With widely availed clinically used radionuclides,Cer enkov luminescence imaging(CLI)has become a potential tool in the field of optical molecular imaging.However,the impulse noises introduced by high-energy gamma ray...With widely availed clinically used radionuclides,Cer enkov luminescence imaging(CLI)has become a potential tool in the field of optical molecular imaging.However,the impulse noises introduced by high-energy gamma rays that are generated during the decay of radionuclide reduce the image quality significantly,which affects the acauracy of quantitative analysis,as well as the three dimensional reconstruction.In this work,a novel denoising framework based on fuzzy dlustering and curvat ure driven difusion(CDD)is proposed to remove this kind of impulse noises.To improve the accuracy,the F u1zzy Local Information C-Means algorithm,where spatial information is evolved,is used.We evaluate the per formance of the proposed framework sys-tematically with a series of experiments,and the corresponding results demonstrate a better denoising effect than those from the commonly used median filter method.We hope this work may provide a useful data pre processing tool for CLI and its following studies.展开更多
The efficient production of high-quality scintillators with long radioluminescence afterglow is crucial for high-performance X-ray luminescence extension imaging.However,scaling-up the synthesis of ligand-free scintil...The efficient production of high-quality scintillators with long radioluminescence afterglow is crucial for high-performance X-ray luminescence extension imaging.However,scaling-up the synthesis of ligand-free scintillators to fabricate large-area X-ray imaging screens for industrial applications remains a challenge.In this study,we report an efficient method to synthesize ligand-free,lanthanide-doped microscintillators by a one-pot reaction via the concentrated hydrothermal method.The as-synthesized microscintillators exhibit prolonged persistent radioluminescence for up to 30 days after X-ray exposure and remain high stability in air or water for more than 18 months without deterioration.Monte Carlo simulations indicate that the size effect is responsible for the excellent afterglow performance of the microscintillators.We employ these high-quality lanthanide-doped microscintillators to fabricate a large-area X-ray imaging detector using a blade-coating method,a spatial resolution of 24.9 lp/mm for X-ray imaging.Our study offers a solution for scaling-up the synthesis of low-cost microscintillators for practical applications.展开更多
The current work is focused on the study of optical clearing of skeletal muscles under local compression.The experiments were performed on in vitro bovine skeletal muscle.The time dependence of optical clearing was st...The current work is focused on the study of optical clearing of skeletal muscles under local compression.The experiments were performed on in vitro bovine skeletal muscle.The time dependence of optical clearing was studied by monitoring the luminescence intensity of NaYF_(4)∶Er,Yb upconverting particles located under tissue layers.This study shows the possibility to use upconverting nanoparticles(UCNPs)both for studying the dynamics of the optical clearing of biological tissue under compression and to detect moments of cell wall damage under excessive pressure.The advantage of using UCNPs is the presence of several bands in their luminescence spectra,located both at close wavelengths and far apart.展开更多
Organic room-temperature phosphorescence(RTP)materials have been used in high-resolution imaging.However,the development of long-wavelength-emis sion RTP materials in aqueous solution remains a challenge.Here,we repor...Organic room-temperature phosphorescence(RTP)materials have been used in high-resolution imaging.However,the development of long-wavelength-emis sion RTP materials in aqueous solution remains a challenge.Here,we report red-emissive RTP materials via integration of the ring-fusing effect and host–guest interaction.展开更多
Developing scintillators with high light yield(LY),superior irradiation stability,and weak afterglow is of significance for the realization of low-dose high-resolution X-ray excited optical luminescence(XEOL)imaging.L...Developing scintillators with high light yield(LY),superior irradiation stability,and weak afterglow is of significance for the realization of low-dose high-resolution X-ray excited optical luminescence(XEOL)imaging.Lanthanide doped fluoride nanoparticles possess low toxicity,superior environmental stability,facial fabrication process,and tunable emissions,which are appropriate candidates for the next generation nanoscintillators(NSs).However,the low LY and strong positive hysteresis greatly restrict their practical application.Here,we propose an effective strategy that engineers energy gap to significantly enhance the LY.Our results verify that the tetragonal LiLuF4 host benefits the crystal level splitting of Tb^(3+)ions,which greatly promotes the electrons population on the Tb^(3+):5D4 level followed by the enhanced LY.The LY of LiLuF4:Tb@LiLuF4 NSs is calculated to be~31,169 photons/MeV,which is much higher than the lead halide perovskite colloidal CsPbBr3(~21,000 photons/MeV)and LuAG:Ce(~22,000 photons/MeV)scintillators.Moreover,the positive hysteresis is remarkably restricted after coating a thin shell.The X-ray detection limit and spatial resolution are measured to be~21.27 nGy/s and~7.2 lp/mm,respectively.We further verify that this core/shell NS can be employed as scintillating screen to realize XEOL imaging under the low dose rate of 13.86μGy/s.Our results provide an effective route to develop high performance NSs,which will promote great opportunities for the development of low-dose high-resolution XEOL imaging devices.展开更多
Bioimaging,as a powerful and helpful tool,which allows people to investigate deeply within living organisms,has contributed a lot for both clinical theranostics and scientific research.Pure organic room temperature ph...Bioimaging,as a powerful and helpful tool,which allows people to investigate deeply within living organisms,has contributed a lot for both clinical theranostics and scientific research.Pure organic room temperature phosphorescence(RTP)materials with the unique features of ultralong luminescence lifetime and large Stokes shift,can efficiently avoid biological autofluorescence and scattered light through a time-resolved imaging modality,and thus are attracting increasing attention.This review classifies pure organic RTP materials into three categories,including small molecule RTP materials,polymer RTP materials and supramolecular RTP materials,and summarizes the recent advances of pure organic RTP materials for bioimaging applications.展开更多
Persistent luminescence nanoparticles (PLNPs) and upconversion nanoparticles (UCNPs) are two special optical imaging nanoprobes. In this study, efficient upconverted persistent luminescence (UCPL) is realized by...Persistent luminescence nanoparticles (PLNPs) and upconversion nanoparticles (UCNPs) are two special optical imaging nanoprobes. In this study, efficient upconverted persistent luminescence (UCPL) is realized by combining their unique features into polymethyl methacrylate, forming a film composed of both PLNPs and UCNPs. The red persistent luminescence (-640 nm) of the PLNPs (CaS:Eu,Tm, Ce) can be activated by upconverted green emission of UCNPs (-NaYF4:Yb, Er@NaYF4) excited by near-infrared light (NIR). Using this strategy, both the unique optical properties of PLNPs and UCNPs can be optimally synergized, thus generating efficient upconversion, photoluminescence, and UCPL simultaneously. The UCPL system has potential applications in in vivo bioimaging by simply monitoring the biocompatible low power density of NIR-light-excited persistent luminescence. Due to its simplicity, we anticipate that this method for the preparation of UCPL composite can be easily adjusted using other available upconversion and persistent phosphor pairs for a number of biophotonic and photonic applications.展开更多
基金the Program of the National Natural Science Foundation of China under Grant Nos.61701403,61601363,11571012,61372046 and 61640418the Natural Science Basic Research Plan in Shaanxi Province of China under Grant Nos.2017JQ6006 and 2017JQ6017.
文摘With widely availed clinically used radionuclides,Cer enkov luminescence imaging(CLI)has become a potential tool in the field of optical molecular imaging.However,the impulse noises introduced by high-energy gamma rays that are generated during the decay of radionuclide reduce the image quality significantly,which affects the acauracy of quantitative analysis,as well as the three dimensional reconstruction.In this work,a novel denoising framework based on fuzzy dlustering and curvat ure driven difusion(CDD)is proposed to remove this kind of impulse noises.To improve the accuracy,the F u1zzy Local Information C-Means algorithm,where spatial information is evolved,is used.We evaluate the per formance of the proposed framework sys-tematically with a series of experiments,and the corresponding results demonstrate a better denoising effect than those from the commonly used median filter method.We hope this work may provide a useful data pre processing tool for CLI and its following studies.
基金the National Key Research&Development Program of China(Nos.2020YFA0709900,2020YFA0210800)the National Natural Science Foundation of China(Nos.22027805,62134003,22104016)+1 种基金the Natural Science Foundation of Fujian Province(Nos.2022J01709,2023J01384)the Major Project of Science and Technology of Fujian Province(No.2020HZ06006)。
文摘The efficient production of high-quality scintillators with long radioluminescence afterglow is crucial for high-performance X-ray luminescence extension imaging.However,scaling-up the synthesis of ligand-free scintillators to fabricate large-area X-ray imaging screens for industrial applications remains a challenge.In this study,we report an efficient method to synthesize ligand-free,lanthanide-doped microscintillators by a one-pot reaction via the concentrated hydrothermal method.The as-synthesized microscintillators exhibit prolonged persistent radioluminescence for up to 30 days after X-ray exposure and remain high stability in air or water for more than 18 months without deterioration.Monte Carlo simulations indicate that the size effect is responsible for the excellent afterglow performance of the microscintillators.We employ these high-quality lanthanide-doped microscintillators to fabricate a large-area X-ray imaging detector using a blade-coating method,a spatial resolution of 24.9 lp/mm for X-ray imaging.Our study offers a solution for scaling-up the synthesis of low-cost microscintillators for practical applications.
基金This work was supported by the Russian Science Foundation,project no.19-12-00118.
文摘The current work is focused on the study of optical clearing of skeletal muscles under local compression.The experiments were performed on in vitro bovine skeletal muscle.The time dependence of optical clearing was studied by monitoring the luminescence intensity of NaYF_(4)∶Er,Yb upconverting particles located under tissue layers.This study shows the possibility to use upconverting nanoparticles(UCNPs)both for studying the dynamics of the optical clearing of biological tissue under compression and to detect moments of cell wall damage under excessive pressure.The advantage of using UCNPs is the presence of several bands in their luminescence spectra,located both at close wavelengths and far apart.
基金supported by the National Natural Scientific Foundation of China(grant nos.21975021,51803009,21905021,51673024,21975020,and 21875019)supported by Beijing National Laboratory for Molecular Sciences(no.BNLMS202007),China Postdoctoral Science Foundation 2019TQ0034.
文摘Organic room-temperature phosphorescence(RTP)materials have been used in high-resolution imaging.However,the development of long-wavelength-emis sion RTP materials in aqueous solution remains a challenge.Here,we report red-emissive RTP materials via integration of the ring-fusing effect and host–guest interaction.
基金supported by Zhejiang Provincial Natural Science Foundation of China(No.LZ21A040002)the National Natural Science Foundation of China(Nos.52172164 and 51872270)+1 种基金the National Natural Science Foundation of China Joint Fund Project(No.U190920054)the Project funded by China Postdoctoral Science Foundation(No.2022T150582).
文摘Developing scintillators with high light yield(LY),superior irradiation stability,and weak afterglow is of significance for the realization of low-dose high-resolution X-ray excited optical luminescence(XEOL)imaging.Lanthanide doped fluoride nanoparticles possess low toxicity,superior environmental stability,facial fabrication process,and tunable emissions,which are appropriate candidates for the next generation nanoscintillators(NSs).However,the low LY and strong positive hysteresis greatly restrict their practical application.Here,we propose an effective strategy that engineers energy gap to significantly enhance the LY.Our results verify that the tetragonal LiLuF4 host benefits the crystal level splitting of Tb^(3+)ions,which greatly promotes the electrons population on the Tb^(3+):5D4 level followed by the enhanced LY.The LY of LiLuF4:Tb@LiLuF4 NSs is calculated to be~31,169 photons/MeV,which is much higher than the lead halide perovskite colloidal CsPbBr3(~21,000 photons/MeV)and LuAG:Ce(~22,000 photons/MeV)scintillators.Moreover,the positive hysteresis is remarkably restricted after coating a thin shell.The X-ray detection limit and spatial resolution are measured to be~21.27 nGy/s and~7.2 lp/mm,respectively.We further verify that this core/shell NS can be employed as scintillating screen to realize XEOL imaging under the low dose rate of 13.86μGy/s.Our results provide an effective route to develop high performance NSs,which will promote great opportunities for the development of low-dose high-resolution XEOL imaging devices.
基金This work was supported by the National Natural Science Foundation of China(Nos.21871060,21864020)the Grassland Talent Program of Inner Mongolia Autonomous Region of China,the Natural Science Foundation of Inner Mongolia Autonomous Region of China(Nos.2020JQ02,2020MS02004)the Natural Science Foundation of Jiangxi Province of China(No.20192BCBL23013).
文摘Bioimaging,as a powerful and helpful tool,which allows people to investigate deeply within living organisms,has contributed a lot for both clinical theranostics and scientific research.Pure organic room temperature phosphorescence(RTP)materials with the unique features of ultralong luminescence lifetime and large Stokes shift,can efficiently avoid biological autofluorescence and scattered light through a time-resolved imaging modality,and thus are attracting increasing attention.This review classifies pure organic RTP materials into three categories,including small molecule RTP materials,polymer RTP materials and supramolecular RTP materials,and summarizes the recent advances of pure organic RTP materials for bioimaging applications.
文摘Persistent luminescence nanoparticles (PLNPs) and upconversion nanoparticles (UCNPs) are two special optical imaging nanoprobes. In this study, efficient upconverted persistent luminescence (UCPL) is realized by combining their unique features into polymethyl methacrylate, forming a film composed of both PLNPs and UCNPs. The red persistent luminescence (-640 nm) of the PLNPs (CaS:Eu,Tm, Ce) can be activated by upconverted green emission of UCNPs (-NaYF4:Yb, Er@NaYF4) excited by near-infrared light (NIR). Using this strategy, both the unique optical properties of PLNPs and UCNPs can be optimally synergized, thus generating efficient upconversion, photoluminescence, and UCPL simultaneously. The UCPL system has potential applications in in vivo bioimaging by simply monitoring the biocompatible low power density of NIR-light-excited persistent luminescence. Due to its simplicity, we anticipate that this method for the preparation of UCPL composite can be easily adjusted using other available upconversion and persistent phosphor pairs for a number of biophotonic and photonic applications.