A kind of loop function LoopN in Genetic Programming (GP) isproposed. Different from other forms of loop function, such as While-Do and Repeat-Until, LoopN takes only one argument as its loop body and makes its loop b...A kind of loop function LoopN in Genetic Programming (GP) isproposed. Different from other forms of loop function, such as While-Do and Repeat-Until, LoopN takes only one argument as its loop body and makes its loop bodysimply run N times, so infinite loops will never happen. The problem of how to avoidtoo many layers of loops in Genetic Programming is also solved. The advantage ofLoopN in GP is shown by the computational results in solving the mower problem.展开更多
A transmission bottleneck occurs during each human immunodeficiency virus(HIV) transmission event, which allows only a few viruses to establish new infection. However, the genetic characteristics of the transmitted vi...A transmission bottleneck occurs during each human immunodeficiency virus(HIV) transmission event, which allows only a few viruses to establish new infection. However, the genetic characteristics of the transmitted viruses that are preferentially selected have not been fully elucidated. Here, we analyzed amino acids changes in the envelope protein during simian immunodeficiency virus(SIV)/HIV deep transmission history and current HIV evolution within the last 15–20 years. Our results confirmed that the V1V2 region of gp120 protein, particularly V1, was preferentially selected. A shorter V1 region was preferred during transmission history, while during epidemic, HIV may evolve to an expanded V1 region gradually and thus escape immune recognition. We then constructed different HIV-1 V1 mutants using different HIV-1 subtypes to elucidate the role of the V1 region in envelope function. We found that the V1 region, although highly variable, was indispensable for virus entry and infection, probably because V1 deletion mutants exhibited impaired processing of gp160 into mature gp120 and gp41. Additionally, the V1 region affected Env incorporation. These results indicated that the V1 region played a critical role in HIV transmission and infection.展开更多
In this paper, the authors consider limit cycle bifurcations for a kind of nonsmooth polynomial differential systems by perturbing a piecewise linear Hamiltonian system with a center at the origin and a heteroclinic l...In this paper, the authors consider limit cycle bifurcations for a kind of nonsmooth polynomial differential systems by perturbing a piecewise linear Hamiltonian system with a center at the origin and a heteroclinic loop around the origin. When the degree of perturbing polynomial terms is n(n ≥ 1), it is obtained that n limit cycles can appear near the origin and the heteroclinic loop respectively by using the first Melnikov function of piecewise near-Hamiltonian systems, and that there are at most n + [(n+1)/2] limit cycles bifurcating from the periodic annulus between the center and the heteroclinic loop up to the first order in ε. Especially, for n = 1, 2, 3 and 4, a precise result on the maximal number of zeros of the first Melnikov function is derived.展开更多
文摘A kind of loop function LoopN in Genetic Programming (GP) isproposed. Different from other forms of loop function, such as While-Do and Repeat-Until, LoopN takes only one argument as its loop body and makes its loop bodysimply run N times, so infinite loops will never happen. The problem of how to avoidtoo many layers of loops in Genetic Programming is also solved. The advantage ofLoopN in GP is shown by the computational results in solving the mower problem.
基金supported by the International Science & Technology Cooperation Program of China (2011DFA31030)Deutsche Forschungsgemeinschaft (Transregio TRR60),National Natural Science Foundation of China (No.81461130019)
文摘A transmission bottleneck occurs during each human immunodeficiency virus(HIV) transmission event, which allows only a few viruses to establish new infection. However, the genetic characteristics of the transmitted viruses that are preferentially selected have not been fully elucidated. Here, we analyzed amino acids changes in the envelope protein during simian immunodeficiency virus(SIV)/HIV deep transmission history and current HIV evolution within the last 15–20 years. Our results confirmed that the V1V2 region of gp120 protein, particularly V1, was preferentially selected. A shorter V1 region was preferred during transmission history, while during epidemic, HIV may evolve to an expanded V1 region gradually and thus escape immune recognition. We then constructed different HIV-1 V1 mutants using different HIV-1 subtypes to elucidate the role of the V1 region in envelope function. We found that the V1 region, although highly variable, was indispensable for virus entry and infection, probably because V1 deletion mutants exhibited impaired processing of gp160 into mature gp120 and gp41. Additionally, the V1 region affected Env incorporation. These results indicated that the V1 region played a critical role in HIV transmission and infection.
基金supported by the National Natural Science Foundation of China(No.11271261)the Natural Science Foundation of Anhui Province(No.1308085MA08)the Doctoral Program Foundation(2012)of Anhui Normal University
文摘In this paper, the authors consider limit cycle bifurcations for a kind of nonsmooth polynomial differential systems by perturbing a piecewise linear Hamiltonian system with a center at the origin and a heteroclinic loop around the origin. When the degree of perturbing polynomial terms is n(n ≥ 1), it is obtained that n limit cycles can appear near the origin and the heteroclinic loop respectively by using the first Melnikov function of piecewise near-Hamiltonian systems, and that there are at most n + [(n+1)/2] limit cycles bifurcating from the periodic annulus between the center and the heteroclinic loop up to the first order in ε. Especially, for n = 1, 2, 3 and 4, a precise result on the maximal number of zeros of the first Melnikov function is derived.
