^(177)Lu标记的前列腺特异性膜抗原(prostate specific membrane antigen,PSMA)放射性配体疗法已在国外获批应用于晚期前列腺癌治疗,且正在国内开展多项临床试验。专家组参考国外经验和观点,并结合国内临床实践和实测数据,形成^(177)Lu-...^(177)Lu标记的前列腺特异性膜抗原(prostate specific membrane antigen,PSMA)放射性配体疗法已在国外获批应用于晚期前列腺癌治疗,且正在国内开展多项临床试验。专家组参考国外经验和观点,并结合国内临床实践和实测数据,形成^(177)Lu-PSMA放射性配体疗法在前列腺癌临床应用中的专家共识。展开更多
由于现有协议的安全性为基于某种安全假设的计算安全,依赖于敌手的计算能力,因此,本文针对恶意敌手模型,使用矩阵伪装技术对方程的系数矩阵进行隐藏,结合矩阵的LU分解(lower-upper decomposition)算法,提出一种新的信息论安全外包求解...由于现有协议的安全性为基于某种安全假设的计算安全,依赖于敌手的计算能力,因此,本文针对恶意敌手模型,使用矩阵伪装技术对方程的系数矩阵进行隐藏,结合矩阵的LU分解(lower-upper decomposition)算法,提出一种新的信息论安全外包求解线性代数方程组(information-theoretically secure outsourcing of linear algebraic equations,ITS-OutsLAE)方法 .与之前的研究相比,在保持计算和通信复杂度与现有最优方案保持一致的同时,首次将方程组唯一解的安全性提升至信息论安全(完美保密).给出了形式化的安全性证明,并通过理论分析和实验证明了所提方法的实用性.展开更多
For the reduction of atmospheric effects,observed gravity has initially been corrected by using the computed barometric admittance k of the in situ measured pressure,expressed in nms-2/hPa units and estimated by least...For the reduction of atmospheric effects,observed gravity has initially been corrected by using the computed barometric admittance k of the in situ measured pressure,expressed in nms-2/hPa units and estimated by least squares method.However,the local pressure changes alone cannot account for the atmospheric mass attraction and loading when the coherent pressure field exceeds a specific size,i.e.,with increasing periodicities.To overcome this difficulty,it is necessary to compute the total atmospheric effect at each station using the global pressure field.However,the direct subtraction of the total gravity effect,provided by the models of pressure correction,is not yet satisfactory for S2 and other tidal components,such as K2 and P1,which include solar heating pressure tides.This paper identifies the origin of the problem and presents strategies to obtain a satisfactory solution.First,we set up a difference vector between the tidal factors of M2 and S2 after correction of the pressure and ocean tides effects.This vector,hereafter denoted as RES,presents the advantage of being practically insensitive to calibration errors.The minimum discrepancy between the tidal parameters of M2 and S2 corresponds to the minimum of the RES vector norm d.Secondly we adopt the hybrid pressure correction method,separating the local and the global pressure contribution of the models and replacing the local contribution by the pressure measured at the station multiplied by an admittance kATM.We tested this procedure on 8 stations from the IGETS superconducting gravimeters network(former GGP network).For stations at an altitude lower than 1000 m,the value of dopt is always smaller than0.0005.The discrepancy between the tidal parameters of the M2 and S2 waves is always lower than0.05% on the amplitude factors and 0.025° on the phases.For these stations,a correlation exists between the altitude and the value kopt.The results at the three Central European stations Conrad,Pecny and Vienna are in excellent agreement(0.05%) with the DDW99NH model for all the main tidal waves.展开更多
Flax is a crucial fiber crop that exhibits excellent textile properties and serves as a model plant for investigating phloem fiber development. The regulation of multiple genes significantly influences fiber developme...Flax is a crucial fiber crop that exhibits excellent textile properties and serves as a model plant for investigating phloem fiber development. The regulation of multiple genes significantly influences fiber development, notably involving NAC(NAM, ATAF1/2, CUC2) transcription factors in forming the fiber secondary cell wall(SCW).Overexpression of LuNAC61 in flax resulted in sparse top meristematic zone leaves and significantly reduced stem cellulose content. Scanning electron microscopy and staining observations revealed a significant reduction in fiber bundles. β-Glucuronidase(GUS) staining analysis demonstrated high activity of the LuNAC61 promoter in the bast fibers of the flax stem. Additionally, several members of the LuPLATZ and LuCesA families exhibited significant coexpression with LuNAC61. Subcellular localization indicated the presence of LuPLATZ24 protein in the nucleus and cytoplasm, LuNAC61 protein exclusively in the nucleus, and LuCesA10 in the nucleus and endoplasmic reticulum. LuPLATZ24 positively regulates LuNAC61, whereas LuNAC61 negatively affects LuCesA10, suggesting the involvement of a metabolic network in regulating flax fiber development. In conclusion, this study provides a critical opportunity for a comprehensive and in-depth analysis of the mechanisms governing flax fiber development and the potential use of biotechnology to enhance flax fiber yield.展开更多
Three new records from Vietnam,Phlegmariurus guangdongensis Ching,Adiantum longzhouensis A.H.Wang,F.G.Wang&F.W.Xing,and Lepisorus bicolor Ching,are reported.The identification characteristics,information of specim...Three new records from Vietnam,Phlegmariurus guangdongensis Ching,Adiantum longzhouensis A.H.Wang,F.G.Wang&F.W.Xing,and Lepisorus bicolor Ching,are reported.The identification characteristics,information of specimen,and geographical distribution of the species are described.The discovery of new records not only enriches the study of plant diversity in Vietnam,but also provides important information for biodiversity conservation and botanical research in the region.The voucher specimens are kept in the Herbarium of Kunming Institute of Botany,Chinese Academy of Sciences(KUN),Herbarium of Institute of Botany,Chinese Academy of Sciences(PE)and Herbarium of Guangxi Forestry Research Institute(GXFI).展开更多
Island ecosystems support diverse aquatic invertebrate communities comprising endemic taxa.Documentation of existing species is important for conservation.In this study,a checklist of marine opisthobranch from the Rep...Island ecosystems support diverse aquatic invertebrate communities comprising endemic taxa.Documentation of existing species is important for conservation.In this study,a checklist of marine opisthobranch from the Republic of Mauritius is presented.A combination of benthic surveys(50 m×5 m in triplicates),rover diving techniques and photo documentation were used over two years(2018–2020)within 35 sheltered and unsheltered lagoons.Morphological and molecular analysis were used for identification.Species composition within sheltered and unsheltered areas in Mauritius was estimated using the Bray-Curtis similarity.The checklist featured 117 species belonging to 61 genera and 28families,of which 13 are new records.The findings increased the knowledge of opisthobranch diversity from the Mauritius by 15.4%.Among the listed species,the distribution range of Cyerce nigra,Actinocyclus papillatus,and Phyllidia picta extended from the Western Pacific to the South Western Indian Ocean.Molecular analysis of the undescribed Gymnodoris sp.showed it resembled Gymnodoris sp.from Hawaii and were different by a genetic distance value of 10.6%.The species richness and evenness were higher within the sheltered regions of Mauritius which harboured the food resource of opisthobranch.These areas as compared to unsheltered regions were heavily populated,suggesting the probable influence of wave actions on opisthobranch diversity and abundance.The order Nudibranchia was reported as most speciose,with 86 species.The Sacoglossa and Nudibranchia were observed only on macroalgae and sponges respectively.High abundance was also recorded on shipwrecks which are the most common form of artificial reefs.With the inclusion of observations from previous studies,201species belonging to 94 genera and 36 families are now known from the Mauritius.展开更多
Due to the complexity and variability of carbonate formation leakage zones, lost circulation prediction and control is one of the major challenges of carbonate drilling. It raises well-control risks and production exp...Due to the complexity and variability of carbonate formation leakage zones, lost circulation prediction and control is one of the major challenges of carbonate drilling. It raises well-control risks and production expenses. This research utilizes the H oilfield as an example, employs seismic features to analyze mud loss prediction, and produces a complete set of pre-drilling mud loss prediction solutions. Firstly, 16seismic attributes are calculated based on the post-stack seismic data, and the mud loss rate per unit footage is specified. The sample set is constructed by extracting each attribute from the seismic trace surrounding 15 typical wells, with a ratio of 8:2 between the training set and the test set. With the calibration results for mud loss rate per unit footage, the nonlinear mapping relationship between seismic attributes and mud loss rate per unit size is established using the mixed density network model.Then, the influence of the number of sub-Gausses and the uncertainty coefficient on the model's prediction is evaluated. Finally, the model is used in conjunction with downhole drilling conditions to assess the risk of mud loss in various layers and along the wellbore trajectory. The study demonstrates that the mean relative errors of the model for training data and test data are 6.9% and 7.5%, respectively, and that R2is 90% and 88%, respectively, for training data and test data. The accuracy and efficacy of mud loss prediction may be greatly enhanced by combining 16 seismic attributes with the mud loss rate per unit footage and applying machine learning methods. The mud loss prediction model based on the MDN model can not only predict the mud loss rate but also objectively evaluate the prediction based on the quality of the data and the model.展开更多
Research on the use of EHR is contradictory since it presents contradicting results regarding the time spent documenting. There is research that supports the use of electronic records as a tool to speed documentation;...Research on the use of EHR is contradictory since it presents contradicting results regarding the time spent documenting. There is research that supports the use of electronic records as a tool to speed documentation;and research that found that it is time consuming. The purpose of this quantitative retrospective before-after project was to measure the impact of using the laboratory value flowsheet within the EHR on documentation time. The research question was: “Does the use of a laboratory value flowsheet in the EHR impact documentation time by primary care providers (PCPs)?” The theoretical framework utilized in this project was the Donabedian Model. The population in this research was the two PCPs in a small primary care clinic in the northwest of Puerto Rico. The sample was composed of all the encounters during the months of October 2019 and December 2019. The data was obtained through data mining and analyzed using SPSS 27. The evaluative outcome of this project is that there is a decrease in documentation time after implementation of the use of the laboratory value flowsheet in the EHR. However, patients per day increase therefore having an impact on the number of patients seen per day/week/month. The implications for clinical practice include the use of templates to improve workflow and documentation as well as decreasing documentation time while also increasing the number of patients seen per day. .展开更多
Background and Aims While chest X-ray (CXR) has been a conventional tool in intensive care units (ICUs) to identify lung pathologies, computed tomography (CT) scan remains the gold standard. Use of lung ultrasound (LU...Background and Aims While chest X-ray (CXR) has been a conventional tool in intensive care units (ICUs) to identify lung pathologies, computed tomography (CT) scan remains the gold standard. Use of lung ultrasound (LUS) in resource-rich ICUs is still under investigation. The present study compares the utility of LUS to that of CXR in identifying pulmonary edema and pleural effusion in ICU patients. In addition, consolidation and pneumothorax were analyzed as secondary outcome measures. Material and Methods This is a prospective, single centric, observational study. Patients admitted in ICU were examined for lung pathologies, using LUS by a trained intensivist;and CXR done within 4 hours of each other. The final diagnosis was ascertained by an independent senior radiologist, based on the complete medical chart including clinical findings and the results of thoracic CT, if available. The results were compared and analyzed. Results Sensitivity, specificity and diagnostic accuracy of LUS was 95%, 94.4%, 94.67% for pleural effusion;and 98.33%, 97.78%, 98.00% for pulmonary edema respectively. Corresponding values with CXR were 48.33%, 76.67%, 65.33% for pleural effusion;and 36.67%, 82.22% and 64.00% for pulmonary edema respectively. Sensitivity, specificity and diagnostic accuracy of LUS was 91.30%, 96.85%, 96.00% for consolidation;and 100.00%, 79.02%, 80.00% for pneumothorax respectively. Corresponding values with CXR were 60.87%, 81.10%, 78.00% for consolidation;and 71.3%, 97.20%, 96.00% for pneumothorax respectively. Conclusion LUS has better diagnostic accuracy in diagnosis of pleural effusion and pulmonary edema when compared with CXR and is thus recommended as an effective alternative for diagnosis of these conditions in acute care settings. Our study recommends that a thoracic CT scan can be avoided in most of such cases.展开更多
文摘^(177)Lu标记的前列腺特异性膜抗原(prostate specific membrane antigen,PSMA)放射性配体疗法已在国外获批应用于晚期前列腺癌治疗,且正在国内开展多项临床试验。专家组参考国外经验和观点,并结合国内临床实践和实测数据,形成^(177)Lu-PSMA放射性配体疗法在前列腺癌临床应用中的专家共识。
文摘由于现有协议的安全性为基于某种安全假设的计算安全,依赖于敌手的计算能力,因此,本文针对恶意敌手模型,使用矩阵伪装技术对方程的系数矩阵进行隐藏,结合矩阵的LU分解(lower-upper decomposition)算法,提出一种新的信息论安全外包求解线性代数方程组(information-theoretically secure outsourcing of linear algebraic equations,ITS-OutsLAE)方法 .与之前的研究相比,在保持计算和通信复杂度与现有最优方案保持一致的同时,首次将方程组唯一解的安全性提升至信息论安全(完美保密).给出了形式化的安全性证明,并通过理论分析和实验证明了所提方法的实用性.
基金supported by Major Program of the National Natural Science Foundation of China (42192535)。
文摘For the reduction of atmospheric effects,observed gravity has initially been corrected by using the computed barometric admittance k of the in situ measured pressure,expressed in nms-2/hPa units and estimated by least squares method.However,the local pressure changes alone cannot account for the atmospheric mass attraction and loading when the coherent pressure field exceeds a specific size,i.e.,with increasing periodicities.To overcome this difficulty,it is necessary to compute the total atmospheric effect at each station using the global pressure field.However,the direct subtraction of the total gravity effect,provided by the models of pressure correction,is not yet satisfactory for S2 and other tidal components,such as K2 and P1,which include solar heating pressure tides.This paper identifies the origin of the problem and presents strategies to obtain a satisfactory solution.First,we set up a difference vector between the tidal factors of M2 and S2 after correction of the pressure and ocean tides effects.This vector,hereafter denoted as RES,presents the advantage of being practically insensitive to calibration errors.The minimum discrepancy between the tidal parameters of M2 and S2 corresponds to the minimum of the RES vector norm d.Secondly we adopt the hybrid pressure correction method,separating the local and the global pressure contribution of the models and replacing the local contribution by the pressure measured at the station multiplied by an admittance kATM.We tested this procedure on 8 stations from the IGETS superconducting gravimeters network(former GGP network).For stations at an altitude lower than 1000 m,the value of dopt is always smaller than0.0005.The discrepancy between the tidal parameters of the M2 and S2 waves is always lower than0.05% on the amplitude factors and 0.025° on the phases.For these stations,a correlation exists between the altitude and the value kopt.The results at the three Central European stations Conrad,Pecny and Vienna are in excellent agreement(0.05%) with the DDW99NH model for all the main tidal waves.
基金supported by the National Natural Science Foundation of China(31801409)the Safe Preservation and Accurate Identification of Flax Germplasm Resources in South,China(23ZH174)+2 种基金the Construction of Modern Agricultural Industrial Technology System,China(CARS-16-E01)the Protection and Utilization of Crop Germplasm Resources,China(2016NWB044)the National Science and Technology Resource Sharing Service Platform Project,China(NCGRC-2020-15)。
文摘Flax is a crucial fiber crop that exhibits excellent textile properties and serves as a model plant for investigating phloem fiber development. The regulation of multiple genes significantly influences fiber development, notably involving NAC(NAM, ATAF1/2, CUC2) transcription factors in forming the fiber secondary cell wall(SCW).Overexpression of LuNAC61 in flax resulted in sparse top meristematic zone leaves and significantly reduced stem cellulose content. Scanning electron microscopy and staining observations revealed a significant reduction in fiber bundles. β-Glucuronidase(GUS) staining analysis demonstrated high activity of the LuNAC61 promoter in the bast fibers of the flax stem. Additionally, several members of the LuPLATZ and LuCesA families exhibited significant coexpression with LuNAC61. Subcellular localization indicated the presence of LuPLATZ24 protein in the nucleus and cytoplasm, LuNAC61 protein exclusively in the nucleus, and LuCesA10 in the nucleus and endoplasmic reticulum. LuPLATZ24 positively regulates LuNAC61, whereas LuNAC61 negatively affects LuCesA10, suggesting the involvement of a metabolic network in regulating flax fiber development. In conclusion, this study provides a critical opportunity for a comprehensive and in-depth analysis of the mechanisms governing flax fiber development and the potential use of biotechnology to enhance flax fiber yield.
文摘Three new records from Vietnam,Phlegmariurus guangdongensis Ching,Adiantum longzhouensis A.H.Wang,F.G.Wang&F.W.Xing,and Lepisorus bicolor Ching,are reported.The identification characteristics,information of specimen,and geographical distribution of the species are described.The discovery of new records not only enriches the study of plant diversity in Vietnam,but also provides important information for biodiversity conservation and botanical research in the region.The voucher specimens are kept in the Herbarium of Kunming Institute of Botany,Chinese Academy of Sciences(KUN),Herbarium of Institute of Botany,Chinese Academy of Sciences(PE)and Herbarium of Guangxi Forestry Research Institute(GXFI).
文摘Island ecosystems support diverse aquatic invertebrate communities comprising endemic taxa.Documentation of existing species is important for conservation.In this study,a checklist of marine opisthobranch from the Republic of Mauritius is presented.A combination of benthic surveys(50 m×5 m in triplicates),rover diving techniques and photo documentation were used over two years(2018–2020)within 35 sheltered and unsheltered lagoons.Morphological and molecular analysis were used for identification.Species composition within sheltered and unsheltered areas in Mauritius was estimated using the Bray-Curtis similarity.The checklist featured 117 species belonging to 61 genera and 28families,of which 13 are new records.The findings increased the knowledge of opisthobranch diversity from the Mauritius by 15.4%.Among the listed species,the distribution range of Cyerce nigra,Actinocyclus papillatus,and Phyllidia picta extended from the Western Pacific to the South Western Indian Ocean.Molecular analysis of the undescribed Gymnodoris sp.showed it resembled Gymnodoris sp.from Hawaii and were different by a genetic distance value of 10.6%.The species richness and evenness were higher within the sheltered regions of Mauritius which harboured the food resource of opisthobranch.These areas as compared to unsheltered regions were heavily populated,suggesting the probable influence of wave actions on opisthobranch diversity and abundance.The order Nudibranchia was reported as most speciose,with 86 species.The Sacoglossa and Nudibranchia were observed only on macroalgae and sponges respectively.High abundance was also recorded on shipwrecks which are the most common form of artificial reefs.With the inclusion of observations from previous studies,201species belonging to 94 genera and 36 families are now known from the Mauritius.
基金the financially supported by the National Natural Science Foundation of China(Grant No.52104013)the China Postdoctoral Science Foundation(Grant No.2022T150724)。
文摘Due to the complexity and variability of carbonate formation leakage zones, lost circulation prediction and control is one of the major challenges of carbonate drilling. It raises well-control risks and production expenses. This research utilizes the H oilfield as an example, employs seismic features to analyze mud loss prediction, and produces a complete set of pre-drilling mud loss prediction solutions. Firstly, 16seismic attributes are calculated based on the post-stack seismic data, and the mud loss rate per unit footage is specified. The sample set is constructed by extracting each attribute from the seismic trace surrounding 15 typical wells, with a ratio of 8:2 between the training set and the test set. With the calibration results for mud loss rate per unit footage, the nonlinear mapping relationship between seismic attributes and mud loss rate per unit size is established using the mixed density network model.Then, the influence of the number of sub-Gausses and the uncertainty coefficient on the model's prediction is evaluated. Finally, the model is used in conjunction with downhole drilling conditions to assess the risk of mud loss in various layers and along the wellbore trajectory. The study demonstrates that the mean relative errors of the model for training data and test data are 6.9% and 7.5%, respectively, and that R2is 90% and 88%, respectively, for training data and test data. The accuracy and efficacy of mud loss prediction may be greatly enhanced by combining 16 seismic attributes with the mud loss rate per unit footage and applying machine learning methods. The mud loss prediction model based on the MDN model can not only predict the mud loss rate but also objectively evaluate the prediction based on the quality of the data and the model.
文摘Research on the use of EHR is contradictory since it presents contradicting results regarding the time spent documenting. There is research that supports the use of electronic records as a tool to speed documentation;and research that found that it is time consuming. The purpose of this quantitative retrospective before-after project was to measure the impact of using the laboratory value flowsheet within the EHR on documentation time. The research question was: “Does the use of a laboratory value flowsheet in the EHR impact documentation time by primary care providers (PCPs)?” The theoretical framework utilized in this project was the Donabedian Model. The population in this research was the two PCPs in a small primary care clinic in the northwest of Puerto Rico. The sample was composed of all the encounters during the months of October 2019 and December 2019. The data was obtained through data mining and analyzed using SPSS 27. The evaluative outcome of this project is that there is a decrease in documentation time after implementation of the use of the laboratory value flowsheet in the EHR. However, patients per day increase therefore having an impact on the number of patients seen per day/week/month. The implications for clinical practice include the use of templates to improve workflow and documentation as well as decreasing documentation time while also increasing the number of patients seen per day. .
文摘Background and Aims While chest X-ray (CXR) has been a conventional tool in intensive care units (ICUs) to identify lung pathologies, computed tomography (CT) scan remains the gold standard. Use of lung ultrasound (LUS) in resource-rich ICUs is still under investigation. The present study compares the utility of LUS to that of CXR in identifying pulmonary edema and pleural effusion in ICU patients. In addition, consolidation and pneumothorax were analyzed as secondary outcome measures. Material and Methods This is a prospective, single centric, observational study. Patients admitted in ICU were examined for lung pathologies, using LUS by a trained intensivist;and CXR done within 4 hours of each other. The final diagnosis was ascertained by an independent senior radiologist, based on the complete medical chart including clinical findings and the results of thoracic CT, if available. The results were compared and analyzed. Results Sensitivity, specificity and diagnostic accuracy of LUS was 95%, 94.4%, 94.67% for pleural effusion;and 98.33%, 97.78%, 98.00% for pulmonary edema respectively. Corresponding values with CXR were 48.33%, 76.67%, 65.33% for pleural effusion;and 36.67%, 82.22% and 64.00% for pulmonary edema respectively. Sensitivity, specificity and diagnostic accuracy of LUS was 91.30%, 96.85%, 96.00% for consolidation;and 100.00%, 79.02%, 80.00% for pneumothorax respectively. Corresponding values with CXR were 60.87%, 81.10%, 78.00% for consolidation;and 71.3%, 97.20%, 96.00% for pneumothorax respectively. Conclusion LUS has better diagnostic accuracy in diagnosis of pleural effusion and pulmonary edema when compared with CXR and is thus recommended as an effective alternative for diagnosis of these conditions in acute care settings. Our study recommends that a thoracic CT scan can be avoided in most of such cases.
