In-situ XRD,^(31)P NMR and ^(23)Na NMR were used to analyze the interaction behavior of Na_(3)V_(2)(PO_(4))_(3) at low voltage,and then a new intercalation model was proposed.During the transition from Na_(3)V_(2)(PO_...In-situ XRD,^(31)P NMR and ^(23)Na NMR were used to analyze the interaction behavior of Na_(3)V_(2)(PO_(4))_(3) at low voltage,and then a new intercalation model was proposed.During the transition from Na_(3)V_(2)(PO_(4))_(3) to Na_(4)V_(2)(PO_(4))_(3),Na ions insert into M1,M2 and M3 sites simultaneously.Afterwards,during the transition of Na_(4)V_(2)(PO_(4))_(3)to Na_(5)V_(2)(PO_(4))_(3),Na ions mainly insert into M3 site.展开更多
AIM:To evaluate effects of endogenous dopamine induced by low concentration atropine eye drops on choroidal neovascularization(CNV)in high myopia mice.METHODS:The C57BL/6J mice were deprived of the right eye for 4wk,a...AIM:To evaluate effects of endogenous dopamine induced by low concentration atropine eye drops on choroidal neovascularization(CNV)in high myopia mice.METHODS:The C57BL/6J mice were deprived of the right eye for 4wk,and the high myopia was diagnosed by optometry,the diopter was less than-6.00 D,and CNV was induced by 532 nm laser.The changes of dopamine D1 receptor(DRD1),dopamine D2 receptor(DRD2),and vascular endothelial growth factor A(VEGFA)were detected by Western blot technology at 0.5,1,2h,and 7d after 0.01%,0.05%,and 0.1%atropine eye drops,respectively,the area of CNV was measured.RESULTS:Significant increases were observed on the expression of DRD2 in mouse high myopia model at 0.5,1,2h,7d with 0.05%and 0.1%atropine eye drops(P<0.05).Significant decreases were observed on the expression of DRD1 and VEGFA in mouse high myopia model at 0.5,1,2h,7d with 0.05%and 0.1%atropine eye drops(P<0.05).The area of CNV induced by laser in the drug-treated group was significantly smaller than that in the control group,and the higher the concentration,the more significant the inhibitory effect(P<0.05).CONCLUSION:The 0.01%,0.05%,0.1%atropine eye drops can decrease the level of VEGFA and inhibit high myopia CNV indirectly by up-regulating the level of DRD2 and down-regulating the level of DRD1,and the effect of 0.05%and 0.1%atropine eye drops is more significant.展开更多
This study sought to review whether large-scale experimentation can apply to actual rivers concerning the effect of topographical change by scour in the downstream area of natural-type low drop structures on the fish ...This study sought to review whether large-scale experimentation can apply to actual rivers concerning the effect of topographical change by scour in the downstream area of natural-type low drop structures on the fish habitat. The large-scale applicability experiment performed in this study installed low drop structures as the study object within the experiment channel and precisely surveyed topography in the downstream area of drop structures along with the hydraulic amount including water level and flow velocity under certain flow conditions. Based on topographical data acquired through the survey after the experiment ended, this study reviewed the change of suitability index and difference of weighted usable area by performing 2D habitat simulation. Ultimately, through the habitat simulation results in cases of considering and not considering scour in the downstream area of drop structures, this study analyzed the effects of topographical change in actual rivers on the habitat.展开更多
Although ecologically disadvantageous since a river is interrupted because of drop structure installation, such structure installation is also deemed ecologically advantageous in terms of scour and complex flows in th...Although ecologically disadvantageous since a river is interrupted because of drop structure installation, such structure installation is also deemed ecologically advantageous in terms of scour and complex flows in the direct downstream area. This study started from the premise that scour hole carries value as a habitat and sought to analyze quantitatively the local scour adjustment possibility in the downstream area through drop structure type change and to offer a habitat through scouring. This study provided changes in drop structure types, such as straight line type and V type. For local scour analysis impacting the downstream area by drop structure type, quantitative analysis of scour scope, depth, and length was comparatively performed for a tentative physical habitat through hydraulic experiments. As a result of the experiments, this study found that scour scope increases and various water depth conditions are offered as the angle of the drop structure’s apex becomes smaller. Future studies accompanied by various fish habitation evaluations are considered useful in finding an alternative to upgrade the ecological environment.展开更多
目的基于静息态功能磁共振技术探究脑安滴丸治疗偏头痛的中枢机制。方法纳入19例偏头痛患者作为观察组,16例健康受试者作为对照组。观察组给予12周的脑安滴丸治疗,对照组不予任何干预。观察组在治疗前后进行静息态功能磁共振(resting st...目的基于静息态功能磁共振技术探究脑安滴丸治疗偏头痛的中枢机制。方法纳入19例偏头痛患者作为观察组,16例健康受试者作为对照组。观察组给予12周的脑安滴丸治疗,对照组不予任何干预。观察组在治疗前后进行静息态功能磁共振(resting state function magnetic resonance imaging,rs-fMRI)扫描,对照组仅在入组当天进行1次扫描。记录观察组治疗前后、随访4周头痛发作天数、头痛发作次数、头痛持续时间、视觉模拟评分(visual analogue scale,VAS)及患者报告的结局(patients-reported outcomes,PRO)量表评分。分析治疗前两组间的低频振幅(amplitude of low frequency fluctuation,ALFF)、局部一致性(regional homogeneity,ReHo)差异脑区,以ALFF、ReHo的共同差异脑区为感兴趣脑区(region of interest,ROI),分析计算观察组治疗前后ROI与全脑体素的功能连接(functional connectivity,FC)变化,并将FC的变化值与临床数据的改善值进行Pearson相关分析。结果观察组治疗后、随访4周的头痛发作天数、头痛发作次数、头痛持续时间及PRO量表评分均显著低于治疗前(P<0.05),且观察组随访4周的VAS评分亦显著降低(P<0.05);与对照组比较,治疗前观察组左侧背外侧额上回、右侧前扣带和旁扣带脑回、右侧岛叶、双侧内侧额上回、双侧额中回和左侧楔前叶的ALFF值显著降低(P<0.05),右侧中央前回的ReHo值显著升高(P<0.05),左侧楔前叶的ReHo值显著降低(P<0.05)。以左侧楔前叶为ROI,治疗后左侧楔前叶与左侧壳核的FC值较治疗前降低(P<0.05),未发现治疗前后FC的变化值与临床数据的相关性(P>0.05)。结论偏头痛患者存在认知、情感、感觉等多个脑区的功能活动异常,而脑安滴丸可能是通过调控楔前叶—壳核的FC达到治疗偏头痛的作用。展开更多
基金supported by grants from the National Natural Science Foundation of China(No.22272055)multifunctional platform for innovation of ECNU(EPR).
文摘In-situ XRD,^(31)P NMR and ^(23)Na NMR were used to analyze the interaction behavior of Na_(3)V_(2)(PO_(4))_(3) at low voltage,and then a new intercalation model was proposed.During the transition from Na_(3)V_(2)(PO_(4))_(3) to Na_(4)V_(2)(PO_(4))_(3),Na ions insert into M1,M2 and M3 sites simultaneously.Afterwards,during the transition of Na_(4)V_(2)(PO_(4))_(3)to Na_(5)V_(2)(PO_(4))_(3),Na ions mainly insert into M3 site.
文摘AIM:To evaluate effects of endogenous dopamine induced by low concentration atropine eye drops on choroidal neovascularization(CNV)in high myopia mice.METHODS:The C57BL/6J mice were deprived of the right eye for 4wk,and the high myopia was diagnosed by optometry,the diopter was less than-6.00 D,and CNV was induced by 532 nm laser.The changes of dopamine D1 receptor(DRD1),dopamine D2 receptor(DRD2),and vascular endothelial growth factor A(VEGFA)were detected by Western blot technology at 0.5,1,2h,and 7d after 0.01%,0.05%,and 0.1%atropine eye drops,respectively,the area of CNV was measured.RESULTS:Significant increases were observed on the expression of DRD2 in mouse high myopia model at 0.5,1,2h,7d with 0.05%and 0.1%atropine eye drops(P<0.05).Significant decreases were observed on the expression of DRD1 and VEGFA in mouse high myopia model at 0.5,1,2h,7d with 0.05%and 0.1%atropine eye drops(P<0.05).The area of CNV induced by laser in the drug-treated group was significantly smaller than that in the control group,and the higher the concentration,the more significant the inhibitory effect(P<0.05).CONCLUSION:The 0.01%,0.05%,0.1%atropine eye drops can decrease the level of VEGFA and inhibit high myopia CNV indirectly by up-regulating the level of DRD2 and down-regulating the level of DRD1,and the effect of 0.05%and 0.1%atropine eye drops is more significant.
文摘This study sought to review whether large-scale experimentation can apply to actual rivers concerning the effect of topographical change by scour in the downstream area of natural-type low drop structures on the fish habitat. The large-scale applicability experiment performed in this study installed low drop structures as the study object within the experiment channel and precisely surveyed topography in the downstream area of drop structures along with the hydraulic amount including water level and flow velocity under certain flow conditions. Based on topographical data acquired through the survey after the experiment ended, this study reviewed the change of suitability index and difference of weighted usable area by performing 2D habitat simulation. Ultimately, through the habitat simulation results in cases of considering and not considering scour in the downstream area of drop structures, this study analyzed the effects of topographical change in actual rivers on the habitat.
文摘Although ecologically disadvantageous since a river is interrupted because of drop structure installation, such structure installation is also deemed ecologically advantageous in terms of scour and complex flows in the direct downstream area. This study started from the premise that scour hole carries value as a habitat and sought to analyze quantitatively the local scour adjustment possibility in the downstream area through drop structure type change and to offer a habitat through scouring. This study provided changes in drop structure types, such as straight line type and V type. For local scour analysis impacting the downstream area by drop structure type, quantitative analysis of scour scope, depth, and length was comparatively performed for a tentative physical habitat through hydraulic experiments. As a result of the experiments, this study found that scour scope increases and various water depth conditions are offered as the angle of the drop structure’s apex becomes smaller. Future studies accompanied by various fish habitation evaluations are considered useful in finding an alternative to upgrade the ecological environment.
文摘目的基于静息态功能磁共振技术探究脑安滴丸治疗偏头痛的中枢机制。方法纳入19例偏头痛患者作为观察组,16例健康受试者作为对照组。观察组给予12周的脑安滴丸治疗,对照组不予任何干预。观察组在治疗前后进行静息态功能磁共振(resting state function magnetic resonance imaging,rs-fMRI)扫描,对照组仅在入组当天进行1次扫描。记录观察组治疗前后、随访4周头痛发作天数、头痛发作次数、头痛持续时间、视觉模拟评分(visual analogue scale,VAS)及患者报告的结局(patients-reported outcomes,PRO)量表评分。分析治疗前两组间的低频振幅(amplitude of low frequency fluctuation,ALFF)、局部一致性(regional homogeneity,ReHo)差异脑区,以ALFF、ReHo的共同差异脑区为感兴趣脑区(region of interest,ROI),分析计算观察组治疗前后ROI与全脑体素的功能连接(functional connectivity,FC)变化,并将FC的变化值与临床数据的改善值进行Pearson相关分析。结果观察组治疗后、随访4周的头痛发作天数、头痛发作次数、头痛持续时间及PRO量表评分均显著低于治疗前(P<0.05),且观察组随访4周的VAS评分亦显著降低(P<0.05);与对照组比较,治疗前观察组左侧背外侧额上回、右侧前扣带和旁扣带脑回、右侧岛叶、双侧内侧额上回、双侧额中回和左侧楔前叶的ALFF值显著降低(P<0.05),右侧中央前回的ReHo值显著升高(P<0.05),左侧楔前叶的ReHo值显著降低(P<0.05)。以左侧楔前叶为ROI,治疗后左侧楔前叶与左侧壳核的FC值较治疗前降低(P<0.05),未发现治疗前后FC的变化值与临床数据的相关性(P>0.05)。结论偏头痛患者存在认知、情感、感觉等多个脑区的功能活动异常,而脑安滴丸可能是通过调控楔前叶—壳核的FC达到治疗偏头痛的作用。
