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Properties and Characterization of Two Clays Raw Material from Mountain District (West of Côte d’Ivoire) for Use in Low-Carbon Cements
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作者 Wedjers Max Robin Manouan Bi Irié Hervé Gouré Doubi +3 位作者 Lébé Prisca Marie-Sandrine Kouakou Atta Kouamé Brice Koffi Alfred Niamien Kouamé Namory Méité 《Advances in Materials Physics and Chemistry》 CAS 2024年第8期137-145,共9页
This work was devoted to the study of the physico-chemical properties of two clay minerals from the Mountain District (West Côte d'Ivoire) referenced ME1 and ME2. These samples were characterized by the exper... This work was devoted to the study of the physico-chemical properties of two clay minerals from the Mountain District (West Côte d'Ivoire) referenced ME1 and ME2. These samples were characterized by the experimental techniques, such as X-ray diffraction (XRD), Infrared spectroscopy (IR), Inductively Coupled Plasma Atomic Emission Spectrometry (ICP-AES), Differential Thermal Analysis and Thermogravimetry (DTA-TG), Brunauer, Emett and Teller method (BET), laser particle size analysis and Scanning Electron Microscope (SEM). The main results of these analyses reveal that the two clay samples mainly contain quartz (52.91% for ME1 and 51.72% for ME2), kaolinite (36.60% for ME1 and 41.6% for ME2) and associated phases, namely goethite and hematite (13.47% for ME1 and 11.00% for ME2). The specific surface values obtained for samples ME1 and ME2 are 34.78 m2/g and 29.18 m2/g respectively. The results obtained show that the samples studied belong to the kaolinite family. After calcination, they could have good pozzolanic activity and therefore be used in the manufacture of low-carbon cements. 展开更多
关键词 QUARTZ KAOLINITE Mountain District low-carbon Cements
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Does China's digital economy contribute to low-carbon transition?
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作者 LI Jun-jun HUANG Xin-yu +2 位作者 CHEN Mu ZHANG Meng-jiang ZHANG Zhen 《Ecological Economy》 2024年第2期102-122,共21页
The digital economy,as a new emerging economic form,has become an important power for realizing Chinese-style modernization and promoting green development in China.This paper measures the digital economy and low-carb... The digital economy,as a new emerging economic form,has become an important power for realizing Chinese-style modernization and promoting green development in China.This paper measures the digital economy and low-carbon transition index based on the data of 30 provinces in China from 2013 to 2020 and analyzes the mechanism and path of the digital economy affecting low-carbon transition using the fixed effect panel data model and the threshold effect model.It is found that,(1)The digital economy and low-carbon transition in China are various in different regions,with characteristics of being unbalanced and insufficient.(2)The digital economy significantly promotes low-carbon transition,with the greatest influence in the Central region,followed by the Eastern region and the Western region.Under different dimensions,the development of informatization and digital transactions promote low-carbon transition,but the development of the internet plays an inhibiting role.(3)The higher the degree of urbanization and environmental regulation,the greater the influence of the digital economy on low-carbon transition. 展开更多
关键词 digital economy low-carbon transition threshold effect model instrumental variables quantile regression
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Effect of ZrC Modified Graphite on Structure and Properties of Low-carbon Al_(2)O_(3)-C Refractories
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作者 HU Chen WANG Xing +3 位作者 LIU Zhenglong DING Jun YU Chao DENG Chengji 《China's Refractories》 CAS 2024年第1期18-22,共5页
To address the issues of reduced performance and shortened lifespan during the low-carbonizating process of Al_(2)O_(3)-C refractories,nano-crystalline ZrC modified graphite was prepared using Zr powder and flake grap... To address the issues of reduced performance and shortened lifespan during the low-carbonizating process of Al_(2)O_(3)-C refractories,nano-crystalline ZrC modified graphite was prepared using Zr powder and flake graphite as raw materials,with NaCl and NaF mixed salt serving as the medium.The flake graphite was gradually replaced by ZrC modified graphite in the preparation of Al_(2)O_(3)-C refractories,and its impact on the material’s structure and properties was investigated.The results indicate that,compared to samples with only flake graphite,the introduction of 1 mass%to 5 mass%nano-crystalline ZrC modified graphite can significantly enhance the mechanical performance of low-carbon Al_(2)O_(3)-C refractories.When 5 mass%ZrC modified graphite is added,the mechanical properties of the samples are optimal,with the cold modulus of rupture and elastic modulus reaching 22.5 MPa and 65.0 GPa,respectively. 展开更多
关键词 ZRC modified graphite low-carbon Al_(2)O_(3)-C refractories microstrcucture mechanical properties
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Performance Evaluation of Low-Carbon and Clean Transformation of China’s Coal Economy
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作者 Liangfeng Zhu 《Journal of Environmental Science and Engineering(B)》 2024年第1期21-38,共18页
In China,the oversupply of coal occurred in 2009,and from that year onwards,China’s coal economy began a low-carbon and clean transformation.Evaluating transformation performance is the research goal of this paper.Th... In China,the oversupply of coal occurred in 2009,and from that year onwards,China’s coal economy began a low-carbon and clean transformation.Evaluating transformation performance is the research goal of this paper.The data collection for this paper includes data on deep processing of Chinese coal products from 2009 to 2020,as well as data on asset structure evolution and financial performance of 34 listed companies in the Chinese coal mining.Entropy value method is used to calculate the entropy value of low-carbon transformation,and the regression analysis is used to study the performance of cleaner transformation,the conclusion is as follows:(1)From 2009 to 2020,in China’s total energy consumption,coal consumption accounted for 71.6%in 2009 and 56.8%in 2020,the goals set by the state have been achieved.(2)The national goal of reducing the proportion of coal consumption and reducing carbon emissions has forced the transformation of deep processing of coal products.The transformation of coal enterprises towards low-carbon and clean production has achieved remarkable results.(3)From 2009 to 2020,the non coal industry income of 34 listed companies in China’s coal mining industry increased by 8.21%annually.At the same time,the asset structure was adjusted,and nearly 80%of the asset structure evolution showed an orderly development trend.(4)The regression analysis results show that the entropy value of coal deep processing products and the entropy value of asset structure adjustment are significantly related to transformation performance.The paper proposes to summarize the successful experience of China’s coal energy economic transformation,lay a foundation for achieving the carbon peak and carbon neutral goals in the future,further increase the intensity of coal deep processing,increase the proportion of clean energy in total energy consumption,and strive to control asset operation towards the goal of increasing the proportion of non coal industry income. 展开更多
关键词 Coal economy low-carbon and clean transformation deep processing of coal evolution of asset structure performance appraisal
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A Mechanism for Digital Finance to Drive Green and Low-Carbon Development
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作者 Shenhui Huang 《Proceedings of Business and Economic Studies》 2024年第3期59-64,共6页
Given the global focus on green and low-carbon development and the increasing prominence of digital finance,it is particularly important to explore how to leverage digital finance to achieve these environmental goals.... Given the global focus on green and low-carbon development and the increasing prominence of digital finance,it is particularly important to explore how to leverage digital finance to achieve these environmental goals.This study,through mechanism analysis,deeply examines how China’s digital finance promotes green and low-carbon development and elucidates the positive interaction between digital finance and the green industry.The study found that digital finance,through more flexible and efficient financial functions,alters the cost structure of carbon emissions,and reduces the risks and costs of green investments,thereby creating a cooperative green mechanism benefiting all parties,and guiding social groups toward a green and low-carbon transformation.Additionally,the rapid development of digital finance has strengthened the implementation of environmental protection policies,effectively promoted the expansion of the environmental protection industry,and established the green ethos as a mainstream concept in financial development.This study aims to provide reference perspectives and suggestions,assist policymakers in promoting the green and lowcarbon development of digital finance,and offer insights into the integrated development of digital finance and the green environmental protection industry. 展开更多
关键词 Digital finance Green and low-carbon development carbon emission cost Environmental protection policy Green environmental protection industry
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Approach and Strategy of Constructing Low-carbon Communities 被引量:3
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作者 陈江美 李志英 《Meteorological and Environmental Research》 CAS 2010年第7期97-101,共5页
The developing focus of low-carbon society is constructing low-carbon cities which are based on the construction of low-carbon communities.The main ways of constructing low-carbon communities conclude low carbonizatio... The developing focus of low-carbon society is constructing low-carbon cities which are based on the construction of low-carbon communities.The main ways of constructing low-carbon communities conclude low carbonization of planning and designing,low carbonization of construction materials,low carbonization of community environment,low carbonization of energy system,low carbonization of energy use and low carbonization of life style.The basic strategies of constructing low-carbon communities contain enhancing propaganda and education,strengthening technical innovation,cultivating low-carbon culture,advocating public participation and consolidating leadership in organizations. 展开更多
关键词 low-carbon economy low-carbon city low-carbon community APPROACH STRATEGY China
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Cultivation and Management of Low-carbon Scenic Spots——A case study of Yuntai Mountain Scenic Area in Henan Provicne of China 被引量:1
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作者 史云 田甜 许晓明 《Journal of Landscape Research》 2011年第4期57-60,64,共5页
After analysis of connotation of low-carbon scenic spots,the paper considered that a perfect low-carbon scenic spot is a comprehensive integrity with satisfying tourists' lowest tourist experience effect as the pr... After analysis of connotation of low-carbon scenic spots,the paper considered that a perfect low-carbon scenic spot is a comprehensive integrity with satisfying tourists' lowest tourist experience effect as the premise and with low energy consumption,low pollution and low emission as the foundation.Low-carbon tourist scenic spots had been classified into three types which are ecological type,cultural type and coupling type of ecology and culture.Representatives of each type of tourist scenic spot were illustrated.It proposed that government should play the leading role in cultivation of low-carbon scenic spot;tourism industry should enhance self supervision;tourism development mode should be transformed and upgrading of tourist products should be realized.By taking Yuntai Mountain Scenic Area of Henan Province for example,based on low-carbon tourist resources,low-carbon development of management,following measures realizing low-carbon economy were put forward:① purifying air quality and beautifying environment of scenic area;② sifting laggard productivity and protecting ecological resources in the scenic area by many means;③ sticking to low-carbon environmental protection concept and completing infrastructure service;④ developing tourist native products and souvenirs based on local resources;⑤ applying electronic access control ticket system,intelligent monitor system and LED information and communication platform,so as to achieve low-carbon management. 展开更多
关键词 low-carbon SCENIC SPOT CULTIVATION and development Yuntai MOUNTAIN SCENIC Area Management
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Transitional Road of Resources-exhausted Cities to Low-carbon Economy:Tourism Resources Development——A Case Study of Gejiu City 被引量:2
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作者 张家友 胡剑波 《Journal of Landscape Research》 2011年第1期95-99,共5页
Tourism is of vital practical significance to low-carbon economic transition of resources-exhausted cities.By taking Gejiu City of Yunnan Province for example,the paper discussed that Gejiu City as the resources-exhau... Tourism is of vital practical significance to low-carbon economic transition of resources-exhausted cities.By taking Gejiu City of Yunnan Province for example,the paper discussed that Gejiu City as the resources-exhausted city should positively develop tourism,particularly industrial heritage tourism,treating tourism development as the breakthrough and motive power of low-carbon economic transition of resources-exhausted cities,so as to walk out a unique road of tourism promoting low-carbon economic development. 展开更多
关键词 Resources-exhausted CITY low-carbon economy TOURISM resources Industrial HERITAGE TOURISM
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Low-carbon Living Environment Design 被引量:4
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作者 韦宇航 《Journal of Landscape Research》 2012年第1期49-51,共3页
Based on the review of the influence of human activity on global environment,and recognition of current climate warming,it is considered that human activity is the primary reason and climate change has caused serious ... Based on the review of the influence of human activity on global environment,and recognition of current climate warming,it is considered that human activity is the primary reason and climate change has caused serious global environmental problems and threatened human's survival and development.After the introduction of low carbon and conclusion of the main contents and development of researches,it has emphasized that low-carbon urban living mode is an important component of low-carbon urban planning.In view of the situation of China,the main content of low-carbon urban living mode has been illustrated from the perspective of low-carbon life behavior,low-carbon life consumption and carbon budget life mode.On this basis,the purpose and significance of low-carbon living environment design,design principles and requirements,low-carbon life measures have been analyzed. 展开更多
关键词 low-carbon LIFE LIVING environment design "People orientation" carBON EMISSION
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Low-carbon and Energy-saving Designs Preserving Primitive Ecological Conditions——With the Planning of Ancient Banyan Park in Mengshan County,Guangxi,China as a Case Study 被引量:1
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作者 叶明琴 《Journal of Landscape Research》 2011年第5期27-31,共5页
It was proposed that park planning should be based on local economic development,should focus on the preservation of primitive ecological conditions and the application of low-carbon and energy-saving concepts.The pla... It was proposed that park planning should be based on local economic development,should focus on the preservation of primitive ecological conditions and the application of low-carbon and energy-saving concepts.The planning of Ancient Banyan Park in Mengshan County by following the principles of respecting local history and culture,improving functions and supporting facilities,human-centered,overall planning and all-around consideration,respecting characteristics of the local area(the planning site),satisfying operation requirements of the park,applying low-carbon and energy-saving concepts,and avoiding over-engineering,aimed at protecting natural images of the park,primitive history,culture and characteristics of the local area and providing a space for local residents' various activities.Modern aesthetic forms were combined,cultural connotation of natural environment stressed to build a landscape space system of the Ancient Banyan Park that matches well with environment of the planning site.The park was designed into 4 functional areas:sport area,fitness plaza area,garden recreational area and ancient banyan cultural area.Different functions of these subareas were taken into consideration to create conservation-minded garden landscapes which were both independent and unified. 展开更多
关键词 GARDEN PLANNING ORIGINAL ecological conditions low-carbon ENERGY-SAVING
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Overall Design of Low-carbon Campus Landscapes 被引量:1
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作者 陈波 《Journal of Landscape Research》 2012年第4期65-67,共3页
In view of the global warming and the significant role of campus environment in a city, the traditional "high-carbon" urban development pattern has to be improved through exploring a low-carbon urban plannin... In view of the global warming and the significant role of campus environment in a city, the traditional "high-carbon" urban development pattern has to be improved through exploring a low-carbon urban planning and sustainable development mode. This study focused on the overall design of low-carbon campus by elaborating the concept of overall campus design, campus planning, functional layout, landscape and architectural design, traffic organization, energy conservation and expansion of carbon sink. 展开更多
关键词 low-carbon CONCEPT CAMPUS Overall DESIGN
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Positioning of Developing Low-carbon Agriculture in Local Governments
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作者 万玉山 李娜 +2 位作者 张平 李定龙 王明新 《Agricultural Science & Technology》 CAS 2012年第2期468-472,共5页
[Objective] To analyze the positioning of low-carbon agriculture development in local governments of China. [Method] The emissions of green-house gas, the connotation and characteristics of low-carbon agriculture, and... [Objective] To analyze the positioning of low-carbon agriculture development in local governments of China. [Method] The emissions of green-house gas, the connotation and characteristics of low-carbon agriculture, and the necessity of developing low-carbon agriculture were analyzed, obtaining the positioning and measures for the development of low-carbon agriculture in local government. [Result] Government plays a leading role in the development of low-carbon agriculture. The development of low-carbon agriculture can be promoted through the formulation of scientific low-carbon agricultural development plan, culturing new talents on low-carbon agriculture, promoting low-carbon agricultural technology, establishing low-carbon agricultural risk prevention mechanisms. [Conclusion] Making economy, environment and resources coordinated with each other, leading by the concept of scientific development with the concept of sustainable development, is where the future of agricultural development in China lies. 展开更多
关键词 GOVERNMENT low-carbon agriculture low-carbon technology Greenhouse gas
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Low-carbon Agriculture Development Models in Southern Jiangsu Province
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作者 万玉山 李娜 +2 位作者 丁庆忠 张平 王明新 《Agricultural Science & Technology》 CAS 2012年第4期867-871,共5页
[Objective] To investigate the appropriate low-carbon agriculture model in Southern Jiangsu Province. [Method] Through the analysis of regional features in Southern Jiangsu and several matured low-carbon agriculture d... [Objective] To investigate the appropriate low-carbon agriculture model in Southern Jiangsu Province. [Method] Through the analysis of regional features in Southern Jiangsu and several matured low-carbon agriculture development models at present, the low-carbon agriculture development modes suitable for Southern Jiangsu were investigated, and corresponding supporting measures for the development of the models were put forward. [Result] Low-carbon agriculture is the environment- friendly agriculture which achieves low emissions, low pollution, high efficiency and high-yield through efficient recycling of energy and resources and continuous im- provements on ecological environment. With a variety of development models, the specific development model for practical use should be determined according to the local conditions, and supported by corresponding supporting measures, to achieve the rapid development of low-carbon agriculture. [Conclusion] This study laid the foundation for the development of low-carbon agriculture model in Southern Jiangsu. 展开更多
关键词 Southern Jiangsu Province low-carbon agriculture low-carbon technol- ogy Development model
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Low-carbon Landscape Construction Approaches Based on Human Behavior
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作者 陈晓刚 罗文艳 林辉 《Journal of Landscape Research》 2012年第1期3-5,共3页
After the analysis of connotations of human behavior and low-carbon landscape,according to relevant theories of behavioral science and psychology,the internal relation between behavior and lowcarbon landscape has been... After the analysis of connotations of human behavior and low-carbon landscape,according to relevant theories of behavioral science and psychology,the internal relation between behavior and lowcarbon landscape has been discussed.They relate to,interact on and are the precondition of each other.Reasonable landscape environment has carried people's expectation for nature,and different landscapes give people different feelings and present to be of different behavior features.Finally,the paper has proposed constructing low-carbon landscape in the perspective of landscape design idea,design methods,construction process and later management,providing a theoretical basis for advocating energy saving and environmental protection,and creating green ecology. 展开更多
关键词 HUMAN BEHAVIOR low-carbon LANDSCAPE RELATION CONSTRUCTION APPROACHES
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Study on Low-carbon Landscape Design of Residential Areas
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作者 张成 曹加杰 《Journal of Landscape Research》 2010年第8期32-34,40,共4页
With landscape design of residential areas as the study object, by combining with the "low energy consumption, low pollution and low emission" principle of low-carbon economy, this paper tries to analyze the... With landscape design of residential areas as the study object, by combining with the "low energy consumption, low pollution and low emission" principle of low-carbon economy, this paper tries to analyze the relatively systematic low-carbon landscape designs of modern residential areas. 展开更多
关键词 low-carbon ECONOMY LANDSCAPE DESIGN RESIDENTIAL area
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Research on Products Design of Low-carbon Tourism Development in Nature Reserve——A Case Study of Guangxi Longhu Mountain Scenic Area in China
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作者 廖钟迪 《Journal of Landscape Research》 2011年第4期65-67,75,共4页
After analyzing three misunderstandings about eco-tourism development,the paper pointed out that low-carbon tourism based on control of carbon emission had larger implementation space,which could be applied in all typ... After analyzing three misunderstandings about eco-tourism development,the paper pointed out that low-carbon tourism based on control of carbon emission had larger implementation space,which could be applied in all types of tourist destinations,with strong operability and the effectiveness evaluation of which was easier to be quantized.On this basis,low-carbon development thought of nature reserve was proposed by taking Guangxi Longhu Mountain Nature Reserve as the example.Through introduction of general situation of low-carbon tourist resources in Longhu Mountain,it analyzed necessity to design low-carbon tourist products in Longhu Mountain Nature Reserve,designed low-carbon tourist activities according to resources characteristics,and proposed five distinctive low-carbon tour routes in light with different tourists markets.Finally,some relevant suggestions on development had been put forward. 展开更多
关键词 Longhu MOUNTAIN Nature RESERVE low-carbon TOURISM PRODUCTS DESIGN
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Production of Low-carbon Light Olefins from Catalytic Cracking of Crude Bio-oil 被引量:5
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作者 袁燕妮 王铁军 李全新 《Chinese Journal of Chemical Physics》 SCIE CAS CSCD 2013年第2期237-244,I0004,共9页
Low-carbon light olefins are the basic feedstocks for the petrochemical industry. Catalytic cracking of crude bio-oil and its model compounds (including methanol, ethanol, acetic acid, acetone, and phenol) to light ... Low-carbon light olefins are the basic feedstocks for the petrochemical industry. Catalytic cracking of crude bio-oil and its model compounds (including methanol, ethanol, acetic acid, acetone, and phenol) to light olefins were performed by using the La/HZSM-5 catalyst. The highest olefins yield from crude bio-oil reached 0.19 kg/(kg crude bio-oil). The reaction conditions including temperature, weight hourly space velocity, and addition of La into the HZSM-5 zeolite can be used to control both olefins yield and selectivity. Moderate adjusting the acidity with a suitable ratio between the strong acid and weak acid sites through adding La to the zeolite effectively enhanced the olefins selectivity and improved the catalyst stability. The production of light olefins from crude bio-oil is closely associated with the chemical composition and hydrogen to carbon effective ratios of feedstock. The comparison between the catalytic cracking and pyrolysis of bio-oil was studied. The mechanism of the bio-oil conversion to light olefins was also discussed. 展开更多
关键词 Crude bio-oil low-carbon olefin Catalytic cracking Zeolite catalyst
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Low-carbon Concepts in the Planning of Residential Communities 被引量:1
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作者 胡晓康 李国庆 《Journal of Landscape Research》 2011年第1期44-47,51,共5页
It has become a common pursuit of designers to construct comfortable,energy-conserving,high-efficiency and natural living environment since the early 21st century.In the coming low-carbon age,the evolution of low-carb... It has become a common pursuit of designers to construct comfortable,energy-conserving,high-efficiency and natural living environment since the early 21st century.In the coming low-carbon age,the evolution of low-carbon concepts will surely bring positive influence on the present planning concepts of residential community,and meanwhile,propose higher requirements on the natural and ecological properties of residential community,such as its infrastructure construction,traffic organization,environment greening and so on.Through analyzing relevant concepts of low carbon,the authors studied the development of low-carbon concepts in "human-centered" designs,and its applications in architecture,traffic and green spaces.This study proposed that the improvement of low-carbon society could be started from the design of low-carbon residential communities,so as to satisfy the increasing ecological needs of people on living environment,and play a promotional role in facilitating the sustainable development of society. 展开更多
关键词 low-carbon concepts Development of HUMAN-CENTERED concepts low-carbon ARCHITECTURE low-carbon TRAFFIC Green space PLANNING
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香蕉枯萎病菌内源报告基因Foc4carS的鉴定及其应用
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作者 彭军 曾凡云 +5 位作者 王艳玮 漆艳香 丁兆建 王少伶 谢艺贤 张欣 《热带作物学报》 CSCD 北大核心 2024年第5期873-885,共13页
香蕉枯萎病是由尖孢镰刀菌古巴转化型(Fusarium oxysporum f. sp. cubense, Foc)引起的香蕉毁灭性土传病害,其中4号生理小种(Foc4)能感染几乎所有的香蕉品系,危害最严重。carS基因通过调控下游car结构基因参与调控镰刀菌类胡萝卜素的生... 香蕉枯萎病是由尖孢镰刀菌古巴转化型(Fusarium oxysporum f. sp. cubense, Foc)引起的香蕉毁灭性土传病害,其中4号生理小种(Foc4)能感染几乎所有的香蕉品系,危害最严重。carS基因通过调控下游car结构基因参与调控镰刀菌类胡萝卜素的生物合成,本研究克隆鉴定了Foc4carS基因(FOIG_05085),Foc4carS蛋白具有典型的RING-finger蛋白结构域。利用分割标记法(Split-marker PCR)获得Foc4carS基因的融合片段,同时构建含有Foc4carS基因sgRNA591序列的pUC-fFuCas9-HTBNLS-hph-Foc4carS基因编辑载体,通过PEG介导的原生质体转化获得该基因的敲除突变体、回补突变体以及基因编辑敲除体,并对敲除和回补突变体的生物学特性和致病力进行分析。结果显示:ΔFoc4carS突变体的菌落直径、产孢量和致病力等生物学表型与野生菌株Foc4无显著差异,而ΔFoc4carS突变体菌落颜色呈深橙色,Foc4carS基因的缺失影响了次生代谢产物类胡萝卜素的生物合成;基因编辑的ΔFoc4carS(HDR)突变体不论是再生筛选板还是继代后的PDA平板,其菌落均出现典型的深橙色,表明Foc4carS可作为内源报告基因,在香蕉枯萎菌Foc4中进行基因质粒型CRISPR/Cas9编辑可行。 展开更多
关键词 香蕉枯萎菌Foc4 Foc4carS基因 类胡萝卜素 基因敲除 CRISPR/Cas9基因编辑
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CAR-T细胞治疗后复发/难治性多发性骨髓瘤患者的临床特征
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作者 王慧娟 陈文明 +1 位作者 耿传营 杨光忠 《中国癌症防治杂志》 CAS 2024年第5期549-553,共5页
目的分析嵌合抗原受体T(chimeric antigen receptor,CAR-T)细胞治疗后复发/难治多发性骨髓瘤(relapsed/refractory multiple myeloma,RRMM)患者的临床特征,初步探索此类患者未来可能的治疗策略。方法以2020年1月至2024年6月在首都医科... 目的分析嵌合抗原受体T(chimeric antigen receptor,CAR-T)细胞治疗后复发/难治多发性骨髓瘤(relapsed/refractory multiple myeloma,RRMM)患者的临床特征,初步探索此类患者未来可能的治疗策略。方法以2020年1月至2024年6月在首都医科大学附属北京朝阳医院住院治疗的RRMM患者为研究对象,分析CAR-T细胞治疗后复发的临床特征及生存情况。结果共收集14例符合条件的RRMM患者,均接受靶向BCMA的CAR-T细胞治疗,中位无进展生存时间为17个月(范围:3~47个月)。疾病复发进展时,1例仅表现为髓外复发,2例继发浆细胞白血病,11例为髓内复发;7例检查细胞遗传学,其中4例患者存在1个高危基因,1例患者存在2个高危基因。首次挽救治疗中,常用药物包括达雷妥尤单抗(6例)、泊马度胺(5例)、卡非佐米(3例),3例患者入组临床试验。13例患者可评价疗效,总有效率为61.5%(8/13),其中完全缓解率为30.8%(4/13),非常好的部分缓解率为23.1%(3/13)。中位随访时间为15个月(范围:1~32个月),中位无进展生存时间为7个月。截至末次随访,死亡6例,中位总生存期为32个月;1例患者出现第二肿瘤,类型为肺癌。结论接受CAR-T细胞治疗后RRMM患者常见多类药物耐药,挽救治疗疗效及预后不佳。 展开更多
关键词 多发性骨髓瘤 car-T细胞治疗 复发 难治 挽救治疗 预后
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