Chemotherapeutic drugs eliminate tumor cells at relatively high doses and are considered weapons against tumors in clinics and hospitals.However,despite their ability to induce cellular apoptosis,chemotherapeutic drug...Chemotherapeutic drugs eliminate tumor cells at relatively high doses and are considered weapons against tumors in clinics and hospitals.However,despite their ability to induce cellular apoptosis,chemotherapeutic drugs should probably be regarded more as a class of cell regulators than cell killers,if the dosage used and the fact that their targets are involved in basic molecular events are considered.Unfortunately,the regulatory properties of chemotherapeutic drugs are usually hidden or masked by the massive cell death induced by high doses.Recent evidence has begun to suggest that low dosages of chemotherapeutic drugs might profoundly regulate various intracellular aspects of normal cells,especially immune cells.Here,we discuss the immune regulatory roles of three kinds of chemotherapeutic drugs under low-dose conditions and propose low dosages as potential new chemotherapeutic weapons on the battlefield of immune-related disease.展开更多
In petroleum exploration and production operations,gas hydrates pose serious flow assurance,economic and safety concerns.Thermodynamic inhibitors are widely used to reduce the risks associated with gas hydrate formati...In petroleum exploration and production operations,gas hydrates pose serious flow assurance,economic and safety concerns.Thermodynamic inhibitors are widely used to reduce the risks associated with gas hydrate formation.In the present study,systematic laboratory work was undertaken to determine synergistic effects between methanol and a Poly Vinyl Methyl Ether as Low Dosage Hydrate Inhibitors（LDHIs）.A valuable effect was discovered at a certain ratio of methanol to the low dosage hydrate inhibitor.展开更多
基金the National Natural Science Foundation of China(30871020 and 30972667)Funds for International Cooperation and Exchange of the National Natural Science Foundation of China(30911120482)+2 种基金Program for New Century Excellent Talents in University(NCET-08-0219)Fundamental Research Funds for the Central Universities(HUST-2010JC024)Scientific Research Foundation of Wuhan City Human Resource for Returned Scholars.
文摘Chemotherapeutic drugs eliminate tumor cells at relatively high doses and are considered weapons against tumors in clinics and hospitals.However,despite their ability to induce cellular apoptosis,chemotherapeutic drugs should probably be regarded more as a class of cell regulators than cell killers,if the dosage used and the fact that their targets are involved in basic molecular events are considered.Unfortunately,the regulatory properties of chemotherapeutic drugs are usually hidden or masked by the massive cell death induced by high doses.Recent evidence has begun to suggest that low dosages of chemotherapeutic drugs might profoundly regulate various intracellular aspects of normal cells,especially immune cells.Here,we discuss the immune regulatory roles of three kinds of chemotherapeutic drugs under low-dose conditions and propose low dosages as potential new chemotherapeutic weapons on the battlefield of immune-related disease.
基金supported by Research Institute of Petroleum Industry-Kermanshah campus
文摘In petroleum exploration and production operations,gas hydrates pose serious flow assurance,economic and safety concerns.Thermodynamic inhibitors are widely used to reduce the risks associated with gas hydrate formation.In the present study,systematic laboratory work was undertaken to determine synergistic effects between methanol and a Poly Vinyl Methyl Ether as Low Dosage Hydrate Inhibitors（LDHIs）.A valuable effect was discovered at a certain ratio of methanol to the low dosage hydrate inhibitor.
