An identification of Phe dipeptide from L-phenylalanine monomers after keV nitro- gen and argon ion implantation, by using the HPLC （high performance liquid chromatography） and LC-MS（liquid chromatography mass spec...An identification of Phe dipeptide from L-phenylalanine monomers after keV nitro- gen and argon ion implantation, by using the HPLC （high performance liquid chromatography） and LC-MS（liquid chromatography mass spectrometer） methods is reported. The results showed a similar yield behavior for both ion species, namely： 1） the yield of dipeptides under alkalescent conditions was distinctly higher than that under acidic or neutral conditions; 2） for different ion species, the dose-yield curves tracked a similar trend which was called a counter-saddle curve. The dipeptide formation may implicate a recombination repair mechanism of damaged biomolecules that energetic ions have left in their wake. Accordingly a physicochemical self-repair mechanism by radiation itself for the ion-beam radiobiological effects is proposed.展开更多
基金the Innovative Project of Chinese Academy of Science:Single Ion Beam Micro-irradiation Technology of Molecular and Cytology Effect Research(KSCX2-SW-324)
文摘An identification of Phe dipeptide from L-phenylalanine monomers after keV nitro- gen and argon ion implantation, by using the HPLC （high performance liquid chromatography） and LC-MS（liquid chromatography mass spectrometer） methods is reported. The results showed a similar yield behavior for both ion species, namely： 1） the yield of dipeptides under alkalescent conditions was distinctly higher than that under acidic or neutral conditions; 2） for different ion species, the dose-yield curves tracked a similar trend which was called a counter-saddle curve. The dipeptide formation may implicate a recombination repair mechanism of damaged biomolecules that energetic ions have left in their wake. Accordingly a physicochemical self-repair mechanism by radiation itself for the ion-beam radiobiological effects is proposed.
