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Computed tomography fluoroscopy guided percutaneous lung biopsy for ground-glass opacity pulmonary lesions:A meta-analysis 被引量:2
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作者 Gao-Wu Yan Gao-Wen Yan +6 位作者 Qin-Quan Sun Xiang-Ke Niu Bing Li Anup Bhetuwal Xiao-Xue Xu Yong Du Han-Feng Yang 《World Journal of Meta-Analysis》 2016年第2期55-62,共8页
AIM: To obtain the diagnostic performance of percu-taneous transthoracic needle biopsy (PTNB) under Computed tomography (CT) fuoroscopy guidance for lung ground-glass opacity (GGO).METHODS: We searched for Eng... AIM: To obtain the diagnostic performance of percu-taneous transthoracic needle biopsy (PTNB) under Computed tomography (CT) fuoroscopy guidance for lung ground-glass opacity (GGO).METHODS: We searched for English- and Chinese-language studies in PubMed, EMBASE, EBSCO, OVID, and CNKI (China National Knowledge Infrastructure) database. Data were calculated with Meta-Disc version 1.4 and Rev Man version 5.2 software. From the pooled data, we calculated sensitivity (Sen), specificity (Spe), positive likelihood ratio (+LR), negative likelihood ratio (-LR), and diagnostic odds ratio (DOR). Summary receiver operating characteristic (SROC) curves were constructed and incidence of complications was recorded.RESULTS: Four documents included in this present meta-analysis met the criteria for analysis. The pooled Sen, Spe, +LR, -LR and DOR with 95%CI were 0.91 (0.86-0.95), 1.0 (0.91-1.0), 18.64 (4.83-71.93), 0.11 (0.05-0.26) and 153.17 (30.78-762.33), respectively. The area under the SROC curve was 0.98. The incidence of pneumothorax and hemoptysis was 17.86%-51.80% and 10.50%-19.40%, respectively.CONCLUSION: CT fuoroscopy-guided PTNB, which has an acceptable incidence of complications, can be used as a primary examination method for lung GGO, with moderate sensitivity and specifcity. 展开更多
关键词 lung biopsy META-ANALYSIS ground-glass opacity Computed tomography fuoroscopy
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Evaluating the Growth of Pulmonary Nodular Ground-glass Opacity on CT: Comparison of Volume Rendering and Thin Slice Images
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作者 梁明柱 柳学国 +5 位作者 李伟栋 李坤炜 陈相猛 王国杰 陈凯 张晋昕 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2011年第6期846-851,共6页
This study examined the value of volume rendering (VR) interpretation in assessing the growth of pulmonary nodular ground-glass opacity (nGGO). A total of 47 nGGOs (average size, 9.5 mm; range, 5.7-20.6 mm) were... This study examined the value of volume rendering (VR) interpretation in assessing the growth of pulmonary nodular ground-glass opacity (nGGO). A total of 47 nGGOs (average size, 9.5 mm; range, 5.7-20.6 mm) were observed by CT scanning at different time under identical parameter settings. The growth of nGGO was analyzed by three radiologists by comparing the thin slice (TS) CT images of initial and repeat scans with side-by-side cine mode. One week later synchronized VR images of the two scans were compared by side-by-side cine mode to evaluate the nGGO growth. The nodule growth was rated on a 5-degree scale: notable growth, slight growth, dubious growth, stagnant growth, shrinkage. Growth standard was defined as: Density increase 〉 30 HU and (or) diameter increase (by 20% in nodules 〉_10 mm, 30% in nodules of 5-9 mm). Receiver operating characteristic (ROC) was performed. The results showed that 32 nGGOs met the growth criteria (29 nGGOs showed an increase in density; 1 nGGO showed an increase in diameter; 2 nGGOs showed an increase in both diameter and density). Area under ROC curve revealed that the performance with VR interpretation was better than that with TS interpretation (P〈0.01, P〈0.05 and P〈0.05 for observers A, B and C respectively). Consistency between different observers was excellent with both VR interpretation (κ=0.89 for observers A&C A&B, B&C) and TS interpretation (κ=0.71 for A&B, κ=0.68 for A&C, κ=0.74 for B&C), but time spending was less with VR interpretation than with TS interpretation (P〈0.0001, P〈0.0001 and P〈0.05 for observers A, B and C, respectively). It was concluded that VR is a useful technique for evaluating the growth of nGGO. 展开更多
关键词 computed tomography ground-glass opacity pulmonary nodule GROWTH volume rendering
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Which surgery for ground glass opacity lung nodules?
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作者 Sara Ricciardi Federico Davini +6 位作者 Greta Alì Annalisa De Liperi Agnese Nesti Carmelina C.Zirafa Gaetano Romano Gabriella Fontanini Franca M.A.Melfi 《临床与病理杂志》 CAS 2021年第7期1483-1489,共7页
Objective:Pulmonary ground glass opacity(GGO)nodules represent a significant dilemma in oncology since its diagnosis in clinical practice has increased because of growing application of low dose computed tomography an... Objective:Pulmonary ground glass opacity(GGO)nodules represent a significant dilemma in oncology since its diagnosis in clinical practice has increased because of growing application of low dose computed tomography and screening program.The aim of this study is to analyze the clinical and pathological features,the overall survival(OS)and disease-free interval(DFI)in surgically resected solitary ground glass nodules in order to assess the surgical treatment of choice.Methods:We retrospectively analyzed 49 patients(M/F=25/24)with a mean age of 67.7(range,40-81)years who underwent lung resection for solitary GGO nodules among 570 reviewed CT of patients who were treated for lung neoplasms between 2010 and 2016.The cohort included 22 pure GGO nodules and 27 part solid GGOs(also called mixed GGOs).Results:Median maximum diameter of GGOs,defined as the largest axial diameter of the lesion on the lung-window setting,was 17(range,5-30)mm.GGO nodules were removed by wedge resection,segmentectomy,or lobectomy in 17(35%),9(18%),and 23(47%)cases,respectively.Pathologic diagnosis was atypical adenomatous hyperplasia(AAH),adenocarcinoma in situ(AIS),minimally invasive adenocarcinoma(MIA),invasive adenocarcinoma(IA)or multifocal adenocarcinoma(MAC)in 4(8.2%),9(18.4%),11(22.4%),22(44.9%)and 3(6.1%)cases,respectively.With a median follow up of 47 months the OS and DFI of the entire cohort was 46.3 and 43 months,respectively.The histotype(P=0.008),the dimension of GGO(P=0.014)and the PET-SUV max(P=0.001)were independent prognostic factors of worse survival.Sex,age,previous lung surgery,type of surgical resection and the mediastinal lymph-node evaluation did not impact on OS and DFI.Analyzing the 22 pure GGO nodules,we found a 3-year OS and DFI of 98%and 100%respectively,significantly different from 80%and 75%respectively of part-solid GGOs(log-rank P=0.043 and P=0.011).Conclusion:Our data suggest an indolent behaviour of tumour presenting as solitary GGO nodules,especially in case of pure GGOs.In our series wedge resections guarantee the same results in terms of OS and DFI when compared to lobectomies.Sublobar resections without mediastinal lymph-nodes evaluation represent the treatment of choice for pure-GGO.More studies are needed to assess its role for part-solid GGO nodules. 展开更多
关键词 ground glass opacity GGN non-small cell lung cancer SURGERY
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Circulating tumor cells with epithelial-mesenchymal transition markers as potential biomarkers for the diagnosis of lung cancer 被引量:1
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作者 Sha-Sha Jiang Chun-Guo Mao +4 位作者 Yong-Geng Feng Bin Jiang Shao-Lin Tao Qun-You Tan Bo Deng 《World Journal of Clinical Cases》 SCIE 2021年第12期2721-2730,共10页
BACKGROUND Circulating tumor cells(CTCs) can be clustered into three subtypes according to epithelial-mesenchymal transition(EMT) markers: CTCs with epithelial markers(E-CTCs), CTCs with mesenchymal markers(M-CTCs), a... BACKGROUND Circulating tumor cells(CTCs) can be clustered into three subtypes according to epithelial-mesenchymal transition(EMT) markers: CTCs with epithelial markers(E-CTCs), CTCs with mesenchymal markers(M-CTCs), and CTCs with both markers(E&M-CTCs). CTC detection has clinical implications in the diagnosis of lung cancer(LC).AIM To clarify the diagnostic value of CTCs categorized by EMT markers in LC.METHODS The study included 106 patients with lung adenocarcinoma, including 42 groundglass opacities(GGO) and 64 solid lesions, who underwent surgery between July 2015 and December 2019. Eleven patients with benign tumors and seventeen healthy controls were included. CTCs in peripheral blood and associated EMT markers were detected preoperatively using the CanPatrol TM technique. The diagnostic power of CTCs for discriminating LC cases from controls was analyzed by the receiver operating characteristic(ROC) curve. The CytoploRare technique was used in 20 cases and 18 controls for validation, and Kappa values were calculated to evaluate consistency between techniques.RESULTS Of the 106 LC cases, 94(89.6%) had at least one CTC. CTCs were detectable in 35(83.3%) of 42 GGO cases. Total CTCs and E&M-CTCs were significantly more frequent in LC cases than in benign or healthy controls. The proportion of MCTCs plus E&M-CTCs increased gradually from healthy controls, to benign controls, to LC cases. The area under the ROC curve of total CTCs and E&M-CTCs was > 0.8 and > 10.75, respectively. The combined sensitivity of total-CTCs and E&M-CTCs was 85.85% for LC patients(80.95% for GGO patients) and the specificity was 78.57%.The Kappa value was 0.415,indicating relative consistency between CanPatrol TM and CytoploRare.CONCLUSION CTC detection is valuable for distinguishing LC from controls,and particularly E&M-CTC detection warrants further study. 展开更多
关键词 Circulating tumor cells Epithelial-to-mesenchymal transition DIAGNOSIS lung cancer ground-glass opacities CanPatrol
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Evaluation of the dual vascular supply patterns in ground-glass nodules with a dynamic volume computed tomography 被引量:2
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作者 Chao Wang Ning Wu +2 位作者 Zhuang Zhang Lai-Xing Zhang Xiao-Dong Yuan 《World Journal of Radiology》 2022年第6期155-164,共10页
BACKGROUND In recent years,the detection rate of ground-glass nodules(GGNs)has been improved dramatically due to the popularization of low-dose computed tomography(CT)screening with high-resolution CT technique.This p... BACKGROUND In recent years,the detection rate of ground-glass nodules(GGNs)has been improved dramatically due to the popularization of low-dose computed tomography(CT)screening with high-resolution CT technique.This presents challenges for the characterization and management of the GGNs,which depends on a thorough investigation and sufficient diagnostic knowledge of the GGNs.In most diagnostic studies of the GGNs,morphological manifestations are used to differentiate benignancy and malignancy.In contrast,few studies are dedicated to the assessment of the hemodynamics,i.e.,perfusion parameters of the GGNs.AIM To assess the dual vascular supply patterns of GGNs on different histopathology and opacities.METHODS Forty-seven GGNs from 47 patients were prospectively included and underwent the dynamic volume CT.Histopathologic diagnoses were obtained within two weeks after the CT examination.Blood flow from the bronchial artery[bronchial flow(BF)]and pulmonary artery[pulmonary flow(PF)]as well as the perfusion index(PI)=[PF/(PF+BF)]were obtained using first-pass dual-input CT perfusion analysis and compared respectively between different histopathology and lesion types(pure or mixed GGNs)and correlated with the attenuation values of the lesions using one-way ANOVA,student’s t test and Pearson correlation analysis.RESULTS Of the 47 GGNs(mean diameter,8.17 mm;range,5.3-12.7 mm),30(64%)were carcinoma,6(13%)were atypical adenomatous hyperplasia and 11(23%)were organizing pneumonia.All perfusion parameters(BF,PF and PI)demonstrated no significant difference among the three conditions(all P>0.05).The PFs were higher than the BFs in all the three conditions(all P<0.001).Of the 30 GGN carcinomas,14 showed mixed GGNs and 16 pure GGNs with a higher PI in the latter(P<0.01).Of the 17 benign GGNs,4 showed mixed GGNs and 13 pure GGNs with no significant difference of the PI between the GGN types(P=0.21).A negative correlation(r=-0.76,P<0.001)was demonstrated between the CT attenuation values and the PIs in the 30 GGN carcinomas.CONCLUSION The GGNs are perfused dominantly by the PF regardless of its histopathology while the weight of the BF in the GGN carcinomas increases gradually during the progress of its opacification. 展开更多
关键词 ground-glass nodules Tomography X-ray computed lung cancer Perfusion computed tomography Dual blood supply
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Prognostic value of ground glass opacity on computed tomography in pathological stage I pulmonary adenocarcinoma: A meta-analysis
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作者 Xue-Lin Pan Zi-Ling Liao +4 位作者 Hui Yao Wei-Jie Yan De-Ying Wen Yan Wang Zhen-Lin Li 《World Journal of Clinical Cases》 SCIE 2021年第33期10222-10232,共11页
BACKGROUND The clinical role of ground glass opacity(GGO)on computed tomography(CT)in stage I pulmonary adenocarcinoma patients currently remains unclear.AIM To explore the prognostic value of GGO on CT in lung adenoc... BACKGROUND The clinical role of ground glass opacity(GGO)on computed tomography(CT)in stage I pulmonary adenocarcinoma patients currently remains unclear.AIM To explore the prognostic value of GGO on CT in lung adenocarcinoma patients who were pathologically diagnosed with tumor-node-metastasis stage I.METHODS A comprehensive and systematic search was conducted through the PubMed,EMBASE and Web of Science databases up to April 3,2021.The hazard ratio(HR)and corresponding 95%confidence interval(CI)were combined to assess the association between the presence of GGO and prognosis,representing overall survival and disease-free survival.Subgroup analysis based on the ratio of GGO was also conducted.STATA 12.0 software was used for statistical analysis.RESULTS A total of 12 studies involving 4467 patients were included.The pooled results indicated that the GGO predicted favorable overall survival(HR=0.44,95%CI:0.34-0.59,P<0.001)and disease-free survival(HR=0.35,95%CI:0.18-0.70,P=0.003).Subgroup analysis based on the ratio of GGO further demonstrated that the proportion of GGO was a good prognostic indicator in pathological stage I pulmonary adenocarcinoma patients,and patients with a higher ratio of GGO showed better prognosis than patients with a lower GGO ratio did.CONCLUSION This meta-analysis manifested that the presence of GGO on CT predicted favorable prognosis in tumor-node-metastasis stage I lung adenocarcinoma.Patients with a higher GGO ratio were more likely to have a better prognosis than patients with a lower GGO ratio. 展开更多
关键词 Ground glass opacity Stage I lung adenocarcinoma Prognosis Metaanalysis
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Clinical outcomes and lipid-laden macrophages in Electronic cigarette/Vaping product use-Associated Lung Injury(EVALI)in a South Texas population
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作者 Mahnoor Mir Moeezullah Beg +1 位作者 Jay I.Peters Sandra G.Adams 《Discussion of Clinical Cases》 2021年第1期1-6,共6页
Objective:To describe the clinical features,proportion of lipid-laden alveolar macrophages in bronchoalveolar lavage(BAL),and short-term and 6-month to 12-month outcomes of patients with Electronic cigarette/Vaping pr... Objective:To describe the clinical features,proportion of lipid-laden alveolar macrophages in bronchoalveolar lavage(BAL),and short-term and 6-month to 12-month outcomes of patients with Electronic cigarette/Vaping product use-Associated Lung Injury(EVALI).Methods:Retrospective review of clinical characteristics,radiographs,and BAL samples for all patients with a history of vaping who presented with acute hypoxemic respiratory failure to the University Hospital in San Antonio,Texas from 9/2019 to 6/2020 was performed.Results:We report 16 cases(15 men;median age,30 years[range 19-75])of EVALI with a history of vaping Tetrahydrocannabinol(THC),nicotine,or both.The most common presenting symptoms were tachycardia,dyspnea,cough,and fever.All patients required supplemental oxygen,including two who required noninvasive positive pressure ventilation,and five who required mechanical ventilation.All 16 patients had bilateral ground-glass opacities(GGO)with peripheral sparing on chest computerized tomography(CT).Cultures were negative,except for one patient who tested positive for rhinovirus.COVID-19 PCR was done in one individual which was negative.Cytology demonstrated lipid-laden macrophages on Oil-Red-O stain on fresh(i.e.,without fixative)BAL in the majority of patients(N=12)with a mean lipid-saturation percentage of 78%[range,44%-100%]and the mean Colombo count of 194[range,101-359].Fifteen patients were treated with systemic corticosteroids.The median length of hospital stay was 10 days.At discharge,three patients required supplemental oxygen.Eight of those who had follow-up imaging showed resolution of GGO.One patient had a relapse of symptoms and was again treated with systemic corticosteroids and mycophenolate,with resolution of symptoms.Fourteen patients who were evaluated after discharge denied vaping post-discharge(two patients were not able to be contacted and did not keep follow-up appointments).Conclusions:Successful diagnosis and management of EVALI requires a high clinical suspicion,thorough evaluation to rule out infectious etiologies,and aggressive treatment with systemic corticosteroids,along with sustained abstinence from vaping. 展开更多
关键词 EVALI Vaping Acute lung injury Lipid-laden macrophages Diffuse ground glass opacities
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基于AI的肺磨玻璃结节中医临床特点研究
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作者 刘言 安鹏 +4 位作者 侯海军 边灵杰 李雁 王林洋 王洪武 《吉林中医药》 2024年第2期188-191,共4页
目的通过客观、规范的方法分析肺磨玻璃中医临床特点,利用人工智能(AI)分析肺磨玻璃结节恶性风险,初步探究不同风险肺磨玻璃结节中医临床特点,为中医药干预肺结节提供参考。方法采集75例肺磨玻璃结节患者中医四诊信息,运用证素辨证方法... 目的通过客观、规范的方法分析肺磨玻璃中医临床特点,利用人工智能(AI)分析肺磨玻璃结节恶性风险,初步探究不同风险肺磨玻璃结节中医临床特点,为中医药干预肺结节提供参考。方法采集75例肺磨玻璃结节患者中医四诊信息,运用证素辨证方法提取证素;利用AI判读患者胸部CT,分析不同风险肺磨玻璃结节中医临床特点。结果肺磨玻璃结节患者中医证素以阴虚(77.33%)、气虚(56.00%)、阳虚(54.67%)、血虚(52.00%)等证素多见,亦可见痰(40.00%)、寒(37.33%)、气滞(32.00%)等实性证素;AI判读为高风险组较中低风险组气虚证素权值差异有统计学意义(P<0.05)。结论肺磨玻璃结节患者中医辨证以虚证为主,中医病机为气虚或气滞导致肺之气机不畅,引起局部痰、湿聚集于肺络而形成,而热证、瘀血证较少。 展开更多
关键词 肺磨玻璃结节 AI 中医 证素
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基于胸部薄层CT扫描的肺磨玻璃影病变“四分型法”在临床中的应用研究
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作者 苏雷 张毅 +5 位作者 高艳 王腾腾 李元博 张培龙 王雷明 魏秀芹 《中国临床新医学》 2024年第10期1114-1118,共5页
目的探讨基于胸部薄层CT扫描(TSCT)的肺磨玻璃影(GGO)病变“四分型法”在临床中的应用价值。方法回顾性分析2020年1月至2022年12月于首都医科大学宣武医院接受胸腔镜手术治疗的1541例患者的临床资料,共包含肺GGO病变2005例次。采用“四... 目的探讨基于胸部薄层CT扫描(TSCT)的肺磨玻璃影(GGO)病变“四分型法”在临床中的应用价值。方法回顾性分析2020年1月至2022年12月于首都医科大学宣武医院接受胸腔镜手术治疗的1541例患者的临床资料,共包含肺GGO病变2005例次。采用“四分型法”对肺GGO病变进行分型:Ⅰ型,无空泡征和(或)细支气管征的纯GGO(p-GGO);Ⅱ型,有空泡征和(或)细支气管征的p-GGO;Ⅲ型,仅在肺窗可见实性成分的异质性磨玻璃影(h-GGO);Ⅳ型,在肺窗和纵隔窗均可见实性成分的部分实性磨玻璃影(ps-GGO)。分析肺GGO病变影像学特征[最大径、病变类型、发生部位、分型、肿瘤实性成分占比(CTR)等]与术后病理检查结果的关联性。结果1541例患者自发现肺GGO至接受手术治疗的时间为0.10~156.00个月,平均11.23个月,其间肺GGO病变变化不明显1255例次(62.59%),最大径增大536例次(26.73%),密度增高45例次(2.24%),最大径增大伴密度增高169例次(8.43%)。术前肺GGO最大径为(13.21±7.90)mm;主要为单发病变[1098例次(54.76%)];多分布于右肺上叶[757例次(37.76%)]。肺GGO类型:Ⅰ型248例次(12.37%),Ⅱ型682例次(34.01%),Ⅲ型862例次(42.99%),Ⅳ型213例次(10.62%)。CTR≤25%有950例次(47.38%),25%<CTR≤50%有616例次(30.72%)、50%<CTR≤75%有314例次(15.66%),CTR>75%有125例次(6.23%)。肺GGO病变中,良性病变186例次(9.28%),恶性病变1819例次(90.72%),其中包括腺体前驱病变744例次,浸润期病变1075例次。分析结果显示,肺GGO病变术后病理检查结果与GGO最大径、病变类型、发生部位、分型、CTR及随访变化情况均存在关联性(P<0.05)。对应分析结果显示,与肺GGO病变CTR相比,肺GGO病变分型散点与术后病理恶性变[不典型腺瘤样增生(AAH)、原位腺癌(AIS)、微浸润腺癌(MIA)、浸润期腺癌(IA)]散点在二维分布图中更为接近,提示基于“四分型法”的肺GGO影像学特征与术后病理恶性变有更好的对应关系。结论基于TSCT的肺GGO病变“四分型法”有助于临床医师更好地评估以GGO为主要影像学表现的早期肺癌的风险度。 展开更多
关键词 肺磨玻璃影病变 胸部薄层CT扫描 四分型法 术后病理 肺癌
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利伐沙班桥接策略在抗血栓治疗的肺结节患者行经皮穿刺活检联合微波消融治疗中的应用
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作者 王楠 薛天宇 +1 位作者 徐静雯 叶欣 《现代肿瘤医学》 CAS 2024年第20期3879-3885,共7页
目的:评估利伐沙班作为桥接药物应用于正在进行抗血栓治疗的肺磨玻璃结节患者行经皮穿刺活检联合微波消融治疗的安全性及有效性。方法:本研究共纳入138例长期抗血栓治疗的肺磨玻璃结节患者,在2020年01月01日至2021年12月31日期间共进行... 目的:评估利伐沙班作为桥接药物应用于正在进行抗血栓治疗的肺磨玻璃结节患者行经皮穿刺活检联合微波消融治疗的安全性及有效性。方法:本研究共纳入138例长期抗血栓治疗的肺磨玻璃结节患者,在2020年01月01日至2021年12月31日期间共进行了138次CT引导下同步经皮穿刺活检联合微波消融治疗。患者分为两组:A组患者术前5天桥接利伐沙班(10 mg/天),术前1天停止并在术后3天经评估后尽早恢复原剂量抗血栓药物;B组患者术前5天直接停止所有抗血栓药物,术后3天评估后尽早恢复。收集并分析两组患者的技术成功率、活检阳性率、局部控制率、出血和血栓并发症等,以明确利伐沙班作为桥接药物在这些患者治疗中的临床价值。采用欧洲心血管和介入放射学会并发症分类标准记录并发症级别,≥3级定为主要并发症。结果:A组患者58例[男:39例,女:19例;平均年龄±标准差:(71.12±6.46)岁],B组患者80例[男:55例,女:25例;平均年龄±标准差:(70.72±7.33)岁]。两组的技术成功率均为100%。A组和B组活检阳性率分别为94.83%(55/58)和96.25%(77/80)(P=0.4236)。A组和B组1个月、6个月、12个月和24个月的局部控制率分别为100.0%vs 98.75%、96.55%vs 98.75%、96.55%vs 93.75%和89.66%vs 91.25%。两组在围手术期及随访期的主要出血性并发症无统计学差异;术后3天至术后1个月随访时间内,B组的主要血栓性并发症发生率11.25%(9/80)显著高于A组1.72%(1/58)(P=0.0331)。结论:对于长期抗血栓治疗的肺磨玻璃结节患者行同步经皮穿刺活检联合微波消融治疗时,与围手术期直接停止抗凝药物的策略相比,使用利伐沙班作为桥接药物是安全且有效的,并可减少围手术期的主要血栓性并发症的发生。 展开更多
关键词 肺磨玻璃结节 抗血栓治疗 微波消融 活检 安全性 有效性
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不同浸润程度肺腺癌患者应用高分辨CT检测肺内磨玻璃密度结节及胸膜凹陷征和支气管阳性征的临床意义分析
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作者 邹志刚 刘晓辉 邓煜 《当代医学》 2024年第10期117-121,共5页
目的探讨不同浸润程度肺腺癌患者应用高分辨CT(HRCT)检测肺内磨玻璃密度结节(CTGGO)及胸膜凹陷征、支气管阳性征的效果,分析HRCT对不同浸润程度肺腺癌的诊断价值。方法选取2021年7月至2022年7月瑞金市人民医院收治的80例肺腺癌(病理侵袭... 目的探讨不同浸润程度肺腺癌患者应用高分辨CT(HRCT)检测肺内磨玻璃密度结节(CTGGO)及胸膜凹陷征、支气管阳性征的效果,分析HRCT对不同浸润程度肺腺癌的诊断价值。方法选取2021年7月至2022年7月瑞金市人民医院收治的80例肺腺癌(病理侵袭性)患者作为病理侵袭性组,随机选取同期80例肺腺癌(病理非侵袭性)患者作为病理非侵袭性组,所有患者均行HRCT检查。根据2015年WHO制定的《肺腺癌新分类》,将肺腺癌(病理侵袭性)患者分为浸润前病变(PI)、微浸润性腺癌(MIA)和浸润性腺癌(IA)。比较两组与病理侵袭性组不同浸润程度肺腺癌患者CTGGO、胸膜凹陷征、支气管阳性征占比情况及双侧肺部不同大小病灶的检出率。结果病理侵袭性组CTGGO、胸膜凹陷征、支气管阳性征占比均高于病理非侵袭性组(P<0.05)。病理侵袭性组双侧肺部不同大小病灶总检出率为93.75%,病理非侵袭性组为86.25%,两组比较差异无统计学意义。不同浸润程度肺腺癌患者CTGGO及胸膜凹陷征、支气管阳性征占比比较差异有统计学意义(P<0.05);IA患者CTGGO、支气管阳性征均低于PI患者,胸膜凹陷征、支气管阳性征均低于MIA患者,MIA患者CTGGO占比低于PI患者,差异有统计学意义(P<0.05)。病理侵袭性组PI、MIA、IA患者0~5、>5~10、>10~15、>15~20 mm病灶检出率比较差异无统计学意义。结论HRCT征象可应用于不同浸润程度的肺腺癌患者,通过HRCT图像中的CTGGO、胸膜凹陷征和支气管阳性征,进一步诊断肺腺癌。 展开更多
关键词 肺腺癌 高分辨CT 肺内磨玻璃密度结节 胸膜凹陷征 支气管阳性征
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1cm以下磨玻璃密度肺腺癌的CT征象与病理亚型及免疫组织化学的相关性 被引量:43
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作者 吴芳 蔡祖龙 +5 位作者 田树平 金鑫 景瑞 杨越清 李颖娜 赵绍宏 《中国医学科学院学报》 CAS CSCD 北大核心 2015年第2期163-170,共8页
目的探讨1 cm以下局灶性磨玻璃密度(f GGO)肺腺癌的CT征象与病理亚型及免疫组织化学的相关性。方法回顾性分析本院59例经手术病理证实为肺腺癌的最大直径≤1 cm的f GGO患者的CT、病理以及免疫组织化学资料,将CT征象(包括位置、大小、密... 目的探讨1 cm以下局灶性磨玻璃密度(f GGO)肺腺癌的CT征象与病理亚型及免疫组织化学的相关性。方法回顾性分析本院59例经手术病理证实为肺腺癌的最大直径≤1 cm的f GGO患者的CT、病理以及免疫组织化学资料,将CT征象(包括位置、大小、密度、形状、空泡征、空气支气管征、病灶边缘、胸膜凹陷征、瘤肺界面)与病理亚型[不典型腺瘤样增生(AAH)、原位腺癌(AIS)、微浸润性腺癌(MIA)及浸润性腺癌(IPA)]和免疫组织化学结果 [人表皮生长因子受体(HER)-1、HER-2、Ki-67、血管内皮生长因子(VEGF)、拓扑异构酶Ⅱα(Top-Ⅱα)]对照,患者年龄、病变大小、密度与病理亚型比较采用单因素方差分析或秩和检验;患者性别、病变位置、形状、空泡征、空气支气管征、病灶边缘、胸膜凹陷征、瘤肺界面与病理亚型和免疫组织化学结果对照采用卡方检验或Fisher精确检验。结果 CT表现为1 cm以下f GGO的肺腺癌各病理亚型间,性别分布、年龄大小、病变位置、形状、空气支气管征、胸膜凹陷征、瘤肺界面差异无统计学意义(P值分别为0.194、0.126、0.609、0.678、0.091、0.374、0.339),各病理亚型间病变大小、密度、空泡征的有无以及边缘情况差异有统计学意义(P值分别为0.028、0.002、0.003、0.046),Ki-67在不同形状结节间表达程度差异有统计学意义(P=0.015),HER-1在瘤肺界面是否清晰的结节间表达程度差异有统计学意义(P=0.019),HER-2在是否有空泡征的结节间表达程度差异有统计学意义(P=0.049),而CT征象与VEGF和Top-Ⅱα的表达无相关性(P均>0.05)。结论表现为1 cm以下f GGO的肺腺癌中,IPA的空泡征出现率最高,而AAH最低,且浸润前病变(AAH+AIS)多表现为边缘光滑,MIA和IPA则多表现为分叶征+毛刺征;且一些CT征象在特定免疫组织化学结果之间也有相关性。 展开更多
关键词 局灶性磨玻璃密度 肺腺癌 免疫组织化学 病理亚型 计算机断层成像
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胸腔镜治疗肺部微小结节(129例报告) 被引量:25
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作者 王通 闫天生 +7 位作者 万峰 马少华 王可毅 王京弟 宋金涛 贺未 白洁 金亮 《中国肺癌杂志》 CAS CSCD 北大核心 2017年第1期35-40,共6页
背景与目的影像技术的发展导致肺部微小结节尤其是肺磨玻璃结节(ground-glass opacity,GGO)检出逐年增多,但术前定性困难。本研究探讨肺部微小结节的临床诊断及微创手术治疗的必要性和可行性、病理诊断,微创切除及淋巴结切除的手术方式... 背景与目的影像技术的发展导致肺部微小结节尤其是肺磨玻璃结节(ground-glass opacity,GGO)检出逐年增多,但术前定性困难。本研究探讨肺部微小结节的临床诊断及微创手术治疗的必要性和可行性、病理诊断,微创切除及淋巴结切除的手术方式。方法对2013年12月-2016年11月接受电视胸腔镜手术(video-assisted thoracic surgery,VATS)治疗并有明确病理诊断的共129例患者的临床资料回顾性分析。所有患者术前行薄层计算机断层扫描(computed tomography,CT)扫描,其中21个微小结节术前行CT引导下Hook-wire定位,并根据病理性质及患者身体状况采用不同手术方式。结果共129个微小结节,实性结节(solid pulmonary nodule,SPN)37个,恶性比例是24.3%(9/37),术后病理结果为:肺原发性鳞状细胞癌3个,浸润性腺癌(invasive adenocarcioma,IA)3个,转移癌2个,小细胞肺癌(small cell lung cancer,SCLC)1个,错构瘤16个,其他炎症等良性病变12个;49个混合性GGO(mixed ground-glass opacity,m GGO)的恶性比例是63.3%(31/49),术后病理结果为:IA 19个,微浸润腺癌(micro invasive adenocarcioma,MIA)6个,原位腺癌(adenocarcioma in situ,AIS)4个,非典型性腺瘤样增生(atipical adenomatous hyperplasia,AAH)1个,SCLC 1个,炎症等良性病变18个;43个纯GGO(pure ground-glass opacity,p GGO)的恶性比例是86.0%(37/43),术后病理结果为:AIS 19个,MIA 6个,IA 6个,AAH 6个,炎症等良性病变6个;GGO总的恶性比例是73.9%(68/92)。52个良性病变均采用VATS肺楔形切除;原发性非小细胞肺癌(non-small cell lung cancer,NSCLC)共73例,VATS肺叶切除和淋巴结清扫33例,VATS肺楔形切除和选择性淋巴结切除6例,VATS肺段切除和选择性淋巴结切除6例,VATS肺楔形切除28例;2个转移癌和2个SCLC,采用VATS肺楔形切除术。另有6例患者术中冰冻病理存在误差,其中2例选择二次手术行肺叶切除和淋巴结清扫。45例有淋巴结病理结果NSCLC只有两例以SPN为表现的IA出现纵隔淋巴结转移,其余均未出现淋巴结转移。术后随访1个月-35个月,平均(15.1±10.2)个月,无复发及转移。结论肺部微小结节尤其是GGO,是恶性病灶的概率大,应积极外科处理;围手术期应与患者及家属充分告知冰冻病理结果存在误差可能性,避免医疗纠纷。 展开更多
关键词 肺肿瘤 电视胸腔镜手术 肺磨玻璃样结节
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34例肺单纯性磨玻璃样病灶的临床分析 被引量:15
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作者 仲晨曦 谷志涛 +2 位作者 方文涛 茅腾 陈文虎 《上海交通大学学报(医学版)》 CAS CSCD 北大核心 2011年第3期378-380,共3页
目的探讨肺单纯性磨玻璃样病灶(pGGO)临床病理学特征、手术方式及预后。方法收集34例pGGO患者的临床资料,回顾性分析患者的性别构成、吸烟状况、手术方式、病灶大小、肿瘤组织学类型及淋巴结转移和患者预后情况。结果本组女性和不吸烟... 目的探讨肺单纯性磨玻璃样病灶(pGGO)临床病理学特征、手术方式及预后。方法收集34例pGGO患者的临床资料,回顾性分析患者的性别构成、吸烟状况、手术方式、病灶大小、肿瘤组织学类型及淋巴结转移和患者预后情况。结果本组女性和不吸烟患者明显多于男性和吸烟患者(P<0.05,P<0.01)。34例患者中,接受局部切除(楔形切除或肺段切除)19例(电视胸腔镜下手术18例),肺叶切除15例。术后病理学检查显示:非典型腺瘤样增生13例,肺泡细胞癌21例;均无淋巴结转移。肺泡细胞癌病灶直径明显大于非典型腺瘤样增生病灶(P<0.05);局部切除与肺叶切除病灶大小比较差异无统计学意义。术后随访3个月~5年,患者均存活,无肿瘤复发及远处转移。结论 pGGO多发于不吸烟女性。pGGO中多数肺泡细胞癌病灶直径大于非典型腺瘤样增生病灶。电视胸腔镜下局部切除对pGGO的治疗效果良好。 展开更多
关键词 肺肿瘤 单纯性磨玻璃样病灶 手术
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不同病理类型肺部磨玻璃结节的CT鉴别诊断 被引量:19
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作者 马建勇 费锡峰 +1 位作者 高煜 王东 《医学影像学杂志》 2019年第8期1341-1344,共4页
目的 探讨肺部磨玻璃结节CT征象,对于鉴别浸润前病变及浸润性病变的诊断价值。方法 回顾性分析45例表现为肺部磨玻璃结节的患者术前CT图像。根据最终病理结果将病灶分为浸润前病变组和浸润性病变组,盲法阅片对两组病灶位置、形态、病灶... 目的 探讨肺部磨玻璃结节CT征象,对于鉴别浸润前病变及浸润性病变的诊断价值。方法 回顾性分析45例表现为肺部磨玻璃结节的患者术前CT图像。根据最终病理结果将病灶分为浸润前病变组和浸润性病变组,盲法阅片对两组病灶位置、形态、病灶密度、边缘及边界情况、内部实性成分以及三维大小进行对比分析。结果 两组病灶位置分布无明显统计学差异;浸润前病变与浸润性病变病灶形态、密度、边缘及边界情况、内部实性成分及大小均有统计学差异(P<0.05),即浸润前病变多表现为类圆形纯磨玻璃结节,而浸润性病变以不规则型混合磨玻璃结节为主;由浸润前病变到浸润性病变病灶边缘分叶、毛刺、边界毛糙比例逐渐升高;浸润前病变到浸润性病变病灶逐渐增大,且边缘光滑型结节及血管旁型结节体积测量具有更高稳定性。结论 肺部磨玻璃结节CT综合影像学征像有助于术前鉴别浸润前病变和浸润性病变,为术式选择提供参考依据;推荐应用体积测量评估结节大小。 展开更多
关键词 磨玻璃结节 体积 体层摄影术 X线计算机
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表现为磨玻璃结节的肺腺癌薄层CT征象分析及病理分型对照 被引量:13
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作者 顾康琛 田楷 +2 位作者 姚文君 王龙胜 杨进 《安徽医科大学学报》 CAS 北大核心 2021年第10期1675-1678,共4页
探讨薄层CT(TSCT)表现为磨玻璃结节(GGN)的肺腺癌的CT征象,并与病理分型对照。回顾性搜集肺内TSCT发现的83个磨玻璃结节,根据病理结果分为浸润前病变组20个,微浸润腺癌组32个,浸润性腺癌组31个,分析不同病理分型的结节在薄层CT上的表现... 探讨薄层CT(TSCT)表现为磨玻璃结节(GGN)的肺腺癌的CT征象,并与病理分型对照。回顾性搜集肺内TSCT发现的83个磨玻璃结节,根据病理结果分为浸润前病变组20个,微浸润腺癌组32个,浸润性腺癌组31个,分析不同病理分型的结节在薄层CT上的表现。83个结节中,34个表现为纯磨玻璃结节(pGGN),49个表现为混合磨玻璃结节(mGGN)。浸润前病变组共18个结节(18/20,90.0%)表现为pGGN,微浸润腺癌组共16个结节(16/32,50.0%)表现为pGGN,浸润性腺癌组无结节(0/31,0%)表现为pGGN。3组分叶征、空气支气管征、血管集束征、胸膜凹陷征的比例呈上升趋势,圆形/类圆形、瘤肺界面清晰征象的比例呈下降趋势。3组圆形或类圆形、分叶征、瘤肺界面清晰、空气支气管征、血管集束征、胸膜凹陷征的差异有统计学意义(P<0.05)。浸润前病变组与浸润性腺癌组比较,圆形或类圆形、分叶征、瘤肺界面清晰、空气支气管征、血管集束征、胸膜凹陷征差异有统计学意义(P<0.05);微浸润腺癌组与浸润性腺癌组间类圆形、分叶征、瘤肺界面清晰、血管集束征差异有统计学意义(P<0.05)。不同病理分型的GGN在TSCT上的表现具有一定的特异性,熟悉TSCT表现有助于浸润前病变、微浸润腺癌及浸润性腺癌的诊断及鉴别诊断。 展开更多
关键词 肺肿瘤 腺癌 磨玻璃结节 计算机体层摄影
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肺部多发磨玻璃影的外科治疗 被引量:13
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作者 王群 蒋伟 奚俊杰 《中国肺癌杂志》 CAS CSCD 北大核心 2016年第6期355-358,共4页
肺部磨玻璃影(ground glass opacity,GGO)的发病率近年来日益增高,很多患者发现有多发GGO,但多发GGO的诊疗还存在争议。肺部GGO是一种影像学表现,包含了多种病理类型,其中有一部分GGO是早期肺癌。GGO是一种惰性结节,只有少数GGO会发生变... 肺部磨玻璃影(ground glass opacity,GGO)的发病率近年来日益增高,很多患者发现有多发GGO,但多发GGO的诊疗还存在争议。肺部GGO是一种影像学表现,包含了多种病理类型,其中有一部分GGO是早期肺癌。GGO是一种惰性结节,只有少数GGO会发生变化,且随访不会影响外科治疗的效果。多发GGO的手术时机主要由主病灶决定,主病灶中实性成分大于5 mm时建议外科干预。手术方式可以选择肺叶切除或亚肺叶切除,除主病灶以外,其他GGO不必全部切除。具有高危因素的多发GGO需要纵隔淋巴结清扫或采样。 展开更多
关键词 肺肿瘤 肺部磨玻璃影 手术
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含不同实性成分比例磨玻璃密度病灶肺腺癌侵袭性分析 被引量:10
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作者 齐丽萍 张晓鹏 +5 位作者 孙应实 李晓婷 孙宇 唐磊 曹崑 高顺禹 《中国医学影像技术》 CSCD 北大核心 2014年第10期1519-1522,共4页
目的探讨含不同实性成分比例磨玻璃密度病灶(GGO)肺腺癌的侵袭性差异。方法回顾性分析59例含GGO、经手术病理证实为肺腺癌患者的CT及病理资料。分析病灶薄层CT影像征象.根据肿瘤内实性成分最大径与肿瘤最大径比值将患者分为GGO为主组即... 目的探讨含不同实性成分比例磨玻璃密度病灶(GGO)肺腺癌的侵袭性差异。方法回顾性分析59例含GGO、经手术病理证实为肺腺癌患者的CT及病理资料。分析病灶薄层CT影像征象.根据肿瘤内实性成分最大径与肿瘤最大径比值将患者分为GGO为主组即G_G组和实性成分为主组即G_C组,比较两组肿瘤CT征象和侵袭性差异。结果病灶平均直径(2.71±1.08)cm;纯GGO 8例,混杂GGO 51例;43例病灶内见空泡征及含气支气管征(43/51,72.9%),53例病灶边界清晰(53/59,89.83%)。G_C组19例、G_C组40例。CT征象:两组病灶直径、部位、形状及边界是否清晰差异均无统计学意义(P均>0.05);G_C组边缘分叶和(或)毛刺比例、空泡征及胸膜凹陷征比例均明显高于G_G组(P均<0.05)。病理结果:G_C组与G_G组淋巴结转移、脉管癌栓发生率差异均无统计学意义(P均>0.05);G_C组胸膜侵犯率和病理分期高于G_G组(P均<0.05)。结论表现为GGO的肺腺癌随肿瘤实性成分比例增高,出现恶性CT征象比例和肿瘤侵袭性升高。 展开更多
关键词 磨玻璃密度灶 腺癌 肺肿瘤 体层摄影术 x线计算机 病理学
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肺癌伴多发磨玻璃密度结节的多层螺旋CT表现及其临床意义 被引量:20
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作者 肖静 吴玉芬 +2 位作者 徐亮 黄勇 刘聿辉 《中国肺癌杂志》 CAS 北大核心 2012年第11期663-666,共4页
背景与目的部分肺癌患者除原发灶外,还伴多发纯的磨玻璃影(pure ground-glass opacities,pGGO),本研究对pGGO的数目、分布、形态特征进行评估。对没有手术切除的pGGO进行CT随访,观察其变化。方法回顾性分析25例在CT图像上伴有多发pGGO... 背景与目的部分肺癌患者除原发灶外,还伴多发纯的磨玻璃影(pure ground-glass opacities,pGGO),本研究对pGGO的数目、分布、形态特征进行评估。对没有手术切除的pGGO进行CT随访,观察其变化。方法回顾性分析25例在CT图像上伴有多发pGGO的肺癌病例。结果pGGO的数目总共207个,最大直径2mm-31mm。原发灶和pGGO都可出现分叶。183(88.4%)处pGGO边缘清晰或为圆形。87处pGGO中,经外科手术切除17处病变,病理结果为:AAH13例,BAC3例,局灶性纤维化1例。120处随访的pGGO,CT随访的中位时间是61.5个月,113(94.2%)处病变没有变化,1处缩小,6处消失。结论肺癌和pGGO中可以出现在相同和/或不同的叶。大多数pGGO的大小在随访期间没有变化。很多小的病变在病理上诊断为AAH和BAC。这些数据证明外科手术切除原发肿瘤对余下的pGGO的预后没有影响。 展开更多
关键词 肺肿瘤 磨玻璃 非典型腺瘤样增生 细支气管肺泡癌 计算机断层扫描
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磨玻璃密度小肺癌CT表现与病理类型相关性研究 被引量:16
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作者 张善华 陈志军 +4 位作者 王和平 林奇辉 曹捍波 张铁英 王兆宇 《医学影像学杂志》 2009年第8期970-972,共3页
目的:探讨磨玻璃密度(GCO)小肺癌的CT表现与病理类型相关性。方法:搜集43例(45个)表现为纯磨玻璃密度(pGGO)或混合磨玻璃密度(mGGO)的周围型小肺癌,根据GGO占整个病灶比例的不同分三型,分别与病理对照。并有12个小肺癌术前... 目的:探讨磨玻璃密度(GCO)小肺癌的CT表现与病理类型相关性。方法:搜集43例(45个)表现为纯磨玻璃密度(pGGO)或混合磨玻璃密度(mGGO)的周围型小肺癌,根据GGO占整个病灶比例的不同分三型,分别与病理对照。并有12个小肺癌术前行中长期动态观察。结果:I型(GGO成分占91%-100%)11个,病理均为细支气管肺泡癌(BAC);II型(GGO成分占51%。90%)21个,BAC11,BAC伴高分化腺癌4个,高分化腺癌4个,中分化腺癌2个;Ⅲ型(GGO成分占≤50%)13个,BAC3个,中分化腺癌5个,低分化腺癌3个,低分化鳞癌2个;通过三型间比较发现GGO所占比例越高,小肺癌的病理分化越好,GGO成分占≥50%时,病理多数为BAC(22/32);同时对部分小肺癌术前中长期动态观察及术后随访,发现肿瘤生长缓慢、预后良好。结论:局限性GGO不仅是周围型肺癌的重要征象之一,而且通过半定量分析GGO所占比例的多少,能一定程度上预测其病理类型、分化程度、倍增时间及预后。 展开更多
关键词 磨玻璃密度 周围型小肺癌 体层摄影术 X线计算机 病理
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