Objective:The aim of this study was to examine angiotensin converting enzyme(ACE)insertion/deletion,alpha adducin,and interleukin-10(IL-10)gene polymorphisms(GPs)in terms of both idiopathic sudden sensorineural hearin...Objective:The aim of this study was to examine angiotensin converting enzyme(ACE)insertion/deletion,alpha adducin,and interleukin-10(IL-10)gene polymorphisms(GPs)in terms of both idiopathic sudden sensorineural hearing loss(ISSNHL)risk and their potential prognostic effects.Methods:The study group consisted of 70 patients and the control group consisted of 50 patients.Venous blood samples were analyzed for relevant GPs via kompetitive allele-specific polymerase chain reaction.Age,sex,affected side,tinnitus,and vertiginous symptom status,number of days between symptom onset and hospital admission,pure tone audiometry results at admission and after treatment were included in the study.Data were compared statistically.Results:The D allele of ACE insertion/deletion GP was significantly more frequent in patients with ISSNHL than in the control group(p=0.032).II genotype was associated with a reduced risk of ISSNHL(p=0.036).The amount of hearing loss was significantly higher in patients with the TT genotype(p=0.027)and T allele of the IL-10 GP(p=0.035)than in the patients without this allele.Severe hearing loss was a poor prognostic factor(p=0.008).Conclusions:The D allele of ACE insertion/deletion GP may be involved in the ISSNHL etiology.Due to the association of this allele with occlusive vascular pathologies,ischemia is believed to be a common pathway in the etiopathogenesis of ISSNHL.展开更多
AIM: To assess the association between Interleu-kin-10 (IL-10) gene IL-10-1082 (G/A), IL-10-592(C/A), IL-10-819 (T/C) polymorphisms and hepatocellular carcinoma (HCC) susceptibility.METHODS: Two investigators independ...AIM: To assess the association between Interleu-kin-10 (IL-10) gene IL-10-1082 (G/A), IL-10-592(C/A), IL-10-819 (T/C) polymorphisms and hepatocellular carcinoma (HCC) susceptibility.METHODS: Two investigators independently searched the Medline, Embase, China National Knowledge Infrastructure, and Chinese Biomedicine Database. Summary odds ratios (ORs) and 95% conf idence intervals (95% CIs) for IL-10 polymorphisms and HCC were cal-culated in a fixed-effects model (the Mantel-Haenszel method) and a random-effects model (the DerSimonian and Laird method) when appropriate. RESULTS: This meta analysis included seven eligiblestudies, which included 1012 HCC cases and 2308 controls. Overall, IL-10-1082 G/A polymorphism was not associated with the risk of HCC (AA vs AG + GG, OR = 1.11, 95% CI = 0.90-1.37). When stratifying for ethnicity, the results were similar (Asian, OR = 1.12, 95% CI = 0.87-1.44; non-Asian, OR = 1.10, 95% CI = 0.75-1.60). In the overall analysis, the IL-10 polymorphism at position -592 (C/A) was identified as a genetic risk factor for HCC among Asians; patients carrying the IL-10-592*C allele had an increased risk of HCC (OR = 1.29, 95% CI = 1.12-1.49). No association was observed between the IL-10-819 T/C polymorphism and HCC susceptibility (TT vs TC + CC, OR = 1.02, 95% CI = 0.79-1.32).CONCLUSION: This meta-analysis suggests that IL-10-592 A/C polymorphism may be associated with HCC among Asians. IL-10-1082 G/A and IL-10-819 T/C polymorphisms were not detected to be related to the risk for HCC.展开更多
AIM:To clarify the current understanding of the association between interleukin-10(IL-10)polymorphisms and the risk of irritable bowel syndrome(IBS).METHODS:We searched for studies in any language recorded in PubMed,E...AIM:To clarify the current understanding of the association between interleukin-10(IL-10)polymorphisms and the risk of irritable bowel syndrome(IBS).METHODS:We searched for studies in any language recorded in PubMed,Embase and Cochrane library before August 2013.The associations under allele contrast model,codominant model,dominant model,and recessive model were analyzed.The strengths of the association between IL-10 polymorphisms and IBS risk were estimated using odds ratios(OR)with 95%confidence interval(CI).Fixed effects model was used to pool the result if the test of heterogeneity was not significant,otherwise the random-effect model was selected.RESULTS:Eight case-control studies analyzing three single-nucleotide polymorphisms rs1800870(-1082 A/G),rs1800871(-819C/T),and rs1800872(-592A/C)of the IL-10 gene,which involved 928 cases and 1363 controls,were eligible for our analysis.The results showed that rs1800870 polymorphisms were associated with a decreased risk of IBS(GG+GA vs AA:OR=0.80,95%CI:0.66-0.96),(AA+GA vs GG:OR=0.68,95%CI:0.52-0.90).Subgroup analysis revealed such association only existed in Caucasian ethnicity(AA+GA vs GG,OR=0.70,95%CI:0.55-0.89).The rs1800872 polymorphisms were associated with an increased risk of IBS in Asian ethnicity(CC vs GG:OR=1.29,95%CI:1.01-1.16).There were no associations between rs1800871 polymorphisms and the IBS risk.CONCLUSION:The results suggest that IL-10 rs1800870confers susceptibility to the risk of IBS in Caucasian ethnicity,and the rs1800872 may associate with IBS risk in Asians.However,no significant associations are found between rs1800871 and IBS risk.展开更多
目的评价白介素-10（IL-10）基因启动子区域592（A／C）及-1082（A／G）位点多态性与系统性红斑狼疮（SLE）的关系。方法通过电子检索PubMed、EMBASE、Cochrane Central Register of Controlled Trials、中国知网（CNKI）、中国生物医...目的评价白介素-10（IL-10）基因启动子区域592（A／C）及-1082（A／G）位点多态性与系统性红斑狼疮（SLE）的关系。方法通过电子检索PubMed、EMBASE、Cochrane Central Register of Controlled Trials、中国知网（CNKI）、中国生物医学文献数据库（CBMD）、维普等常用的中外文数据库，采用主题词结合自由词的检索方法，检索时间从建库至2013-04—15。对检索到的文献进行筛选后，利用Meta分析（荟萃分析）对IL-10基因启动子区域592（A／C）、-1082（A／G）位点基因多态性与SLE发病风险之间的关联进行分析，使用基因频率对比、显性及隐性等遗传模式，对比两位点基因型或等位基因频率分布在病例组与对照组间的差异。用Stata 11．0软件进行Meta分析。结果本研究共纳入该两位点合格文献10篇，其中6篇文献同时涉及两个位点。在文献研究和资料检索中未发现两个位点有连锁不平衡现象，按照独立的基因多态性位点进行分析。其中-592（A／C）位点纳入文献8篇，Meta分析的结果显示，在总人群中，3种模型下差异均无统计学意义；对人群按照人种进行亚组分析后发现，欧洲人群A／C等位基因频率分布（OR=1．21，95％CI=1．011～1．456，P=0．040）及显性模型下（OR=2．53，95％CI=1．642～3．904，P〈0．01）分布的差异有统计学意义；而亚裔人群中3种模型差异均有统计学意义（Aus C：OR=0．84，95％CI=0．739～0．962，P〈0．01；隐性：OR=0．56，95％CI=0．472～0．662，P〈0．01；显性：OR=0．65，95％CI=0．481～0．870，P〈O．01），且在欧裔中A等位基因相对C为危险因素，在亚洲人群中则是保护因素。另外，-1082（A／G）位点纳入文献8篇，Meta分析的结果显示，总人群的3个模型下差异均无统计学意义且有较大的异质性；因此按人群亚组分析后，欧裔人群中A／C等位基因在两组中的分布差异有统计学意义（OR=1．30，95％CI=1．101～1．547，P〈0．01）；亚裔人群中显性模型（OR=0.35，95％CI=0．199-0．607，P〈0．01）下差异有统计学意义。结论IL-10启动子区域的-592（A／C）、-1082（A／G）位点多态性可能与SLE的易感性相关，但是有种族人群的差异。展开更多
基金supported by The Coordinatorship of Scientific Research Projects Department,Süleyman Demirel University(Grant Number:TTU-2021-8402).
文摘Objective:The aim of this study was to examine angiotensin converting enzyme(ACE)insertion/deletion,alpha adducin,and interleukin-10(IL-10)gene polymorphisms(GPs)in terms of both idiopathic sudden sensorineural hearing loss(ISSNHL)risk and their potential prognostic effects.Methods:The study group consisted of 70 patients and the control group consisted of 50 patients.Venous blood samples were analyzed for relevant GPs via kompetitive allele-specific polymerase chain reaction.Age,sex,affected side,tinnitus,and vertiginous symptom status,number of days between symptom onset and hospital admission,pure tone audiometry results at admission and after treatment were included in the study.Data were compared statistically.Results:The D allele of ACE insertion/deletion GP was significantly more frequent in patients with ISSNHL than in the control group(p=0.032).II genotype was associated with a reduced risk of ISSNHL(p=0.036).The amount of hearing loss was significantly higher in patients with the TT genotype(p=0.027)and T allele of the IL-10 GP(p=0.035)than in the patients without this allele.Severe hearing loss was a poor prognostic factor(p=0.008).Conclusions:The D allele of ACE insertion/deletion GP may be involved in the ISSNHL etiology.Due to the association of this allele with occlusive vascular pathologies,ischemia is believed to be a common pathway in the etiopathogenesis of ISSNHL.
基金Supported by The National Natural Science foundation of China, No. 30901720
文摘AIM: To assess the association between Interleu-kin-10 (IL-10) gene IL-10-1082 (G/A), IL-10-592(C/A), IL-10-819 (T/C) polymorphisms and hepatocellular carcinoma (HCC) susceptibility.METHODS: Two investigators independently searched the Medline, Embase, China National Knowledge Infrastructure, and Chinese Biomedicine Database. Summary odds ratios (ORs) and 95% conf idence intervals (95% CIs) for IL-10 polymorphisms and HCC were cal-culated in a fixed-effects model (the Mantel-Haenszel method) and a random-effects model (the DerSimonian and Laird method) when appropriate. RESULTS: This meta analysis included seven eligiblestudies, which included 1012 HCC cases and 2308 controls. Overall, IL-10-1082 G/A polymorphism was not associated with the risk of HCC (AA vs AG + GG, OR = 1.11, 95% CI = 0.90-1.37). When stratifying for ethnicity, the results were similar (Asian, OR = 1.12, 95% CI = 0.87-1.44; non-Asian, OR = 1.10, 95% CI = 0.75-1.60). In the overall analysis, the IL-10 polymorphism at position -592 (C/A) was identified as a genetic risk factor for HCC among Asians; patients carrying the IL-10-592*C allele had an increased risk of HCC (OR = 1.29, 95% CI = 1.12-1.49). No association was observed between the IL-10-819 T/C polymorphism and HCC susceptibility (TT vs TC + CC, OR = 1.02, 95% CI = 0.79-1.32).CONCLUSION: This meta-analysis suggests that IL-10-592 A/C polymorphism may be associated with HCC among Asians. IL-10-1082 G/A and IL-10-819 T/C polymorphisms were not detected to be related to the risk for HCC.
基金Supported by National Natural Science Foundation of China,No.81260083 and No.31360221
文摘AIM:To clarify the current understanding of the association between interleukin-10(IL-10)polymorphisms and the risk of irritable bowel syndrome(IBS).METHODS:We searched for studies in any language recorded in PubMed,Embase and Cochrane library before August 2013.The associations under allele contrast model,codominant model,dominant model,and recessive model were analyzed.The strengths of the association between IL-10 polymorphisms and IBS risk were estimated using odds ratios(OR)with 95%confidence interval(CI).Fixed effects model was used to pool the result if the test of heterogeneity was not significant,otherwise the random-effect model was selected.RESULTS:Eight case-control studies analyzing three single-nucleotide polymorphisms rs1800870(-1082 A/G),rs1800871(-819C/T),and rs1800872(-592A/C)of the IL-10 gene,which involved 928 cases and 1363 controls,were eligible for our analysis.The results showed that rs1800870 polymorphisms were associated with a decreased risk of IBS(GG+GA vs AA:OR=0.80,95%CI:0.66-0.96),(AA+GA vs GG:OR=0.68,95%CI:0.52-0.90).Subgroup analysis revealed such association only existed in Caucasian ethnicity(AA+GA vs GG,OR=0.70,95%CI:0.55-0.89).The rs1800872 polymorphisms were associated with an increased risk of IBS in Asian ethnicity(CC vs GG:OR=1.29,95%CI:1.01-1.16).There were no associations between rs1800871 polymorphisms and the IBS risk.CONCLUSION:The results suggest that IL-10 rs1800870confers susceptibility to the risk of IBS in Caucasian ethnicity,and the rs1800872 may associate with IBS risk in Asians.However,no significant associations are found between rs1800871 and IBS risk.
文摘目的评价白介素-10（IL-10）基因启动子区域592（A／C）及-1082（A／G）位点多态性与系统性红斑狼疮（SLE）的关系。方法通过电子检索PubMed、EMBASE、Cochrane Central Register of Controlled Trials、中国知网（CNKI）、中国生物医学文献数据库（CBMD）、维普等常用的中外文数据库，采用主题词结合自由词的检索方法，检索时间从建库至2013-04—15。对检索到的文献进行筛选后，利用Meta分析（荟萃分析）对IL-10基因启动子区域592（A／C）、-1082（A／G）位点基因多态性与SLE发病风险之间的关联进行分析，使用基因频率对比、显性及隐性等遗传模式，对比两位点基因型或等位基因频率分布在病例组与对照组间的差异。用Stata 11．0软件进行Meta分析。结果本研究共纳入该两位点合格文献10篇，其中6篇文献同时涉及两个位点。在文献研究和资料检索中未发现两个位点有连锁不平衡现象，按照独立的基因多态性位点进行分析。其中-592（A／C）位点纳入文献8篇，Meta分析的结果显示，在总人群中，3种模型下差异均无统计学意义；对人群按照人种进行亚组分析后发现，欧洲人群A／C等位基因频率分布（OR=1．21，95％CI=1．011～1．456，P=0．040）及显性模型下（OR=2．53，95％CI=1．642～3．904，P〈0．01）分布的差异有统计学意义；而亚裔人群中3种模型差异均有统计学意义（Aus C：OR=0．84，95％CI=0．739～0．962，P〈0．01；隐性：OR=0．56，95％CI=0．472～0．662，P〈0．01；显性：OR=0．65，95％CI=0．481～0．870，P〈O．01），且在欧裔中A等位基因相对C为危险因素，在亚洲人群中则是保护因素。另外，-1082（A／G）位点纳入文献8篇，Meta分析的结果显示，总人群的3个模型下差异均无统计学意义且有较大的异质性；因此按人群亚组分析后，欧裔人群中A／C等位基因在两组中的分布差异有统计学意义（OR=1．30，95％CI=1．101～1．547，P〈0．01）；亚裔人群中显性模型（OR=0.35，95％CI=0．199-0．607，P〈0．01）下差异有统计学意义。结论IL-10启动子区域的-592（A／C）、-1082（A／G）位点多态性可能与SLE的易感性相关，但是有种族人群的差异。
