIPERPAVII showed approximately the same performance for the PCC thickness ranging from 215 mm to 300 mm for this project. Performance prediction from HIPERPAVII is very sensitive to the change in PCC thickness less than 230 mm whereas MEPDG prediction is not as sensitive to the thickness change as with HIPERPAV 1I.展开更多
This article focuses on a technique for shallow mechanical improvement of soil which deals with the utilization of crushed granite mixed in a certain percentage with lateritic soils during road construction in Burkina...This article focuses on a technique for shallow mechanical improvement of soil which deals with the utilization of crushed granite mixed in a certain percentage with lateritic soils during road construction in Burkina Faso.Lithostab is the simplified name for litho-stabilization,a technique for improving laterite by adding crushed granite that increases the CBR(California bearing ratio)of that material for being used in road construction.Class 0/25 of crushed granite added to a laterite in our case gives good performance in terms of CBR.Indeed,the CBR index which was initially 48 at 98%of the OMP(optimum modified Proctor)goes to 88.And from 84 at 98%of the OMP,it goes to 128 for 30%of class 0/25 of crushed granite added.This means that class 0/25 of crushed granite provides better CBR index to that material when it is incorporated at 30%.So,lithostab is an easy to implement eco-friendly material for road construction because of the utilization of local materials.Then,it contributes to the protection of the environment in the sense that its production does not require a lot of energy and does not release large quantities of carbon dioxide into the atmosphere.展开更多
Roads are the major asset of any country and to conserve them maintenance is essential. The delay of maintenance works can lead the road in the stage of expensive rehabilitation and reconstruction. In Nepal, Departmen...Roads are the major asset of any country and to conserve them maintenance is essential. The delay of maintenance works can lead the road in the stage of expensive rehabilitation and reconstruction. In Nepal, Department of Roads (DoR) is responsible for maintenance of strategic roads of country. The maintenance practice of the road under Department of Road is predominantly based on Strengthen Maintenance Division Process where several maintenance activities like Routine maintenance, Recurrent Maintenance, Periodic Maintenance and Emergency Maintenance are planned and carried out. The maintenance work is based on traditional quantity and unit price based short term maintenance contracts, where maintenance of physical works is outsourced. Client demands the contractor what work is to be done, when to be do it and the extent of the work. The contractor is paid on the basis of a defined output or quantity accomplished, and the schedule of the rates. DoR engineers required full time supervision of work. Pilot based performance based maintenance practice of road started in Nepal in 2003. The study assesses performance road maintenance practices of road maintenance in Nepal on the basis of the framework of cost efficiency, level of service effectiveness and quality of service. The study concluded that implementation of Performance Based Maintenance Contract (PBMC) was not successful in Nepal as Road Asset condition was not maintained to performance standard. One of the reasons is the weak service delivery of contractor alongside weak contract enforcement from the road agency.展开更多
The efficient exploitation of geothermal energy through enhanced geothermal systems(EGS)has been a relevant topic for hot dry rock(HDR)geothermal resources.When cryogenic fluid is injected into a thermal reservoir,imp...The efficient exploitation of geothermal energy through enhanced geothermal systems(EGS)has been a relevant topic for hot dry rock(HDR)geothermal resources.When cryogenic fluid is injected into a thermal reservoir,improving heat exchange efficiency is key to achieving the optimal exploitation of HDR.In this paper,granite outcrops from Gonghe Basin were used as the testing sample.The natural fractures in the granite samples were relatively well developed.To simulate long-term injection and production from multi-wells in situ,physical ex-periments were performed in a newly-developed,in-house large-scale true triaxial experimental system.Geothermal extraction performance of an HDR was simulated for long-term injection and production operations.Simultaneously,the mode of one-injection and multiple-production wells was represented.In the paper,the ef-fects of the production-injection well spacing,the number of production wells and the injection rate on the production temperature and flow rate are discussed.The results show that,during long-term injection and pro-duction,there are two stages of production temperature variation,namely stabilization and attenuation.When the number of the production wells is increased,the heat extraction efficiency is accelerated.Moreover,competitive diversion of fluid among fractures occurred due to different conductivities.Furthermore,under different pro-duction modes,the production flow rate contributed differently to the heat extraction.Finally,the effect of the production-injection wells spacing on the heat exchange performance was analyzed;this is mainly reflected in the change of the effective heat exchange area between the rock and the injected fluid.The results emphasize the importance of designing an appropriate production mode and optimizing the injection-production parameters to ensure efficient HDR exploitation.展开更多
Asphalt-rubber pavements often become dam-aged in high-temperature regions and appear rutted or wavy, and experience slippage. To improve the high-temperature performance of the asphalt-rubber mixture, technical measu...Asphalt-rubber pavements often become dam-aged in high-temperature regions and appear rutted or wavy, and experience slippage. To improve the high-temperature performance of the asphalt-rubber mixture, technical measurements, such as, the optimal adjustment of gradation, technique of composite modification, and control of compaction were investigated. An optimal adjustment of aggregate gradation based on stone matrix asphalt improves the high-temperature stability of the asphaltrubber mixture significantly. Through composite modifi- cation, the effect of asphalt-rubber modification was enhanced, and the dynamic stability and relative defor- mation indices of the asphalt-rubber mixture were improved significantly. Furthermore, compaction parame- ters had a significant influence on the high-temperature stability of the asphalt-rubber mixture. The rolling times for compacting the asphalt-rubber mixture should be controlled to within 18-20 round-trips at a molding temperature at 180℃; if the rolling time is a 12 round-trip, the compaction temperature of the asphalt-rubber mixture should be controlled between 180 and 190℃.展开更多
Evaluation of high temperature performance of SBS-modified asphalt mixture was presented.Both wheel loaded method and creep method were adopted for two different mixtures and two kinds of specimens with different heig...Evaluation of high temperature performance of SBS-modified asphalt mixture was presented.Both wheel loaded method and creep method were adopted for two different mixtures and two kinds of specimens with different height,and corresponding indicators were measured.Meanwhile,the correlation between these indicators was thoroughly analyzed and two kinds of mixtures were compared.The experimental results show that there is a good linear relationship between LWT indicators and CT indicators for M-13,while a relatively poor relationship for M-25,especially that between dynamic stiffness and static stiffness and that between dynamic stability and static creep stiffness.Besides,logarithmic relationship between DS and RD has a higher determination coefficient than that for linear relationship.Thus,multi-index evaluation should be taken for synthetically assessing high temperature performance of asphalt mixture.展开更多
Motivated by the huge practical engineering demand for the fundamental understanding of mechanical characteristics of high-speed railway infrastructure,a fullscale multi-functional test platform for high-speed railway...Motivated by the huge practical engineering demand for the fundamental understanding of mechanical characteristics of high-speed railway infrastructure,a fullscale multi-functional test platform for high-speed railway track–subgrade system is developed in this paper,and its main functions for investigating the mechanical performance of track–subgrade systems are elaborated with three typical experimental examples.Comprising the full-scale subgrade structure and all the five types of track structures adopted in Chinese high-speed railways,namely the CRTS I,the CRTS II and the CRTS III ballastless tracks,the double-block ballastless track and the ballasted track,the test platform is established strictly according to the construction standard of Chinese high-speed railways.Three kinds of effective loading methods are employed,including the real bogie loading,multi-point loading and the impact loading.Various types of sensors are adopted in different components of the five types of track–subgrade systems to measure the displacement,acceleration,pressure,structural strain and deformation,etc.Utilizing this test platform,both dynamic characteristics and long-term performance evolution of high-speed railway track–subgrade systems can be investigated,being able to satisfy the actual demand for large-scale operation of Chinese high-speed railways.As examples,three typical experimental studies are presented to elucidate the comprehensive functionalities of the full-scale multi-functional test platform for exploring the dynamic performance and its long-term evolution of ballastless track systems and for studying the long-term accumulative settlement of the ballasted track–subgrade system in high-speed railways.Some interesting phenomena and meaningful results are captured by the developed test platform,which provide a useful guidance for the scientific operation and maintenance of high-speed railway infrastructure.展开更多
Genome-wide studies have reported that Parkinson’s disease is associated with abnormal expression of various growth factors. In this study, male C57 BL/6 mice aged 10 weeks were used to establish Parkinson’s disease...Genome-wide studies have reported that Parkinson’s disease is associated with abnormal expression of various growth factors. In this study, male C57 BL/6 mice aged 10 weeks were used to establish Parkinson’s disease models using an intraperitoneal injection of 60 mg/kg 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. 28 days later, 10 or 100 ng fibroblast growth factor 20 was injected intracerebroventricularly. The electrophysiological changes in the mouse hippocampus were recorded using a full-cell patch clamp. Expression of Kv4.2 in the substantia nigra was analyzed using a western blot assay. Serum malondialdehyde levels were analyzed by enzyme-linked immunosorbent assay. The motor coordination of mice was evaluated using the rotarod test. The results showed that fibroblast growth factor 20 decreased A-type potassium current in neurons of the substantia nigra, increased long-term potentiation amplitude in the hippocampus, and downregulated Kv4.2 expression. A high dose of fibroblast growth factor 20 reduced serum malondialdehyde levels and enhanced the motor coordination of mice. These findings confirm that fibroblast growth factor 20 has a therapeutic effect on the toxicity induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, and its mechanism of action is associated with the inhibition of A-type K+ currents and Kv4.2 expression. All animal procedures were approved by the Animal Care and Use Committee of Qilu Hospital of Shandong University, China in 2017(approval No. KYLL-2017-0012).展开更多
基金the financial supports provided by the National Natural Science Foundation of China(U2040222,52293431,and 52278259)。
文摘This study investigates the long-term performance of laboratory dam concrete in different curing environments over ten years and the microstructure of 17-year-old laboratory concrete and actual concrete cores drilled from the Three Gorges Dam.The mechanical properties of the laboratory dam concrete,whether cured in natural or standard environments,continued to improve over time.Furthermore,the laboratory dam concrete exhibited good resistance to diffusion and a refined microstructure after 17 years.However,curing and long-term exposure to the local natural environment reduced the frost resistance.Microstructural analyses of the laboratory concrete samples demonstrated that moderate-heat cement and fine fly ash(FA)particles were almost fully hydrated to form compact micro structures consisting of large quantities of homogeneous calcium(alumino)silicate hydrate(C-(A)-S-H)gels and a few crystals.No obvious interfacial transition zones were observed in the microstructure owing to the longterm pozzolanic reaction.This dense and homogenous microstructure was the crucial reason for the excellent long-term performance of the dam concrete.A high FA volume also played a significant role in the microstructural densification and performance growth of dam concrete at a later age.The concrete drilled from the dam surface exhibited a loose microstructure with higher microporosity,indicating that concrete directly exposed to the actual service environment suffered degradation caused by water and wind attacks.In this study,both macro-performance and microstructural analyses revealed that the application of moderate-heat cement and FA resulted in a dense and homogenous microstructure,which ensured the excellent long-term performance of concrete from the Three Gorges Dam after 17 years.Long-term exposure to an actual service environment may lead to microstructural degradation of the concrete surface.Therefore,the retained long-term dam concrete samples need to be further researched to better understand its microstructural evolution and development of its properties.
基金supported by National Natural Science Fund for Excellent Young Scientists Fund Program (Overseas) (Grant No.22FAA02811)Pearl River Talent Plan for the Introduction of High-level Talents (Young Top-notch Talents) (Grant No.2021QN02G744)+1 种基金National Natural Science Foundation of China (Grant No.52178426)the Fundamental Research Funds for the Central Universities (Grant No.SCUT 2022ZYGXZR066 and 2023ZYGXZR001).
文摘The application of reclaimed asphalt pavement(RAP)and reclaimed asphalt shingles(RAS)on asphalt pavement can reduce the asphalt paving cost,conserve energy and protect the environment.However,the use of high contents of RAP and RAS in asphalt pavement may lead to durability issues,especially the fatigue cracking and thermal cracking.It is necessary to conduct a series of analyses on asphalt mixtures containing high RAP and RAS,and seek methods to enhance their long-term performance.This paper provides a comprehensive over-view of the long-term performance of recycled asphalt mixtures containing high contents of RAP and RAS.The findings in this research show that rutting resistance of high recycled asphalt mixtures is not a concern,whereas their resistance to fatigue and thermal cracking is not conclusive.Recycling agents can be used to improve the thermal cracking resistance of high recycled asphalt mixtures.An optimum decision on recycling agents will improve the durability properties of high recycled asphalt mixtures.It is recommended that to use a balanced mixture design approach with testing of the blended asphalt binders will provide better understanding of long-term performance of recycled asphalt mixtures containing high RAP and RAS.
基金Funded by the Key Research and Development Projects in Shaanxi Province(No.2022SF-328)Science and Technology Project of Shaanxi Department of Transportation(Nos.19-10K,19-28K)Science and Technology Project of Henan Department of Transportation(No.2020J-2-3)。
文摘In order to comprehensively utilize the remaining bamboo residue of bamboo products,this paper presents a research on recycling the bamboo fibers from bamboo residue for improving the performance of the asphalt mixtures.First of all,the basic performance parameters of sinocalamus affinis fiber,phyllostachys pubescens fiber,green bamboo fiber were tested and analyzed,and the optimal content and length were put forward.Then,the mix ratio design of the bamboo fiber modified asphalt mixture was further designed through the response surface method,and was verified the rationality of the mix ratio.Finally,the mixture specimens were made according to the experimental design mix ratio,and the high temperature,low temperature performance and moisture susceptibility of the bamboo fiber modified mixtures asphalt were tested.The results showed that the high temperature performance,low temperature performance and moisture susceptibility of bamboo fiber modified asphalt mixtures were improved compared with the performance of SBS modified asphalt mixture.When the length of bamboo fiber is 7.25 mm and the content of 0.22%,the road performance of the asphalt mixture was optimal.Consequentially,the decomposition of bamboo residue into bamboo fiber and its application in asphalt pavement can improve the reuse of bamboo waste,with remarkable environmental benefits and great promotion value.
基金financially supported by the National Natural Science Foundation of China(51702038)the Science&Technology Department of Sichuan Province(2020YFG0061)+2 种基金the Recruitment Program for Young Professionalsthe National Key Research and Development Program of China(2017YFA0206600)the National Natural Science Foundation of China(51773045,21772030,51922032,21961160720)for financial support。
文摘Tin halide perovskites(THPs)have received extensive attention due to their low toxicity and excellent optoelectronic properties,and are considered to be the most promising alternatives to develop efficient lead-free perovskite solar cells.However,due to the unique and inherent characteristics of Sn^(2+)being easily oxidized to Sn^(4+)and fast crystallization,tin perovskite solar cells(TPSCs)show relatively poor performance and stability,compared to the lead counterparts.Recently,the introduction of bulky organic spacers into three-dimensional(3D)THPs for dimensional regulation can not only prevent the intrusion of water and oxygen,but also inhibit the self-doping effect and ion migration.In this review,we will detail how dimensional regulation enables TPSCs with high performance and superior stability.First,we summarize the intrinsic properties of THPs and analyze the root causes of their poor performance and instability.Next,we discuss the specific structure and types of the dimensional regulation strategy.Then,the mechanism of dimensional regulation is discussed in detail,mainly from inhibiting the Sn^(2+)oxidation,optimizing crystallization,passivating defects,and improving energy level alignment.Finally,future challenges and prospects for dimensional regulation are elaborated to help researchers develop more efficient and stable TPSCs.
基金Funded by the National Key Technology R&D Program for the 12th Five-Year Plan(No.2011BAE27B04)
文摘To research the dynamic mechanical properties and road performances of flame retardant asphalt mortars and mixtures, four different asphalt mortars/mixtures were prepared: a reference group and three asphalt mortars/mixtures containing composite flame retardant materials(M-FRs) of different proportions. Temperature sweep, frequency sweep, repeated creep test, force ductility test and bending beam rheological test were carried out to research the dynamic mechanical properties of asphalt mortars containing M-FRs; wheeltracking test, low-temperature bending test and freeze-thaw split test were used to study the road performances of asphalt mixtures containing M-FRs. The results show that high-temperature performances of the three flame retardant asphalt mortars improve greatly, while low-temperature cracking resistances decline. Both hightemperature performances and water stabilities of asphalt mixtures containing M-FRs are quite good and exceed the specification requirements. However, their low-temperature performances decline in different degrees. In summary, besides their good flame retardancy, the flame retardant asphalt mortars and mixtures also exhibit acceptable road performance.
文摘An understanding of the influence of contractor monitoring on performance of road infrastructural projects in Uganda provided an impetus for this study. The objectives of the study were to: assess the relationship between contractors monitoring and performance of national road infrastructure projects and the relationship between contractor monitoring components and performance of national road infrastructure projects in Uganda. Purposive sampling was employed in selecting the procurement professionals, engineers and simple random sampling was adopted in selecting private consultants, members of parliament and respondents from the civil society organizations. Data for this study were collected using a closed ended questionnaire and interviews. Some of the major finding from this study include: weak procurement rules which lead to awarding road projects to incompetent contractors;contractor monitoring being handled by unqualified, incompetent and inexperienced professionals;lack of contractors and contract supervisors appraisal system;delay of contractors payments which affects timelines in services delivery;lack of a strong internal project monitoring and evaluation mechanism at the Uganda National Roads Agency (UNRA). The research therefore recommends the establishment of an Independent Public Infrastructure Development and Monitoring Unit by government and adoption of systems that appraise both contractors and contract supervisors with clear disciplinary actions for unsatisfactory performance by the UNRA.
基金supported by the National Science and Engineering Research Council of Canada(NSERC)Ontario Research Fund–Research Excellence(ORF-RE)+3 种基金the Ministry of Transportation Ontario(MTO)through Its Highway Infrastructure Innovation Funding Program(HIIFP)Beijing Postdoctoral Science Foundation(ZZ-2019-65)Beijing Chaoyang District Postdoctoral Science Foundation(2019ZZ-45)Beijing Municipal Education Commission(KM201811232016)。
文摘Road safety performance function(SPF) analysis using data-driven and nonparametric methods, especially recent developed deep learning approaches, has gained increasing achievements. However, due to the learning mechanisms are hidden in a"black box" in deep learning, traffic features extraction and intelligent importance analysis are still unsolved and hard to generate.This paper focuses on this problem using a deciphered version of deep neural networks(DNN), one of the most popular deep learning models. This approach builds on visualization, feature importance and sensitivity analysis, can evaluate the contributions of input variables on model's "black box" feature learning process and output decision. Firstly, a visual feature importance(Vi FI) method that describes the importance of input features is proposed by adopting diagram and numerical-analysis. Secondly,by observing the change of weights using Vi FI on unsupervised training and fine-tuning of DNN, the final contributions of input features are calculated according to importance equations for both steps that we proposed. Sequentially, a case study based on a road SPF analysis is demonstrated, using data collected from a major Canadian highway, Highway 401. The proposed method allows effective deciphering of the model's inner workings and allows the significant features to be identified and the bad features to be eliminated. Finally, the revised dataset is used in crash modeling and vehicle collision prediction, and the testing result verifies that the deciphered and revised model achieves state-of-theart performance.
基金supported by the Ministry of Science and Technology of China(2006BAJ04A01 and 2006BAJ03A04-01)
文摘Dynamic environmental testing is an effective means to study the energy and long-term hygrothermal performance of building enclosures. Southeast University is designing and building a large-scale dynamic environment simulation testing facility. It can simuhaneously and dynamically simulate temperature, relative humidity, infrared solar radiation, UV radiation, and precipitation. A transformation is needed to predict the energy and long-term hygrothermal performance of building enclosures under real service conditions using data obtained from accelerated tests.
文摘Based on the investigation of long-life asphalt pavement at home and abroad,the development of long-life asphalt pavement technology in Shandong Province,China is reviewed in this paper.The structural combination char-acteristics of typical long-life asphalt pavement in Shandong Province and their popularization and application are introduced.The application effect of combined base long-life asphalt pavement,which has been widely promoted,is evaluated.At the same time,taking the Binda perpetual pavement test road in Shandong Province as an example,the dynamic response and long-term performance evolution of long-life asphalt pavement are analyzed over a period of more than 17 years.Sections S1,S2,and S3 present information about full-depth asphalt pavement.Section S4 describes combined base asphalt pavement.The results show that the maximum strain of S1–S4 is within the endurance strain limit.S1,S2,S3 and S4 are all expected to be long-life asphalt pavements.In the current study,Sections S1–S4 were maintained in good condition during a service period of more than 17 years with no structural cracks and good deflection,rutting,and IRI indexes.The deflection index was stable without growth,and the IRI was also relatively stable following the opening to traffic.The rutting depth un-derwent a slight cumulative increase within 8 years of opening,and then stabilized.The average rutting depth over the 17-year period was less than 15 mm.Therefore,S1–S4 meet the design standards required for use as long-life pavements.From the perspectives of resource saving,energy saving,and emission reduction and service performance,full-depth asphalt pavement can be considered to represent a new generation of green and durable pavement structures with great future promotion potential.
文摘Ordinary concrete presents short service life when used for building and repairing high-grade road with heavy traffic due to its large brittleness, poor bending flexibility and serious shrinkage on drying. In this paper, a new kind of high performance concrete has been designed by means of combination of organic, inorganic material as well as metal material. The research and application have shown that this new concrete can significantly counteract the deficiency of ordinary concrete and give excellent mechanical properties and pavement performances. The application of this new kind of concrete is of great social and economic significance.
基金Funded by National Natural Science Foundation of China (No.59493604)Zhejiang Provincial Natural Science Foundation of China (No.597082)China Yangtze River Three Gorges General
文摘The long-term performance of moderate heat Portland cement with double-expansive sources (DE cement) in the system of high MgO clinker and gypsum was studied by XRD, SEM/EDAX and test methods for strength and expansion of cement. Results indicate that the periclase particle, whose size was 5-7.5μm in DE cement clinker containing 4.8 % MgO, existed individually. The periclase hydration in hardened DE cement paste started at about 60 days and completed up to 2 000 days, and ettringite in the paste was stable from 3 days to 2 000 days. Under the conditions of 4.5%-5.0 % MgO in clinker and 2.8%-3.4 %SO3 in cement, ettringite expansion and brucite expansion in DE cement paste had a continuity, entirety and stability. At the ages of 90, 365,730 and 2 000 days the expansion of the paste reached 0.07%-0.11%, 0.16%-0.21%, 0.21%-0.27 %, and 0.29%-0.38%, respectively. The results suggest that by using this cement in mass concrete it may compensate its temperature shrinkage and autogenous shrinkage to some extent.
文摘A number of studies conducted in Kenya </span><span style="font-family:Verdana;">and </span><span style="font-family:Verdana;">internationally indicate</span><span style="font-family:Verdana;">d</span><span style="font-family:""><span style="font-family:Verdana;"> that most of the construction firms and contractors do not seem to strictly observe safety administration in construction industry, hence compromised performance at implementation stage of projects and even later in the post implementation or post-delivery stage. The study aimed to examine the influence of contractors’ safety record on road performance. This is to create better understanding of how the safety record of contractors could either positively or negatively influence performance of roads during post-delivery stage. The study used both descriptive survey research design and correlation design based on a pragmatic mixed method approach. Through stratified sampling and proportionate sampling, a sample of 210 was drawn from a population of 460 comprising of registered contractors and Public Service Vehicles (PSV) drivers within Nairobi County in Kenya. Questionnaires were distributed using simple random sampling. The questionnaires returned were 153 in total representing 72.8% of all questionnaires distributed to the respondents. Data was descriptively analyzed using percentages, frequencies, means and standard deviations for measuring central tendency and variability. Inferential analysis was done by use of correlation and regression. The descriptive analysis revealed that safety policy management system, insurance policy, and adequacy of standards in addressing safety outcome are to some extent practiced and adhered to. However, compliance behavior to safety procedures is still weak and requires improvement. The null hypothesis was tested and the results obtained from a simple linear regression indicated that, R = 0.657, R</span><sup><span style="font-size:12px;font-family:Verdana;">2</span></sup><span style="font-family:Verdana;"> = 0.431, B = 0.359, t = 10.703, F (1,151) = 114.558, p = 0.000 < 0.05. This means that contractors’ safety record has a strong positive and significant relationship with road performance and that 43.1% of variation in performance is explained by safety record. This study recommends that contractors’ safety record should be part</span></span><span style="font-family:Verdana;">,</span><span style="font-family:Verdana;"> and parcel of the evaluation criteria used in selection of a suitable road contractor to ensure road performance is achieved even after construction is completed. The study is significant in that it contributes to the body of knowledge by providing empirical data on the need for safety procedures in urban road construction and beyond.
文摘Curling results from the temperature differential across the concrete slab thickness and may induce undue stresses in newly placed slab. This study deals with the finite element (FE) analysis of curling, curling stresses, field measurement of curling on a newly built jointed plain concrete pavement, and comparison of its long-term performance using both Mechanistic-Empirical Pavement Design Guide (MEPDG) and HIPERPAVII software. The FE analysis was performed with a software program, ANSYS. The test section was modeled as a three-layer system with 300 mm concrete slab, 100 mm treated drainable base, and 150 mm lime-treated subgrade. All layers were assumed to be linear elastic. Temperature data was collected at five different depth locations across the concrete slab with digital data loggers. Curling was measured on five different days with a simple setup. The effect of temperature nonlinearities across the slab thickness was also examined. The results show that both upward and downward curling increase as the temperature differential increases. The maximum stress resulting from the combined effect of curling and traffic loading due to positive temperature differential is higher than that due to the negative temperature differential of the same magnitude. Since temperature differential has a significant influence on curling, both curling and curling stresses can be mitigated at an early age with temperature control, namely via enhanced curing. Both MEPDG and HIPERPAVII showed approximately the same performance for the PCC thickness ranging from 215 mm to 300 mm for this project. Performance prediction from HIPERPAVII is very sensitive to the change in PCC thickness less than 230 mm whereas MEPDG prediction is not as sensitive to the thickness change as with HIPERPAV 1I.
文摘This article focuses on a technique for shallow mechanical improvement of soil which deals with the utilization of crushed granite mixed in a certain percentage with lateritic soils during road construction in Burkina Faso.Lithostab is the simplified name for litho-stabilization,a technique for improving laterite by adding crushed granite that increases the CBR(California bearing ratio)of that material for being used in road construction.Class 0/25 of crushed granite added to a laterite in our case gives good performance in terms of CBR.Indeed,the CBR index which was initially 48 at 98%of the OMP(optimum modified Proctor)goes to 88.And from 84 at 98%of the OMP,it goes to 128 for 30%of class 0/25 of crushed granite added.This means that class 0/25 of crushed granite provides better CBR index to that material when it is incorporated at 30%.So,lithostab is an easy to implement eco-friendly material for road construction because of the utilization of local materials.Then,it contributes to the protection of the environment in the sense that its production does not require a lot of energy and does not release large quantities of carbon dioxide into the atmosphere.
文摘Roads are the major asset of any country and to conserve them maintenance is essential. The delay of maintenance works can lead the road in the stage of expensive rehabilitation and reconstruction. In Nepal, Department of Roads (DoR) is responsible for maintenance of strategic roads of country. The maintenance practice of the road under Department of Road is predominantly based on Strengthen Maintenance Division Process where several maintenance activities like Routine maintenance, Recurrent Maintenance, Periodic Maintenance and Emergency Maintenance are planned and carried out. The maintenance work is based on traditional quantity and unit price based short term maintenance contracts, where maintenance of physical works is outsourced. Client demands the contractor what work is to be done, when to be do it and the extent of the work. The contractor is paid on the basis of a defined output or quantity accomplished, and the schedule of the rates. DoR engineers required full time supervision of work. Pilot based performance based maintenance practice of road started in Nepal in 2003. The study assesses performance road maintenance practices of road maintenance in Nepal on the basis of the framework of cost efficiency, level of service effectiveness and quality of service. The study concluded that implementation of Performance Based Maintenance Contract (PBMC) was not successful in Nepal as Road Asset condition was not maintained to performance standard. One of the reasons is the weak service delivery of contractor alongside weak contract enforcement from the road agency.
文摘The efficient exploitation of geothermal energy through enhanced geothermal systems(EGS)has been a relevant topic for hot dry rock(HDR)geothermal resources.When cryogenic fluid is injected into a thermal reservoir,improving heat exchange efficiency is key to achieving the optimal exploitation of HDR.In this paper,granite outcrops from Gonghe Basin were used as the testing sample.The natural fractures in the granite samples were relatively well developed.To simulate long-term injection and production from multi-wells in situ,physical ex-periments were performed in a newly-developed,in-house large-scale true triaxial experimental system.Geothermal extraction performance of an HDR was simulated for long-term injection and production operations.Simultaneously,the mode of one-injection and multiple-production wells was represented.In the paper,the ef-fects of the production-injection well spacing,the number of production wells and the injection rate on the production temperature and flow rate are discussed.The results show that,during long-term injection and pro-duction,there are two stages of production temperature variation,namely stabilization and attenuation.When the number of the production wells is increased,the heat extraction efficiency is accelerated.Moreover,competitive diversion of fluid among fractures occurred due to different conductivities.Furthermore,under different pro-duction modes,the production flow rate contributed differently to the heat extraction.Finally,the effect of the production-injection wells spacing on the heat exchange performance was analyzed;this is mainly reflected in the change of the effective heat exchange area between the rock and the injected fluid.The results emphasize the importance of designing an appropriate production mode and optimizing the injection-production parameters to ensure efficient HDR exploitation.
文摘Asphalt-rubber pavements often become dam-aged in high-temperature regions and appear rutted or wavy, and experience slippage. To improve the high-temperature performance of the asphalt-rubber mixture, technical measurements, such as, the optimal adjustment of gradation, technique of composite modification, and control of compaction were investigated. An optimal adjustment of aggregate gradation based on stone matrix asphalt improves the high-temperature stability of the asphaltrubber mixture significantly. Through composite modifi- cation, the effect of asphalt-rubber modification was enhanced, and the dynamic stability and relative defor- mation indices of the asphalt-rubber mixture were improved significantly. Furthermore, compaction parame- ters had a significant influence on the high-temperature stability of the asphalt-rubber mixture. The rolling times for compacting the asphalt-rubber mixture should be controlled to within 18-20 round-trips at a molding temperature at 180℃; if the rolling time is a 12 round-trip, the compaction temperature of the asphalt-rubber mixture should be controlled between 180 and 190℃.
基金Funded by the National Natural Science Foundation of China (No.50868003)Guangxi Key Laboratory of Architecture Engineering’s Detecting and Testing (No.07109005-9)
文摘Evaluation of high temperature performance of SBS-modified asphalt mixture was presented.Both wheel loaded method and creep method were adopted for two different mixtures and two kinds of specimens with different height,and corresponding indicators were measured.Meanwhile,the correlation between these indicators was thoroughly analyzed and two kinds of mixtures were compared.The experimental results show that there is a good linear relationship between LWT indicators and CT indicators for M-13,while a relatively poor relationship for M-25,especially that between dynamic stiffness and static stiffness and that between dynamic stability and static creep stiffness.Besides,logarithmic relationship between DS and RD has a higher determination coefficient than that for linear relationship.Thus,multi-index evaluation should be taken for synthetically assessing high temperature performance of asphalt mixture.
基金This work was supported by the National Natural Science Foundation of China[Grant Nos.11790283,51978587,51708457]the Program of Introducing Talents of Discipline to Universities(111 Project)[Grant No.B16041].
文摘Motivated by the huge practical engineering demand for the fundamental understanding of mechanical characteristics of high-speed railway infrastructure,a fullscale multi-functional test platform for high-speed railway track–subgrade system is developed in this paper,and its main functions for investigating the mechanical performance of track–subgrade systems are elaborated with three typical experimental examples.Comprising the full-scale subgrade structure and all the five types of track structures adopted in Chinese high-speed railways,namely the CRTS I,the CRTS II and the CRTS III ballastless tracks,the double-block ballastless track and the ballasted track,the test platform is established strictly according to the construction standard of Chinese high-speed railways.Three kinds of effective loading methods are employed,including the real bogie loading,multi-point loading and the impact loading.Various types of sensors are adopted in different components of the five types of track–subgrade systems to measure the displacement,acceleration,pressure,structural strain and deformation,etc.Utilizing this test platform,both dynamic characteristics and long-term performance evolution of high-speed railway track–subgrade systems can be investigated,being able to satisfy the actual demand for large-scale operation of Chinese high-speed railways.As examples,three typical experimental studies are presented to elucidate the comprehensive functionalities of the full-scale multi-functional test platform for exploring the dynamic performance and its long-term evolution of ballastless track systems and for studying the long-term accumulative settlement of the ballasted track–subgrade system in high-speed railways.Some interesting phenomena and meaningful results are captured by the developed test platform,which provide a useful guidance for the scientific operation and maintenance of high-speed railway infrastructure.
文摘Genome-wide studies have reported that Parkinson’s disease is associated with abnormal expression of various growth factors. In this study, male C57 BL/6 mice aged 10 weeks were used to establish Parkinson’s disease models using an intraperitoneal injection of 60 mg/kg 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. 28 days later, 10 or 100 ng fibroblast growth factor 20 was injected intracerebroventricularly. The electrophysiological changes in the mouse hippocampus were recorded using a full-cell patch clamp. Expression of Kv4.2 in the substantia nigra was analyzed using a western blot assay. Serum malondialdehyde levels were analyzed by enzyme-linked immunosorbent assay. The motor coordination of mice was evaluated using the rotarod test. The results showed that fibroblast growth factor 20 decreased A-type potassium current in neurons of the substantia nigra, increased long-term potentiation amplitude in the hippocampus, and downregulated Kv4.2 expression. A high dose of fibroblast growth factor 20 reduced serum malondialdehyde levels and enhanced the motor coordination of mice. These findings confirm that fibroblast growth factor 20 has a therapeutic effect on the toxicity induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, and its mechanism of action is associated with the inhibition of A-type K+ currents and Kv4.2 expression. All animal procedures were approved by the Animal Care and Use Committee of Qilu Hospital of Shandong University, China in 2017(approval No. KYLL-2017-0012).